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NASA NTRS2015

Wearable Health Monitoring Systems

The shrinking size and weight of electronic circuitry has given rise to a new generation of smart clothing that enables biological data to be measured and transmitted. As the variation in the number and type of deployable devices and sensors increases, technology must allow their seamless integration so they can be electrically powered, operated, and recharged over a digital pathway. Nyx Illuminated Clothing Company has developed a lightweight health monitoring system that integrates medical sensors, electrodes, electrical connections, circuits, and a power supply into a single wearable assembly. The system is comfortable, bendable in three dimensions, durable, waterproof, and washable. The innovation will allow astronaut health monitoring in a variety of real-time scenarios, with data stored in digital memory for later use in a medical database. Potential commercial uses are numerous, as the technology enables medical personnel to noninvasively monitor patient vital signs in a multitude of health care settings and applications.

Bell, John↗

NASA NTRS2015

Individualized Behavioral Health Monitoring Tool

Behavioral health risks during long-duration space exploration missions are among the most difficult to predict, detect, and mitigate. Given the anticipated extended duration of future missions and their isolated, extreme, and confined environments, there is the possibility that behavior conditions and mental disorders will develop among astronaut crew. Pulsar Informatics, Inc., has developed a health monitoring tool that provides a means to detect and address behavioral disorders and mental conditions at an early stage. The tool integrates all available behavioral measures collected during a mission to identify possible health indicator warning signs within the context of quantitatively tracked mission stressors. It is unobtrusive and requires minimal crew time and effort to train and utilize. The monitoring tool can be deployed in space analog environments for validation testing and ultimate deployment in long-duration space exploration missions.

Mollicone, Daniel↗

NASA NTRS2016

Integrated System for Health Management and Autonomous Control (ISHM-AC): Development and Application

Autonomous control systems represent a technological barrier from manual and automated operated control systems in an industry wide application. An increase in energy-efficient storage, transfer and use of cryogens and cryogenic propellants on Earth and in space has been observed in space related industries between NASA, government and commercial programs. An increase in efficiency of cryogenic systems demands an increase in the capabilities of the control and monitoring system that manages them. As new technologies are developed for cryogenic systems, complexity and capability increases. The increase in complexities are a natural drive to develop better and more capable health monitoring and control system management. Current research and development efforts lead the Cryogenics Test Laboratory at the Kennedy Space Center to improve its automated control and health monitoring system from a Programmable Logic Control (PLC) based-only system to a fully Integrated System for Health Management (ISHM) - Autonomous Control (AC) capable of performing autonomous operations on a cryogenic propellant transfer system. This ISHM-AC system has been developed and tested by controlling a complete simulated propellant transfer operation. The capabilities and test results of this fully integrated autonomous system for cryogenics propellant transfer operation will be presented in this paper.

Toro, Jaime A.↗

NASA NTRS2016

Integrated System for Health Management and Autonomous Control (ISHM-AC) for Cryogenic Operations on the Simulated Propellant Loading System

Toro Medina, Jaime A.↗

NASA NTRS2016

Risk of Adverse Health Outcomes & Decrements in Performance due to Inflight Medical Conditions: ExMC Pharmacy Research Plan

The Exploration Medical Capabilities (ExMC) Element of NASA's Human Research Program is charged with identifying medical capabilities that can address the challenges of prevention, diagnosis, and treatment of disease and injuries that could occur during exploration missions beyond Earth's orbit. Faced with the obstacle of access to in-flight medical care, and limitations of vehicle space, time, and communications; it is necessary to prioritize what medical consumables are manifested for the flight, and which medical conditions are addressed. Studies of astronaut health establish the incidence of common and high risk medical conditions that require medical intervention during long-duration exploration missions. In 2000, the Institute of Medicine (IOM) convened a committee of experts, Committee on Creating a Vision for Space Medicine during Travel beyond Earth Orbit, to examine the issues surrounding astronaut health and safety for long duration space missions. Two themes run throughout the committee's final report: (1) that not enough is known about the risks to human health during long-duration missions beyond Earth's orbit or about what can effectively mitigate those risks to enable humans to travel and work safely in the environment of deep space and (2) that everything reasonable should be done to gain the necessary information before humans are sent on missions of space exploration (IOM, 2001). Although several spaceflight focused pharmaceutical research studies have been conducted, few have provided sufficient data regarding medication usage or potency changes during spaceflight. The Du pharmaceutical stability study assessed medications flown on space shuttles to and from the International Space Station (ISS) from 2006 until 2008; of which some medications were still viable beyond their expiration dates (Du et al, 2011). However, as with many spaceflight studies, the small 'n' associated with this study limits the ability to draw strong conclusions from it. Dr. Wotring and others have recently published articles containing information regarding medication usage, indications, and efficacy gleaned from spaceflight records (Wotring et al, 2015, 2016; Barger et al, 2014; Basner and Dinges, 2014). Although some conclusions can be drawn from these studies, the inability to fully quantify medication usage, indications, side effects, and effectiveness, limits insight as to which medications should be prioritized for further research.

Antonsen, Erik↗

NASA NTRS2016

Review of NASA's Evidence Reports on Human Health Risks

NASA has requested a study from the Institute of Medicine (IOM) to provide an independent review of more than 30 evidence reports on human health risks for long duration and exploration spaceflight. The evidence reports, which are publicly available, are categorized into five broad categories: (1) behavioral health and performance; (2) human health countermeasures (with a focus on bone metabolism and orthopedics, nutrition, immunology, and cardiac and pulmonary physiology); (3) radiation; (4) human factors issues; and (5) exploration medical capabilities. The reports are revised on an ongoing basis to incorporate new scientific information. In conducting this study, an IOM ad hoc committee will build on the 2008 IOM report Review of NASA's Human Research Program Evidence Books. That report provided an assessment of the process used for developing the evidence reports and provided an initial review of the evidence reports that had been completed at that time. Each year, NASA staff will identify a set of evidence reports for committee review. Over the course of the study all evidence reports will be reviewed. The committee will hold an annual scientific workshop to receive input on the evidence reports it is reviewing that year and an update on the recent literature. The committee will issue an annual letter report that addresses the following questions relevant to each evidence report: 1. Does the evidence report provide sufficient evidence, as well as sufficient risk context, that the risk is of concern for long-term space missions? 2. Does the evidence report make the case for the research gaps presented? 3. Are there any additional gaps in knowledge or areas of fundamental research that should be considered to enhance the basic understanding of this specific risk? 4. Does the evidence report address relevant interactions among risks? 5. Is input from additional disciplines needed? 6. Is the breadth of the cited literature sufficient? 7. What is the overall readability and quality? 8. Is the expertise of the authors sufficient to fully cover the scope of the given risk? 9. Has the evidence report addressed previous recommendations made by the IOM in the 2008 letter report?

Scott-Conner, Carol E. H.↗

NASA NTRS2018

Pilot Study on the Investigation of Tear Fluid Biomarkers as an Indicator of Ocular, Neurological, and Immunological Health in Astronauts

The purpose of this pilot study is to investigate the collection, preparation, and analysis of tear biomarkers as a means of assessing ocular, neurological, and immunological health. At present, no published data exists on the cytokine profiles of tears from astronauts exposed to long periods of microgravity and space irradiations. In addition, no published data exist on cytokine (biomarker) profiles of tears that have been collected from irradiated non-human biological systems (primates and other animal models). A goal for the proposed pilot study is to discover novel tear biomarkers which can help inform researchers, clinicians, epidemiologist and healthcare providers about the health status of a living biological system, as well as informing them when a disease state is triggered. This would be done via analysis of the onset of expression of pro-inflammatory cytokines, leading up to the full progression of a disease (i.e. cancer, loss of vision, radiation-induced oxidative stress, cardiovascular disorders, fibrosis in major organs, bone loss). Another goal of this pilot study is to investigate the state of disease against proposed medical countermeasures, in order to determine whether the countermeasures are efficacious in preventing or mitigating these injuries. An example of an up and coming tear biomarker technology, Ascendant Dx, a clinical stage diagnostic company, is developing a screening test to detect breast cancer using proteins from tears. The team utilized Liquid Chromatography -Mass Spectrometry with Mass analysis (LC MS/MS) as a discovery platform followed by validation with ELISA to come up with a panel of protein biomarkers that can differentiate breast cancer samples from control ("cancer free") samples with results far surpassing the results of imaging techniques in use today. Continued research into additional proteins is underway to increase the sensitivity and specificity of the test and development efforts are on the way to transfer the test onto a fast, accurate and inexpensive point of care platform. In conclusion, the expected results from this proposed pilot study are to: a) establish an SOP for retrieving/storing/transporting tear fluid samples from multicentre sites b) establish a normal range for relevant biomarkers in tears; and c) establish a database (biobank) of tears of space naïve versus veteran astronauts, to establish a personal baseline for long-term ocular health monitoring

Morton, Stephen↗

NASA NTRS2018

New Sensors and Techniques for Aircraft Engine Health Monitoring

The ability to monitor the health of the rotating components in aircraft engines is of major interest to aero community in improving safety and reliability. The use of instrumentation for these applications remains very challenging. It requires sensors and techniques that are highly accurate, able to operate in a high temperature environment, and sensitive enough to detect minute changes and hidden flaws before undesired events occur. The National Aeronautics and Space Administration (NASA), through several Aviation Safety Programs, has taken a leadership role in the development of new sensor technologies and techniques for the in-situ health monitoring of aircraft turbine engines. Along with the development of new instrumentation for aircraft engines, the Glenn Research Center has a diverse set of ground test facilities that are used to simulate the conditions that a vehicle would see in flight allowing new concepts to be safely developed and evaluated on the ground before progressing to actual flight. In this presentation Mark will give an overview of the NASA Glenn Research Center, discuss its past aviation safety initiatives, present some select sensors that have been developed for aircraft engine safety, and then conclude with some new measurement techniques that have been developed for use at the NASA Glenn test facilities, enabling better measurement and simulation of flight conditions. He will discuss current research and development efforts that he is working on at the NASA Glenn Research Center in the areas of new sensors and techniques for aircraft engine health monitoring. This work is being conducted in support of aviation safety.

Turbine↗

NASA NTRS2018

Systems Health Monitoring and Prognostics Using Model Based Approach

In order to tackle and solve the prediction problem, it is essential to have awareness of the current state and health of the system, especially since it is necessary to perform condition-based predictions. To be able to accurately predict the future state of any system, it is required to possess knowledge of its current and future operations. Given models of the current and future system behavior, the general approach of model-based prognostics can be employed as a solution to the prior stated prediction problem. In case of electric aircrafts, computing remaining flying time is safety-critical, since an aircraft that runs out of power (battery charge) while in the air will eventually lose control leading to catastrophe. In order to tackle and solve the prediction problem, it is essential to have awareness of the current state and health of the system, especially since it is necessary to perform condition-based predictions. To be able to predict the future state of the system, it is also required to possess knowledge of the current and future operations of the vehicle. Our research approach is to develop a system level health monitoring safety indicator which runs estimation and prediction algorithms to estimate remaining useful life predictions at system as well as subsystem levels. Given models of the current and future system behavior, a general approach of model-based prognostics can be employed as a solution to the prediction problem and further for decision making. In addition a digital twin concept is being implemented in the framework to demonstrate verification and validation of developed algorithms.

Electronics Prognostics↗

NASA NTRS2019

Cardiopulmonary Inflammatory Response to Meteorite Dust Exposures - Implications for Human Health on Earth and Beyond

This year marks the 50th anniversary of Apollo 11, the first time humans set foot on the Moon. The Apollo missions not only help answer questions related to our solar system, they also highlight many hazards associated with human space travel. One major concern is the effect of extraterrestrial dust on astronaut health. In an effort to expand upon previous work indicating lunar dust is respirable and reactive, the authors initiated an extensive study evaluating the role of a particulate’s innate geochemical features (e.g., bulk chemistry, internal composition, morphology, size, and reactivity) in generating adverse toxicological responses in vitro and in vivo. To allow for a broader planetary and geochemical assessment, seven samples were evaluated: six meteorites from either the Moon, Mars, or Asteroid 4 Vesta and a terrestrial basalt analogue. Even with the relatively small geochemical differences (all samples basaltic in nature), significant difference in cardiopulmonary inflammatory markers developed in both single exposure and multiple exposure studies. More specifically: 1) the single exposure studies reveal relationships between toxicity and a meteorite sample’s origin, its pre-ejected state (weathered versus un-weathered), and geochemical features (e.g. bulk iron content) and 2) multiple exposure studies reveal a correlation with particle derived reactive oxygen species (ROS) formation and neutrophil infiltration. Extended human exploration will further increase the probability of inadvertent and repeated exposures to extraterrestrial dusts. This comprehensive dataset allows for not only the toxicological evaluation of extraterrestrial materials but also clarifies important correlations between geochemistry and health. The utilization of an array of extraterrestrial samples from Moon, Mars, and asteroid 4Vesta will enable the development of a geochemical based toxicological hazard model that can be used for: 1) mission planning, 2) rapid risk assessment in cases of unexpected exposures, and 3) evaluation of the efficacy of various in situ techniques in gauging surface dust toxicity. Furthermore, by better understanding the importance of geochemical features on exposure related health outcomes in space, it is possible to better understand of the deleterious nature of dust exposure on Earth.

Harrington, A. D.↗

NASA NTRS2020

Model Based Diagnostics and Prognostics Framework for Systems Health Management

In order to tackle and solve the system health prediction problem, it is essential to have awareness of the current state and health of the system, especially since it is necessary to perform condition-based predictions. To be able to accurately predict the future state of any system, it is required to possess knowledge of its current and future operations. Given models of the current and future system behavior, the general approach of model-based prognostics can be employed as a solution to the prior stated prediction problem. In case of electric aircrafts, computing remaining flying time is safety-critical, since an aircraft that runs out of power (battery charge) while in the air will eventually lose control leading to catastrophe. In order to tackle and solve the prediction problem, it is essential to have awareness of the current state and health of the system, especially since it is necessary to perform condition-based predictions. To be able to predict the future state of the system, it is also required to possess knowledge of the current and future operations of the vehicle. This presentation will cover a physics based-modeling approach implemented for case-studies in battery and composite structures for prognostics. Given models of the current and future system behavior, a general approach of model-based prognostics can be employed as a solution to the prediction problem and further for decision making.

Banerjee, Portia↗

NASA NTRS2020

Circulating miRNA Signature Predicts Health Risks Associated with Cancer and Spaceflight

Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach, our previous NASA work has shown both TGF signaling pathways and miRNAs have a critical impact on defining health risks with and without space irradiation. We hypothesize that circulating microRNA (miRNA) signatures are driving microvascular disease and muscle degeneration associated with accelerating aging and will be enhanced by exposure to the space environment (radiation and microgravity). We are investigating this hypothesis with both in vivo and in vitro models to test novel antagonist therapies to these miRNA signatures as countermeasures to reduce space radiation-induced health risks. A comprehensive Systems Biology approach is utilized to examine the influence by high atomic number by high (H) atomic number (Z) and energy (E) (HZE) irradiation. To simulate low-dose exposure due to galactic cosmic rays (GCR), we used ions, energy, and doses determined by a NASA consensus formula of 7 different ions to represent GCR (referred to as GCR sim model). To similate high-dose radiation exposure due to solar particle events (SPE), we used a solar particle event (SPE) sim model which gave a total dose of 1Gy protons with energy ranges from 50MeV to 150MeV. C57BL/6 wild-type female mice were utilized for the irradiations with our established simulated microgravity model (hindlimb suspension model) and an in vitro 3D microvasculature tissue model under simulated microgravity (clinostat) conditions was also irradiated. To expand on the circulating miRNA signature determined from our preliminary data, we determined a group of conserved miRNAs which are commonly being regulated in the majority of the organs and tissues throughout the host using our established techniques. MiRNA-sequencing was done on serum (at time of sacrifice), liver, heart, and muscle (soleus muscle) tissue for all radiation groups. Additional validation of the key miRNAs was performed by droplet digital PCR (ddPCR). This revealed a key circulating miRNA signature (consisting of multiple miRNAs) impacting cardiovascular and muscular disease risk. Further in vitro experiments with CRISPR/Cas9 system to knockout the key miRNA signatures, novel self-delivering antagomirs, overexpression of the miRNAs test the functional impact of the miRNA signatures on both microvascular disease and muscle degeneration due to space irradiation. The current work has started to allow the possible development of a novel minimally invasive miRNA based radioprotector to be used as a countermeasure for space radiation. Collectively, understanding of how whole body space radiation impacts microvascular and tissue degeneration through circulating miRNAs will greatly enhance health risk prognostication and provide possible new mechanisms for protection against space radiation. This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (T-0404) awarded to AB.

Beheshti, Afshin↗

NASA NTRSDate not supplied

A Method for Validating Causal Diagrams of Human Health Risk in Space Flight

The complexity of cause-and-effect relationships between spaceflight hazards and resulting health conditions clouds understanding of the totality of human system risk in space. In response, NASA has introduced Directed Acyclic Graphs (causal diagrams) into the human systems risk management process. These diagrams allow for a common understanding of the mechanisms that lead from unique hazards of spaceflight to the health outcomes important to agencies and astronauts. However, the paucity of available biomedical data from spaceflight creates a need for methods of validating causal models that can accommodate data from spaceflight model analogs. Here we outline one approach utilizing open-access rodent bone datasets from the Ames Life Sciences Data Archive. The properties of directed acyclic graphs themselves can provide an epistemological and statistical framework for validation of a priori causal representations of human system risk in space flight. The assumed causal connections on the graph creates sets of logical implications: variables that – if the causal diagram is correct – should be correlated, as well as sets that should be conditionally independent. By testing these implied correlations and conditional independencies both statistically and heuristically, we can provide evidence for or against specific causal pathways on the causal diagram. In addition to validation of expert-generated causal diagrams, machine learning techniques can learn the most likely structure of a causal diagram from a given dataset. Comparison with and reconciliation between machine-learned causal diagrams and expert-generated diagrams is another technique for challenging assumptions and improving our understanding of causal mechanisms. Accurately representing complex causation is essential to systemic understanding of human health risks in space travel. Having a robust system of validating causal diagrams helps us arrive at more accurate representations of causal systems. This process will be integral to developing the countermeasures necessary for extended exploration of the moon and Mars.

Robert Reynolds↗

NASA NTRS2021

NASA Kennedy Space Center Indian River Lagoon Health Initiative Plan

The National Aeronautics and Space Administration (NASA) Kennedy Space Center (KSC) Medical and Environmental Services Division, which includes both the Environmental Management Branch (EMB) and Environmental Assurance Branch (EAB), identified lagoon health as a high priority for the mission. This document provides NASA KSC and its partners a plan which considers the unique relationship between the approximately 140,000-acre Federal property and the Indian River Lagoon (IRL) estuary on and adjacent to KSC, and proposes projects and restoration actions that will ensure NASA KSC’s continued role as a responsible steward promoting IRL health and biodiversity. Additionally, this document provides NASA KSC a reference document to enable informed decisions regarding future IRL health projects.

Indian River Lagoon↗

NASA NTRSDate not supplied

Structural Health Monitoring of Vertical Lift Structures Operating in an Urban Environment

Verifying the structural integrity of aeronautical vehicles is of critical importance for the safety of passengers and crew. When operating in a densely populated urban area, pedestrian safety and collateral damage to buildings and other infrastructure also become important concerns. Damage modes, including fatigue from an increased frequency of take-off and landing cycles and a higher probability of impacts from bird strikes, also pose different failure risks as compared to commercial long-haul aircraft and thus require a change in structural health monitoring philosophy. This presentation will review the state of the art in structural health monitoring with an eye toward applications for vertical lift systems operated in the urban environment. Structural health monitoring methods including eddy current, fiber optic, ultrasonic plate wave, surface acoustic wave and electrical impedance tomography will be explored for use in on-board monitoring of impact and overstrain events as well as damage detection and characterization. Infusion of the data into an early warning system to help ensure damage will not propagate to failure during flight will also be discussed.

Russell A Wincheski↗

NASA NTRSDate not supplied

Behavioral Health and Performance Operations and Research in Human Spaceflight

There are two distinct functions of the Behavioral Health and Performance (BHP) specialists at NASA Johnson Space Center (JSC), with a shared goal of promoting optimal performance during all mission phases, beginning with selection to the NASA Astronaut Corps through training for and completing a spaceflight mission. The BHP Operations team is active in areas such as selection, training, routine behavioral healthcare services, and work-rest schedule. The BHP Laboratory is engaged in research in space and analog platforms to address the risks and other challenges associated with future deep space missions. Their research focuses on topics that align with the NASA Human Research Program’s Human Factors Behavioral Performance Element goals. This panel will provide details of recent work by BHP Operations and the BHP Laboratory at NASA JSC, and will demonstrate their shared goals, and contributions toward, optimizing performance and maintaining the behavioral health and well-being of astronauts during all mission phases.In 2020-2021, NASA engaged another astronaut applicant screening process to identify its 23rd group of astronaut candidates. The BHP Operations team completed a significant amount of work to evaluate applicants and provide valuable input to the Astronaut Selection Board and the Aerospace Medical Board. One presentation will provide an overview of the work completed by BHP; and one presentation will discuss a critical competency important for successful job performance of the astronauts – Team Orientation. The former will summarize aspects of BHP’s Select-in and Select-out process and provide lessons learned for future selection cycles; the latter will briefly discuss the competencies of BHP’s applicant screening work, with focus on the importance of Team Orientation and the challenges of its measure. A third presentation will provide an overview of BHP’s current fatigue management work with astronauts and mission-critical operators at JSC (e.g., flight directors, pilots), and provide a look at the direction these fatigue management services may take in future exploration missions. Two other presentations will focus on the research completed by the BHP Lab to measure in a standardized way the critical aspects of behavioral health and well-being. One of the presentations will provide an overview of the Exploration Measures being collected during all space and analog missions, and the importance these objective measures have for future research and operations. The final presentation will summarize analyses completed with these measures, as they have been harmonized across both ISS and Analog missions.

Gary Beven↗

NASA NTRS2021

Topical: Stem Cell-Based Tissue Regenerative Health in Space

The maintenance of healthy adult tissues in mammals requires a complex homeostasis of molecular, cellular, tissue, and metabolic processes which are fundamentally different from the development and aging processes that bookend life. Cellular homeostasis in the adult requires molecular maintenance and repair of non-dividing cells such as cardiomyocytes and neurons, but also stem cell-based tissue regeneration via direct replacement of cell loss, such as in the blood, immune system, bone, skin, liver, intestine, and other tissues. Because stem cell-based tissue regenerative health requires constant proliferation and differentiation of stem cell progenitors in the bone marrow, and other adult stem cell niches, it is uniquely sensitive to the stresses of spaceflight including exposure to space radiation and mechanical unloading in microgravity. A key central hypothesis in this field is that those spaceflight stress factors can have profound negative effects on long-term tissue regenerative health mediated by adult stem cells, and that unmitigated, they may lead to premature tissue aging and functional failure. Specifically, it is thought that mechanical unloading due to lack of weight-bearing in space reduces mitogenic mechanotransduction necessary to promote adult stem cell proliferation and differentiation, and that space radiation can also lead to activation of cell cycle arrest mechanisms, further reducing adult stem cell proliferation. These hypotheses are being tested in low earth orbit(LEO)using a variety of cellular and whole organism tissue model systems, suggesting that spaceflight consistently interferes with stem cell tissue regenerative processes such as in mammalian embryoid bodies, regenerating newt tails, and mouse bone marrow hematopoietic and osteoprogenitor cells. Furthermore, potential molecular mechanisms integrating both space radiation and mechanical disuse via oxidative stress and the cell cycle inhibitor Cdkn1aare now under study using single cell (scRNAseq) expressome analysis of bone marrow osteoprogenitors, both under stretch loading, and spaceflight conditions including in various mouse transgenic null backgrounds relevant to these mechanisms. Future work in the area of tissue regenerative health in space for the coming decade should seek to understand the responses the various tissue regenerative stem cell niches in humans and relevant model organisms, and how they respond to long-term exposure to the space environment. Special emphases of future work should be on how regenerative deficits in whole-organism stem cell niches may lead to tissue degeneration and premature aging, and on the long-term proliferation and differentiation of stem cell derived tissue organoid models in the deep space environment outside of LEO.

Eduardo A C Almeida↗

NASA NTRSDate not supplied

Operational Health Physics for Radiation Source Payloads

Spacecraft payloads processed at the Kennedy Space Center (KSC) frequently include ionizing and nonionizing radiation sources that require controls to protect the health of the workers involved in the ground operations. At KSC, a robust radiation protection program ensures that radiation hazards are identified, and appropriate controls are implemented using a radiation use authorization (RUA) process and Radiation Protection Committee review and approval. The Health Physics Office provides monitoring and oversight to ensure compliance. A brief overview of health physics activities in support of the Mars 2020 mission will be described to illustrate the overall management of radiation sources during payload ground processing.

Kurt R Geber↗