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At least 397 records · Page 22

Precursor Analysis Report: Industroyer Targeting Ukraine Electric Power Transport Utility (Ukrenergo) 2016

The Industroyer Targeting Ukraine Electric Power Transport Utility (Ukrenergo) 2016 Precursor Analysis Report leverages publicly available information about the December 2016 cyber attack against the Ukrainian Ukrenergo electric transmission utility and catalogs anomalous observables for each technique employed in the attack. This analysis is based upon the methodology of the Cybersecurity for the Operational Technology Environment (CyOTE) program. Industroyer is a modular malware framework designed to deploy several Industrial Control System (ICS) protocol-specific attack payloads to disrupt electricity distribution. Adversaries deployed Industroyer within the target network on a Microsoft Windows endpoint capable of directly manipulating or communicating with ICS. Industroyer abuses the functionality of a targeted ICS’s legitimate control system to achieve its intended impact. Adversaries likely first gained access to Ukrenergo enterprise networks in early 2016 after a successful spearphishing campaign against organizations in the electric power sector. Adversaries then began capturing credentials beginning on 1 December 2016. This allowed access to the ICS environment at the Pivnichna electric transmission substation outside Kyiv through a device dual-homed on the Information Technology (IT) and ICS networks. Adversaries conducted discovery, targeting, and access to this device using information and previously captured credentials from compromised enterprise IT machines. Finally, the adversaries deployed and launched the Industroyer malware just before midnight on 17 December. By midnight, Ukrenergo had lost control of a targeted substation, resulting in electric power outages for over an hour in the city of Kyiv and the Kyiv region. Researchers and analysts identified 31 unique techniques (used in a sequence of 33 steps) utilized during the attack with a total of 846 observables using MITRE ATT&CK® for Industrial Control Systems. The CyOTE program assesses observables accompanying techniques used prior to the triggering event to identify opportunities to detect malicious activity. If observables accompanying the attack techniques are perceived and investigated prior to the triggering event, earlier comprehension of malicious activity can take place. Twenty-nine of the identified techniques used during the Industroyer cyber attack were precursors to the triggering event. Analysis identified 548 observables associated with these precursor techniques, 353 of which were assessed to have an increased likelihood of being perceived in the 300 days preceding the triggering event. The response and comprehension time could have been reduced if the observables had been identified earlier. The information gathered in this report contributes to a library of observables tied to a repository of artifacts, data sources, and technique detection references for practitioners and developers to support the comprehension of indicators of attack. Asset owners and operators can use these products if they experience similar observables or to prepare for comparable scenarios.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗

Cyclotron Production of PET Radiometals in Liquid Targets: Aspects and Prospects

: The present review describes the methodological aspects and prospects of the productionof Positron Emission Tomography (PET) radiometals in a liquid target using low-medium energymedical cyclotrons. The main objective of this review is to delineate and discuss the critical factorsinvolved in the liquid target production of radiometals, including type of salt solution, solutioncomposition, beam energy, beam current, the effect of irradiation duration (length of irradiation)and challenges posed by in-target chemistry in relation with irradiation parameters. We also summarizethe optimal parameters for the production of various radiometals in liquid targets. : Additionally, we discuss the future prospects of PET radiometals production in the liquid targetsfor academic research and clinical applications. Significant emphasis has been given to the productionof 68 Ga using liquid targets due to the growing demand for 68 Ga labeled PSMA vectors, [ 68 Ga]-Ga-DOTATATE, [ 68 Ga]Ga-DOTANOC and some upcoming 68 Ga labeled radiopharmaceuticals.Other PET radiometals included in the discussion are 86 Y, 63 Zn and 89 Zr.

Pharmacology & Pharmacy↗

1 K refrigerator for the CLAS12 Polarized Target Design, Construction, and First Results

A dynamically polarized target of protons and deuterons in irradiated NH3 and ND3 will be employed with the CLAS12 detector system to explore the spin structure of the nucleon in Hall B at Jefferson Lab. This target will feature a versatile, horizontal 1 K refrigerator that has been constructed by a collaboration of Christopher Newport University, Old Dominion University, the University of Virginia, and the JLab Target Group. A description of the challenges involved with designing the target for the CLAS12 experiments and the collaboration’s solutions will be presented. These include a modular and compact design of the 1 K refrigerator and its ancillary equipment, as well as a novel mechanism for loading the target samples. Initial test results of the system will also be included.

Brock, James↗

A High-Magnetic-Field Polarized 3He Target for JLab's CLAS12 Spectrometer

We are developing a polarized 3He target for use in high luminosity electron scattering experiments within the high magnetic field environment of Jefferson Lab's CLAS12 spectrometer. By combining recent advancements in metastability exchange optical pumping (MEOP) of 3He with cryogenic, double-cell target methods as used for the MIT-Bates 88-02 experiment, a target with polarization and gas density comparable to traditional, low-field polarized 3He targets can be reached within high magnetic field environments. We have begun polarizing sealed 3He cells at fields up to 5 T at Jefferson Lab, and are preparing for our first tests exploring polarization performance versus magnetic field and gas pressure in a single cell before we move to the construction of a full, cryogenic, double-cell prototype target. A key focus of our research is the determination of polarization relaxation under the irradiation of an ionizing particle beam within high magnetic fields.

Maxwell, James↗

CRISPR/Cas9-Mediated Multi-Allelic Gene Targeting in Sugarcane Confers Herbicide Tolerance

Sugarcane is the source of 80% of the sugar and 26% of the bioethanol produced globally. However, its complex, highly polyploid genome (2n = 100 – 120) impedes crop improvement. Here, we report efficient and reproducible gene targeting (GT) in sugarcane, enabling precise co-editing of multiple alleles via template-mediated and homology-directed repair (HDR) of DNA double strand breaks induced by the programmable nuclease CRISPR/Cas9. The evaluation of 146 independently transformed plants from five independent experiments revealed a targeted nucleotide replacement that resulted in both targeted amino acid substitutions W574L and S653I in the acetolactate synthase (ALS) in 11 lines in addition to single, targeted amino acid substitutions W574L or S653I in 25 or 18 lines, respectively. Co-editing of up to three ALS copies/alleles that confer herbicide tolerance was confirmed by Sanger sequencing of cloned long polymerase chain reaction (PCR) amplicons. This work will enable crop improvement by conversion of inferior alleles to superior alleles through targeted nucleotide substitutions.

Altpeter, Fredy (ORCID:0000000208944976)↗

Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

Introduction: 43 Sc and 44g Sc are both positron-emitting radioisotopes of scandium with suitable half-lives and favorable positron energies for clinical positron emission tomography (PET) imaging. Irradiation of isotopically enriched calcium targets has higher cross sections compared to titanium targets and higher radionuclidic purity and cross sections than natural calcium targets for reaction routes possible on small cyclotrons capable of accelerating protons and deuterons. Methods: In this work, we investigate the following production routes via proton and deuteron bombardment on CaCO 3 and CaO target materials: 42 Ca(d,n) 43 Sc, 43 Ca(p,n) 43 Sc, 43 Ca(d,n) 44g Sc, 44 Ca(p,n) 44g Sc, and 44 Ca(p,2n) 43 Sc. Radiochemical isolation of the produced radioscandium was performed with extraction chromatography using branched DGA resin and apparent molar activity was measured with the chelator DOTA. The imaging performance of 43 Sc and 44g Sc was compared with 18 F, 68 Ga, and 64 Cu on two clinical PET/CT scanners. Discussion: The results of this work demonstrate that proton and deuteron bombardment of isotopically enriched CaO targets produce high yield and high radionuclidic purity 43 Sc and 44g Sc. Laboratory capabilities, circumstances, and budgets are likely to dictate which reaction route and radioisotope of scandium is chosen.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Applying Two Active Acoustic Technologies to Document Presence of Large Marine Animal Targets at a Marine Renewable Energy Site

Coastal regions are highly used by humans. The growing marine renewable energy (MRE) industry will add to existing anthropogenic pressures in these regions. Regulatory bodies require animal risk assessment before new industrial activities can progress, and MRE is no exception. Preliminary data of marine mammal use of an MRE device deployment location could be informative to permitting. A combination of downlooking hydroacoustics using an echosounder and acoustic camera (imaging sonar) was used to provide a number of large targets (proxy for large fish and marine mammals) in an area of interest for MRE tidal turbine deployment in Western Passage, Maine, USA. Data were collected in May, June, August, and September of 2010 and 2011. Of the nine large targets confirmed to be animals, eight were porpoises and one was a shark. Few large targets were observed in May and June, with the majority (90%) being present in August and September of both years. The most large targets were observed when tidal current speed was less than 1 m·s−1. These data provide a preliminary assessment of large targets in a single location over sixteen 24-h surveys. The aforementioned methodology could be used for future pre- and post-installation assessments at MRE device deployment locations. Their use in concert with visual and passive acoustic monitoring can provide water depth usage by marine mammals, which is a metric that is difficult to assess with passive acoustic and visual techniques.

Staines, Garrett↗

Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

Proteins containing a FIC domain catalyze AMPylation and other post-translational modifications (PTMs). In bacteria, they are typically part of FicTA toxin-antitoxin modules that control conserved biochemical processes such as topoisomerase activity, but they have also repeatedly diversified into host-targeted virulence factors. Among these, Bartonella effector proteins (Beps) comprise a particularly diverse ensemble of FIC domains that subvert various host cellular functions. However, no comprehensive comparative analysis has been performed to infer molecular mechanisms underlying the biochemical and functional diversification of FIC domains in the vast Bep family. Here, we used X-ray crystallography, structural modelling, and phylogenetic analyses to unravel the expansion and diversification of Bep repertoires that evolved in parallel in three Bartonella lineages from a single ancestral FicTA toxin-antitoxin module. Our analysis is based on 99 non-redundant Bep sequences and nine crystal structures. Inferred from the conservation of the FIC signature motif that comprises the catalytic histidine and residues involved in substrate binding, about half of them represent AMP transferases. A quarter of Beps show a glutamate in a strategic position in the putative substrate binding pocket that would interfere with triphosphate-nucleotide binding but may allow binding of an AMPylated target for deAMPylation or another substrate to catalyze a distinct PTM. The β-hairpin flap that registers the modifiable target segment to the active site exhibits remarkable structural variability. The corresponding sequences form few well-defined groups that may recognize distinct target proteins. The binding of Beps to promiscuous FicA antitoxins is well conserved, indicating a role of the antitoxin to inhibit enzymatic activity or to serve as a chaperone for the FIC domain before translocation of the Bep into host cells. Taken together, our analysis indicates a remarkable functional plasticity of Beps that is mostly brought about by structural changes in the substrate pocket and the target dock. These findings may guide future structure–function analyses of the highly versatile FIC domains.

59 BASIC BIOLOGICAL SCIENCES↗

The Breakthrough Listen Search for Intelligent Life: Searching for Technosignatures in Observations of TESS Targets of Interest

Exoplanetary systems are prime targets for the Search for Extraterrestrial Intelligence (SETI). With the recent uptick in the identification of candidate and confirmed exoplanets through the work of missions like the Transiting Exoplanet Survey Satellite (TESS), we are beginning to understand that Earth-like planets are common. In this work, we extend the Breakthrough Listen (BL) search for extraterrestrial intelligence to include targeted searches of stars identified by TESS as potential exoplanet hosts. We report on 113 30 minute cadence observations collected for 28 targets selected from the TESS Input Catalog from among those identified as containing signatures of transiting planets. The targets were searched for narrowband signals from 1 to 11 GHz using the turboSETI pipeline architecture modified for compatibility with the Google Cloud environment. Data were searched for drift rates of ±4 Hz s{sup −1} above a minimum signal-to-noise threshold of 10, following the parameters of previous searches conducted by Price et al. and Enriquez et al. The observations presented in this work establish some of the deepest limits to date over such a wide band (1–11 GHz) for life beyond Earth. We determine that fewer than 12.72% of the observed targets possess transmitters operating at these frequencies with an equivalent isotropic radiated power greater than our derived threshold of 4.9×10{sup 14} W.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Final Targeting Strategy for the Sloan Digital Sky Survey IV Apache Point Observatory Galactic Evolution Experiment 2 North Survey

The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is a dual-hemisphere, near-infrared (NIR), spectroscopic survey with the goal of producing a chemodynamical mapping of the Milky Way. The targeting for APOGEE-2 is complex and has evolved with time. In this paper, we present the updates and additions to the initial targeting strategy for APOGEE-2N presented in Zasowski et al. (2017). These modifications come in two implementation modes: (i) “Ancillary Science Programs” competitively awarded to Sloan Digital Sky Survey IV PIs through proposal calls in 2015 and 2017 for the pursuit of new scientific avenues outside the main survey, and (ii) an effective 1.5 yr expansion of the survey, known as the Bright Time Extension (BTX), made possible through accrued efficiency gains over the first years of the APOGEE-2N project. For the 23 distinct ancillary programs, we provide descriptions of the scientific aims, target selection, and how to identify these targets within the APOGEE-2 sample. The BTX permitted changes to the main survey strategy, the inclusion of new programs in response to scientific discoveries or to exploit major new data sets not available at the outset of the survey design, and expansions of existing programs to enhance their scientific success and reach. After describing the motivations, implementation, and assessment of these programs, we also leave a summary of lessons learned from nearly a decade of APOGEE-1 and APOGEE-2 survey operations. Finally, a companion paper, F. Santana et al. (submitted; AAS29036), provides a complementary presentation of targeting modifications relevant to APOGEE-2 operations in the Southern Hemisphere.

79 ASTRONOMY AND ASTROPHYSICS↗

LHCspin: a Polarized Gas Target for LHC

The goal of the LHCspin project is to develop innovative solutions for measuring the 3D structure of nucleons in high-energy polarized fixed-target collisions at LHC, exploring new processes and exploiting new probes in a unique, previously unexplored, kinematic regime. A precise multi-dimensional description of the hadron structure has, in fact, the potential to deepen our understanding of the strong interactions and to provide a much more precise framework for measuring both Standard Model and Beyond Standard Model observables. This ambitious task poses its basis on the recent experience with the successful installation and operation of the SMOG2 unpolarized gas target in front of the LHCb spectrometer. Besides allowing for interesting physics studies ranging from astrophysics to heavy-ion physics, SMOG2 provides an ideal benchmark for studying beam-target dynamics at the LHC and demonstrates the feasibility of simultaneous operation with beam-beam collisions. With the installation of the proposed polarized target system, LHCb will become the first experiment to simultaneously collect data from unpolarized beam-beam collisions at $\sqrt{s}$=14 TeV and polarized and unpolarized beam-target collisions at $\sqrt{s_{NN}}\sim$100 GeV. LHCspin has the potential to open new frontiers in physics by exploiting the capabilities of the world's most powerful collider and one of the most advanced spectrometers. This document also highlights the need to perform an R&D campaign and the commissioning of the apparatus at the LHC Interaction Region 4 during the Run 4, before its final installation in LHCb. This opportunity could also allow to undertake preliminary physics measurements with unprecedented conditions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A High-Magnetic-Field Polarized 3He Target for Jefferson Lab’s CLAS12 Spectrometer

We are developing a polarized 3He target concept for use in high luminosity electron scattering experiments in the high magnetic field environment of Jefferson Lab's CLAS12 spectrometer. By combining recent advancements in metastability exchange optical pumping of 3He with cryogenic, double-cell target methods such as those used for the MIT-Bates 88-02 experiment, a target with polarization and gas density comparable to traditional, low-field polarized 3He targets can be reached within high magnetic fields. We have established a new 3He pumping system at JLab, and are preparing for our first tests exploring polarization performance versus magnetic field and gas pressure in a single cell before we move to the construction of a full, cryogenic, double-cell prototype target.

Maxwell, James↗

Penetration of electrons and associated bremsstrahlung through aluminum targets

This paper contains a brief description of Monte Carlo programs designed to calculate the transport of fast electrons and associated bremsstrahlung through extended media. Two applications are discussed: (1) transmission of electrons through plane-parallel targets, and (2) emergence of secondary bremsstrahlung from such targets. It is shown that the predicted results are in reasonably good agreement with recent experiments for electron beams with energies up to 8 MeV incident normally on aluminum targets. Extensive new calculated data for transmission and thick-target bremsstrahlung production are presented for aluminum targets exposed to an isotropic electron flux.

M. J. Berger↗

Apollo experience report: Development of guidance targeting techniques for the command module and launch vehicle

The development of the guidance targeting techniques for the Apollo command module and launch vehicle is discussed for four types of maneuvers: (1) translunar injection, (2) translunar midcourse, (3) lunar orbit insertion, and (4) return to earth. The development of real-time targeting programs for these maneuvers and the targeting procedures represented are discussed. The material is intended to convey historically the development of the targeting techniques required to meet the defined target objectives and to illustrate the solutions to problems encountered during that development.

Yencharis, J. D.↗

Launch window definition for sky target experiments.

This paper is a brief report on the computer program developed for the Extraterrestrial Physics Barium Ion Cloud (BIC) Project. The mathematical analysis developed for the program along with its programing characteristics are pointed out to show that this program is adaptable to similar sky target projects. Definite viewing constraints are specified so that the chosen ground tracking stations can photograph the behavior of the sky target after its release. Viewing factors include the illumination of the target by the sun, the relative elevation look angle to the target from each tracking station, the solar and lunar depression angles at each tracking station, and the total sky background brightness of the target relative to each tracking station. Numeric values are assigned to each factor through program input. The program output is flexible so that the results of the window calculations can be studied to the depth required.

Michaud, N. H.↗

Simulator method and apparatus for practicing the mating of an observer-controlled object with a target

A servo controlled target replica, and a surface bearing a computer generated line drawing of an object are individually viewed by separate television cameras allowing a two-dimensional composite of the target replica and the object to be displayed on a monitor simulating what an observer would see through a window in a spacecraft. The target replica is coded along one self coordinate axis in such a way that the distance of an elemental area on the target along the axis is capable of being remotely readout by a television camera. A third television camera responsive to the code reads out this information by which the Z-coordinate, relative to the observer, can be calculated, on-line with the scan, for the contents of each picture element of the scene televised by the target camera.

Polstorff, W. K.↗

Probability of error and radiometric resolution for target discrimination in radar images

A straightforward statistical analysis is presented of the problem of discriminating between two distributed targets in a radar image. The probability of making an error is calculated as a function of the target contrast, the number of samples averaged to form each observation, and the system noise. In the absence of system noise, it is observed that a target contrast of 1 dB could not be detected with less than 10 samples averaged; it is also seen that the error probability is sensitive to the number of samples averaged, as expected. Setting the target contrast at the radiometric resolution, a comparison is made of different definitions for this resolution. The comparison shows that each definition yields a different error probability, ranging from less than 0.05 to 0.35. Attention is also given to the effect of system noise, and it is shown that thermal noise does not have a significant effect on the error probability for a fixed target contrast.

Frost, V. S.↗

Self-Identifying Reflecting Targets

Proposed scheme for target identification requires no radiation of energy by target itself. Instead, target alters light beam reflected from itself back to interrogating station in unique way. Interrogator then identifies target from its signature impressed on returned beam. Selfidentifying target useful in surveying, navigation, and remote monitoring (for example, of mountain-climbing parties.)

Frazer, R. E.↗