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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 379 records · Page 21

Improving CLM5.0 Biomass and Carbon Exchange Across the Western United States Using a Data Assimilation System

The Western United States is dominated by natural lands that play a critical role for carbon balance, water quality, and timber reserves. This region is also particularly vulnerable to forest mortality from drought, insect attack, and wildfires, thus requiring constant monitoring to assess ecosystem health. Carbon monitoring techniques are challenged by the complex mountainous terrain, thus there is an opportunity for data assimilation systems that combine land surface models and satellite-derived observations to provide improved carbon monitoring. Here, we use the Data Assimilation Research Testbed to adjust the Community Land Model (CLM5.0) with remotely sensed observations of leaf area and above-ground biomass. The adjusted simulation significantly reduced the above-ground biomass and leaf area, leading to a reduction in both photosynthesis and respiration fluxes. The reduction in the carbon fluxes mostly offset, thus both the adjusted and free simulation projected a weak carbon sink to the land. This result differed from a separate observation-constrained model (FLUXCOM) that projected strong carbon uptake to the land. Simulation diagnostics suggested water limitation had an important influence upon the magnitude and spatial pattern of carbon uptake through photosynthesis. We recommend that additional observations important for water cycling (e.g., snow water equivalent, land surface temperature) be included to improve the veracity of the spatial pattern in carbon uptake. Furthermore, the assimilation system should be enhanced to maximize the number of the simulated state variables that are adjusted, especially those related to the recommended observed quantities including water cycling and soil carbon.

54 ENVIRONMENTAL SCIENCES↗

Laser cutting apparatus for high energy density and diamond anvil cell science

In this paper, we present a low-cost, high-resolution laser cutting system designed for use in the fabrication of samples for high energy density physics. Such samples are necessarily small but require precision and repeatability, particularly with the recently available high repetition rates possible at modern facilities. The system allows simultaneous laser cutting, using nanosecond near-infrared laser pulses, and optical microscopy so that the cut can be monitored in real time. The capabilities of the system are demonstrated on a range of materials for both laser-matter interaction targets and components for high pressure diamond anvil cell experiment.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Design of Ionization Profile Monitors at the Integrable Optics Test Accelerator Facility at Fermilab

The Integrable Optics Test Accelerator (IOTA) at Fermilab is transitioning from an electron beam facility to a proton beam facility for studies in nonlinear accelerator optics and space-charge dominated proton beams. This project involves the commissioning and fabrication of Ionization Profile Monitors (IPMs) to enable beam profile measurements at IOTA. In general, IPMs work on principle of residual gas ionization by the beam to generate beam profile. This work focuses on a mechanical design that leverages a controlled injection of noble gases, primarily Argon, as the ultra-high vacuum of the IOTA ring provides insufficient residual gas for ionization. Efforts to understand vacuum integration to ensure compatibility with the storage ring environment, the integration of real-time data acquisition systems and the commissioning of the IPMs will be discussed. This project provides a versatile diagnostic tool, supporting IOTA’s role as a testbed for larger-scale accelerator facilities and contributing to the broader understanding of beam physics in high-intensity, high-space-charge regimes.

Mwaniki, M. W. [IIT, Chicago] (ORCID:0000000169057↗

The case for digital twins in metal additive manufacturing

The digital twin (DT) is a relatively new concept that is finding increased acceptance in industry. A DT is generally considered as comprising a physical entity, its virtual replica, and two-way digital data communications in-between. Its primary purpose is to leverage the process intelligence captured within digital models—or usually their faster-solving surrogates—towards generating increased value from the physical entities. The surrogate models are created using machine learning based on data obtained from the field, experiments and digital models, which may be physics-based or statistics-based. Anomaly detection and correction, and diagnostic closed-loop process control are examples of how a process DT can be deployed. In the manufacturing industry, its use can achieve improvements in product quality and process productivity. Metal additive manufacturing (AM) stands to gain tremendously from the use of DTs. This is because the AM process is inherently chaotic, resulting in poor repeatability. However, a DT acting in a supervisory role can inject certainty into the process by actively keeping it within bounds through real-time control commands. Closed-loop feedforward control is achieved by observing the process through sensors that monitor critical parameters and, if there are any deviations from their respective optimal ranges, suitable corrective actions are triggered. The type of corrective action (e.g. a change in laser power or a modification to the scanning speed) and its magnitude are determined by interrogating the surrogate models. Because of their artificial intelligence (AI)-endowed predictive capabilities, which allow them to foresee a future state of the physical twin (e.g. the AM process), DTs proactively take context-sensitive preventative steps, whereas traditional closed-loop feedback control is usually reactive. Apart from assisting a build process in real-time, a DT can help with planning the build of a part by pinpointing the optimum processing window relevant to the desired outcome. Again, the surrogate models are consulted to obtain the required information. In this article, we explain how the application of DTs to the metal AM process can significantly widen its application space by making the process more repeatable (through quality assurance) and cheaper (by getting builds right the first time).

36 MATERIALS SCIENCE↗

A physics-based parametric regression approach for feedwater pump system diagnosis

Here in this paper, we assessed the performance of a model-based approach for fault diagnosis of a nuclear power plant feedwater pump system. Physics-based models were constructed to monitor the performance of the system components. Plant data were used for the calibration of the models and subsequently in the diagnosis of abnormal events. We considered two real-time events representing scenarios of a pump fault and component performance degradation. The two events were correctly diagnosed, and the results demonstrated the high detection sensitivity of the physics-based models. Various sensor fault scenarios were simulated to show the capability of the approach to detect and uniquely identify sensor faults. Results for a scenario in which the plant operated in flexible power mode also showed that the diagnostic approach is insensitive to changes of operating conditions, which is one of the advantages of the model-based approach using physics-based models over purely data-driven approach.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations

A main cause of vision loss in the elderly is age-related macular degeneration (AMD). Among the cellular, biochemical, and molecular changes linked to this disease, inflammation and angiogenesis appear as being crucial in AMD pathogenesis and progression. There are two forms of the disease: dry AMD, accounting for 80–90% of cases, and wet AMD. The disease usually begins as dry AMD associated with retinal pigment epithelium and photoreceptor degeneration, whereas wet AMD is associated with choroidal neovascularization resulting in severe vision impairment. The new vessels are largely malformed, leading to blood and fluid leakage within the disrupted tissue, which provokes inflammation and scar formation and results in retinal damage and detachment. MicroRNAs are dysregulated in AMD and may facilitate the early detection of the disease and monitoring disease progression. Two recent reviews of microRNAs in AMD had indicated weaknesses or limitations in four earlier investigations. Studies in the last three years have shown considerable progress in overcoming some of these concerns and identifying specific microRNAs as biomarkers for AMD. Further large-scale studies are warranted using appropriate statistical methods to take into account gender and age disparity in the study populations and confounding factors such as smoking status.

60 APPLIED LIFE SCIENCES↗

Design improvements to the SNS ion source and diagnostics

The U.S. Spallation Neutron Source (SNS) is a state-of-the-art neutron scattering facility delivering the world's most intense pulsed-neutron beams to a wide array of instruments which are used to conduct investigations in many fields of science and engineering. The accelerator system is fed by an RF-driven, multicusp, H - ion source which nominally provides pulsed beam currents of 50-60 mA (1ms, 60Hz). This report provides a discussion of ongoing design improvements to the SNS ion source and Low Energy Beam Transport (LEBT) as well as diagnostic upgrades undertaken since the previous ICIS conference. These improvements include (i) simple mechanical modifications to the source outlet aperture which resulted in dramatically increased extracted beam current and comparable or lower emittance at similar beam currents, (ii) design improvements to the LEBT chopper target which will enable full power beam-dumping during physics studies, (iii) refinement of the SNS Allison emittance scanner that has enabled the first reliable LEBT beam measurements at full beam power (65kV, 50-100mA, 1ms, 60Hz) on the SNS ion source test stand and (iv) the implementation of a thermal imaging camera for the monitoring the LEBT electrode temperatures. (v) The design of an advanced Cs system, capable of more efficient Cs utilization with significantly lower Cs losses from the source is also presented. Mechanical details, computational simulations and experimental results are discussed within the context of these improvements.

47 OTHER INSTRUMENTATION↗

Fast response, optical radiance measurements of low intensity impurity emission in WEST plasmas with staggered wavelength filters

Fast response acquisition of atomic line emission through the use of a filterscope has been implemented on the WEST tokamak at multiple poloidal locations. Filterscopes consist of a fiber-optic-based transmission from the tokamak to specifically engineered optical bandpasses and photomultiplier tubes (PMT) that collect the emission intensity to measure a radiance, L [W/cm2/str], over the specified bandpass. This diagnostic records plasma-wall interaction (PWI) properties (e.g. impurity emission and recycling of main fuel ions) up to a max acquisition rate of 100 kHz. These PMT radiometric measurements are calibrated into a line-normalized radiance, LN [photons/sec/cm2/str], similar to traditional spectrometers, which can later be converted to a particle flux. Low intensity emission peaks are difficult to quantify due to often comparable continuum levels, thus a secondary filter shifted to a judiciously-selected, line-free region (~1 nm away) allows for background subtraction. The system currently installed on WEST targets tungsten (W) gross sputtering specifically by monitoring, with a filter pair, the spectral region near the neutral W line emission (W I 400.9 nm). The line and background filters of the pair are centered at 400.6 nm and 403.1 nm, respectively. Through a set beam splitters on each sight line, the filter pair are measuring from the same location. The two L signals near W I are then subtracted from each other yielding only the W I LN. W I LN data from a recent WEST experimental campaign is presented and compared with plasma parameters and traditional spectrometer measurements of W I line emission to demonstrate the capabilities of this staggered-filter filterscope method. Specifically, the choice of WEST-specific bandpass curves for the W I LN will be illustrated based on this latter comparison.

Neff, Anton↗

Development of a novel bunch oscillation recorder with RFSoC technology

The SuperKEKB accelerator is designed to achieve unprecedented luminosity levels, but this goal is currently hindered by Sudden Beam Loss (SBL) events. These events not only obstruct luminosity improvement but also pose a significant risk to accelerator components, the Belle II detectors, and the superconducting focusing system, potentially leading to severe damage and quenching of the superconducting system. Here, to address this critical challenge, we have developed a novel Bunch Oscillation Recorder (BOR) based on RFSoC technology. The BOR has demonstrated high precision with a position resolution of 0.03 mm, making it a powerful tool for real-time beam monitoring. In its initial deployment, the BOR successfully recorded multiple SBL events, providing valuable data for further analysis. By strategically positioning BORs at the suspected points of SBL origin, we aim to directly identify sources of beam instability. We anticipate that this portable, high-speed BOR monitor will play a crucial role in resolving the SBL issue, ultimately helping achieve SuperKEKB's luminosity targets.

Beam diagnostics↗

Eliminating Signal Bias Caused by Vacuum System Backstreaming in the Diagnostic Residual Gas Analyzer of ITER

In fusion neutral gas analysis, such as with the Diagnostic Residual Gas Analyzer (DRGA) for ITER, the primary measurement range of interest comprises the low-amu species (1 to 6), especially deuterium and helium. The challenge in successfully obtaining accurate measurements is two-fold. First, the sensitivity of the method must be sufficient to resolve trace amounts accurately; typically, one percent or less. Second, the gas signal from the fusion processes must be free of bias caused by the latent presence (from system outgassing and/or vacuum backstreaming) of these gases to enable accurate interpretation of the measured signal. This latter criterion can be problematic for the lightest gases since there is a propensity for some fraction of the pumped gas load to undergo a phenomenon known as backstreaming. This behavior is manifested in pumping systems for gas properties related to relative atomic weight (lightest) and size (smallest). Backstreaming results in a significant amount of the pumped gas undertaking a reverse flow and re-entering the measurement region; thus, contaminating the forward, real-time measurement. To fully eliminate this adverse effect, a conductance-limiting device – or orifice – has been installed in the high-vacuum pumping system of the present ITER DRGA prototype. The system was already equipped with a secondary turbomolecular pump (TMP), but with limited effectiveness against backstreaming in the inter-pump volume (IPV). This orifice is placed within the suction inlet coupling of the secondary TMP, which is downstream of the IPV. Its objective is to eliminate the backstreaming phenomenon by increasing the back pressure in the IPV. However, the orifice sizing must take into consideration other factors, such as the diagnostic measurement objectives. For example, in the ITER DRGA, one of the measurement requirements is a dynamic response time of ~1s. Fortunately, an added benefit of the pumping restriction created by the orifice is that the upstream pressure increase is beneficial for the DRGA’s optical gas analysis (OGA) sensors. These sensors are attached to the IPV in the present design. The glow discharges, when used as an OGA light source, will typically have a brighter light emission with increasing plasma cell pressure. In addition to the fusion machine research sector, there are other potential applications of this pumping technique where the monitoring of lighter gas concentrations is essential, such as the photolithography process for the semiconductor fabrication of integrated circuits. This presentation will describe the vacuum system used to demonstrate a process to eliminate backstreaming as well as show test results to verify the accomplishment of this critical objective.

Marcus, Chris↗

Label-Free Anti-Brownian Trapping of Single Nanoparticles in Solution

Today, biomolecular nanoparticles are prevalent as diagnostic tools and molecular delivery carriers, and it is particularly useful to examine individuals within a sample population to quantify the variations between objects and directly observe the molecular dynamics involving these objects. Using interferometric scattering as a highly sensitive label-free detection scheme, we recently developed the interferometric scattering anti-Brownian electrokinetic (ISABEL) trap to hold a single nanoparticle in solution for extended optical observation. In this perspective, we describe how we implemented this trap, how it extends the capabilities of previous ABEL traps, and how we have begun to study individual carboxysomes, a fascinating biological carbon fixation nanocompartment. By monitoring single nanocompartments for seconds to minutes in the ISABEL trap using simultaneous interferometric scattering and fluorescence spectroscopy, we have demonstrated single-compartment mass measurements, cargo-loading trends, and redox sensing inside individual particles. These experiments benefit from rich multiplexed correlative measurements utilizing both scattering and fluorescence with many exciting future capabilities within reach.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Laser Powder Bed Fusion Additive Manufacturing In-Process Monitoring and Optimization Using Thermionic Emission Detection

In this project, the emission of electrons during laser powder bed fusion additive manufacturing was identified and investigated to resolve the underlying dynamics driven by laser-material interactions. Laser powder bed fusion involves the selective laser melting of metal powder particles layer by layer which fuse together forming a larger 3D structure. Laser-based additive manufacturing approaches such as laser powder bed fusion hold the potential to revolutionize manufacturing of complex metal components in the aerospace, medical, and automotive industries. However, the difficulty in producing defect-free components by metal 3D printing is a major hurdle for widespread commercial adoption. This project resolved important dynamics in laser powder bed fusion including the identification of plasma formation mechanisms, transitions between laser-induced melting modes and stochastic precursors to defect formation. These findings were realized through implementation of electronic sensing diagnostics into an existing testbed system and harnessing capabilities developed for the time dependent analysis of laser powder bed fusion datasets. Importantly, the results advance our understanding of laser-material interactions and reveal that detection of thermionic emission can also resolve information critical to optimization of the laser powder bed fusion fabrication process. The findings are critical for advancing our fundamental understanding of the laser powder bed fusion process and can help assure the requisite fidelity of fabricated components.

36 MATERIALS SCIENCE↗

Nonlinear integrable optics beam dynamics experiment and diagnostics

All present circular particle accelerators are built around linear focusing optics. Un-avoidable nonlinear elements appear in accelerators, such as magnetic aberrations and space-charge effects, which are typically corrected using nonlinear magnets. However, these added nonlinearities degrade particle beam stability, and in most cases, the system becomes non-integrable. The Integrable Optics Test Accelerator (IOTA), at Fermi National Accelerator Laboratory (Fermilab), is a test bed to study beam dynamics in integrable lattices for both electron and proton beams, independently. This work presents experimental results of the nonlinear electron beam dynamics behavior in IOTA using an elliptical nonlinear magnet. The elliptical nonlinear magnet allows for a large betatron tune spread, allowing for a stable high-intensity beam. In a future experimental run, minimally invasive beam instrumentation is needed to study time-dependent collective instabilities, and halo formation in space-chargedominated proton beams. Traditional profile monitors are too destructive to the beam or just measure one dimension of the beam. A gas sheet can be injected perpendicular to theproton beam at an angle. By doing so, a two-dimensional, turn-by-turn, transverse profile measurement can be made, which will preserve the integrity of the beam. The developmentand progress of a gas sheet beam profile monitor will also be presented.

43 PARTICLE ACCELERATORS↗

Novel theranostic agent for PET imaging and targeted radiopharmaceutical therapy of tumour-infiltrating immune cells in glioma

Background: Malignant gliomas are deadly tumours with few therapeutic options. Although immunotherapy may be a promising therapeutic strategy for treating gliomas, a significant barrier is the CD11b + tumour-associated myeloid cells (TAMCs), a heterogeneous glioma infiltrate comprising up to 40% of a glioma's cellular mass that inhibits anti-tumour T-cell function and promotes tumour progression. A theranostic approach uses a single molecule for targeted radiopharmaceutical therapy (TRT) and diagnostic imaging; however, there are few reports of theranostics targeting the tumour microenvironment. Methods: Utilizing a newly developed bifunctional chelator, Lumi804, an anti-CD11b antibody (αCD11b) was readily labelled with either Zr-89 or Lu-177, yielding functional radiolabelled conjugates for PET, SPECT, and TRT. Findings: 89 Zr/ 177 Lu-labeled Lumi804-αCD11b enabled non-invasive imaging of TAMCs in murine gliomas. Additionally, 177 Lu-Lumi804-αCD11b treatment reduced TAMC populations in the spleen and tumour and improved the efficacy of checkpoint immunotherapy. Interpretation: 89 Zr- and 177 Lu-labeled Lumi804-αCD11b may be a promising theranostic pair for monitoring and reducing TAMCs in gliomas to improve immunotherapy responses.

60 APPLIED LIFE SCIENCES↗

SEM Grid Testing at NLCTA in BeamNetUS Program

We report on the performance of a secondary electron monitor (SEM) grid used to measure the transverse profile of an MeV range electron beam at SLAC National Accelerator Laboratory’s Next Linear Collider Test Accelerator (NLCTA) facility. When inserted into the path of the electron beam, secondary electron emission results in a measurable current on the wires that make up the grid. We present measurements using this technique to reconstruct the beam profile. The SEM grid was designed and manufactured by a team of undergraduate students at Harvey Mudd College (HMC) and was tested at SLAC’s NLCTA facility in collaboration with NCLTA staff as part of the BeamNetUS program. Developed for real-time diagnostics of MeV-range electron beams, this SEM grid has potential applications in both industrial and medical contexts.

43 PARTICLE ACCELERATORS↗

An adaptive masking method for beam halo measurement by a digital micro mirror device

We report that in high intensity particle beams, irregularities in cathode emission, scattering effects, dark current and space charge forces can lead to a common phenomenon termed beam halo with associated emittance growth, beam loss and overall beam quality degradation. It is of fundamental interest and practical importance to precisely monitor such beam halo, which could offer valuable insights into the experimental strategy for the suppression of this undesired feature. A Digital Micro mirror Device (DMD) is a computer-controlled micro-electrical-mechanical system that contains a compact array of physically independent reflective mirrors. Using a standard DMD, we come up with an adaptive masking method for halo measurement, which demonstrates superior robustness and efficiency comparing to the conventional approaches as confirmed by simulation and experimental results. Our development includes an integrated package of hardware, software and a graphic user interface (GUI) that is robust and portable and can be applied as a beam halo diagnostic for electron guns or radiating charged particle beams in general.

43 PARTICLE ACCELERATORS↗

Characterization of a 2016-2017 Human Seasonal H3 Influenza A Virus Spillover Now Endemic to U.S. Swine

In 2017, the Iowa State University Veterinary Diagnostic Laboratory detected a reverse-zoonotic transmission of a human seasonal H3 influenza A virus into swine (IAV-S) in Oklahoma. Pairwise comparison between the recently characterized human seasonal H3 IAV-S (H3.2010.2) hemagglutinin (HA) sequences detected in swine and the most similar 2016–2017 human seasonal H3 revealed 99.9% nucleotide identity. To elucidate the origin of H3.2010.2 IAV-S, 45 HA and 27 neuraminidase (NA) sequences from 2017 to 2020 as well as 11 whole-genome sequences (WGS) were genetically characterized. Time to most recent common human ancestor was estimated between August and September 2016. The N2 NA was of human origin in all but one strain from diagnostic submissions with NA sequences, and the internal gene segments from WGS consisted of matrix genes originating from the 2009 pandemic H1N1 and another 5 internal genes of triple reassortant swine origin (TTTTPT). Pigs experimentally infected with H3.2010.2 demonstrated efficient nasal shedding and replication in the lungs, mild pneumonia, and minimal microscopic lung lesions and transmitted the virus to indirect contact swine. Antigenically, H3.2010.2 viruses were closer to a human seasonal vaccine strain, A/Hong Kong/4801/2014, than to the H3.2010.1 human seasonal H3 viruses detected in swine in 2012. This was the second sustained transmission of a human seasonal IAV into swine from the 2010 decade after H3.2010.1. Monitoring the spillover and detection of novel IAV from humans to swine may help vaccine antigen selection and could impact pandemic preparedness.

59 BASIC BIOLOGICAL SCIENCES↗

Position-specific isotope effects during alkaline hydrolysis of 2,4-dinitroanisole resolved by compound-specific isotope analysis, 13 C NMR, and density-functional theory

Compound-specific isotope analysis (CSIA), position-specific isotope analysis (PSIA), and computational modeling (e.g., quantum mechanical models; reactive-transport models) are increasingly being used to monitor and predict biotic and abiotic transformations of organic contaminants in the field. However, identifying the isotope effect(s) associated with a specific transformation remains challenging in many cases. We describe and interpret the position-specific isotope effects of C and N associated with a SN 2 Ar reaction mechanism by a combination of CSIA and PSIA using quantitative 13 C nuclear magnetic resonance spectrometry, and density-functional theory, using 2,4-dinitroanisole (DNAN) as a model compound. The position-specific 13 C enrichment factor of O–C 1 bond at the methoxy group attachment site (ε C1 ) was found to be approximately -41‰, a diagnostic value for transformation of DNAN to its reaction products 2,4-dinitrophenol and methanol. Theoretical kinetic isotope effects calculated for DNAN isotopologues agreed well with the position-specific isotope effects measured by CSIA and PSIA. This combination of measurements and theoretical predictions demonstrates a useful tool for evaluating degradation efficiencies and/or mechanisms of organic contaminants and may promote new and improved applications of isotope analysis in laboratory and field investigations.

13C NMR↗