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At least 397 records · Page 22

Pharmacology in space. Part 1. Influence of adaptive changes on pharmacokinetics

The topic of pharmacology in space, i.e. the administration of drugs during space flight and the subsequent pharmacokinetic handling of the pharmaceuticals, is a new field about which little is known. In a two-part series, Claire Lathers and colleagues highlight some of the current questions in this field. In this first article the physiological and biochemical changes associated with weightlessness in space are discussed. These changes induce adaptive alterations which may influence the pharmacokinetic properties of drugs. The cardiovascular system is of particular relevance here. Also discussed are the classes of pharmacological agent that are most likely to be used during space flight for medical problems and thus, by necessity, will become drugs to be examined in space to determine whether their pharmacokinetic and pharmacodynamic properties are altered. Therapy of the most common spaceflight ailment-motion sickness-will be considered next month in Part 2.

NASA Center JSC↗

Boundary Layer Stability and Transition in a Chemically Reacting Martian Atmosphere Using LASTRAC

The Thermal Protection System (TPS) is a significant portion of the mass of reentry vehicles, planetary probes, and Martian entry vehicles. Reducing this mass has benefits in terms of decreased fuel requirements and increased payload; however, due to the high risk and uncertainty, the TPS or heat shields are designed conservatively by assuming fully turbulent flow. Laminar flow results in reduced heat flux, and improved transition prediction has the potential to reduce TPS mass and uncertainty in aerothermodynamic predictions. Limited previous research exists examining the problem of transition prediction for Martian atmospheric entry, with studies available on transition on the Mars Science Laboratory TPS. Although transition was demonstrated in wind-tunnel tests, uncertainty in the transition location resulted in a TPS designed for fully turbulent flow, and therefore greater mass than required for a partially laminar condition. In this work, we extend the boundary layer stability code LASTRAC, recently modified to include chemical and thermal nonequilibrium capabilities, to a model of the Martian atmosphere. LASTRAC provides Parabolized Stability Equations (PSE) as well as Linear Stability Theory (LST) to predict the stability of a boundary layer and transition with semi-empirical e(sup N) methods. Results included in this work compare disturbance growth characteristics between air and Martian atmosphere at similar non-dimensional freestream conditions on a simple flat plate geometry. Both chemical nonequilibrium and thermochemical nonequilibrium, as well as both PSE and LST, are used.

Kline, H. L.↗

Accessible solitons of fractional dimension

We demonstrate that accessible solitons described by an extended Schrödinger equation with the Laplacian of fractional dimension can exist in strongly nonlocal nonlinear media. The soliton solutions of the model are constructed by two special functions, the associated Legendre polynomials and the Laguerre polynomials in the fraction-dimensional space. Our results show that these fractional accessible solitons form a soliton family which includes crescent solitons, and asymmetric single-layer and multi-layer necklace solitons. -- Highlights: •Analytic solutions of a fractional Schrödinger equation are obtained. •The solutions are produced by means of self-similar method applied to the fractional Schrödinger equation with parabolic potential. •The fractional accessible solitons form crescent, asymmetric single-layer and multilayer necklace profiles. •The model applies to the propagation of optical pulses in strongly nonlocal nonlinear media.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Preconditioned steepest descent methods for some nonlinear elliptic equations involving p-Laplacian terms

We describe and analyze preconditioned steepest descent (PSD) solvers for fourth and sixth-order nonlinear elliptic equations that include p-Laplacian terms on periodic domains in 2 and 3 dimensions. The highest and lowest order terms of the equations are constant-coefficient, positive linear operators, which suggests a natural preconditioning strategy. Such nonlinear elliptic equations often arise from time discretization of parabolic equations that model various biological and physical phenomena, in particular, liquid crystals, thin film epitaxial growth and phase transformations. The analyses of the schemes involve the characterization of the strictly convex energies associated with the equations. We first give a general framework for PSD in Hilbert spaces. Based on certain reasonable assumptions of the linear pre-conditioner, a geometric convergence rate is shown for the nonlinear PSD iteration. We then apply the general theory to the fourth and sixth-order problems of interest, making use of Sobolev embedding and regularity results to confirm the appropriateness of our pre-conditioners for the regularized p-Lapacian problems. Our results include a sharper theoretical convergence result for p-Laplacian systems compared to what may be found in existing works. We demonstrate rigorously how to apply the theory in the finite dimensional setting using finite difference discretization methods. Numerical simulations for some important physical application problems – including thin film epitaxy with slope selection and the square phase field crystal model – are carried out to verify the efficiency of the scheme.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Analysis of Capture Trajectories to the Vicinity of Libration Points

Spacecraft capture trajectories to the periodic orbits of the L1 and L2 points in the restricted Hill three-body problem are studied. The specific focus is on transfer to these vicinities from interplanetary trajectories. This application is motivated by future proposals to place "Deep Space ports" at the Earth and Mars L1 or L2 points. These spaceports are considered as candidate gateways for interplanetary transfers in the future. We utilize stable manifolds for capture trajectories to periodic orbits around the libration points. As a result, the cost of capture into a periodic orbit is also reduced relative to direct capture into a parabolic orbit. The way of linking between interplanetary transfer trajectories and the stable manifold is also discussed.

Nakamiya, M.↗

Boundary Layer Stability and Transition in a Chemically Reacting Martian Atmosphere using LASTRAC

The Thermal Protection System (TPS) is a significant portion of the mass of reentry vehicles, planetary probes, and Martian entry vehicles. Reducing this mass has benefits in terms of decreased fuel requirements and increased payload; however, due to the high risk and un-certainty, the TPS or heat shields are designed conservatively by assuming fully turbulent flow. Laminar flow results in reduced heat flux, and improved transition prediction has the potential to reduce TPS mass and uncertainty in aerothermodynamic predictions. Limited previous research exists examining the problem of transition prediction for Martian atmospheric entry, with studies available on transition on the Mars Science Laboratory TPS. Although transition was demonstrated in wind-tunnel tests, uncertainty in the transition location resulted in a TPS designed for fully turbulent flow, and therefore greater mass than required for a partially-laminar condition. In this work, we extend the boundary layer stability code LASTRAC, recently modified to include chemical and thermal nonequilibrium capabilities, to a model of the Martian atmosphere. LASTRAC provides Parabolized Stability Equations (PSE) as well as Linear Stability Theory (LST) to predict the stability of a boundary layer and transition with semi-empirical eN methods. Results included in this work compare disturbance growth characteristics between air and Martian atmosphere at similar nondimensional freestream conditions on a simple flat plate geometry. Both chemical nonequilibrium and thermochemical nonequilibrium, as well as both PSE and LST, are used.

Heather L Kline↗

The evolution of comet orbits

The origin of comets and the evolution of their orbits are discussed. Factors considered include: the law of survival of comets against ejection on hyperbolic orbits; short-period comets are not created by single close encounters of near-parabolic comets with Jupiter; observable long-period comets do not evolve into observable short-period comets; unobservable long-period comets with perihelia near Jupiter can evolve into observable short-period comets; long-period comets cannot have been formed or created within the planetary region of the solar system (excluding the effects of stellar perturbations); it is possible that some of the short-period comets could have been formed inside the orbit of Neptune; circularly-restricted three-body problem, and its associated Jacobi integral, are not valid approximations to use in studying origin and evolution of comets.

Everhart, E.↗

Fronts propagating with curvature dependent speed: Algorithms based on Hamilton-Jacobi formulations

New numerical algorithms are devised (PSC algorithms) for following fronts propagating with curvature-dependent speed. The speed may be an arbitrary function of curvature, and the front can also be passively advected by an underlying flow. These algorithms approximate the equations of motion, which resemble Hamilton-Jacobi equations with parabolic right-hand-sides, by using techniques from the hyperbolic conservation laws. Non-oscillatory schemes of various orders of accuracy are used to solve the equations, providing methods that accurately capture the formation of sharp gradients and cusps in the moving fronts. The algorithms handle topological merging and breaking naturally, work in any number of space dimensions, and do not require that the moving surface be written as a function. The methods can be used also for more general Hamilton-Jacobi-type problems. The algorithms are demonstrated by computing the solution to a variety of surface motion problems.

Osher, Stanley↗

Application of a self-adaptive grid method to complex flows

A directional-split, modular, user-friendly grid point distribution code is applied to several test problems. The code is self-adaptive in the sense that grid point spacing is determined by user-specified constants denoting maximum and minimum grid spacings and constants relating the relative influence of smoothness and orthogonality. Estimates of truncation error, in terms of flow-field gradients and/or geometric features, are used to determine the point distribution. Points are redistributed along grid lines in a specified direction in an elliptic manner over a user-specified subdomain, while orthogonality and smoothness are controlled in a parabolic (marching) manner in the remaining directions. Multidirectional adaption is achieved by sequential application of the method in each coordinate direction. The flow-field solution is redistributed onto the newly distributed grid points after each unidirectional adaption by a simple one-dimensional interpolation scheme. For time-accurate schemes such interpolation is not necessary and time-dependent metrics are carried in the fluid dynamic equations to account for grid movement.

Deiwert, G. S.↗

Comparison Between Navier-Stokes and Thin-Layer Computations for Separated Supersonic Flow

In the numerical simulation of high Reynolds-number flow, one can frequently supply only enough grid points to resolve the viscous terms in a thin layer. As a consequence, a body-or stream-aligned coordinate system is frequently used and viscous terms in this direction are discarded. It is argued that these terms cannot be resolved and computational efficiency is gained by their neglect. Dropping the streamwise viscous terms in this manner has been termed the thin-layer approximation. The thin-layer concept is an old one, and similar viscous terms are dropped, for example, in parabolized Navier-Stokes schemes. However, such schemes also make additional assumptions so that the equations can be marched in space, and such a restriction is not usually imposed on a thin-layer model. The thin-layer approximation can be justified in much the same way as the boundary-layer approximation; it requires, therefore, a body-or stream-aligned coordinate and a high Reynolds number. Unlike the boundary-layer approximation, the same equations are used throughout, so there is no matching problem. Furthermore, the normal momentum equation is not simplified and the convection terms are not one-sided differenced for marching. Consequently, the thin-layer equations are numerically well behaved at separation and require no special treatment there. Nevertheless, the thin-layer approximation receives criticism. It has been suggested that the approximation is invalid at separation and, more recently, that it is inadequate for unsteady transonic flow. Although previous comparisons between the thin-layer and Navier-Stokes equations have been made, these comparisons have not been adequately documented.

Degani, David↗

On the Theory of the Laval Nozzle

In the present paper, the motion of a gas in a plane-parallel Laval nozzle in the neighborhood of the transition from subsonic to supersonic velocities is studied. In a recently published paper, F. I. Frankl, applying the holograph method of Chaplygin, undertook a detailed investigation of the character of the flow near the line of transition from subsonic to supersonic velocities. From the results of Tricomi's investigation on the theory of differential equations of the mixed elliptic-hyperbolic type, Frankl introduced as one of the independent variables in place of the modulus of the velocity, a certain specially chosen function of this modulus. He thereby succeeded in explaining the character of the flow at the point of intersection of the transition line and the axis of symmetry (center of the nozzle) and in studying the behavior of the stream function in the neighborhood of this point by separating out the principal term having, together with its derivatives, the maximum value as compared with the corresponding corrections. This principal term is represented in Frankl's paper in the form of a linear combination of two hypergeometric functions. In order to find this linear combination, it is necessary to solve a number of boundary problems, which results in a complex analysis. In the investigation of the flow with which this paper is concerned, a second method is applied. This method is based on the transformation of the equations of motion to a form that may be called canonical for the system of differential equations of the mixed elliptic-hyperbolic type to which the system of equations of the motion of an ideal compressible fluid refers. By studying the behavior of the integrals of this system in the neighborhood of the parabolic line, the principal term of the solution is easily separated out in the form of a polynomial of the third degree. As a result, the computation of the transitional part of the nozzle is considerably simplified.

Falkovich, S. V.↗

Sharp front tracking with geometric interface reconstruction

Here, this paper presents a novel sharp front-tracking method designed to address limitations in classical front-tracking approaches, specifically their reliance on smooth interpolation kernels and extended stencils for coupling the front and fluid mesh. In contrast, the proposed method employs exclusively sharp, localized interpolation and spreading kernels, restricting the coupling to the interfacial fluid cells–those containing the interface/front. This localized coupling is achieved by integrating a divergence-preserving velocity interpolation method with a piecewise parabolic interface calculation (PPIC) and a polyhedron intersection algorithm to compute the indicator function and local interface curvature. Surface tension is computed using the Continuum Surface Force (CSF) method, maintaining consistency with the sharp representation. Additionally, we propose an efficient local roughness smoothing implementation to account for surface mesh undulations, which is easily applicable to any triangulated surface mesh. Building on our previous work, the primary innovation of this study lies in the localization of the coupling for both the indicator function and surface tension calculations. By reducing the interface thickness on the fluid mesh to a single cell, as opposed to the 4–5 cell spans typical in classical methods, the proposed sharp front-tracking method achieves a highly localized and accurate representation of the interface. This sharper representation mitigates parasitic currents and improves force balancing, making it particularly suitable for scenarios where the interface plays a critical role, such as microfluidics, fluid-fluid interactions, and fluid-structure interactions. The proposed method is comprehensively validated and tested on canonical interfacial flow problems, including stationary and translating Laplace equilibria, oscillating droplets, and rising bubbles. The presented results demonstrate that the sharp front-tracking method significantly outperforms the classical approach in terms of accuracy, stability, and computational efficiency. Notably, parasitic currents are reduced by approximately two orders of magnitude and stable results are obtained for parameter ranges where classical front tracking fails to converge.

42 ENGINEERING↗

Semi-discrete Galerkin solution of the compressible boundary-layer equations with viscous-inviscid interaction

A semi-discrete Galerkin (SDG) method is under development to model attached, turbulent, and compressible boundary layers for transonic airfoil analysis problems. For the boundary-layer formulation the method models the spatial variable normal to the surface with linear finite elements and the time-like variable with finite differences. A Dorodnitsyn transformed system of equations is used to bound the infinite spatial domain thereby providing high resolution near the wall and permitting the use of a uniform finite element grid which automatically follows boundary-layer growth. The second-order accurate Crank-Nicholson scheme is applied along with a linearization method to take advantage of the parabolic nature of the boundary-layer equations and generate a non-iterative marching routine. The SDG code can be applied to any smoothly-connected airfoil shape without modification and can be coupled to any inviscid flow solver. In this analysis, a direct viscous-inviscid interaction is accomplished between the Euler and boundary-layer codes through the application of a transpiration velocity boundary condition. Results are presented for compressible turbulent flow past RAE 2822 and NACA 0012 airfoils at various freestream Mach numbers, Reynolds numbers, and angles of attack.

Day, Brad A.↗

Development of attenuation and diffraction corrections for linear and nonlinear Rayleigh surface waves radiating from a uniform line source

In recent studies with nonlinear Rayleigh surface waves, harmonic generation measurements have been successfully employed to characterize material damage and microstructural changes, and found to be sensitive to early stages of damage process. A nonlinearity parameter of Rayleigh surface waves was derived and frequently measured to quantify the level of damage. The accurate measurement of the nonlinearity parameter generally requires making corrections for beam diffraction and medium attenuation. These effects are not generally known for nonlinear Rayleigh waves, and therefore not properly considered in most of previous studies. In this paper, the nonlinearity parameter for a Rayleigh surface wave is defined from the plane wave displacement solutions. We explicitly define the attenuation and diffraction corrections for fundamental and second harmonic Rayleigh wave beams radiated from a uniform line source. Attenuation corrections are obtained from the quasilinear theory of plane Rayleigh wave equations. To obtain closed-form expressions for diffraction corrections, multi-Gaussian beam (MGB) models are employed to represent the integral solutions derived from the quasilinear theory of the full two-dimensional wave equation without parabolic approximation. Diffraction corrections are presented for a couple of transmitter-receiver geometries, and the effects of making attenuation and diffraction corrections are examined through the simulation of nonlinearity parameter determination in a solid sample.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Assessment of a parabolic analysis for axisymmetric internal flows in rocket and turbomachinery ducts

The flow paths in gas turbine passages encompass a wide range of flow properties such as Reynolds number and Mach number as well as many other variable flow conditions such as swirl, free-stream turbulence, and laminar/turbulent transition. An existing computer program, the Axisymmetric Diffuser Duct (ADD) code, which calculates compressible, turbulent, swirling flow through axisymmetric ducts has been modified to include the effects of free-stream turbulence and laminar/turbulent transition. The program has been evaluated on a matrix of test cases to determine its accuracy, robustness, and limits of applicability. This improved version of the ADD code calculates solutions which compare well with available data and can now be applied to a wider range of problems than previously possible. In addition a concept called local enhancement was developed and tested on a simple two-dimensional geometry in order to demonstrate a method to reduce computer time. In this concept the pressure distribution is calculated on a coarse grid using the ADD code and the viscous layer is locally enhanced using a boundary layer analysis. By applying this concept, an order of magnitude reduction in computer time was possible without any loss in accuracy.

Power, G. D.↗

Laser pulse self-compression in an active fibre with a finite gain bandwidth under conditions of a nonstationary nonlinear response

We study the influence of a nonstationary nonlinear response of a medium on self-compression of soliton-like laser pulses in active fibres with a finite gain bandwidth. Based on the variational approach, we qualitatively analyse the self-action of the wave packet in the system under consideration in order to classify the main evolution regimes and to determine the minimum achievable laser pulse duration during self-compression. The existence of stable soliton-type structures is shown in the framework of the parabolic approximation of the gain profile (in the approximation of the Gnizburg – Landau equation). An analysis of the self-action of laser pulses in the framework of the nonlinear Schrödinger equation with a sign-constant gain profile demonstrate a qualitative change in the dynamics of the wave field in the case of a nonstationary nonlinear response that shifts the laser pulse spectrum from the amplification region and stops the pulse compression. Expressions for a minimum duration of a soliton-like laser pulse are obtained as a function of the problem parameters, which are in good agreement with the results of numerical simulation. (paper)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Leading-edge receptivity for blunt-nose bodies

This research program investigates boundary-layer receptivity in the leading-edge region for bodies with blunt leading edges. Receptivity theory provides the link between the unsteady distrubance environment in the free stream and the initial amplitudes of the instability waves in the boundary layer. This is a critical problem which must be addressed in order to develop more accurate prediction methods for boundary-layer transition. The first phase of this project examines the effects of leading-edge bluntness and aerodynamic loading for low Mach number flows. In the second phase of the project, the investigation is extended to supersonic Mach numbers. Singular perturbation techniques are utilized to develop an asymptotic theory for high Reynolds numbers. In the first year, the asymptotic theory was developed for leading-edge receptivity in low Mach number flows. The case of a parabolic nose is considered. Substantial progress was made on the Navier-Sotkes computations. Analytical solutions for the steady and unsteady potential flow fields were incorporated into the code, greatly expanding the types of free-stream disturbances that can be considered while also significantly reducing the the computational requirements. The time-stepping algorithm was modified so that the potential flow perturbations induced by the unsteady pressure field are directly introduced throughout the computational domain, avoiding an artificial 'numerical diffusion' of these from the outer boundary. In addition, the start-up process was modified by introducing the transient Stokes wave solution into the downstream boundary conditions.

Kerschen, Edward J.↗

Optical solitons in nematic liquid crystals with Kerr and parabolic law nonlinearities

In this work, a study is carried out to analyze nematicons in liquid crystals in the presence of Kerr and parabolic law nonlinearity. Exp(−ϕ(ξ))-Expansion method is incorporated in this regard. Solutions obtained include hyperbolic, periodic and rational solutions along with their combo type solutions in both cases of nonlinearity and their existence is guaranteed by the constraints retrieved during the process.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗