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The objective of this document is to report the biokinetics of inhaled 238 Pu inferred from the Bayesian analysis of bioassay data collected from workers who have had an intake resulting in a reportable dose within the last two decades at Los Alamos National Laboratory (LANL).
The numerical solution of highly compressible, multi-material flows is an ongoing research area. These types of flows can be solved with a Lagrangian type mesh which moves with the material in a simulation to allow precise material interface tracking. Currently, researchers at Los Alamos National Laboratory and elsewhere are investigating cell-centered Lagrangian algorithms with the aim of producing methods that have second-order accuracy, preserve symmetry, and do not generate spurious vorticity. The new cell-centered algorithms solve a Riemann-like problem at the vertex of a cell. Professor Phil Roe at the University of Michigan has proposed a new structure for Lagrangian hydrodynamic algorithms that does not rely on the solution of the Riemann problem. The new approach utilizes Flux Corrected Transport (FCT) and it implements a form of vorticity control. The first step in the development of this method has been to construct an algorithm that solves the acoustic equations on an Eulerian mesh. The algorithm, which builds on the work of Morton and Roe, calculates fluxes at cell vertices, attains second-order accuracy using FCT, and has the special property of preserving vorticity. Results are presented that confirm the second order accuracy of the scheme and the vorticity preserving properties. The results are compared to the output produced by a MUSCL-Hancock algorithm. Some discussion of limiting methods for the FCT algorithm is also given.
Fostemsavir, a prodrug of the gp120-directed attachment inhibitor temsavir, is indicated for use in heavily treatment-experienced individuals with MDR HIV-1. Reduced susceptibility to temsavir in the clinic maps to discrete changes at amino acid positions in gp160: S375, M426, M434 and M475.To query the Los Alamos National Laboratory (LANL) HIV Sequence Database for the prevalence of polymorphisms at gp160 positions of interest. Full-length gp160 sequences (N = 7560) were queried for amino acid polymorphisms relative to the subtype B consensus at positions of interest; frequencies were reported for all sequences and among subtypes/circulating recombinant forms (CRFs) with ≥10 isolates in the database. Among 239 subtypes in the database, the 5 most prevalent were B (n = 2651, 35.1%), C (n = 1626, 21.5%), CRF01_AE (n = 674, 8.9%), A1 (n = 273, 3.6%) and CRF02_AG (n = 199, 2.6%). Among all 7560 sequences, the most prevalent amino acids at positions of interest (S 375 , 73.5%; M 426 , 82.1%; M 434 , 88.2%; M 475 , 89.9%) were the same as the subtype B consensus. Specific polymorphisms with the potential to decrease temsavir susceptibility (S 375 H/I/M/N/T/Y, M 426 L/P, M 434 I/K and M475I) were found in <10% of isolates of subtypes D, G, A6, BC, F1, CRF07_BC, CRF08_BC, 02A, CRF06_cpx, F2, 02G and 02B. S 375 H and M 475 I were predominant among CRF01_AE (S375H, 99.3%; M 475 I, 76.3%; consistent with previously reported low temsavir susceptibility of this CRF) and 01B (S 375 H, 71.7%; M 475 I, 49.5%). Analysis of the LANL HIV Sequence Database found a low prevalence of gp160 amino acid polymorphisms with the potential to reduce temsavir susceptibility overall and among most of the common subtypes.
Associated with the Meteorological Tower Network Expansion Pilot Project by the Environmental Protection and Compliance (EPC) Compliance Programs (CP) Meteorology and Air Quality (MAQ) team, the purpose of this technical report is to establish requisite justification for the siting of three 10-meter high instrumented meteorological towers at three new locations on the Los Alamos National Laboratory (LANL) site. These towers and their associated instrumentation are similar in scope to the existing 10-meter meteorological tower that is collecting meteorological data in Mortandad Canyon (MDCN). The conclusions and recommendations in this technical report will inform LANL management, EPC-CP MAQ staff, and other LANL divisions of the criteria employed for the selection of the final location for siting these three new towers. Meeting such comprehensive criteria will ensure that all data acquired will be spatially representative for meeting the diverse Safety Basis (SB), emergency management, and operations organizations programmatic needs and analytical data input requirements to its codes.
The results of an experiment can never be considered a failure. Analyses of the results often suggest modifications to theories and procedures to improve the understanding of the underlying principles. In a similar way, observation and analyses of accidents suggest modifications to procedures and behavior to minimize repetition. The lecture covers early accidents at Los Alamos National Laboratory.
The National Nuclear Security Administration (NNSA), a semi-autonomous agency within the U.S. Department of Energy (DOE), is proposing new construction in lower Sandia Canyon at Technical Area (TA) 72 at the Outdoor Live Fire Range facility at Los Alamos National Laboratory (LANL). The proposed upgrades are intended to improve range safety.
The National Nuclear Security Administration (NNSA), a semi-autonomous agency within the U.S. Department of Energy (DOE), is proposing new construction in lower Sandia Canyon at Technical Area (TA) 72 at the Guard Post 10 vehicle inspection station at Los Alamos National Laboratory (LANL). The proposed project is intended to provide expedited inspection times for vehicles transporting time sensitive loads, such as concrete and asphalt. The project activities within the 100-year floodplain include installation of 1) installation of an expedited vehicle inspection lane, 2) relocation of a 4-strand wire fence, 3) possible relocation of at least one power pole, and 4) a laydown area (Figures 1 and 2).
The National Nuclear Security Administration (NNSA), a semi-autonomous agency within the U.S. Department of Energy (DOE), is proposing new construction in lower Sandia Canyon at Technical Area (TA) 72 at the Outdoor Live Fire Range facility at Los Alamos National Laboratory (LANL). The proposed project is intended to provide storage for firing range supplies and consumables. The project activities within the 100-year floodplain include installation of at least seven prefabricated metal transportainer type storage units located at one of four locations (Figure 1).
Coastal cities offer a unique environment for studying aerosol-cloud interactions and the effects of urban emissions on aerosol and cloud properties. As part of the U.S. Department of Energy Atmospheric Radiation Measurement (ARM)’s Eastern Pacific Cloud Aerosol Precipitation Experiment (EPCAPE), the Partitioning Thrust by Los Alamos National Laboratory (EPCAPE-PT-LANL) was conducted to complement the science goals of EPCAPE and add additional in-depth measurements of aerosols and clouds at Mt. Soledad. Our campaign focused on measuring the physical, optical, and chemical properties of aerosols, trace gases, and their interactions within marine stratocumulus clouds in La Jolla, California (see Figure 1).
Incidents involving release of nuclear materials stored in containers of convenience such as food pack cans, slip lid taped cans, paint cans, etc. has resulted in defense board concerns over the lack of prescriptive performance requirements for interim storage of nuclear materials. Los Alamos National Laboratory (LANL) has shared in these incidents and in response proactively moved into developing a performance based storage container design, the SAVY-4000. The SAVY-4000 is the first vented general use nuclear material container demonstrated to meet the requirements of DOE M 441.1-1, Nuclear Material Packaging Manual. The SAVY-4000 is an innovative and creative design demonstrated by the fact that it can be opened and closed in a few seconds without torque wrenches or other tools; has a built-in, fire-rated filter that prevents the build-up of hydrogen gas, yet retains 99.97% of plutonium particulates, and prevents release of material even in a 12 foot drop. Finally, it has been tested to 500C for 2 hours, and will reduce the risk to the public in the event of an earthquake/fire scenario. This will allow major nuclear facilities to credit the container towards source term Material at Risk (MAR) reduction. The container was approved for nuclear material storage in theTA-55 Plutonium Facility on March 15, 2011, and the first order of 79 containers was received at LANL on March 21, 2011. The first four SAVY-4000 containers were packaged with plutonium on August 2, 2011. Key aspects of the SAVY-4000 vented storage container design will be discussed which include design qualification and testing, implementation plan development and status, risk ranking methodology for re-packaging, in use implementation with interface to LANMAS, surveillance strategy, the design life extension program as enhanced by surveillance activities and production status with the intent to extend well beyond the current five year design life.
The Packaging Surveillance Program section of the Department of Energy (DOE) Manual 441.1-1, Nuclear Material Packaging Manual (DOE 2008), requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” The Los Alamos National Laboratory (LANL) SAVY-4000 Field Surveillance Plan was first issued in FY 2013 (Kelly et al. 2013). The surveillance plan is reviewed annually and updated as necessary based on SAVY-4000 surveillance and other surveillance findings, as well as results of the lifetime extension studies (Blair et al. 2012, Weis et al. 2015a). The LANL SAVY-4000 Field Surveillance Plan Update was issued in 2014 (Kelly et al. 2014). This 2016 update reflects changes to the surveillance plan resulting from restrictions on handling residue materials greater than 500 g, the addition of specific engineering judgment containers, and 2015 surveillance findings. The SAVY-4000 container has a design life of five years, which was chosen as a conservative estimate of the functional properties of the materials used in the construction of the SAVY 4000 when exposed to the potential insults including temperature, corrosive materials and gases, and radiation. The SAVY-4000 container design basis is described in a safety analysis report (Anderson et al. 2013). In the National Nuclear Security Administration's (NNSA’s) approval of the safety analysis report, it was recommended that the design life clock begin on March 2014 (Nez et al. 2014). However, it is expected that a technical basis can be developed to extend the design life of the SAVY-4000 containers to approximately 40 years (Blair et al. 2012, Weis et al. 2015a). This surveillance plan update covers five years (2015–2019) and is developed to ensure SAVY-4000 containers meet their design criteria over the current five-year design life and to gather data that can be used in developing the technical basis for a 40-year design life. The technical basis for the longer design life will be developed based on the results of this surveillance plan and the concurrent lifetime extension studies (Blair et al. 2012, Weis et al. 2015a). A long-term surveillance plan will be developed by the completion of this plan and will be based on the results of the first several years of this five-year surveillance plan and the lifetime extension studies. In addition, the current Hagan container population is so large (approximately 3,500 LANL-wide, approximately 3,000 in PF-4) that it is anticipated Hagan containers will be in use for many years to come. Therefore, this plan includes surveillance activities for the Hagan container system during the time it takes to replace the Hagan containers with manually-compliant containers such as the SAVY 4000. These Hagan examinations not only provide information to determine if additional Hagan surveillance is needed, but also support SAVY lifetime-extension studies because some of the container components are made from similar material (e.g., stainless steel and Viton).
The Packaging Surveillance Program section of the Department of Energy ( DOE) Manual 441.1-1, Nuclear Material Packaging Manual (DOE 2008), requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” The Los Alamos National Laboratory (LANL) SAVY-4000 Field Surveillance Plan was first issued in fiscal year (FY) 2013 (Kelly et al. 2013). The surveillance plan is reviewed annually and updated as necessary based on SAVY-4000 surveillance findings, as well as results of the lifetime extension studies. Three surveillance plan updates have been issued, one in 2014 (Kelly et al. 2014), one in 2016 (Kelly et al. 2016) and one in 2017 ( Kelly et al. 2017). This 2018 update documents what was actually done in 2017 and what is planned for 2018. Deviations from the 2017 surveillance plan were necessary because some of the planned surveillance containers were not available for examination.
The Packaging Surveillance Program section of the Department of Energy (DOE) Manual 441.1-1, Nuclear Material Packaging Manual (DOE 2008), requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” The Los Alamos National Laboratory (LANL) SAVY-4000 Field Surveillance Plan was first issued in fiscal year (FY) 2013 (Kelly et al. 2013). The surveillance plan is reviewed annually and updated as necessary based on SAVY-4000 surveillance findings, as well as results of the lifetime extension studies. Four surveillance plan updates have been issued, one in 2014 (Kelly et al. 2014), one in 2016 (Kelly et al. 2016), one in 2017 (Kelly et al. 2017) and one in 2018 (Kelly et al. 2018). This 2019 update documents what was actually done in 2018 and what is planned for 2019. Deviations from the 2018 surveillance plan were necessary because some of the planned surveillance containers were not available for examination.
The Packaging Surveillance Program section of the Department of Energy (DOE) Manual 441.1-1, Nuclear Material Packaging Manual (DOE 2008), requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” The Los Alamos National Laboratory (LANL) SAVY-4000 Field Surveillance Plan was first issued in fiscal year (FY) 2013. The surveillance plan is reviewed annually and updated as necessary based on SAVY-4000 surveillance findings, as well as results of the lifetime extension studies. Five surveillance plan updates have been issued, one in 2014, one in 2016, one in 2017, one in 2018, and one in 2019. This 2020 update documents what was actually done in 2019 and what is planned for 2020. Deviations from the 2019 surveillance plan were necessary because some of the planned surveillance containers were not available for examination. The goal of the surveillance program is to provide data to: evaluate container component performance over time against the initial baseline qualification; validate the current SAVY container design life; provide data for future design life extensions of components as indicated; identify indications of container degradation early and identify similar containers and/or contents that may need remediation; maintain and continuously improve the surveillance information system that documents the complete life cycle of the containers including the initial production baseline, usage history, surveillance, and disposition; identify container issues related to wear and tear that could indicate the need for a maintenance program for in-service containers prior to the end of the design life.
The Packaging Surveillance Program section of the Department of Energy (DOE) Manual 441.1- 1, Nuclear Material Packaging Manual (DOE 2008), requires DOE contractors to “ensure that a surveillance program is established and implemented to ensure the nuclear material storage package continues to meet its design criteria.” The Los Alamos National Laboratory (LANL) SAVY-4000 Field Surveillance Plan was first issued in fiscal year (FY) 2013. The surveillance plan is reviewed annually and updated as necessary based on SAVY-4000 surveillance findings, as well as results of the lifetime extension studies. Six surveillance plan updates have been issued, one in 2014, one in 2016, one in 2017, one in 2018 one in 2019 and one in 2020. This 2021 update documents what was actually done in 2020 and what is planned for 2021. Deviations from the 2020 surveillance plan were necessary because some of the planned surveillance containers were not available for examination.
The National Nuclear Security Administration (NNSA), a semi-autonomous agency within the U.S. Department of Energy (DOE), is proposing new construction and upgrade activities in lower Sandia Canyon at Technical Area (TA) 72 at the Outdoor Live Fire Range facility at Los Alamos National Laboratory (LANL). The proposed upgrades are intended to improve range safety to help fulfill the mission requirements of maintaining a trained and qualified armed Protective Force.
High-energy secondary neutrons, produced by the interaction of galactic cosmic rays (GCR) with the atmosphere, spacecraft structure and planetary surfaces, contribute a significant fraction to the dose equivalent radiation measurement in crew members and passengers of commercial aviation travel as well as astronauts in space missions. The Los Alamos Nuclear Science Center (LANSCE) neutron facility's 30L beam line (4FP30L-A/ICE House) is known to generate neutrons that simulate the secondary neutron spectrum of the Earth's atmosphere at high altitude. The neutron spectrum is also similar to that measured onboard spacecrafts like the MIR and the International Space Station (ISS). To evaluate the biological damage, we exposed human epithelial cells in vitro to the LANSCE neutron beams with an entrance dose rate of 2.5 cGy/hr, and studied the induction of chromosome aberrations that were identified with multicolor-banding in situ hybridization (mBAND) technique. With this technique, individually painted chromosomal bands on one chromosome allowed the identification of inter-chromosomal aberrations (translocation to unpainted chromosomes) and intra-chromosomal aberrations (inversions and deletions within a single painted chromosome). Compared to our previous results with gamma-rays and 600 MeV/nucleon Fe ions of high dose rate at NSRL (NASA Space Radiation Laboratory at Brookhaven National Laboratory), the neutron data from the LANSCE experiments showed significantly higher frequency of chromosome aberrations. However, detailed analysis of the inversion type revealed that all of the three radiation types in the study induced a low incidence of simple inversions. Most of the inversions in gamma-ray irradiated samples were accompanied by other types of intrachromosomal aberrations but few inversions were accompanied by interchromosomal aberrations. In contrast, neutrons and Fe ions induced a significant fraction of inversions that involved complex rearrangements of both inter- and intrachromosome exchanges. The distribution of damage sites on chromosome 3 was also compared for different radiation types. The breakpoints were randomly localized on chromosome 3 with neutrons and Fe ions exposure, whereas non-random distribution with clustering breakpoints was observed with gamma-rays exposure. The specific fingerprint of neutron radiations on chromosomal aberrations will be discussed.
Bats play a critical role in ecosystems and are vulnerable to disturbance and disruption by human activities. In recent decades, bat populations in the United States and elsewhere have decreased tremendously. There are 47 different species of bat in the United States and 28 of these occur in New Mexico with 15 different species documented at the Los Alamos National Laboratory (LANL) and surrounding areas. Euderma maculatum(the spotted bat) is listed as “threatened” by the state of New Mexico and is known to occur at LANL. Four other species of bats are listed as “sensitive” and also occur here. In 1995, a four year study was initiated at LANL to assess the status of bat species of concern, elucidate distribution and relative abundance, and obtain information on roosting sites. There have been no definitive studies since then. Biologists in the Environmental Protection Division at LANL initiated a multi-year monitoring program for bats in May 2013 to implement the Biological Resources Management Plan. The objective of this ongoing study is to monitor bat species diversity and seasonal activity over time at LANL. Bat species diversity and seasonal activity were measured using an acoustic bat detector, the Pettersson D500X. This ultrasound recording unit is intended for long-term, unattended recording of bat and other high frequency animal calls. During 2013, the detector was deployed at two locations around LANL. Study sites were selected based on proximity to water where bats may be foraging. Recorded bat calls were analyzed using Sonobat, software that can help determine specific species of bat through their calls. A list of bat species at the two sites was developed and compared to lists from previous studies. Species diversity and seasonal activity, measured as the number of call sequences recorded each month, were compared between sites and among months. A total of 17,923 bat calls were recorded representing 15 species. Results indicate that there is a statistically significant relationship between bat diversity and month of the year. Future studies will be implemented based on these findings.