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Reliability of Strength Testing using the Advanced Resistive Exercise Device and Free Weights

The Advanced Resistive Exercise Device (ARED) was developed for use on the International Space Station as a countermeasure against muscle atrophy and decreased strength. This investigation examined the reliability of one-repetition maximum (1RM) strength testing using ARED and traditional free weight (FW) exercise. Methods: Six males (180.8 +/- 4.3 cm, 83.6 +/- 6.4 kg, 36 +/- 8 y, mean +/- SD) who had not engaged in resistive exercise for at least six months volunteered to participate in this project. Subjects completed four 1RM testing sessions each for FW and ARED (eight total sessions) using a balanced, randomized, crossover design. All testing using one device was completed before progressing to the other. During each session, 1RM was measured for the squat, heel raise, and deadlift exercises. Generalizability (G) and intraclass correlation coefficients (ICC) were calculated for each exercise on each device and were used to predict the number of sessions needed to obtain a reliable 1RM measurement (G . 0.90). Interclass reliability coefficients and Pearson's correlation coefficients (R) also were calculated for the highest 1RM value (1RM9sub peak)) obtained for each exercise on each device to quantify 1RM relationships between devices.

English, Kirk L.↗

Advancing Innovation Through Collaboration: Implementation of the NASA Space Life Sciences Strategy

On October 18, 2010, the NASA Human Health and Performance center (NHHPC) was opened to enable collaboration among government, academic and industry members. Membership rapidly grew to 90 members (http://nhhpc.nasa.gov ) and members began identifying collaborative projects as detailed in this article. In addition, a first workshop in open collaboration and innovation was conducted on January 19, 2011 by the NHHPC resulting in additional challenges and projects for further development. This first workshop was a result of the SLSD successes in running open innovation challenges over the past two years. In 2008, the NASA Johnson Space Center, Space Life Sciences Directorate (SLSD) began pilot projects in open innovation (crowd sourcing) to determine if these new internet-based platforms could indeed find solutions to difficult technical problems. From 2008 to 2010, the SLSD issued 34 challenges, 14 externally and 20 internally. The 14 external challenges were conducted through three different vendors: InnoCentive, Yet2.com and TopCoder. The 20 internal challenges were conducted using the InnoCentive platform, customized to NASA use, and promoted as NASA@Work. The results from the 34 challenges involved not only technical solutions that were reported previously at the 61st IAC, but also the formation of new collaborative relationships. For example, the TopCoder pilot was expanded by the NASA Space Operations Mission Directorate to the NASA Tournament Lab in collaboration with Harvard Business School and TopCoder. Building on these initial successes, the NHHPC workshop in January of 2011, and ongoing NHHPC member discussions, several important collaborations have been developed: (1) Space Act Agreement between NASA and GE for collaborative projects (2) NASA and academia for a Visual Impairment / Intracranial Hypertension summit (February 2011) (3) NASA and the DoD through the Defense Venture Catalyst Initiative (DeVenCI) for a technical needs workshop (June 2011) (4) NASA and the San Diego Zoo for a joint challenge in biomimicry (5) NASA and the FAA Center of Excellence for Commercial Space Flight for five collaborative projects (6) NASA and ESA for a Space Medicine Workshop (July 2011) (7) NASA and Tufts University for an education pilot (8) Establishment of long-term contracts (August 2011) to enable future challenges (9) Establishment of a new Center of Excellence for Collaborative Innovation (July 2011) for all federal agencies in the US

Davis, Jeffrey R.↗

40 Years of Processing Pieces of Space

This year marks the 40th year anniversary for the Antarctic Search for Meteorite (ANSMET) program. In 1976, the ANSMET program led the first expedition to Antarctica. The ANSMET program is a US-led field-based science project that recovers meteorite samples from Antarctica. Once a year from late November to late January, a field team consisting of 8 to 12 people, spends 6-8 weeks camping on the ice and collecting meteorites. Since 1976, more than 22,000 meteorite samples have been recovered. These meteorites come from asteroids, planets and other bodies of the solar system. Once collected, the Antarctic meteorites are shipped to NASA/Johnson Space Center (JSC) Houston, TX. in a refrigerated truck and are kept frozen to minimize oxidation until they are ready for initial processing. In Antarctica each meteorite is given a field tag which consists of numbers, once in the lab, this is replaced by an official tag, consisting of the Antarctic field location and year collected. The types and numbers of meteorites that have been classified include 849 carbonaceous chondrites, 135 enstatites, 512 achondrites, 64 stony, 115 irons, 48 others (27 R chondrites, 7 ungrouped), 6,161 H chondrites, 7,668 L chondrites, and 4,589 LL chondrites. Although 80-85 percent of the collected meteorites fall in the ordinary chondrite group, the other approximately 15 percent represent rare types of achondrites and carbonaceous chondrites. These rare meteorites include 25 lunar meteorites, 15 Martian meteorites, scores of various types of carbonaceous chondrites, and unique achondrites. The Antarctic meteorites that have been collected are processed in the Meteorite Processing Lab at JSC in Houston, TX. Initial processing of the meteorites begins with thawing/drying the meteorites in a nitrogen glove box for 24 to 48 hours. The meteorites are then photographed, measured, weighed and a description of the interior and exterior of each meteorite is written. The meteorite is broken and a representative sample, either a 1-3 gram chip or thin section is sent to the Smithsonian Institution for classification. After Antarctic meteorites have been classified and approved by the Nomenclature Committee of the Meteoritical Society, they are announced in the Antarctic Meteorite Newsletter, which is published twice per year (fall and spring) so that scientists may review which meteorites are available to study. Requests for Antarctic Meteorite samples are welcomed from research scientists, regardless of their current state of funding for meteorite studies. Since its inception over 3,300 requests have been made for pieces of these meteorites and over 400 investigators worldwide are active in the study of meteorites.. Research on these samples has been published in more than1500 peer reviewed articles; a listing of papers for any meteorite sample can be generated by accessing http://curator.jsc.nasa.gov/antmet/referencesearch.cfm. Antarctic meteorite samples requested by scientists are prepared several different ways. Most samples are prepared as chips, either using a rock splitter or using a chisel and chipping bowl. In special situations, a researcher may request a meteorite slab in which case the samples are cut using a diamond-bladed bandsaw inside of a dry nitrogen glove box. The meteorites are always cut in a 100 percent liquid-free environment. Additionally, thin/thick sections of Antarctic meteorites are also prepared at JSC. The meteorite thin section lab at JSC can prepare standard 30-micron thin sections, thick sections of variable thickness (100 to 200 microns), or demountable sections using superglue, all section are prepared without using water. Although many of the techniques used back in the '70's are still used today, advances in computers, software, databases, available tools and instrumentation have helped to streamline and shorten the duration of the classification process. In conjunction with present day missions to asteroids and other planets, meteorite studies have not only led to a better understanding of the complex histories of these bodies but have also tied certain meteorite groups to particular asteroid bodies. New meteorite discoveries by the ANSMET program provide a cost effective method for obtaining samples of previously unsampled bodies, allowing scientists to learn more about the origin, composition, and evolution of the solar system. Preservation in our cleanrooms at NASA allows material to be archived for future generations and advances in instrumentation and analysis.

Satterwhite, C. E.↗

Maldives Climate II: Evaluating the Potential Impacts of Sea Level Rise on Human Development and Coastal Infrastructure

The Republic of the Maldives is a low-lying island nation in the Indian Ocean which has experienced rapid urbanization, landcover changes, and sea level rise over recent years. The growth of tourism, coastal erosion, and urbanization have all driven land reclamation efforts across many islands. As in-situ landcover change monitoring has proven difficult across the vast archipelago, the NASA DEVELOP team collaborated with the Maldives Ministry of Environment, Climate Change, and Technology; USAID; and the U.S. Department of State, to utilize Earth observations to predict sea level rise impacts on coastal infrastructure. The team used a supervised classification algorithm within Google Earth Engine to create land use maps and time series analyses of nine islands and atolls using imagery from Landsat 7 Enhanced Thematic Mapper Plus, Landsat 8 Operational Land Imager, Sentinel-2 Multispectral Instrument, and PlanetScope, covering a combined period of 2000 through 2023. Additionally, the team projected coastal inundation with a modified deterministic Bathtub model utilizing elevation data from CoastalDEM and 2050-2100 Shared Socioeconomic Pathway scenarios identified in the NASA Sea Level Rise Projection Tool. The team found that islands undergoing urban growth experienced a 23% decrease in vegetation between 2014 and 2022. Furthermore, the model predicted that 51–57% of the study area’s-built environment has a chance of inundation by 2100 under the low and high sea level scenarios. These analyses demonstrate how remote sensing can be used to both track land use changes over time and project how coastlines will be affected by sea level rise.

remote sensing↗

San Joaquin Valley Health & Air Quality II: Assessing Urban Heat Island Distribution and its Intersections with Air Quality to Understand Converging Vulnerabilities

The city of Stockton, California, located within the San Joaquin Valley (SJV), is a major hub for agricultural production and has endured the continuous threat to community health from nitrogen dioxide (NO 2 ) and increasing temperatures. The convergence of these issues occurs within historically segregated communities that are disproportionately facing health risks related to heat and air quality. Little Manila Rising (LMR), a social and environmental justice (EJ) advocacy non-profit, partnered with NASA DEVELOP for a second term project to evaluate county wide urban heat islands, sociodemographic vulnerability, landcover classification, and the convergence of these variables. We utilized Landsat 8 Thermal Infrared Sensor (TIRS) and Operational Land Imager (OLI) data to produce a land surface temperature (LST) and Normalized Difference Vegetation Index map. They added Centers for Disease Control (CDC) socioeconomic data from 2020 to identify which communities in Stockton were more susceptible to these environmental factors. Additionally, we used NAIP imagery to create a landcover map differentiating developed infrastructure from tree canopy cover. We discovered that south Stockton, where LMR resides, had the worst convergence of heat, air pollution, low canopy coverage and sociodemographic vulnerability compared to northern and rural parts of the city. This was further substantiated by statistical analysis showing a strong positive relationship between areas of high LST and low vegetation. The results provided LMR with compelling evidence to use in their EJ advocacy, and in their efforts to inform state officials of the discriminatory issues they face.

Urban Heat Islands↗

Intermountain West Wildland Fires: Mapping Tree Mortality and Burn Patches using NASA Earth Observations to Determine Fire Risk and Inform Fire Management Practices

Within the intermountain west, monitoring fuel loads is a major concern for wildland fire management efforts. To address this concern, we partnered with the U.S. Forest Service to inform the agency which forested areas should be prioritized for prescribed burning and fuel reduction near human communities in the Bridger-Teton National Forest, Wyoming. We created burn maps, fuel load maps, and a tutorial document to identify forest impact trends and provide the partner with the tools to replicate project methods for expansion to other wildfire crisis strategy sites. These end products were made using two NASA Earth observations: Landsat 8 Operational Land Imager and Shuttle Radar Topography Mission. Based on our random forest analysis, our maps identified 998 acres within the Wildland Urban Interface that are predicted to have high fuel loading and high burn severity within the Bridger-Teton National Forest. Forested areas closer to heavily populated areas such as Jackson, Kelly, Moran, New Forks Lake, and Star Valley Ranch should be prioritized for fuel reduction. However, our random forest model analysis was limited to using vegetation and topographical indices with no field data for model validation. Therefore, future studies should use field data for model validation to improve model accuracy and additionally incorporate Global Ecosystem Dynamics Investigation data into models to create better predictions of forested areas with high fuel load and high burn severity.

Remote Sensing↗

Kankakee Water Resources: Monitoring Temperature and Vegetation to Detect River Flow Impediments at Energy Intake Structures

In recent years, unpredictable grassing events have occurred at the Dresden Generating Station, located on the Kankakee River in northern Illinois. Grassing events are characterized by large mats of aquatic vegetation that accumulate downstream, resulting in the clogging of water intake structures and leading to major disruptions in power generation. Currently, employees at the Dresden Generating Station are responsible for reactively responding to each grassing event individually. This project, in partnership with Constellation Nuclear and the United States Geological Survey (USGS), assessed the feasibility of using Earth observations (Landsat 9 OLI-2, Landsat 8 OLI, Sentinel-2 MSI, DOVE PlanetScope, WorldView-3, and GPM IMERG) to detect floating aquatic vegetation within the Kankakee River and identify predictive factors that trigger grassing events, as doing so will provide the Dresden Generating Station the ability to anticipate future grassing events and enhance general hydrologic modeling efforts held by the USGS. The results of this study illustrated that, while aquatic vegetation can be detected by satellites with up to moderate spatial resolution (30 m), temporal resolution is a major limiting factor for tracking movements in floating aquatic vegetation and identifying predictive measures for these events. In addition, correlation results suggest a possible negative relationship between grassing events and river discharge (-0.875 correlation coefficient). In the future, pairing these results with ground control surveys and sensors with higher temporal capabilities would allow our project partners to predict and proactively address future grassing events, ensuring the reliable operation of the Dresden Generating Station.

Marisa Smedsrud↗

Wichita Climate II: Quantifying and Mapping Urban Heat to Inform Equitable and Sustainable Urban Planning Initiatives in Wichita, Kansas

Wichita, Kansas is experiencing a host of climate threats, particularly extreme heat manifested through Urban Heat Islands (UHI). Heat is unevenly distributed within cities due to factors such as income inequality, historical discriminatory practices like redlining, and divestment in neighborhoods of color. This leads to less vegetation and more heat-absorbing infrastructure in specific communities. Moreover, adverse effects of heat, including heat-related morbidity and mortality, disproportionately impact populations that experience vulnerability through social inequities and structural discrimination. Heat vulnerability is a combination of the factors of heat exposure, sensitivity, and adaptive capacity, and can be harnessed to guide urban heat interventions. This DEVELOP project partnered with the City of Wichita to understand the spatial distribution and drivers of UHIs and heat vulnerability indicators. The team modeled outcomes of tree cover interventions using Landsat 8’s Thermal Infrared Sensor (TIRS) and Operational Land Imager (OLI), Landsat 9 TIRS-2 and OLI-2, and the International Space Station’s Ecosystem Spaceborne Thermal Radiometer Experiment on the International Space Station (ECOSTRESS) sensor, along with the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) Urban Cooling model. The team also leveraged statistical analysis by implementing principal component analysis to develop a heat vulnerability index (HVI) specific to Wichita. Ultimately, the project’s outputs will inform the City of Wichita’s Climate Adaptation and Mitigation Plan, identify priority areas for heat mitigation initiatives, and be used in public-facing communications to educate communities on the impacts of urban heat.

Environmental Justice↗

Parallel Eclipse Project Checkout

Parallel Eclipse Project Checkout (PEPC) is a program written to leverage parallelism and to automate the checkout process of plug-ins created in Eclipse RCP (Rich Client Platform). Eclipse plug-ins can be aggregated in a feature project. This innovation digests a feature description (xml file) and automatically checks out all of the plug-ins listed in the feature. This resolves the issue of manually checking out each plug-in required to work on the project. To minimize the amount of time necessary to checkout the plug-ins, this program makes the plug-in checkouts parallel. After parsing the feature, a request to checkout for each plug-in in the feature has been inserted. These requests are handled by a thread pool with a configurable number of threads. By checking out the plug-ins in parallel, the checkout process is streamlined before getting started on the project. For instance, projects that took 30 minutes to checkout now take less than 5 minutes. The effect is especially clear on a Mac, which has a network monitor displaying the bandwidth use. When running the client from a developer s home, the checkout process now saturates the bandwidth in order to get all the plug-ins checked out as fast as possible. For comparison, a checkout process that ranged from 8-200 Kbps from a developer s home is now able to saturate a pipe of 1.3 Mbps, resulting in significantly faster checkouts. Eclipse IDE (integrated development environment) tries to build a project as soon as it is downloaded. As part of another optimization, this innovation programmatically tells Eclipse to stop building while checkouts are happening, which dramatically reduces lock contention and enables plug-ins to continue downloading until all of them finish. Furthermore, the software re-enables automatic building, and forces Eclipse to do a clean build once it finishes checking out all of the plug-ins. This software is fully generic and does not contain any NASA-specific code. It can be applied to any Eclipse-based repository with a similar structure. It also can apply build parameters and preferences automatically at the end of the checkout.

Crockett, Thomas M.↗

Summary of the 2008 NASA Fundamental Aeronautics Program Sonic Boom Prediction Workshop

The Supersonics Project of the NASA Fundamental Aeronautics Program organized an internal sonic boom workshop to evaluate near- and mid-field sonic boom prediction capability at the Fundamental Aeronautics Annual Meeting in Atlanta, Georgia on October 8, 2008. Workshop participants computed sonic boom signatures for three non-lifting bodies and two lifting configurations. A cone-cylinder, parabolic, and quartic bodies of revolution comprised the non-lifting cases. The lifting configurations were a simple 69-degree delta wing body and a complete low-boom transport configuration designed during the High Speed Research Project in the 1990s with wing, body, tail, nacelle, and boundary layer diverter components. The AIRPLANE, Cart3D, FUN3D, and USM3D ow solvers were employed with the ANET signature propagation tool, output-based adaptation, and a priori adaptation based on freestream Mach number and angle of attack. Results were presented orally at the workshop. This article documents the workshop, results, and provides context on previously available and recently developed methods.

Park, Michael A.↗

Debris in the geostationary orbit ring, the endless shooting gallery: The necessity for a disposal policy

NASA is considering establishing a policy for the limitation of the physical crowding of the geostationary orbit. The proposed policy is intended to address the following issues: (1) deal only with geostationary altitudes; (2) illustrate the unique value and usefulness of the geostationary orbit ring; (3) describe the orbital dynamics as simply as possible; (4) describe the current spacecraft and debris situation; (5) briefly review current industry and agency policies; (6) project future trends of physical crowding with the present nonpolicy; (7) propose solutions that can be implemented in the near future; and (8) use previous work as much as desirable.

Suddeth, D. H.↗

Simulation of Conformal Spiral Slot Antennas on Composite Platforms

During the course of the grant, we wrote and distributed about 12 reports and an equal number of journal papers supported fully or in part by this grant. The list of reports (title & abstract) and papers are given in Appendices A and B. This grant has indeed been instrumental in developing a robust hybrid finite element method for the analysis of complex broadband antennas on doubly curved platforms. Previous to the grant, our capability was limited to simple printed patch antennas on mostly planar platforms. More specifically: (1) mixed element formulations were developed and new edge-based prisms were introduced; (2) these elements were important in permitting flexibility in geometry gridding for most antennas of interest; (3) new perfectly matched absorbers were introduced for mesh truncations associated with highly curved surfaces; (4) fast integral algorithms were introduced for boundary integral truncations reducing CPU time from O(N-2) down to O(N-1.5) or less; (5) frequency extrapolation schemes were developed for efficient broadband performance evaluations. This activity has been successfully continued by NASA researchers; (6) computer codes were developed and extensively tested for several broadband configurations. These include FEMA-CYL, FEMA-PRISM and FEMA-TETRA written by L. Kempel, T. Ozdemir and J. Gong, respectively; (7) a new infinite balun feed was designed nearly constant impedance over the 800-3000 MHz operational band; (8) a complete slot spiral antenna was developed, fabricated and tested at NASA Langley. This new design is a culmination of the projects goals and integrates the computational and experimental efforts. this antenna design resulted in a U.S. patent and was revised three times to achieve the desired bandwidth and gain requirements from 800-3000 MHz.

Volakis, J. L.↗

LDSD POST2 Modeling Enhancements in Support of SFDT-2 Flight Operations

Program to Optimize Simulated Trajectories II (POST2) was utilized to develop trajectory simulations characterizing all flight phases from drop to splashdown for the Low-Density Supersonic Decelerator (LDSD) project's first and second Supersonic Flight Dynamics Tests (SFDT-1 and SFDT-2) which took place June 28, 2014 and June 8, 2015, respectively. This paper describes the modeling improvements incorporated into the LDSD POST2 simulations since SFDT-1 and presents how these modeling updates affected the predicted SFDT-2 performance and sensitivity to the mission design. The POST2 simulation flight dynamics support during the SFDT-2 launch, operations, and recovery is also provided.

White, Joseph↗

Revisiting the Microlensing Event OGLE 2012-BLG-0026: A Solar Mass Star with Two Cold Giant Planets

Two cold gas giant planets orbiting a G-type main-sequence star in the galactic disk were previously discovered in the high-magnification microlensing event OGLE-2012-BLG-0026. Here, we present revised host star flux measurements and a refined model for the two-planet system using additional light curve data. We performed high angular resolution adaptive optics imaging with the Keck and Subaru telescopes at two epochs while the source star was still amplified. We detected the lens flux, H = 16.39 +/- 0.08. The lens, a disk star, is brighter than predicted from the modeling in the original study. We revisited the light curve modeling using additional photometric data from the B and C telescope in New Zealand and CTIO 1.3 m H-band light curve. We then include the Keck and Subaru adaptive optic observation constraints. The system is composed of an approximately 4-9 Gyr lens star of M(sub lens) = 1.06 +/- 0.05 solar mass at a distance of D(sub lens) = 4.0 +/- 0.3 kpc, orbited by two giant planets of 0.145 +/- 0.008 M(sub Jup) and 0.86 +/- 0.06 M(sub Jup), with projected separations of 4.0 +/- 0.5 au and 4.8 +/- 0.7 au, respectively. Because the lens is brighter than the source star by 16 +/- 8% in H, with no other blend within one arcsec, it will be possible to estimate its metallicity using subsequent IR spectroscopy with 8-10 m class telescopes. By adding a constraint on the metallicity it will be possible to refine the age of the system.

high-magnification microlensing event OGLE-2012-BL↗

Integrating Satellite and Surface Sensor Networks for Irrigation Management Applications in California

Satellite mapping of evapotranspiration (ET) from irrigated agricultural lands can provide agricultural producers and water managers with information that can be used to optimize agricultural water use, especially in regions with limited water supplies. The timely delivery of information on agricultural crop water requirements has the potential to make irrigation scheduling more practical, convenient, and accurate. We present a system for irrigation scheduling and management support in California and describe lessons learned from the development and implementation of the system. The Satellite Irrigation Management Support (SIMS) framework integrates satellite data with information from agricultural weather networks to map crop canopy development, basal crop coefficients (Kcb), and basal crop evapotranspiration (ETcb) at the scale of individual fields. Information is distributed to agricultural producers and water managers via a web-based irrigation management decision support system and web data services. SIMS also provides an application programming interface (API) that facilitates integration with other irrigation decision support tools, estimation of total crop evapotranspiration (ETc) and calculation of on-farm water use efficiency metrics. Accuracy assessments conducted in commercial fields for more than a dozen crop types to date have shown that SIMS seasonal ETcb estimates are within 10 mean absolute error (MAE) for well-watered crops and within 15 across all crop types studied, and closely track daily ETc and running totals of ETc measured in each field. Use of a soil water balance model to correct for soil evaporation and crop water stress reduces this error to less than 8 MAE across all crop types studied to date relative to field measurements of ETc. Results from irrigation trials conducted by the project for four vegetable crops have also demonstrated the potential for use of ET-based irrigation management strategies to reduce total applied water by 20-40 relative to grower standard practices while maintaining crop yields and quality.

Nemani, Ramakrishna R.↗

Yonkers Urban Development: Utilizing NASA Earth Observations to Identify Environmental and Social Drivers of Urban Heat Vulnerability and Model Urban Cooling Interventions in Yonkers, New York

The City of Yonkers, New York, is located directly north of the Bronx in Westchester County and currently hosts a population of nearly 200,000. In response to increasing hot-weather episodes, the risk of heat-related illnesses and mortality is disproportionately affecting neighborhoods in Yonkers historically subjected to race-based housing segregation. NASA DEVELOP collaborated with Groundwork Hudson Valley to determine regions within Yonkers that are experiencing the most intense urban heat island effects, identify and rank sociodemographic and environmental determinants of increasing community-level vulnerability, map these vulnerabilities as a combined vulnerability index, complete a proximity analysis of walkability to local cooling centers and health facility locations, and model potential cooling strategies. The study area consisted of Yonkers, NY and the analyses used data from 2015-2020 (June through August). The project utilized NASA Earth observation products including Landsat 4 and 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper Plus (ETM+), Landsat 8 Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS), Terra Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), and ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS). We assessed the benefits of different heat-mitigation scenarios by utilizing the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) urban cooling model. Results from these analyses can be used by Groundwork Hudson Valley, supporting the New York State’s Climate Safe Communities Certifiable Planning Actions, expanding knowledge on the relationship between historic redlining and environmental equity, and informing their Climate Safe Neighborhoods initiative to identify and prioritize mitigation efforts to abate the worst impacts of extreme heat.

Jillian Walechka↗

Conditions of the Toll-Like Receptors System of the Human Innate Immunity Cells During the Long-Term Isolation

During long duration missions onboard the International Space Station (ISS), alterations in T cell function and plasma cytokine profiles have been observed. Recent studies involving pattern recognition receptors (PRRs) have established that adaptation of innate immunity to long duration space flight occurs through changes in signal PRRs, Toll-like receptors (TLRs). Despite the fact that fundamental research of PRR molecular biology is far from complete, there are an increasing number of arguments confirming the important role of this system in regulating the initial stages of the adaptive immune response, as well as in the formation of autoimmune and allergic diseases. Long duration isolation is widely used by NASA as an analog for space flight with previous missions including several Antarctic bases, an undersea research station (NEEMO), and other isolation chambers. ‘SIRIUS’ is a multi-compartment pressurized facility at the IMBP in Moscow, Russia, in which subjects will spend 8 months executing tasks similar to those performed by astronauts in space. Prolonged isolation studies like SIRIUS replicate many of the influences expected to occur during long duration spaceflight missions including isolation, stress, confinement, and living in remote conditions. The immune study to be performed on the upcoming SIRIUS mission is being led by Dr. Sergey Ponomarev at the Institute of Biomedical Problems in Moscow, Russia. The NASA JSC Immunology lab will provide analysis of immune cell function, serum cytokines and stress hormones, and salivary cortisol, cytokines, and viruses. This study will be conducted with SIRIUS subjects under the auspices of the parent program. The goal of the study is to evaluate the effect of the 8-month isolation mission on components of human innate immunity at the molecular and cellular level. Successful implementation and completion of this project will provide a unique assortment of new data, significantly expanding the current understanding of the molecular and cellular changes in TLRs during long-term isolation. We hypothesize that mission-like isolation in the Russian NEK facility, consisting of circadian misalignment, isolation, stress, and ‘station lifestyle’, will result in a pattern of immune dysregulation similar to that observed in astronauts onboard ISS. This pattern of alterations can be summarized as phenotypic changes (altered distribution of peripheral cytotoxic, central memory, CD8+ T cell subsets), reductions in T cell function, alterations in plasma cytokine profiles (increased inflammatory and certain chemokines), and reductions in mitogen stimulated cytokine profiles (spans Th1, Th2, Th17). We further hypothesize that these immune changes will correlate with the reactivation of latent herpesviruses (which persists during orbital flight), to be used as measurable adverse clinical manifestation or with other observed symptomology. The SIRIUS-21 mission began in November of 2021 and successfully concluded with the crew emerging in July of 2022. Currently, the logistics of shipping the samples from Russia to the United States is being organized.

Cody L Gutierrez↗

The Impact of NPG 7120.5A Upon Training and Development

NASA Procedures and Guidance 7120.5A for Program and Project Management Processes and Requirements should have minimal effect upon current Agency training and development programs - mainly because the new directive simply formalizes what we have been teaching and learning in the NASA Program/Project Management Initiative all along. A frequent complaint we get from the 8,000 or so graduates of our PPMI courses over the years, however, deals with resistance to what they may have learned in the classroom or training site. Brimming with new ideas, these young men and women often run up against an entrenched program or project manager who insists that things be done "the old way," too often perceived as "the NASA way" or even "the Goddard way." Management was all too often in the eyes of the manager; now we're all reading from the same book, 7120.5A, Still, there is no single method or "one size fits all" approach to project management in NASA. While each Center is responsible for developing policies, processes and procedures to comply with the new NPG, individual program and project managers will still need to tailor their requirements to the specific needs of the project, consistent with the size, complexity, risk and criticality of the project. Under NPG 7120.5A, the results of such tailoring are to be documented in agreements among managers, directors, Enterprise Associate Administrators and the Administrator.

Hoffman, Edward J.↗