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At least 397 records · Page 22

Strategies for "minimal growth maintenance" of cell cultures: a perspective on management for extended duration experimentation in the microgravity environment of a Space station

How cells manage without gravity and how they change in the absence of gravity are basic questions that only prolonged life on a Space station will enable us to answer. We know from investigations carried out on various kinds of Space vehicles and stations that profound physiological effects can and often to occur. We need to know more of the basic biochemistry and biophysics both of cells and of whole organisms in conditions of reduced gravity. The unique environment of Space affords plant scientists an unusual opportunity to carry out experiments in microgravity, but some major challenges must be faced before this can be done with confidence. Various laboratory activities that are routine on Earth take on special significance and offer problems that need imaginative resolution before even a relatively simple experiment can be reliably executed on a Space station. For example, scientists might wish to investigate whether adaptive or other changes that have occurred in the environment of Space are retained after return to Earth-normal conditions. Investigators seeking to carry out experiments in the low-gravity environment of Space using cultured cells will need to solve the problem of keeping cultures quiescent for protracted periods before an experiment is initiated, after periodic sampling is carried out, and after the experiment is completed. This review gives an evaluation of a range of strategies that can enable one to manipulate cell physiology and curtail growth dramatically toward this end. These strategies include cryopreservation, chilling, reduced oxygen, gel entrapment strategies, osmotic adjustment, nutrient starvation, pH manipulation, and the use of mitotic inhibitors and growth-retarding chemicals. Cells not only need to be rendered quiescent for protracted periods but they also must be recoverable and further grown if it is so desired. Elaboration of satisfactory procedures for management of cells and tissues at "near zero or minimal growth" will have great value and practical consequences for experimentation on Earth as well as in Space. All of the parameters and conditions and procedural details needed to meet all the specific objectives will be the basis of the design and fabrication of cell culture units for use in the Space environment. It is expected that this will be an evolutionary process.

STS-61A Shuttle Project↗

In-Flight Rotorcraft Acoustics Program

A key part of NASA's aeronautics research is reducing noise to make helicopters and tiltrotors more acceptable to the public. The objective of the In-Flight Rotorcraft Acoustics Program (IRAP) is to acquire rotorcraft. noise data in flight for comparison to wind tunnel data. The type of noise of concern is "blade-vortex-interaction," or BVI, noise. Microphones on the wing tips and tail fin of the quiet NASA YO-3A Acoustics Research Aircraft measure BVI noise while the YO-3A descends in close formation with the helicopter or tiltrotor emitting the noise.The data acquired through IRAP is needed to validate wind-tunnel test results, or, where the results cannot be validated, to provide researchers with clues as to how to improve testing methods.

Peterson, Randall L.↗

NASA Small Spacecraft Technology Program & Small Spacecraft Systems Virtual Institute

NASA’s Flight Opportunities and Small Spacecraft Technology programs seek to increase the pace of space exploration, discovery, and the expansion of space commerce through the rapid identification, development, and testing of space technologies, including those to advance small spacecraft platform capability. With industry and the innovator community, NASA is fostering a portfolio of commercial suborbital and orbital flight test options that allow innovators to consider the path that best suits their technologies. This cross-agency collaborative session will feature a Q&A section and help researchers understand how flight testing can be impactful and the ways in which NASA is making it more accessible to researchers.

Bruce D Yost↗

Experience with Ada on the F-18 High Alpha Research Vehicle flight test program

Considerable experience has been acquired with Ada at the NASA Dryden Flight Research Facility during the on-going High Alpha Technology Program. In this program, an F-18 aircraft has been highly modified by the addition of thrust-vectoring vanes to the airframe. In addition, substantial alteration was made in the original quadruplex flight control system. The result is the High Alpha Research Vehicle. An additional research flight control computer was incorporated in each of the four channels. Software for the research flight control computer was written Ada. To date, six releases of this software have been flown. This paper provides a detailed description of the modifications to the research flight control system. Efficient ground-testing of the software was accomplished by using simulations that used the Ada for portions of their software. These simulations are also described. Modifying and transferring the Ada flight software to the software simulation configuration has allowed evaluation of this language. This paper also discusses such significant issues in using Ada as portability, modifiability, and testability as well as documentation requirements.

Regenie, Victoria A.↗

NASA Class A Certification of Core Flight Software (cFS)

NASA Gateway program has named cFS as the software architecture for the vehicle. The core CFS team (GSFC+JSC) is tasked to develop a certifiable release of the cFS bundle, by components, as class A, safety-critical flight software. It is to be available to all Gateway software developers, including our element vendors and international partners. Its availability & usage will be as stated by the Gateway User Agreement license. In this presentation, we will describe our general certification process, and more importantly, our certification artifacts that can be re-run to certify cFS on different platforms. Our goal is to also make available these certifiable packages to the open source community, specifically for cFE, OSAL and certain cFS applications and libraries that are currently hosted on NASA github (https://github.com/nasa).

Tam M Ngo↗

NASA Class A Certification of Core Flight Software (cFS)

NASA Gateway program has named cFS as the software architecture for the vehicle. The core CFS team (GSFC+JSC) is tasked to develop a certifiable release of the cFS bundle, by components, as class A, safety-critical flight software. It is to be available to all Gateway software developers, including our element vendors and international partners. Its availability & usage will be as stated by the Gateway User Agreement license. In this presentation, we will describe our general certification process, and more importantly, our certification artifacts that can be re-run to certify cFS on different platforms. Our goal is to also make available these certifiable packages to the open source community, specifically for cFE, OSAL and certain cFS applications and libraries that are currently hosted on NASA github (https://github.com/nasa).

Tam M Ngo↗

Assessment of the A&R Technology associated with the use of supervised autonomy for on-orbit satellite servicing

The Satellite Servicer Flight Demonstration Program is NASA's first definitive attempt at addressing the problems associated with the supervised autonomous servicing of satellites in orbit. NASA has completed a study of its on-orbit requirements for the next decade. Utilizing the results of this study, the necessary key servicing functions, which require on-orbit demonstration before a program would commit to servicing capability, were determined. These capabilities are: (1) autonomous rendezvous and docking; (2) supervised autonomous orbital replacement unit exchange; and (3) supervised autonomous fluid transfer. A satellite servicer system plan to conduct a series of on-orbit flight demonstrations of these capabilities utilizing the Orbital Maneuvering Vehicle, elements of the Flight Telerobotic Servicer and other applicable hardware has been developed. This paper surveys the A&R technologies that must be matured from the laboratory to flight status prior to conducting these on-orbit flight demonstrations.

Levin, George M.↗

NASA HUNCH Hardware

What is NASA HUNCH? High School Students United with NASA to Create Hardware-HUNCH is an instructional partnership between NASA and educational institutions. This partnership benefits both NASA and students. NASA receives cost-effective hardware and soft goods, while students receive real-world hands-on experiences. The 2014-2015 was the 12th year of the HUNCH Program. NASA Glenn Research Center joined the program that already included the NASA Johnson Space Flight Center, Marshall Space Flight Center, Langley Research Center and Goddard Space Flight Center. The program included 76 schools in 24 states and NASA Glenn worked with the following five schools in the HUNCH Build to Print Hardware Program: Medina Career Center, Medina, OH; Cattaraugus Allegheny-BOCES, Olean, NY; Orleans Niagara-BOCES, Medina, NY; Apollo Career Center, Lima, OH; Romeo Engineering and Tech Center, Washington, MI. The schools built various parts of an International Space Station (ISS) middeck stowage locker and learned about manufacturing process and how best to build these components to NASA specifications. For the 2015-2016 school year the schools will be part of a larger group of schools building flight hardware consisting of 20 ISS middeck stowage lockers for the ISS Program. The HUNCH Program consists of: Build to Print Hardware; Build to Print Soft Goods; Design and Prototyping; Culinary Challenge; Implementation: Web Page and Video Production.

manufacturing↗

Education and Outreach at NASA's Goddard Space Flight Center

NASA?s Space Communications and Navigation (SCaN) Program Office maintains a year-round educational program for undergraduate and graduate students. Within NASA?s Goddard Space Flight Center, the Exploration and Space Communications Projects Division implements the SCaN intern program with a focus on space operations, including operations of orbiting spacecraft, space communications, ground activities and networking. The intern program enables students to work with various NASA projects in solving real-world problems inside the Exploration and Space Communications division. Goddard interns have been assigned to the NASA?s Near Earth Network facilities in Greenbelt, Maryland, and Wallops, Virginia. They have also been assigned to NASA?s Space Network facilities in Greenbelt, Maryland, and Las Cruces, New Mexico.

Shaw, Harry C.↗

Lifting Body Flight Vehicles

NASA has a technology program in place to build the X-33 test vehicle and then the full sized Reusable Launch Vehicle, VentureStar. VentureStar is a Lifting Body (LB) flight vehicle which will carry our future payloads into orbit, and will do so at a much reduced cost. There were three design contenders for the new Reusable Launch Vehicle: a Winged Vehicle, a Vertical Lander, and the Lifting Body(LB). The LB design won the competition. A LB vehicle has no wings and derives its lift solely from the shape of its body, and has the unique advantages of superior volumetric efficiency, better aerodynamic efficiency at high angles-of-attack and hypersonic speeds, and reduced thermal protection system weight. Classically, in a ballistic vehicle, drag has been employed to control the level of deceleration in reentry. In the LB, lift enables the vehicle to decelerate at higher altitudes for the same velocity and defines the reentry corridor which includes a greater cross range. This paper outlines our LB heritage which was utilized in the design of the new Reusable Launch Vehicle, VentureStar. NASA and the U.S. Air Force have a rich heritage of LB vehicle design and flight experience. Eight LB's were built and over 225 LB test flights were conducted through 1975 in the initial LB Program. Three LB series were most significant in the advancement of today's LB technology: the M2-F; HL-1O; and X-24 series. The M2-F series was designed by NASA Ames Research Center, the HL-10 series by NASA Langley Research Center, and the X-24 series by the Air Force. LB vehicles are alive again today.

Barret, Chris↗

Space research activities during missions of the past

For over 30 yr, men and women have lived for various periods of time in a weightless (or free-fall) environment while orbiting the Earth. During these years, we have learned that humans function quite well for short periods of weightlessness, that is, for up to a little more than a year. Some space flight missions have provided physiologic data, including cardiovascular data, from the spacefarers. In fact, some missions have provided laboratories for systematic study of cardiovascular responses and adaptation to space flight. However, the opportunity to obtain physiologic data from people in space is a rarity. It is important to remember that the population sample sizes are small, other stresses may confound the effects of weightlessness, and in some situations the crewmembers are subjects for several experiments at the same time. Furthermore, comparison of cardiovascular data from space flight to data obtained on the ground is sometimes difficult because the subject's posture on the ground is not always reported; in a gravity environment, posture influences the hydrostatic gradient. This over view describes what we have learned about cardiovascular function during flight and after return to Earth.

NASA Discipline Cardiopulmonary↗

Solar and airglow measurements aboard the two suborbital flights NASA 36.098 and 36.107

This suborbital program, involving the University of Colorado (CU), National Center for Atmospheric Research (NCAR), University of California at Berkeley (UCB), and Boston University (BU), has resulted in two rocket flights from the White Sands Missile Range, one in 1992 and one in 1993 as NASA 36.098 and 36.107 respectively. The rocket payload includes five solar instruments and one airglow instrument from CU/NCAR and one solar instrument and two airglow instruments from UCB/BU. This report discusses results on solar radiation measurements and the study of thermospheric airglow, namely the photoelectron excited emissions from N2 and O, for the CU/NCAR program.

Woods, Thomas N.↗

Development of a simple, self-contained flight test data acquisition system

The system concepts and the flight test program results for a NASA designed in-flight data acquisition system are described. The system draws power from a rechargeable battery pack and intrudes on the aircraft systems only with a total pressure probe, a static pressure probe, and control position transducers, which are simply taped to the frame. A 4000 byte microcomputer forms the heart of the data recording system for cassette tape storage, and is expansion coupled to an eight-bit interactive microcomputer which interfaces with a transducer package for 16-channel demultiplexing. The transducers, ranges, and accuracies are listed, and a five/sec data acquisition rate minimum requirement is noted, although a 10/sec rate is used. The system components are detailed, along with the control and data processing procedures, and the results of dynamic flight testing are presented.

Renz, R. R. L.↗

Particle Engulfment and Pushing by Solidifying Interfaces (PEPSI)

The preliminary definition phase included the following actions: producing a science requiring document (draft), producing a science requirements document (preliminary), updating the flight program proposal, project review at NASA Marshall Space Flight Center, and research work as defined in the statement of work. The first three items of this plan have been delivered by the University of Alabama to NASA according to schedule. A project review meeting was held at MSFC on June 29, 1993. Consequently, this part of the report will address the results of the research work performed in the Solidification Laboratory at the University of Alabama during the first six months of the project.

Stefanescu, Doru Michael↗

Space Science Research and Technology at NASA's Marshall Space Flight Center

This presentation will summarize the various projects and programs managed in the Space Science Programs and Projects Office at NASA's Marshall Space Flight Center in Huntsville, Alabama. Projects in the portfolio include NASA's Chandra X-Ray telescope, Hinode solar physics satellite, various advanced space propulsion technologies, including solar sails and tethers, as well as NASA's Discovery and New Frontiers Programs.

Johnson, Charles L.↗

Issues in NASA program and project management

This volume is the fifth in an ongoing series on aerospace project management at NASA. Articles in this volume cover: an overview of the project cycle; SE&I management for manned space flight programs; shared experiences from NASA Programs and Projects - 1975; cost control for Mariner Venus/Mercury 1973; and the Space Shuttle - a balancing of design and politics. A section on resources for NASA managers rounds out the publication.

Hoban, Francis T.↗

Digital Fly-By-Wire Flight Control Validation Experience

The experience gained in digital fly-by-wire technology through a flight test program being conducted by the NASA Dryden Flight Research Center in an F-8C aircraft is described. The system requirements are outlined, along with the requirements for flight qualification. The system is described, including the hardware components, the aircraft installation, and the system operation. The flight qualification experience is emphasized. The qualification process included the theoretical validation of the basic design, laboratory testing of the hardware and software elements, systems level testing, and flight testing. The most productive testing was performed on an iron bird aircraft, which used the actual electronic and hydraulic hardware and a simulation of the F-8 characteristics to provide the flight environment. The iron bird was used for sensor and system redundancy management testing, failure modes and effects testing, and stress testing in many cases with the pilot in the loop. The flight test program confirmed the quality of the validation process by achieving 50 flights without a known undetected failure and with no false alarms.

Szalai, K. J.↗

An Earthling to an Astronaut: Medical Challenges

Humans can travel safely into space in low Earth orbit (LEO) or to near-Earth objects if several medical, physiological, environmental, and human factors issues risks are mitigated. Research must be performed in order to set standards in these four areas, and current NASA standards are contained in the Space Flight Human System Standards volumes 1 and 2, and crew medical certification standards. These three sets of standards drive all of the clinical, biomedical research and environmental technology development for the NASA human space flight program. These standards also drive the identification of specific risks to crew health and safety, and we currently manage 65 human system risks within the human space flight program. Each risk has a specific program of research, technology development, and development of operational procedures to mitigate the risks. Some of the more important risks tat will be discussed in this talk include exposure to radiation, behavioral health due to confinement in a closed cabin, physiological changes such as loss of bone, muscle and exercise capability, reduction in immune system capability, environmental threats of maintaining an adequate atmosphere and water for drinking, avoidance of toxic or infectious material, protection of hearing, and human factors issues of equipment and task design. A nutritious and varied food supply must also be provided. All of these risks will be discussed and current strategies for mitigating these risks for long-duration human space flight. In mitigating these 65 human system risks, novel approaches to problem solving must be employed to find the most appropriate research and technology based applications. Some risk mitigations are developed internally to NASA while others are found through research grants, technology procurements, and more recently open innovation techniques to seek solutions from the global technical community. Examples and results will be presented from all of these approaches including the more recent use of prizes to stimulate innovation.

Davis, Jeffrey R.↗