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At least 397 records · Page 22

Ice sheet studies using synthetic aperture radar

The objective was to demonstrate the utility of synthetic aperture radar in ice sheet studies. The major advantage of SAR imagery over visible imagery is the all-weather capability of radar and the ability to specify look angle. Available digital SAR imagery over ice sheets was collected and examined both qualitatively and quantitatively using corroborative data, such as LANDSAT imagery, to confirm feature identification and interpretations. A simple scattering model will be developed to assess the relative importance of surface topography, composition, and subsurface layering to the intensity of radar backscatter. Recommendations of system parameters will be made for optimal SAR operation over ice sheets.

Bindschadler, R.↗

Seasat orbital radar imagery for geologic mapping - Tennessee-Kentucky-Virginia

The purpose of the reported study is to analyze Seasat SAR imagery of a heavily vegetated mountainous land surface and to determine the potential of this microwave imaging system for geologic mapping. It is found that geologic mapping using orbital Seasat SAR imagery is feasible in the Appalachian Valley and Ridge province, where the radar system is highly sensitive to change of surface slope. Image tones and textures correlate with distinctive topography, from which generalized lithologic and structural interpretations are derived. Major and minor linear topographic features are easily mapped from the SAR images. The SAR sensor suppresses subdued geomorphic lineaments that strike parallel with or near to the radar look direction. This deficiency is partly compensated by the dual directions of radar illumination obtainable from the Seasat imaging system.

Ford, J. P.↗

Amplitude calibration of synthetic aperture radars - The effects of nonlinearities

Nonlinearities within a synthetic aperture radar (SAR) present significant obstacles to the calibration of the output imagery. The problem of calibrating a SAR is considerably more involved than that of calibrating a real aperture radar (RAR) or scatterometer, since the SAR relies heavily on the principle of superposition, which fails in nonlinear systems. It is shown in this paper that non-linearities can distort SAR imagery to such an extent that two areas of equal backscatter on the ground can be imaged to have significantly different intensities in the image.

Held, D. N.↗

Doppler parameter estimation for spaceborne synthetic-aperture radars

Problems in the determination of Doppler parameters for spaceborne synthetic-aperture radar (SAR) data processing are examined. The degradations in image quality due to errors in these parameters are summarized. It is shown that these parameters can be estimated using accurate spacecraft ancillary data. In cases where such data are not available, two techniques are proposed to estimate these parameters using the coherent radar return. These techniques were tested with the Seasat SAR data and the test results demonstrate that the accuracies achieved exceed the system performance requirements. Possible applications of these techniques in other areas of SAR data utilization are briefly discussed.

Li, F.-K.↗

Geocoding of AIRSAR/TOPSAR SAR Data

It has been demonstrated and recognized that radar interferometry is a promising method for the determination of digital elevation information and terrain slope from Synthetic Aperture Radar (SAR) data. An important application of Interferometric SAR (InSAR) data in areas with topographic variations is that the derived elevation and slope can be directly used for the absolute radiometric calibration of the amplitude SAR data as well as for scattering mechanisms analysis. On the other hand polarimetric SAR data has long been recognized as permitting a more complete inference of natural surfaces than a single channel radar system. In fact, imaging polarimetry provides the measurement of the amplitude and relative phase of all transmit and receive polarizations. On board the NASA DC-8 aircraft, NASA/JPL operates the multifrequency (P, L and C bands) multipolarimetric radar AIRSAR. The TOPSAR, a special mode of the AIRSAR system, is able to collect single-pass interferometric C- and/or L-band VV polarized data. A possible configuration of the AIRSAR/TOPSAR system is to acquire single-pass interferometric data at C-band VV polarization and polarimetric radar data at the two other lower frequencies. The advantage of this system configuration is to get digital topography information at the same time the radar data is collected. The digital elevation information can therefore be used to correctly calibrate the SAR data. This step is directly included in the new AIRSAR Integrated Processor. This processor uses a modification of the full motion compensation algorithm described by Madsen et al. (1993). However, the Digital Elevation Model (DEM) with the additional products such as local incidence angle map, and the SAR data are in a geometry which is not convenient, since especially DEMs must be referred to a specific cartographic reference system. Furthermore, geocoding of SAR data is important for multisensor and/or multitemporal purposes. In this paper, a procedure to geocode the new AIRSAR/TOPSAR data is presented. As an example an AIRSAR/TOPSAR image acquired in 1994 is geocoded and evaluated in terms of geometric accuracy.

Holecz, Francesco↗

ERS-1 SAR ice routing of l'Astrolabe through the Northeast passage

The use of Synthetic Aperture Radar (SAR) data from the satellite ERS-1 to assist the French polar vessel 'L'Astrolabe' during its navigation through Artic sea ice in the Northeast Passage is reported. The ship spent one month on the voyage from Europe to Japan, and high resolution SAR images and ice maps based on SAR images from ERS-1 and Special Sensor Microwave/Imager were telefaxed to the ship using the Inmarsat system. The time delay from observation to the reception of SAR images aboard the ship varied from 6 hours to two days. The quality of these ice maps was compared with Russian ice maps and observations from the ship. The SAR imagery provided detailed information on ice floe distribution, ice concentration, ice types, open leads, and tracks in ice from icebreakers. The response from the Russian ice specialists on the quality of the SAR ice maps was very positive.

Johannessen, O. M.↗

Spaceborne SAR and sea ice

A number of remote sensing systems deployed in satellites to view the Earth which are successful in gathering data on the behavior of the world's snow and ice covers are described. Considering sea ice which covers over 10% of the world ocean, systems that have proven capable to collect useful data include those operating in the visible, near-infrared, infrared, and microwave frequency ranges. The microwave systems have the essential advantage in observing the ice under all weather and lighting conditions. Without this capability data are lost during the long polar night and during times of storm passage, periods when ice activity can be intense. The margins of the ice pack, a region of particular interest, is shrouded in cloud between 80 and 90% of the time.

Weeks, W. F.↗

Remote Sensing Capabilities to Detect Maritime Vessels in Distress

The National Aeronautics and Space Administration (NASA) has the responsibility for conducting research and development for search and rescue as charged under the National Search and Rescue Plan. For over two decades this task has been undertaken by the Search and Rescue Mission Office at the NASA Goddard Space Flight Center (GSFC). The technology used by the highly successful beacon locating satellite system, Cospas-Sarsat, was conceived and developed at GSFC and is managed by the National Oceanographic and Atmospheric Administration (NOAA). Using beacon-less remote sensing to find people and vessels in distress complements the demonstrated life saving capabilities of this satellite system. The Search and Rescue Mission Office has been investigating the use of fully polarimetric synthetic aperture radar to locate crashed aircraft. An overview of this effort and potential maritime applications of Search and Rescue Synthetic Aperture Radar (SAR) will be presented. The Mission Office has also developed a Laser search and rescue system called L-SAR. The prototype instrument was designed and built by SenSyTech Inc. It specifically targets the location of novel retro-reflective material easily applied to rescue equipment and vessels in distress. An overview of this effort will also be presented.

Larsen, Rudolph K.↗

Diagnostic, Prognostic, and Therapeutic Use of Radiopharmaceuticals in the Context of SARS-CoV-2

The coronavirus disease 2019 (COVID-19) outbreak has devastated the healthcare systems and economies of over 200 countries in just a few months. The etiological agent of COVID-19, SARS-CoV-2, is a highly contagious virus that can be transmitted by asymptomatic and symptomatic carriers alike. While in vitro testing techniques have allowed for population-wide screening, prognostic tools are required to assess the disease severity and therapeutic response, contributing to improve the patient clinical outcomes. Moreover, no specific antiviral against COVID-19 exists at the time of publication, severely limiting treatment against the infection. Hence, there is an urgent clinical need for innovative therapeutic strategies that may contribute to manage the COVID-19 outbreak and prevent future pandemics. In this work, we critically examine recent diagnostic, prognostic, and therapeutic advancements for COVID-19 in the field of radiopharmaceuticals. First, we summarize the gold standard techniques used to diagnose COVID-19, including in vitro assays and imaging techniques, and then discuss how radionuclide-based nuclear imaging provides complementary information for prognosis and treatment management of infected patients. Second, we introduce new emerging types of radiotherapies that employ radioimmunoconjugates, which have shown selective cytotoxic response in oncological studies, and critically analyze how these compounds could be used as therapeutic agents against SARS-CoV-2. Finally, this Perspective further discusses the emerging applications of radionuclides to study the behavior of pulmonary SARS-CoV-2 aerosol particles.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro

A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers a broad-spectrum antiviral (BSA) to inhibit many SARS-CoV-2 variants and diverse human coronavirus strains with >99% reduction of the viral titer. We show that Cas13d-mediated coronavirus inhibition is dependent on the crRNA cellular spatial colocalization with Cas13d and target viral RNA. Cas13d can significantly enhance the therapeutic effects of diverse small molecule drugs against coronaviruses for prophylaxis or treatment purposes, and the best combination reduced viral titer by over four orders of magnitude. Using lipid nanoparticle-mediated RNA delivery, we demonstrate that the Cas13d system can effectively treat infection from multiple variants of coronavirus, including Omicron SARS-CoV-2, in human primary airway epithelium air-liquid interface (ALI) cultures. Our study establishes CRISPR-Cas13 as a BSA which is highly complementary to existing vaccination and antiviral treatment strategies.

60 APPLIED LIFE SCIENCES↗

Multifrequency observations

Analyses of synthetic aperture radar (SAR) image data were performed at DLR to classify various kinds of vegetation and different terrain types. The data were collected both with the DLR experimental synthetic aperture radar (E-SAR) in X-band, C-band, and L-band and with the NASA/JPL DC-8 SAR in C-band, L-band, and P-band. E-SAR is a single frequency and single polarization system (both parameters can be selected) but several flights were used to collect multifrequency/multipolarization data which were geometrically matched after processing. Classification of different crop types was based on comparison of the backscatter coefficients of calibrated SAR data in different frequency bands and polarizations. The DC-8 STAR collects polarimetric data in different bands simultaneously. Data acquired with the NASA/JPL DC-8 STAR are qualified for scientific investigations by reducing the cross-talk and channel imbalance to a tolerable extent. The data are absolutely calibrated by using reference targets with known backscattering cross-sections. The signatures and polarimetric features of terrain types, such as grassland, concrete, sea, forest (coniferous; deciduous) and urban areas, are extracted and discussed with respect to frequency and incidence angle dependence. A multifrequency polarimetric feature vector was applied for classification. The results of this new approach for separating and classifying different object classes are presented.

Glitz, R.↗

A cell-based Papain-like Protease (PLpro) activity assay for rapid detection of active SARS-CoV-2 infections and antivirals

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants are a continuous threat to human life. An urgent need remains for simple and fast tests that reliably detect active infections with SARS-CoV-2 and its variants in the early stage of infection. Here we introduce a simple and rapid activity-based diagnostic (ABDx) test that identifies SARS-CoV-2 infections by measuring the activity of a viral enzyme, Papain-Like protease (PLpro). The test system consists of a peptide that fluoresces when cleaved by SARS PLpro that is active in crude, unprocessed lysates from human tongue scrapes and saliva. Test results are obtained in 30 minutes or less using widely available fluorescence plate readers, or a battery-operated portable instrument for on-site testing. Proof-of-concept was obtained in a study on clinical specimens collected from patients with COVID-19 like symptoms who tested positive (n = 10) or negative (n = 10) with LIAT RT-PCR using nasal mid turbinate swabs. When saliva from these patients was tested with in-house endpoint RT-PCR, 17 were positive and only 5 specimens were negative, of which 2 became positive when tested 5 days later. PLpro activity correlated in 17 of these cases (3 out of 3 negatives and 14 out of 16 positives, with one invalid specimen). Despite the small number of samples, the agreement was significant (p value = 0.01). Two false negatives were detected, one from a sample with a late Ct value of 35 in diagnostic RT-PCR, indicating that an active infection was no longer present. The PLpro assay is easily scalable and expected to detect all viable SARS-CoV-2 variants, making it attractive as a screening and surveillance tool. Additionally, we show feasibility of the platform as a new homogeneous phenotypic assay for rapid screening of SARS-CoV-2 antiviral drugs and neutralizing antibodies.

60 APPLIED LIFE SCIENCES↗

Experimental evaluation of respiratory droplet spread to rooms connected by a central ventilation system

This article presents results from an experimental study to ascertain the transmissibility of the SARS-CoV-2 virus between rooms in a building that are connected by a central ventilation system. Respiratory droplet surrogates made of mucus and virus mimics were released in one room in a test building and measurements of concentration levels were made in other rooms connected via the ventilation system. The paper presents experimental results for different ventilation system configurations, including ventilation rate, filtration level (up to MERV-13), and fractional outdoor air intake. The most important finding is that respiratory droplets can and do transit through central ventilation systems, suggesting a mechanism for viral transmission (and COVID-19 specifically) within the built environment in reasonable agreement with well-mixed models. We also find the deposition of these droplets on room walls to be negligibly small. Furthermore, the energy use impact of the different configuration settings is also quantified to help inform intelligent building operation that can simultaneously address energy use and occupant health.

60 APPLIED LIFE SCIENCES↗

Ka-band High-Rate Downlink System for the NISAR Mission

This paper provides a description and analyses of the high-rate Ka-band telecom system for the upcoming NISAR (NASA-ISRO Synthetic Aperture Radar) mission. NISAR is a collaborative Earth-Science mission between National Aeronautics and Space Administration (NASA) and Indian Space Research Organization (ISRO), which features an L-band SAR instrument and an S-band SAR instrument. The simultaneous dual-frequency radar system at peak rates will produce data at gigabit-per-second speeds, which drives the data-volume requirements. The key driving requirement for the payload communication subsystem is to provide a minimum of 26 Terabits per day of radar science data to the ground. The high-rate transmitter on the flight system is a software-defined radio developed at the Jet Propulsion Laboratory (JPL), based on the Universal Space Transponder platform, providing an offset quadrature phase shift key modulated waveform with Low-Density Parity-Check encoding of the data transfer frames. Two transmitters used in a dual-polarization configuration with each transmitter providing two giga-symbols per second (Gsps) of coded data provides an aggregate rate of four Gsps. In this system, only one watt of signal power is necessary on each polarization to overcome propagation losses and achieve a successful RF link. Several Near Earth Network (NEN) ground station sites (Alaska in the United States, Svalbard in Norway, and Punta Arenas in Chile) are baselined for the space-to-Earth communications link. Each ground station will also feature multiple upgrades to support NISAR’s transmission starting with new Ka-band antennas, wideband downconverters and high-rate receivers. In addition, a baseband data processor called Data Acquisition Processor and Handling Network Environment (DAPHNE), newly developed by the NEN, provides data storage and connectivity to backhaul networks. With NISAR’s large quantities of data (over 3.5 Petabytes over the mission), the processing of science data will be primarily performed on a cloud system to reduce the overall cost to the mission. The system described herein will be the first operational use of Gsps-class downlink rates on an Earth-Science mission.

Dissanayake, Asoka↗

On the Capabilities of Using AIRSAR Data in Surface Energy/Water Balance Studies

The capabilities of using remote sensing data, and in particular multifrequency/multipolarization SAR data, like AIRSAR, for the retrieval of surface parameters, depend considerably on the specificity of each application. The potentials, and limitations, of SAR data in ecological investigations are well known. Because the chemistry is a major component in such studies and because of the almost lacking chemical information at the wavelengths of SAR data, the capabilities of using SAR-derived information in such studies are considerably limited. However, in the case of surface energy/water balance studies, the determination of the amount of water content, both in the soil and in the plants, is a major component in all modeling approaches. As the information about water content is present in the SAR signal, then the role of SAR data in studies where water content is to be determined becomes clearly predominant. Another situation where the role of SAR data becomes dominant over other remote sensing systems is the case of dense canopies. Because of the penetration capabilities of microwave data, which is especially superior as compared to optical data, information about the canopy as a whole and even the underlying soil is contained in the SAR data, while only the top canopy provides the information content in the case of optical data. In the case of relatively dense canopies, as has been demonstrated in this study, such different penetration capabilities provide very different results in terms of the derived total canopy water content, for instance. However, although all such capabilities are well known, unfortunately there are also well known limitations. Apart from calibration-related aspects (that we will not consider in this study), and apart from other intrinsic problems (like image noise, topographic corrections, etc.) which also significantly affect the derived results, we will concentrate on the problem of extracting information from the data. Even at this level, methods are still not fully well established, especially over vegetation-covered areas. In this paper, an algorithm is described which allows derivation of three fundamental parameters from SAR data: soil moisture, soil roughness and canopy water content, accounting for the effects of vegetation cover by using optical (Landsat) data as auxiliary. Capabilities and limitations of the data and algorithms are discussed, as well as possibilities to use these data in energy/water balance modeling studies. All the data used in this study were acquired as part of the Intensive Observation Period in June-July 1991 (European Multisensor Aircraft Campaign-91), as part of the European Field Experiment in a Desertification- threatened Area (EFEDA), a European contribution to the global-change research sponsored by the IGBP program (Bolle et al., 1993).

Moreno, Jose F.↗

SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition

Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.

Strýčková, Alena↗

A synthetic aperture processor using CCD signal processing techniques

Synthetic aperture radar (SAR) imaging was the most suitable technique for achieving high resolution imagery through atmospheric cloud cover. This feature was important for planetary as well as earth orbiting satellite systems, and for military aircraft applications. Such applications require onboard data processing or wide-band data transmission systems in order to handle the large amounts of raw data produced by such systems. A number of techniques were utilized in implementing SAR processors. Frequency filtering and Fourier transform operations using both optical and digital techniques were utilized in SAR processing.

Bailey, W. H.↗