Search NASA⌕ Search

SEARCH · Search NASA

Results for “Well clear”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20

Energetics and structural properties of twist grain boundaries in Cu

Structural and energetics properties of atoms near a grain boundary are of great importance from theoretical and experimental standpoints. From various experimental work it is concluded that diffusion at low temperatures at polycrystalline materials take place near grain boundary. Experimental and theoretical results also indicate changes of up to 70 percent in physical properties near a grain boundary. The Embedded Atom Method (EAM) calculations on structural properties of Au twist grain boundaries are in quite good agreement with their experimental counterparts. The EAM is believed to predict reliable values for the single vacancy formation energy as well as migration energy. However, it is not clear whether the EAM functions which are fitted to the bulk properties of a perfect crystalline solid can produce reliable results on grain boundaries. One of the objectives of this work is to construct the EAM functions for Cu and use them in conjunction with the molecular static simulation to study structures and energetics of atoms near twist grain boundaries in Cu. This provides tests of the EAM functions near a grain boundary. In particular, we determine structure, single vacancy formation energy, migration energy, single vacancy activation energy, and interlayer spacing as a function of distance from grain boundary. Our results are compared with the available experimental and theoretical results from grain boundaries and bulk.

Karimi, Majid↗

Space and time aliasing structure is monthly mean polar-orbiting satellite data

Monthly mean wind fields from the European Remote Sensing Satellite (ERS1) scatterometer are presented. A banded structure which resembles the satellite subtrack is clearly and consistently apparent in the isotachs as well as the u and v components of the routinely produced fields. The structure also appears in the means of data from other polar-orbiting satellites and instruments. An experiment is designed to trace the cause of the banded structure. The European Centre for Medium-Range Weather Forecast (ECMWF) gridded surface wind analyses are used as a control set. These analyses are also sampled with the ERS1 temporal-spatial samplig pattern to form a simulated scatterometer wind set. Both sets are used to create monthly averages. The banded structures appear in the monthly mean simulated data but do not appear in the control set. It is concluded that the source of the banded structure lies in the spatial and temporal sampling of the polar-orbiting satellite which results in undersampling. The problem involves multiple timescales and space scales, oversampling and under-sampling in space, aliasing in the time and space domains, and preferentially sampled variability. It is shown that commonly used spatial smoothers (or filters), while producing visually pleasing results, also significantly bias the true mean. A three-dimensional spatial-temporal interpolator is designed and used to determine the mean field. It is found to produce satisfactory monthly means from both simulated and real ERS1 data. The implications to climate studies involving polar-orbiting satellite data are discussed.

Zeng, Lixin↗

Sputtering Erosion in Ion and Plasma Thrusters

Low energy sputtering of molybdenum, tantalum and boron nitride with xenon ions are being studied using secondary neutral and secondary ion mass spectrometry (SNMS/SIMS). An ultrahigh vacuum chamber was used to conduct the experiment at a base pressure of 1x10(exp -9) torr. The primary ion beam is generated by an ion gun which is capable of delivering ion currents in the range of 20 to 500 nA. The ion beam can be focused to a spot size of approximately 1 mm in diameter. The mass spectrometer is positioned 10 mm from the target and 90 deg to the primary ion beam direction. SNMS and SIMS spectra were collected at various incident angles and different ion energies. For boron nitride sputtering, the target was flooded with an electron beam to neutralize the charge buildup on the surface. In the SNMS mode, sputtering of Mo and Ta can be detected at an ion energy as low as 100 eV whereas in boron nitride the same was observed up to an energy of 300 eV. However, in the positive-SIMS mode, the sputtering of Mo was observed at 10 eV incident ion energy. The SIMS spectra obtained for boron nitride clearly identifies the two isotopes of boron as well as cluster ions such as B2(sup +) and molecular ions such as BN(sup +). From the angle versus yields measurements, it was found that the maximum SNMS yield shifts towards lower incident angles at low ion energies for all three samples.

Ray, Pradosh K.↗

Free Volume in Glassy Poly(arylene Ether Ketone)s

Amorphous polyarylene ether ketones were examined in the glassy state by positron annihilation lifetime spectroscopy ( PALS ) and in the melt by standard rheological techniques. Specimens were well-characterized fractions of two isomeric structures. PALS clearly shows that the polymer with meta linkages in its backbone contains larger voids (greater than 0.25 nm radius). Thus despite their similar bulk densities, the two materials must pack very differently on a local scale. On the other hand, the free volumes inferred from the WLF treatment of melt viscosity data are practically identical in both materials ca. 4% at T(sub g). The comparison between techniques sheds some light on the distribution of free volume.

Hinkley, J. A.↗

Reconstruction of the 1994 Pittsburgh Airplane Accident Using a Computer Simulation

On September 8, 1994, a Boeing 737-300 passenger airplane was on a downwind approach to the Pittsburgh International Airport at an altitude of 5000 feet above ground level (6000 feet MSL). While in a shallow left turn onto a downwind approach heading, the airplane crossed into the vortex trail of a Boeing 727 flying in the same approach pattern about 4 miles ahead. The B-737 airplane rolled and turned sharply to the left, exited the vortex wake and plunged into the ground. Weather was not a factor in the accident. The airplane was equipped with a 11+ channel digital Flight Data Recorder (FDR) and a multiple channel Cockpit Voice Recorder (CVR). Both recorders were recovered from the crash site and provided excellent data for the development of an accident scenario. Radar tracking of the two airplanes as well as the indicated air speed (IAS) perturbations clearly visible on the B-737 FDR recordings indicate that the upset was apparently initiated by the airplane's crossing into the wake of the B-727 flying ahead in the same traffic pattern. A 6 degree-of-freedom simulation program for the B-737 airplane using MATLAB and SIMULINK was constructed. The simulation was initialized at the stabilized flight conditions of the airplane about 13 seconds prior to its entry into the vortex trail of the B-727 airplane. By assuming a certain combination of control inputs, it was possible to produce a simulated motion that closely matched that recorded on the FDR.

Parks, Edwin K.↗

Spinoff 2005

Topics covered include: Lighting the Way for Quicker, Safer Healing; Discovering New Drugs on the Cellular Level; Hydrogen Sensors Boost Hybrids; Today s Models Losing Gas?; 3-D Highway in the Sky; Popping a Hole in High-Speed Pursuits; Monitoring Wake Vortices for More Efficient Airports; From Rockets to Racecars; All-Terrain Intelligent Robot Braves Battlefront to Save Lives; Keeping the Air Clean and Safe--An Anthrax Smoke Detector; Lightning Often Strikes Twice; Technology That's Ready and Able to Inspect Those Cables; Secure Networks for First Responders and Special Forces; Space Suit Spins; Cooking Dinner at Home--From the Office; Nanoscale Materials Make for Large-Scale Applications; NASA s Growing Commitment: The Space Garden; Bringing Thunder and Lightning Indoors; Forty-Year-Old Foam Springs Back With New Benefits; Experiments With Small Animals Rarely Go This Well; NASA, the Fisherman's Friend; Crystal-Clear Communication a Sweet-Sounding Success; Inertial Motion-Tracking Technology for Virtual 3-D; Then Why Do They Call Earth the Blue Planet?; Valiant 'Zero-Valent' Effort Restores Contaminated Grounds; Harnessing the Power of the Sun; Water and Air Measures That Make 'PureSense'; Remote Sensing for Farmers and Flood Watching; Pesticide-Free Device a Fatal Attraction for Mosquitoes Making the Most of Waste Energy Washing Away the Worries About Germs Celestial Software Scratches More Than the Surface A Search Engine That's Aware of Your Needs Fault-Detection Tool Has Companies 'Mining' Own Business; Software to Manage the Unmanageable; Tracking Electromagnetic Energy With SQUIDs; Taking the Risk Out of Risk Assessment; Satellite and Ground System Solutions at Your Fingertips; Structural Analysis Made 'NESSUSary'; Software of Seismic Proportions Promotes Enjoyable Learning; Making a Reliable Actuator Faster and More Affordable; Cost-Cutting Powdered Lubricant NASA s Radio Frequency Bolt Monitor: A Lifetime of Spinoffs Going End to End to Deliver High-Speed Data; Advanced Joining Technology: Simple, Strong, and Secure; Big Results From a Smaller Gearbox; Low-Pressure Generator Makes Cleanrooms Cleaner; and The Space Laser Business Model.

Source record↗

Avoiding Human Error in Mission Operations: Cassini Flight Experience

Operating spacecraft is a never-ending challenge and the risk of human error is ever- present. Many missions have been significantly affected by human error on the part of ground controllers. The Cassini mission at Saturn has not been immune to human error, but Cassini operations engineers use tools and follow processes that find and correct most human errors before they reach the spacecraft. What is needed are skilled engineers with good technical knowledge, good interpersonal communications, quality ground software, regular peer reviews, up-to-date procedures, as well as careful attention to detail and the discipline to test and verify all commands that will be sent to the spacecraft. Two areas of special concern are changes to flight software and response to in-flight anomalies. The Cassini team has a lot of practical experience in all these areas and they have found that well-trained engineers with good tools who follow clear procedures can catch most errors before they get into command sequences to be sent to the spacecraft. Finally, having a robust and fault-tolerant spacecraft that allows ground controllers excellent visibility of its condition is the most important way to ensure human error does not compromise the mission.

guidance and control↗

Could Road Constructions Be More Hazardous Than an Earthquake in Terms of Mass Movement?

Roads can have a significant impact on the frequency of mass wasting events in mountainous areas. However, characterizing the extent and pervasiveness of mass movements over time has rarely been documented due to limitations in available data sources to consistently map such events. We monitored the evolution of a road network and assessed its effect on mass movements for a 11-year window in Arhavi, Turkey. The main road construction projects run in the area are associated with a hydroelectric power plant as well as other road extension works and are clearly associated with the vast majority (90.1%) of mass movements in the area. We also notice that the overall number and size of the mass movements are much larger than in the naturally-occurring comparison area. This means that the sediment load originating from the anthropogenically induced mass movements is larger than its counterpart associated with naturally occurred landslides. Notably, this extra sediment load could cause river channel aggregation, reduce accommodation space and as a consequence, it could lead to an increase in the probability and severity of flooding along the river channel. This marks a strong and negative effect of human activities on the natural course of earth surface processes. We also compare frequency-area distributions of human-induced mass movements mapped in this study and co-seismic landslide inventories from the literature. By doing so, we aim to better understand the consequences of human effects on mass movements in a comparative manner. Our findings show that the damage generated by the road construction in terms of sediment loads to river channels is compatible with the possible effect of a theoretical earthquake with a magnitude greater than Mw=6.0.

Hakan Tanyas↗

Defining the upper boundary of the Asian Tropopause Aerosol Layer (ATAL) using the static stability

The Asian Tropopause Aerosol Layer (ATAL) is located in the Upper Troposphere and Lower Stratosphere (UTLS) during the Asian Summer Monsoon. However, what dynamical feature separates the ATAL from the well-known stratospheric ‘Junge layer’ is not yet clear. In this study, using the in-situ (Radiosonde, Ozonesonde, backscatter sonde and cryogenic frost-point hygrometer) observations from multiple locations in India (Gadanki (13.45° N, 79.18° E), Hyderabad (17.47° N, 78.58° E) and Varanasi (25.27° N, 82.99° E)) and multi-satellite observations ((Cloud-Aerosol Lidar and Infrared Pathfinder Observation, (CALIPSO), Atmospheric Chemistry Experiment (ACE) Fourier Transform Spectrometer (FTS) and Constellation Observation System for Meteorology, Ionosphere and Climate (COSMIC) Global Position System (GPS) Radio Occultation (RO) (COSMIC GPS-RO)) we show that the ATAL can exist up to the layer of maximum stability (LmaxS), located a few kilometers above the tropopause, determined using the square of Brunt Väisäla frequency. These in-situ observations over Indian stations collected during the ISRO-NASA Balloon Measurement Campaigns of the Asian Tropopause Aerosol Layer (BATAL) show that the ATAL top can reach up to ∼442 K potential temperature level over the Indian region. The LmaxS delineated from COSMIC GPSRO observations over the Asian Summer Monsoon Anticyclone (ASMA) region indicates that the top of ATAL can reach up to 454 K potential temperature level, which is lower than the earlier Lagrangian transport model predicted 460 K. The temperature inversion at LmaxS acts as a lid and constrains the direct transport of aerosols to higher altitudes.

S.T. Akhil Raj↗

Automation of Vulnerability and Patch Management: Information Extraction, Association, and Optimization

Vulnerability and patch management is an integral part of a robust cybersecurity program, yet it grows increasingly complex due to the sheer amount of data that must be analyzed. Particularly in Operational Technology (OT) environments, analysis must be done manually because of the lack of automated solutions. Additionally, there are many steps in this process, from the initial discovery of the vulnerability to the implementation of its remediation, and each step in the process requires different data in order to be performed effectively. In this work, we provide approaches and strategies to assist operators in industrial or OT environments throughout the vulnerability management cycle. Security advisories provide key information about mitigation strategies, or actions that can be taken when a patch is unavailable or cannot be installed. Details of these strategies are not shared in public vulnerability databases and must be found manually. We approach this problem by designing a solution to automatically identify that information within vendor security advisories and retrieve it for operator use. We start with an approach that requires domain-specific knowledge of certain frequently-seen reference websites. Next, an approach that can work on an arbitrary website but relies on certain keywords. Finally, an approach that uses Natural Language Processing (NLP) methods and does not require specific knowledge or keywords. Each of these approaches is more general than its predecessor; we demonstrate high accuracy for all approaches Advisories also often contain details of affected products in non-standard or natural language formats. While this information can be easily understood when read by an operator, the non-standard format acts as a barrier to effective automation. We provide an approach for the first step in this process: identifying vendors in security advisories and mapping them to a standard framework for representing digital assets and software products. We evaluate five established string similarity algorithms, plus one of our own design that combines string similarity and information theory, on the task of mapping vendors to their corresponding entries in the Common Platform Enumeration (CPE) repository. Our results show that our proposed metric outperforms all others. Due to the constraints on time, finances, and personnel for organizations, Large Language Models (LLMs) may seem like attractive opportunities for security operators to speed up information gathering; however, it is still not clear whether LLMs can handle vulnerability management tasks well. To answer this question, we perform an empirical study of LLMs’ ability to provide consistent, accurate information about vulnerabilities in order to guide organizations in their adoption of LLMs. We observe poor performance for all models tested, suggesting that these models are not well-suited to the consistent retrieval of accurate vulnerability information. Finally, once vulnerabilities have been identified and any additional information has been obtained, operators must decide which remediation actions to implement based on their available resources. This already-complex problem becomes even more so when we consider that a vulnerability may have multiple avenues for remediation. We formulate this scenario as two knapsack problems and provide solutions, which we then compare against several existing strategies for vulnerability prioritization seen in real operational environments.

McClanahan, Kylie↗

Software for Automation of Real-Time Agents, Version 2

Version 2 of Closed Loop Execution and Recovery (CLEaR) has been developed. CLEaR is an artificial intelligence computer program for use in planning and execution of actions of autonomous agents, including, for example, Deep Space Network (DSN) antenna ground stations, robotic exploratory ground vehicles (rovers), robotic aircraft (UAVs), and robotic spacecraft. CLEaR automates the generation and execution of command sequences, monitoring the sequence execution, and modifying the command sequence in response to execution deviations and failures as well as new goals for the agent to achieve. The development of CLEaR has focused on the unification of planning and execution to increase the ability of the autonomous agent to perform under tight resource and time constraints coupled with uncertainty in how much of resources and time will be required to perform a task. This unification is realized by extending the traditional three-tier robotic control architecture by increasing the interaction between the software components that perform deliberation and reactive functions. The increase in interaction reduces the need to replan, enables earlier detection of the need to replan, and enables replanning to occur before an agent enters a state of failure.

Fisher, Forest↗

Limit on Supernova Emission in the Brightest Gamma-Ray Burst, GRB 221009A

We present photometric and spectroscopic observations of the extraordinary gamma-ray burst (GRB) 221009A in search of an associated supernova. Some past GRBs have shown bumps in the optical light curve that coincide with the emergence of supernova spectral features, but we do not detect any significant light-curve features in GRB 221009A, nor do we detect any clear sign of supernova spectral features. Using two well-studied GRB-associated supernovae (SN 2013dx, M r,max =-19.54;$ SN 2016jca, M r,max =-19.04$) at a similar redshift as GRB 221009A (z = 0.151), we modeled how the emergence of a supernova would affect the light curve. If we assume the GRB afterglow to decay at the same rate as the X-ray data, the combination of afterglow and a supernova component is fainter than the observed GRB brightness. For the case where we assume the best-fit power law to the optical data as the GRB afterglow component, a supernova contribution should have created a clear bump in the light curve, assuming only extinction from the Milky Way. If we assume a higher extinction of E(B - V) = 1.74 mag (as has been suggested elsewhere), the supernova contribution would have been hard to detect, with a limit on the associated supernova of M r,max ≈ -$19.54. We do not observe any clear supernova features in our spectra, which were taken around the time of expected maximum light. The lack of a bright supernova associated with GRB 221009A may indicate that the energy from the explosion is mostly concentrated in the jet, leaving a lower energy budget available for the supernova.

79 ASTRONOMY AND ASTROPHYSICS↗

Common Bolted Joint Analysis Tool

Common Bolted Joint Analysis Tool (comBAT) is an Excel/VB-based bolted joint analysis/optimization program that lays out a systematic foundation for an inexperienced or seasoned analyst to determine fastener size, material, and assembly torque for a given design. Analysts are able to perform numerous what-if scenarios within minutes to arrive at an optimal solution. The program evaluates input design parameters, performs joint assembly checks, and steps through numerous calculations to arrive at several key margins of safety for each member in a joint. It also checks for joint gapping, provides fatigue calculations, and generates joint diagrams for a visual reference. Optimum fastener size and material, as well as correct torque, can then be provided. Analysis methodology, equations, and guidelines are provided throughout the solution sequence so that this program does not become a "black box:" for the analyst. There are built-in databases that reduce the legwork required by the analyst. Each step is clearly identified and results are provided in number format, as well as color-coded spelled-out words to draw user attention. The three key features of the software are robust technical content, innovative and user friendly I/O, and a large database. The program addresses every aspect of bolted joint analysis and proves to be an instructional tool at the same time. It saves analysis time, has intelligent messaging features, and catches operator errors in real time.

Imtiaz, Kauser↗

A Mid-Infrared Imaging Survey of Embedded Young Stellar Objects in the (rho) Ophiuchi Cloud Core

Results of a comprehensive, new, ground-based mid-infrared imaging survey of the young stellar population of the (rho) Ophiuchi cloud are presented. Data were acquired at the Palomar 5m and at the Keck 10m telescopes with the MIRLIN and LWS instruments, at 0'.5 and 0'.25 resolutions, respectively. Of 172 survey objects, 85 were detected. Among the 22 multiple systems observed, 15 were resolved and their individual component fluxes determined. A plot of the frequency distribution of the detected objects with SED spectral slope shows that YSOs spend approx.4 x 10(exp 5) yr in the flat-spectrum phase, clearing out their remnant infall envelopes. Mid-infrared variability is found among a significant fraction of the surveyed objects and is found to occur for all SED classes with optically thick disks. Large-amplitude near-infrared variability, also found for all SED classes with optically thick disks, seems to occur with somewhat higher frequency at the earlier evolutionary stages. Although a general trend of mid-infrared excess and near-infrared veiling exists progressing through SED classes, with Class I objects generally exhibiting r(sub K) >= 1, flat-spectrum objects with r(sub K) >= 0.58, and Class III objects with r(sub K) =0, Class II objects exhibit the widest range of r(sub K) values, ranging from 0 <= r(sub K) <= 4.5. However, the highly variable value of veiling that a single source can exhibit in any of the SED classes in which active disk accretion can take place is striking and is direct observational evidence for highly time-variable accretion activity in disks. Finally, by comparing mid-infrared versus near-infrared excesses in a subsample with well-determined effective temperatures and extinction values, disk-clearing mechanisms are explored. The results are consistent with disk clearing proceeding from the inside out.

planetary systems↗

Seasonal to Decadal Variations of Water Vapor in the Tropical Lower Stratosphere Observed with Balloon-Borne Cryogenic Frost Point Hygrometers

We investigated water vapor variations in the tropical lower stratosphere on seasonal, quasi-biennial oscillation (QBO), and decadal time scales using balloon-borne cryogenic frost point hygrometer data taken between 1993 and 2009 during various campaigns including the Central Equatorial Pacific Experiment (March 1993), campaigns once or twice annually during the Soundings of Ozone and Water in the Equatorial Region (SOWER) project in the eastern Pacific (1998-2003) and in the western Pacific and Southeast Asia (2001-2009), and the Ticosonde campaigns and regular sounding at Costa Rica (2005-2009). Quasi-regular sounding data taken at Costa Rica clearly show the tape recorder signal. The observed ascent rates agree well with the ones from the Halogen Occultation Experiment (HALOE) satellite sensor. Average profiles from the recent five SOWER campaigns in the equatorial western, Pacific in northern winter and from the three Ticosonde campaigns at Costa Rica (10degN) in northern summer clearly show two effects of the QBO. One is the vertical displacement of water vapor profiles associated with the QBO meridional circulation anomalies, and the other is the concentration variations associated with the QBO tropopause temperature variations. Time series of cryogenic frost point hygrometer data averaged in a lower stratospheric layer together with HALOE and Aura Microwave Limb Sounder data show the existence of decadal variations: The mixing ratios were higher and increasing in the 1990s, lower in the early 2000s, and probably slightly higher again or recovering after 2004. Thus linear trend analysis is not appropriate to investigate the behavior of the tropical lower stratospheric water vapor.

Fujiwara, M.↗

Ice-nucleating particles in precipitation samples from the Texas Panhandle

Ice-nucleating particles (INPs) influence the formation of ice crystals in clouds and many types of precipitation. This study reports unique properties of INPs collected from 42 precipitation samples in the Texas Panhandle region from June 2018 to July 2019. We used a cold stage instrument called the West Texas Cryogenic Refrigerator Applied to Freezing Test system to estimate INP concentrations per unit volume of air (nINP) through immersion freezing in our precipitation samples with our detection capability of >0.006 INP L -1 . A disdrometer was used for two purposes: (1) to characterize the ground-level precipitation type and (2) to measure the precipitation intensity as well as size of precipitating particles at the ground level during each precipitation event. While no clear seasonal variations of n INP values were apparent, the analysis of yearlong ground-level precipitation observation as well as INPs in the precipitation samples showed some INP variations, e.g., the highest and lowest n INP values at -25°C both in the summer for hail-involved severe thunderstorm samples (3.0 to 1130 INP L -1 ), followed by the second lowest at the same temperature from one of our snow samples collected during the winter (3.2 INP L -1 ). Furthermore, we conducted bacteria community analyses using a subset of our precipitation samples to examine the presence of known biological INPs. In parallel, we also performed metagenomics characterization of the bacterial microbiome in suspended ambient dust samples collected at commercial open-lot livestock facilities (cattle feedyards hereafter) in the Texas Panhandle (i.e., the northernmost counties of Texas, also known as “West Texas”) to ascertain whether local cattle feedyards can act as a source of bioaerosol particles and/or INPs found in the precipitation samples. Some key bacterial phyla present in cattle feedyard samples appeared in precipitation samples. However, no known ice nucleation active species were detected in our samples. Overall, our results showed that cumulative n INP in our precipitation samples below -20°C could be high in the samples collected while observing > 10 mm h -1 precipitation with notably large hydrometeor sizes and an implication of cattle feedyard bacteria inclusion.

54 ENVIRONMENTAL SCIENCES↗

Trends in Light and Temperature Sensitivity Recommendations among Licensed Biotechnology Drug Products

Inherent structural and functional properties of biotechnology-derived therapeutic biologics make them susceptible to light- and temperature-induced degradation and consequently can influence their quality. Photosensitivity of therapeutic proteins continues to be examined, but the commonalities and trends of storage conditions and information about light and temperature sensitivity among currently licensed therapeutic proteins has not been previously surveyed. Using a comprehensive and relational database approach, we conducted a scientific survey of all licensed biotechnology-derived drug products with the goal of providing evidence-based information about recommended storage conditions of formulations sorted by light- and temperature-related attributes as described for each product at licensure. We report the prevalence of indications for light and temperature sensitivity in formulations categorized by their presentation type, number of doses, container type, dosage form and active molecule type. We also report the storage temperature range across formulations and diluents for reconstitution and dilution. Formulations with excipients that potentially facilitate light-induced and thermal degradation were also noted. The result of our analysis indicates that light and temperature sensitivity are prevalent across therapeutic protein formulations. However, when a formulation is reconstituted or diluted, both light and temperature sensitivity are less clear. In addition, light and temperature sensitivity are more well defined in liquid formulations than lyophilized powder formulations, and more well defined in products manufactured in autoinjectors, prefilled-syringes, and pens than products in vials. Overall, our report provides a data-driven summary of storage conditions among therapeutic protein formulations to support the development of future biologic drug products.

60 APPLIED LIFE SCIENCES↗

Molecular-Scale Insights into the Heterogeneous Interactions between an m -Terphenyl Isocyanide Ligand and Noble Metal Nanoparticles

The structural and chemical properties of metal nanoparticles are often dictated by their interactions with molecular ligand shells. These interactions are highly material-specific and can vary significantly even among elements within the same group or materials with similar crystal structure. In this study, we surveyed the heterogeneous interactions between an m-terphenyl isocyanide ligand and Au and Ag nanoparticles (NPs) at the single-molecule limit. Specifically, we found that the ligation behavior with this molecule differs significantly between that of Au and AgNPs. Surface-enhanced Raman spectroscopy measurements revealed unique enhancement factors for two molecular vibrational modes between two metal surfaces, indicating different ligand binding geometries. Molecular-level characterization using scanning tunneling microscopy allowed us to directly visualize these variations between Ag and Au surfaces, which we assign as two distinct binding mechanisms. This molecular-scale visualization provides clear insights into the different ligand–metal interactions as well as the chemical behavior and spectroscopic characteristics of isocyanide-functionalized NPs.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗