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DOE OSTI2025

Optimizing transmit field inhomogeneity of parallel RF transmit design in 7T MRI using deep learning

Ultrahigh field (UHF) Magnetic Resonance Imaging (MRI) provides a higher signal-to-noise ratio and, thereby, higher spatial resolution. However, UHF MRI introduces challenges such as transmit radiofrequency (RF) field (B+1) inhomogeneities, leading to uneven flip angles and image intensity anomalies. These issues can significantly degrade imaging quality and its medical applications. This study addresses B+1 field homogeneity through a novel deep learning-based strategy. Traditional methods like Magnitude Least Squares (MLS) optimization have been effective but are time-consuming and dependent on the patient’s presence. Recent machine learning approaches, such as RF Shim Prediction by Iteratively Projected Ridge Regression and deep learning frameworks, have shown promise but face limitations like extensive training times and oversimplified architectures. We propose a two-step deep learning strategy. First, we obtain the desired reference RF shimming weights from multi-channel B+1 fields using random-initialized Adaptive Moment Estimation. Then, we employ Residual Networks (ResNets) to train a model that maps B+1 fields to target RF shimming outputs. Our approach does not rely on pre-calculated reference optimizations for the testing process and efficiently learns residual functions. Comparative studies with traditional MLS optimization demonstrate our method’s advantages in terms of speed and accuracy. The proposed strategy achieves a faster and more efficient RF shimming design, significantly improving imaging quality at UHF. This advancement holds potential for broader applications in medical imaging and diagnostics.

Lu, Zhengyi [Vanderbilt University]↗

DOE OSTI2025

Moving beyond post hoc explainable artificial intelligence: a perspective paper on lessons learned from dynamical climate modeling

AI models are criticized as being black boxes, potentially subjecting climate science to greater uncertainty. Explainable artificial intelligence (XAI) has been proposed to probe AI models and increase trust. In this review and perspective paper, we suggest that, in addition to using XAI methods, AI researchers in climate science can learn from past successes in the development of physics-based dynamical climate models. Dynamical models are complex but have gained trust because their successes and failures can sometimes be attributed to specific components or sub-models, such as when model bias is explained by pointing to a particular parameterization. We propose three types of understanding as a basis to evaluate trust in dynamical and AI models alike: (1) instrumental understanding, which is obtained when a model has passed a functional test; (2) statistical understanding, obtained when researchers can make sense of the modeling results using statistical techniques to identify input–output relationships; and (3) component-level understanding, which refers to modelers' ability to point to specific model components or parts in the model architecture as the culprit for erratic model behaviors or as the crucial reason why the model functions well. We demonstrate how component-level understanding has been sought and achieved via climate model intercomparison projects over the past several decades. Such component-level understanding routinely leads to model improvements and may also serve as a template for thinking about AI-driven climate science. Currently, XAI methods can help explain the behaviors of AI models by focusing on the mapping between input and output, thereby increasing the statistical understanding of AI models. Yet, to further increase our understanding of AI models, we will have to build AI models that have interpretable components amenable to component-level understanding. We give recent examples from the AI climate science literature to highlight some recent, albeit limited, successes in achieving component-level understanding and thereby explaining model behavior. The merit of such interpretable AI models is that they serve as a stronger basis for trust in climate modeling and, by extension, downstream uses of climate model data.

54 ENVIRONMENTAL SCIENCES↗

NASA NTRS1990

High-speed fiber-optic links for distribution of satellite traffic

Low-loss fiberoptic links are designed for distribution of data and the frequency reference in large-aperture phased-array antennas based on the transmit/receive-level data mixing architecture. In particular, design aspects of a fiberoptic link satisfying the distribution requirements of satellite data traffic are presented. The design is addressed in terms of reactively matched optical transmitter and receiver modules. Analog and digital characterization of a 50-m fiberoptic link realized using these modules indicates the applicability of this architecture as the only viable alternative for distribution of data signals inside a satellite at present. It is demonstrated that the design of a reactive matching modules enhances the link performance. A dynamic range of 88 dB/MHz was measured for analog data over a 500-1000-MHz bandwidth.

Daryoush, Afshin S.↗

NASA NTRS1992

Interferometer testbed: Overview and hardware summary

Viewgraphs on an overview and hardware summary for an interferometer testbed are presented. Topics covered include: reference mission and science requirements; science requirements derivation; reference spacecraft design summary; testbed requirements and performance metric; disturbance source and signal; and testbed architecture.

Nisbet, Andrew↗

NASA NTRS2010

Lunar Outpost Life Support Architecture Study Based on a High-Mobility Exploration Scenario

This paper presents results of a life support architecture study based on a 2009 NASA lunar surface exploration scenario known as Scenario 12. The study focuses on the assembly complete outpost configuration and includes pressurized rovers as part of a distributed outpost architecture in both stand-alone and integrated configurations. A range of life support architectures are examined reflecting different levels of closure and distributed functionality. Monte Carlo simulations are used to assess the sensitivity of results to volatile high-impact mission variables, including the quantity of residual Lander oxygen and hydrogen propellants available for scavenging, the fraction of crew time away from the outpost on excursions, total extravehicular activity hours, and habitat leakage. Surpluses or deficits of water and oxygen are reported for each architecture, along with fixed and 10-year total equivalent system mass estimates relative to a reference case. System robustness is discussed in terms of the probability of no water or oxygen resupply as determined from the Monte Carlo simulations.

Lange, Kevin E.↗

NASA NTRS2020

SCA Test Report: H4RG-20828 WFIRST

This report summarizes the measured performance for the Sensor Chip Assembly (SCA), which is identified in Table 1. The SCA architecture is a substrate-removed HgCdTe detector with an area of4096x4096 pixels (with a reference pixel area of four pixels deep around all four sides, available to substitute corresponding image pixels) and a pixel pitch of 10 μm. This SCA has been tested at the Goddard Space Flight Center (GSFC/NASA) Detector Characterization Laboratory (DCL). Teledyne (the vendor) classifies its detectors into different grades based on testing performed at its facility. The classification of this SCA and the tested dates are included in Table 1 below.The tests performed on this array are derived from the document WFIRST-PROC-09220_WFIRST-SCA-ATP_-.docx. A summary of the test parameters, requirements, and test results is presented in Table 2. The details of each test are subsequently described in the report. In the Summary (Table 2), SCA results are reported at an operating temperature of 95K, and 1.0 V bias voltage. In the detailed section of each test, the results for 90 K (1.0V bias voltage) and 95 K (0.5V bias voltage) are also reported. For all cases, the frame time used is 2.764 seconds. Reference pixel correction was applied to every raw frame.

Laddawan Miko↗

NASA NTRS2020

SCA Test Report: H4RG-21225 WFIRST

This report summarizes the measured performance for the Sensor Chip Assembly (SCA), which is identified in Table 1. The SCA architecture is a substrate-removed HgCdTe detector with an area of 4096x4096 pixels (with reference pixel area of four pixels deep around all four sides, available to substitute corresponding image pixels) and a pixel pitch of 10 μm. This SCA has been tested at the Goddard Space Flight Center (GSFC/NASA) Detector Characterization Laboratory (DCL). Teledyne (the vendor) classifies its detectors into different grades based on testing performed at its facility. The classification of this SCA and the tested dates are included in Table 1 below. The tests performed on this array are derived from the document WFIRST-PROC-09220_WFIRST-SCA-ATP_-.docx. A summary of the test parameters, requirements, and test results is presented in Table 2. The details of each test are subsequently described in the report. In the Summary (Table 2), SCA results are reported at an operating temperature of 95K, and 1.0 V bias voltage. In the detailed section of each test,the results for 95 K and 0.5V bias voltage is also reported. The data for the result reported in this document was acquired in pixel reset mode. For all cases, the frame time used is 2.830 seconds. Reference pixel correction was applied to every raw frame.

Laddawan Miko↗

NASA NTRS2023

Distributed Spacecraft Mission (DSM) Plume Design Reference Mission (DRM) Inter-Satellite Link Modeling, Analysis and Simulation

NASA Goddard Space Flight Center (GSFC) Radical Innovation Initiative (RI2) plans to focus intently on DSM capability advancements in FY22-24. A DSM mission involves multiple spacecraft, arranged in a constellation, to achieve one or more common goals via the use of inter-satellite links (ISL) between the satellites. Recently, the GSFC Internal Research & Development (IRAD) program established Enceladus as a design reference mission (DRM) for the current DSM effort to foster the conceptual development of communication architecture, requirements, and solutions for future DSM ISL, as well as being able to push other research areas of interest. Enceladus is an icy moon of the planet Saturn. The DRM Enceladus mission concept involves a constellation of 24 small satellites, orbiting Enceladus around 100 km altitude in 3 planes, as observing nodes for science measurement. The mission science data will be sent back to Earth through a relay orbiting Saturn, using the constellation’s inter-satellite links. A QualNet/STK simulation model of the Relay and constellation ISL optical and RF links is developed for the design and optimization of the link and orbital parameters, as well as the inter-networking protocols. Delay Tolerant Networking (DTN) is utilized in the application layer modeling. This paper describes the plume DRM mission concept of an Enceladus constellation to relay science data to Earth and includes the proposed communication architecture and operation concepts. We present details of the QualNet/STK engineering model for this communication scenario to simulate the end-to-end data traffic through multiple layers (physical, data link, networking, transport and application). A link analysis for the constellation’s ISL, constellation to Relay and Direct to Earth (DTE) optical link is provided and discussed. The results of end-to-end traffic simulation for the data throughout/latency evaluation and assessment of the communication architecture are presented. The investigation of the concept of optical multiple access (OMA) for the Plume DRM is discussed. The modeling and simulation methodology developed in this paper is applicable to other DSMs in near Earth and deep space such as Earth-Moon L1/L2 and Lunar regions.

Distributed Spacecraft Mission (DSM) Inter-satelli↗

DOE OSTI2025

The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination

Myrothamnus flabellifolia is a dioecious resurrection plant endemic to southern Africa that has become an important model for understanding desiccation tolerance. Despite its ecological and medicinal significance, genomic and transcriptomic resources for the species are limited. We generated a chromosome-level, haplotype-resolved reference genome assembly and annotation for M. flabellifolia and conducted transcriptomic profiling across a natural dehydration–rehydration time course in the field. Genome architecture and sex determination were characterized, and co-expression network and cis-regulatory element (CRE) enrichment analyses were used to investigate dynamic responses to desiccation. The 1.28-Gb genome exhibits unusually consistent chromatin architecture with unique chromosome organization across highly divergent haplotypes. We identified an XY sexual system with a small sex-determining region on Chromosome 8. Transcriptomic responses varied with dehydration severity, pointing to early suppression of growth, progressive activation of protective mechanisms, and subsequent return to homeostasis upon rehydration. Late embryogenesis abundant and early light-induced protein transcripts were dynamically regulated and showed enrichment of abscisic acid and stress-responsive CREs pointing toward conserved responses. Together, this study provides foundational resources for understanding the genomic architecture and reproductive biology of M. flabellifolia and offers new insights into the mechanisms of desiccation tolerance.

chromosome structure↗

NASA NTRSDate not supplied

Lunar Search & Rescue Applications of Lunar GNSS

Accurate lunar navigation and timing knowledge provides for the development of safety-critical services in the cislunar and lunar surface domain. Currently under development, the Goddard Space Flight Center’s (GSFC) Search and Rescue Mission Office is investigating and integrating search and rescue (SAR) capability into planned and future lunar communication and navigation interfaces. Lunar Search and Rescue (LunaSAR) development has a stated end-goal for assured, reliable, and timely indication of distress events for a wide variety of lunar surface users, including government-sponsored, commercial, and international users. LunaSAR performance requirements are modelled after the current terrestrial Cospas-Sarsat distress notification system, leveraging an internationally robust global navigation satellite system (GNSS) ecosystem as a core element of survivor locating capability. This presentation will discuss NASA’s work to develop user-focused distress messaging capabilities including infusion of example sensor data for triggering of automated distress alerts coupled with location-tagging. Additionally, the presentation will examine overall message structures, rotating fields for use in bi-directional distress messaging, and specific use cases based on NASA’s lunar exploration and lunar communication relay architectures. Modelling and simulation of LunaSAR use by individual lunar explorers will be discussed, based on notional industry and government design reference missions and mission considerations. Results from GSFC-funded Internal Research and Development (IRAD) efforts will be detailed, including successful distress message formulation simulating the ingestion of example legacy space suit telemetry fields. Hardware-in-the-loop testing using high-reliability software defined radio (SDR) modules serve as an example of IRAD successes and the framework for technical requirements. Architectural development and technical evolution from 2020 to 2021 included alignment of LunaSAR distress waveforms with ongoing NASA LunaNet interoperability development, as well as engagement with NASA Lunar Spectrum authorities for allocation of UHF-band distress frequencies on the lunar surface. S-Band and UHF-band transmission characteristics will be detailed, along with band-specific applications of each emission type. Additionally, examples of ingestion and formatting of GNSS signals (using historical terrestrial National Marine Electronics Association-formatted GNSS data) will be detailed, underscoring lunar user needs for a common lunar GNSS receiver output message framework. Maturity and ability to support evolving lunar exploration goals has been demonstrated and will be detailed, with maturity gaps such as position, navigation, and timing (PNT) and lunar reference frames identified within the context of distress message generation. Provision of LunaSAR services for lunar surface users represents a new era of ensured safety for lunar explorers and builds off of forty years of the Cospas-Sarsat program, underscoring the importance of lunar GNSS for safety-critical applications and growing interest in safe, reliable lunar surface operations. Enabled by new GNSS systems being developed by government and industry partners, NASA will continue to evolve and integrate lunar GNSS types into distress message generation, with a focus on compact and efficient message transmission over various lunar communication links. When fielded, LunaSAR will be the first dedicated search and rescue notification system employed on another celestial body. Robust lunar navigation and timing services form the core of LunaSAR capabilities, allowing for system syncing with time-dominant sensors, and high-accuracy location of those in distress while engaged in lunar surface activities.

Search and Rescue↗

NASA NTRS1987

Potential GPS user architecture for the NASA Space Station based on Landsat 4/5 experience

A Landsat 4/5 GPS system is described which uses an inertial reference attitude control system and precision real-time ephemeris generation to achieve precision earth pointing. The system has application to the validation of the use of GPS for the low earth orbit navigation of the Space Station. The present system consists of a receiver/processor assembly (R/PA), an L-band GPS antenna, a precision oscillator, and the Landsat computer. The R/PA is integrated with a GPS receiver which selects, acquires, tracks, times, and decodes navigation signals from GPS satellites in order to derive ephemerides. Ephemeris estimates were found to be accurate to better than 50 meters.

Korenstein, David A.↗

NASA NTRSDate not supplied

Interoperable Services to Mitigate Lunar Position, Navigation, and Timing Challenges

Across the Earth, both civilian and government endeavors enjoy a built-in reliance on a position, navigation, and timing (PNT) infrastructure to which they are largely blind. Whether walking, driving, flying, or orbiting, Earth-centric PNT systems that have evolved over decades provide a core functionality to which we have grown accustomed for these pursuits. As NASA joins with other government space agencies and commercial partners to return humans to the Moon in a sustained manner within the current decade, expectations for PNT knowledge and timeliness at the Moon rival those on Earth. The need exists to develop a viable lunar-centric PNT infrastructure to support the planned human and robotic exploits. Navigating within the influence of the Moon presents its own set of challenges. Identification, understanding, and use of a unified reference frame and time system on which navigation is based becomes a fundamental need at the Moon. In addition to the unified foundational elements, measurement liability, dynamic conditions that require Earth-independent autonomous operations, and standards for PNT signals and message-based data exchange each represent distinct challenges to navigation in a burgeoning operational lunar environment. The PNT services planned as part of the lunar communications and navigation relay architecture known as LunaNet aid in surmounting the challenges. LunaNet interoperability specifications stipulate standards for signal parameters, messages, and lunar reference systems for PNT services. Within LunaNet’s defined interoperability resides the concept of a Reference Signal to provide communication signals specifically structured to enable measurement of pseudorange, Doppler, and time transfer by the recipient. One such signal type, the Augmented Forward Signal (AFS), functions as the mainstay for LunaNet PNT, while also serving the data needs for ubiquitous broadcast of network access and rapid unscheduled dissemination of alerts and messages. The presence of a geometrically distributed network of orbiting nodes transmitting the AFS forms the basis for the Lunar Augmented Navigation System (LANS), that delivers both radio navigation and data to multiple users in the lunar environment simultaneously. After reviewing the challenges associated with lunar navigation, this paper will describe the concepts and rationale behind the LunaNet PNT services. By borrowing techniques from Earth-centric Global Navigation Satellite Services (GNSS), the Tracking and Data Relay Satellite System, and the Consultative Committee for Space Data Standards, PNT from LunaNet aids to overcome challenges faced for accurate lunar navigation.

LunaNet↗

NASA NTRSDate not supplied

Interoperable Services to Mitigate Lunar Position, Navigation, and Timing Challenges

Navigation↗

NASA NTRS2009

Ares V: Shifting the Payload Design Paradigm

NASA's Ares V heavy-lift cargo launch vehicle is being designed send more crew and cargo to more places on the lunar surface than the 1960s-era Apollo program and provide ongoing support to a permanent lunar outpost. In addition to that role, however, its unmatched mass and volume capability represent a global asset for exploration, science, and commerce. The Ares V also is an enabler of a large class of space missions not thought possible by scientists and engineers since the Saturn V program ended over 30 years ago. Compared to current systems, it will offer approximately 5 times the mass and volume to most orbits and locations. This should allow prospective mission planners to build robust payloads with margins that are 3 to 5 times the industry norm. The space inside the planned payload shroud has enough usable volume to launch the volumetric equivalent of approximately 10 Apollo Lunar Excursion Modules or approximately 5 equivalent Hubble Space Telescopes. This mass and volume capability to Low Earth Orbit enables a host of new scientific and observation platforms, such as telescopes, satellites, planetary and solar missions, as well as being able to provide the lift for future large in-space infrastructure missions, such as space based power and mining, Earth asteroid defense, propellant depots, etc. The Ares V team is engaging the potential payload community now, 2-3 years before System Requirements Review, in order to better understand the potential limitations and or additional requirements that could be added to the Ares V from the mission planning community. If a viable mission is determined and added to the Ares V as a design case, tradeoffs will be conducted to determine if other mission design requirements can be included in the system. Multiple shroud options for the Ares V have been analyzed to identify their impact on performance. Ares V is in a conceptual design stage prior to a formal design phase. The initial concept for the cargo launch vehicle (CaLV) that would later be dubbed "Ares V" was produced by the Exploration Systems Architecture Study in 2005. Since then, it has evolved through hundreds of concepts. The current point-of-departure (POD) concept was approved during the Lunar Capabilities Concept Review/Ares V Mission Concept Review in June 2008. This reference concept serves as a starting point for a renewed set of design trades and detailed analysis into its interaction with the other components of the Constellation architecture and existing launch infrastructure. This paper will discuss the Ares V design evolution, the most recent point-of-departure concept, and its capabilities to support future science missions.

Summrall, Phil↗

NASA NTRS1999

Integrated Space Transportation Plan: Defining Technology Requirements and Next Generation Launch Systems to Meet Commercial and Government Needs

NASA continues to focus on improving safety and reliability while reducing the annual cost of meeting human space flight and unique ISS and exploration needs. NASA's Space Transportation Architecture Study (STAS) Phase 2 in early 1998 focused on space transportation options. Subsequently, NASA directed parallel industry and government teams to conduct the Integrated Space Transportation Plan effort (STAS Phase 3). The objective of ISTP was to develop technology requirements, roadmaps, and risk reduction portfolio that considered expanded definition of "clean-sheet" and Shuttle-derived second generation ETO transportation systems in support of a 2005 RLV competition for NASA missions beginning 2010. NASA provided top-level requirements for improvements in safety, reliability, and cost and a set of design reference missions representing NASA ISS, human exploration, commercial, and other civil and government needs. This paper addresses the challenges of meeting NASA's objectives while servicing the varied market segments represented in the ISTP design reference missions and provides a summary of technology development needs and candidate system concepts. A comparison of driving requirements, architectures and technology needs is discussed and descriptions of viable Shuttle-derived and next generation systems to meet the market needs are presented.

Davidoff, Larry D.↗

NASA NTRS2016

Assurance of Fault Management: Risk-Significant Adverse Condition Awareness

Fault Management (FM) systems are ranked high in risk-based assessment of criticality within flight software, emphasizing the importance of establishing highly competent domain expertise to provide assurance for NASA projects, especially as spaceflight systems continue to increase in complexity. Insight into specific characteristics of FM architectures seen embedded within safety- and mission-critical software systems analyzed by the NASA Independent Verification Validation (IVV) Program has been enhanced with an FM Technical Reference (TR) suite. Benefits are aimed beyond the IVV community to those that seek ways to efficiently and effectively provide software assurance to reduce the FM risk posture of NASA and other space missions. The identification of particular FM architectures, visibility, and associated IVV techniques provides a TR suite that enables greater assurance that critical software systems will adequately protect against faults and respond to adverse conditions. The role FM has with regard to overall asset protection of flight software systems is being addressed with the development of an adverse condition (AC) database encompassing flight software vulnerabilities.Identification of potential off-nominal conditions and analysis to determine how a system responds to these conditions are important aspects of hazard analysis and fault management. Understanding what ACs the mission may face, and ensuring they are prevented or addressed is the responsibility of the assurance team, which necessarily should have insight into ACs beyond those defined by the project itself. Research efforts sponsored by NASAs Office of Safety and Mission Assurance defined terminology, categorized data fields, and designed a baseline repository that centralizes and compiles a comprehensive listing of ACs and correlated data relevant across many NASA missions. This prototype tool helps projects improve analysis by tracking ACs, and allowing queries based on project, mission type, domain component, causal fault, and other key characteristics. The repository has a firm structure, initial collection of data, and an interface established for informational queries, with plans for integration within the Enterprise Architecture at NASA IVV, enabling support and accessibility across the Agency. The development of an improved workflow process for adaptive, risk-informed FM assurance is currently underway.

Software Verification & Validation↗

DOE OSTI2024

Hyperparameter Studies for Vision Transformers Trained on High-Fidelity Simulations

This library is a collection of python modules that define, train, and analyze vision-transformer (ViT) machine learning models. The code implements, with mild modifications, ViT models that have been made publicly available through publication and GitHub code. The training data for these models is hydrodynamic simulation output in the form of numpy arrays. This library contains code to train these ViT models on the hydrodynamic simulation output with a variety of hyperparameters, and to compare the results of such models. Furthermore, the library contains definitions of simple convolutional neural network (CNN) machine learning architectures which can be trained on the same hydrodynamic simulation output. These are included as a reference point to compare the ViT models to. Additionally, the library includes trained ViT and CNN models and example input data for demonstration purposes. The code is based on the PyTorch python library.

Callis, Skylar↗

DOE OSTI2025

RatXcan: A framework for cross-species integration of genome-wide association and gene expression data

Genome-wide association studies (GWAS) have implicated specific alleles and genes as risk factors for numerous complex traits. However, translating GWAS results into biologically and therapeutically meaningful discoveries remains extremely challenging. Most GWAS results identify noncoding regions of the genome, suggesting that differences in gene regulation are the major driver of trait variability. To better integrate GWAS results with gene regulatory polymorphisms, we previously developed PrediXcan (also known as “transcriptome-wide association studies” orTWAS), which maps SNPs to predicted gene expression using GWAS data. In this study, we developed RatXcan, a framework that extends this methodology to outbred heterogeneous stock (HS) rats. RatXcan accounts for the close familial relationships among HS rats by modeling the relatedness with a random effect that encodes the genetic relatedness. RatXcan also corrects for polygenic-driven inflation because of the equivalence between a relatedness random effect and the infinitesimal polygenic model. To develop RatXcan, we trained transcript predictors for 8,934 genes using reference genotype and expression data from five rat brain regions. We found that the cis genetic architecture of gene expression in both rats and humans was sparse and similar across brain tissues. We tested the association between predicted expression in rats and two example traits (body length and BMI) using phenotype and genotype data from 5,401 densely genotyped HS rats and identified a significant enrichment between the genes associated with rat and human body length and BMI. Thus, RatXcan represents a valuable tool for identifying the relationship between gene expression and phenotypes across species and paves the way to explore shared biological mechanisms of complex traits.

Genetics & Heredity↗