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NASA NTRS2018

Vegetable Production Systems Component Tests

As long-term spaceflight missions become ever more imminent, astronaut nutrition and diet require further investigation and development. Dehydrated or stabilized food sources are currently used for spaceflight, but growing fresh produce aboard spacecraft can potentially supplement the astronauts’ diets. Further, having astronauts work with plants while in space can provide psychological benefits by serving as a tangible passage of time and representing a living component aboard an otherwise mechanical environment. As spaceflight duration will lengthen as missions head back to the Moon and to Mars, having the ability and knowledge to grow fresh produce will become even more vital. The following experiments were conducted in the late summer and fall of 2018. The purpose of these studies were to examine potential off-gas from a system component that could potentially inhibit plant germination, optimizing lighting methods and protocol for mizuna production, determining a fertilizer method that best promotes healthy mizuna yields, and troubleshooting tomato production for the next generation of the Vegetable Production System.

international space station↗

NASA NTRS2017

BIRCHES and Lunarcubes: Building the First Deep Space Cubesat Broadband IR Spectrometer

The Broadband InfraRed Compact High-resolution Exploration Spectrometer (BIRCHES), which will be described in detail here, is the compact broadband IR spectrometer of the Lunar Ice Cube mission. Lunar Ice Cube is one of 13 6U cubesats that will be deployed by EM1 in cislunar space, qualifying as lunarcubes. The LunarCube paradigm is a proposed approach for extending the affordable CubeSat standard to support access to deep space via cis-lunar/lunar missions. Because the lunar environment contains analogs of most solar system environments, the Moon is an ideal target for both testing critical deep space capabilities and understanding solar system formation and processes. Effectively, as developments are occurring in parallel, 13 prototype deep space cubesats are being flown for EM1. One useful outcome of this ‘experiment’ will be to determine to what extent it is possible to develop a lunarcube ‘bus’ with standardized interfaces to all subsystems using reasonable protocols for a variety of payloads. The lunar ice cube mission was developed as the test case in a GSFC R&D study to determine whether the cubesat paradigm could be applied to deep space, science requirements driven missions, and BIRCHES was its payload. Here, we present the design and describe the ongoing development, and testing, in the context of the challenges of using the cubesat paradigm to fly a broadband IR spectrometer in a 6U platform, including minimal funding and extensive need for leveraging existing assets and relationships on development, the foreshortened schedule for payload delivery on testing, and minimum bandwidth translating into simplified or canned operation.

Chapin, Peter↗

NASA NTRSDate not supplied

Principles for Termination of Medical Care in Austere Analog Environments for Development of Spaceflight Protocols

INTRODUCTION: When compared to operations in low earth orbit, exploration class missions will have substantially limited resources and ground medical support while the risk of a significant medical event is projected to be higher. Termination of care (TOC) may need to be considered in certain instances. We aim to utilize data from earth-based analogs to identify common principles that can help develop future guidelines to this complex medical and ethical challenge. METHODS: A comprehensive literature review was conducted in medline, nasa.gov, Defense Technical Information Center(DTIC) and google scholar. Key search terms including “withdrawal of care, termination of care, termination of CPR, military medicine, wilderness medicine, futility, potentially inappropriate” and others were used to identify analog studies of relevance. These were qualitatively evaluated for recurring principles or themes that were reviewed and structured. RESULTS: Mission planning termination of care principles: definitions of clear medical goals, separate protocols for each relevant condition, protocols developed using best available evidence, crew involvement in development, protocols rehearsal pre-launch, and inclusion of palliative capabilities. In-mission termination of care principles: 1. Crew Medical Officer directed stabilization of the patient; 2. Consultation with mission control with standardized information exchange; 3. Multidisciplinary medical and ethical conference among the mission directors, flight surgeons and relevant specialist experts; 4. Multidisciplinary risk review examining both medical and mission risks for relevant options; 5. Provision of a transparent explanation of the process and decision to crew; 6. Allowing crew feedback and inquiry to review board; 7. Support of the crew in the enacted decision. DISCUSSION: By utilizing the best available evidence in conjunction with expert opinion we have identified common principles from earth-based analogs that could be used to help design future TOC protocols.

Samuel Stephenson↗

NASA NTRS2024

Quantifying Caloric Expenditure During Zero-G Exercise

BACKGROUND: Exercise is a fundamental component of maintaining astronaut health on long-duration space missions, where the microgravity environment poses unique challenges to physiological homeostasis. Accurate quantification of energy expenditure during such exercises is crucial for optimizing nutritional and physical health strategies for spacefarers. OBJECTIVE: This study aims to develop a comprehensive model to estimate caloric expenditure during exercise in a microgravity environment, employing a combination of spirometry, heart rate data, and other relevant parameters. By assessing energy utilization under these conditions, we seek to facilitate enhanced health management protocols for astronauts in space. METHODS & OUTCOMES: A multivariate predictive model will be constructed, utilizing spirometry and heart rate data, coupled with additional physiological and environmental parameters. A systematic approach will be applied to analyze the relationship between these variables and energy expenditure during various exercises. The proposed model will subsequently undergo rigorous validation to ensure accuracy and reliability. This research is expected to yield a precise and reliable predictive model, contributing to improved strategies for exercise prescription and nutritional intake, addressing the unique challenges presented by microgravity environments. We anticipate that our findings will support the development of more effective health maintenance protocols for astronauts during extended space missions, mitigating the adverse effects of space travel on the human body. SIGNIFICANCE: The development of an accurate and adaptable model to quantify caloric expenditure during exercise in space represents a pivotal advancement in space medicine. The insights gained from this study have the potential to inform the design of enhanced health and wellness strategies, ensuring the well-being and operational effectiveness of astronauts in long-duration space missions.

Calorie↗

NASA NTRS2009

Universal Reconfigurable Translator Module (URTM) Final Report

This report describes the Universal Reconfigurable Translation Module, or URTM. The URTM was developed by Sigma Space Corporation for NASA in order to translate specific serial protocols, both logically and physically. At present, the prototype configuration has targeted MIL-STD-1553B (RT and BC), IEEE 1394b (Firewire), and ECSS-E-50-12A (SpaceWire). The objectives of this program were to study the feasibility of a configurable URTM to translate serial link data as might be used in a space-flight mission and to design, develop, document, and deliver an engineering prototype model of the URTM with a path to spaceflight. By simply connecting two of the three Physical Interface Modules (PIM) on either end of the RPTM (Reconfigurable Protocol Translator Module), the URTM then self configures via a library of interface translation functions, thereby allowing the two data links to communicate seamlessly.

Leventhal, Edward↗

NASA NTRS1999

Recovery of postural equilibrium control following space flight

DSO 605 represents the first large study of balance control following spaceflight. Data collected during DSO 605 confirm the theory that postural ataxia following short duration spaceflight is of vestibular origin. We used the computerized dynamic posturography technique developed by Nashner et al. to study the role of the vestibular system in balance control in astronauts during quiet stance before and after spaceflight. Our results demonstrate unequivocally that balance control is disrupted in all astronauts immediately after return from space. The most severely affected returning crew members performed in the same way as vestibular deficient patients exposed to this test battery. We conclude that otolith mediated spatial reference provided by the terrestrial gravitational force vector is not used by the astronauts balance control systems immediately after spaceflight. Because the postflight ataxia appears to be mediated primarily by CNS adaptation to the altered vestibular inputs caused by loss of gravitational stimulation, we believe that intermittent periods of exposure to artificial gravity may provide an effective in-flight countermeasure. Specifically, we propose that in-flight centrifugation will allow crew members to retain their terrestrial sensory-motor adapted states while simultaneously developing microgravity adapted states. The dual-adapted astronaut should be able to make the transition from microgravity to unit gravity with minimal sensory-motor effects. We have begun a ground based program aimed at developing short arm centrifuge prescriptions designed to optimize adaptation to altered gravitational environments. Results from these experiments are expected to lead directly to in-flight evaluation of the proposed centrifuge countermeasure. Because our computerized dynamic posturography system was able to (1) quantify the postflight postural ataxia reported by crew members and observed by flight surgeons and scientists, (2) track the recovery of normal (preflight) balance control, (3) differentiate between rookie and veteran subjects, and (4) provide normative and clinical databases for comparison, and because our study successfully characterized postflight balance control recovery in a large cross-section of Shuttle crew members, we recommend that this system and protocol be adopted as a standard dependent measure for evaluating the efficacy of countermeasures and/or evaluating the postflight effects of changing mission durations or activities.

Paloski, William H.↗

NASA NTRS2015

Evidence-Based Recommendations for Optimizing Light in Day-to-Day Spaceflight Operations

NASA Behavioral Health and Performance Element (BHP) personnel have previously reported on efforts to transition evidence‐based recommendations for a flexible lighting system on the International Space Station (ISS). Based on these recommendations, beginning in 2016 the ISS will replace the current fluorescent‐based lights with an LED‐based system to optimize visual performance, facilitate circadian alignment, promote sleep, and hasten schedule shifting. Additional efforts related to lighting countermeasures in spaceflight operations have also been underway. As an example, a recent BHP research study led by investigators at Harvard Medical School and Brigham and Women's Hospital, evaluated the acceptability, feasibility, and effectiveness of blue‐enriched light exposure during exercise breaks for flight controllers working the overnight shift in the Mission Control Center (MCC) at NASA Johnson Space Center. This effort, along with published laboratory studies that have demonstrated the effectiveness of appropriately timed light for promoting alertness, served as an impetus for new light options, and educational protocols for flight controllers. In addition, a separate set of guidelines related to the light emitted from electronic devices, were provided to the Astronaut Office this past year. These guidelines were based on an assessment led by NASA's Lighting Environment Test Facility that included measuring the spectral power distribution, irradiance, and radiance of light emitted from ISS‐grade laptops and I‐Pads, as well as Android devices. Evaluations were conducted with and without the use of off‐the‐shelf screen filters as well as a software application that touts minimizing the short‐wave length of the visible light spectrum. This presentation will focus on the transition for operations process related to lighting countermeasures in the MCC, as well as the evidence to support recommendations for optimal use of laptops, I‐Pads, and Android devices during all phases of spaceflight operations.

Whitmire, Alexandra↗

NASA NTRSDate not supplied

Does Collection Time Bias the Ecology of Cleanroom Air Samples?

Microbial monitoring of astromaterials collections has taken on increased importance with the return of biologically sensitive samples from the asteroids Ryugu and Bennu and the initiation of the Mars Sample Return Program. Terrestrial bacteria and fungi can alter the mineralogy and organic composition of our collections causing irreversible contamination of pristine samples and increasing the risk of false positives for life detection measurements. NASA has conducted routine microbial monitoring of its existing collections since 20181. Initial monitoring focused on surface samples collected with foam swabs. Although, airborne microbiology is often decoupled from surface microbiology in the built environment2 culture-based air sampling techniques like impactors were not compliant with existing contamination control requirements. Bringing organic rich media, gelatin or liquids into curation cleanrooms presents an unacceptable risk to pristine samples. In 2022 NASA purchased a materials complaint air sampler and began collecting air samples from the cleanrooms in addition to surface samples3. The new instrument uses an electret filter to collect samples that are suitable for cultivating organisms or for direct DNA sequencing. Preliminary DNA sequencing results appeared to indicate that longer sampling times biased the microbial community in favor of hearty, spore-forming bacteria3. We present the results of a study comparing overnight sampling (17 hours) to short (1 hour) sampling of unoccupied curation cleanrooms. The results will help us optimize our monitoring protocols and develop a more detailed inventory of the ecology of astromaterials curation cleanrooms. Methods: We analyzed 72 paired air samples from six different cleanrooms including the meteorite processing lab (ISO 7 equivalent, 16 samples), the lunar lab (ISO 6 equivalent, 10 samples), the stardust lab (ISO 5 equivalent 14 samples), the OSIRIS-REx lab (ISO 5 equivalent, 12 samples), the Hayabusa2 lab (ISO 5 equivalent, 14 samples), and the Genesis lab (ISO 4 equivalent, 6 samples). All the samples were collected with an InnovaPrep Bobcat air sampler operating at a sampling rate of 200 L/min. The sampler operates for 5 minutes out of every 20 minute period. Half of the samples were collected by filtering 3,000L (15 min. of active sampling) of air across an electret filter for one hour. The rest of the samples were collected by filtering approximately 51,000 L air across the filter overnight (~17 hours, 255 min. of active sampling). Cells were eluted from the filter using 6-7 ml of pressurized 0.15% tween 20 in PBS (phosphate buffered saline). This liquid was used to cultivate bacteria according to previously published methods1,4,5 and for DNA extraction and next generation sequencing. DNA was extracted with a Qiagen MagAttract PowerMicrobiome kit6. To identify bacteria and archaea, the 16S rRNA gene was amplified using Earth Microbiome primers for the V4 region 7. The amplified DNA was sequenced on an Illumina MiSeq using a V3 reagent kit. The resulting sequences were processed using DADA2 and QIIME2 as implemented on the EDGE bioinformatics platform8–10. Results: Only two of the 72 samples had no amplifiable DNA. Amplified DNA concentrations ranged from 2.67 – 0.272 ng/µl. The median concentration of amplified DNA for the 1 hour samples was 0.770 ± 0.368 ng/µl. The median concentration of amplified DNA for the overnight samples was 0.877 ± 0.434 ng/µl. On average the overnight samples had slightly more sequences (58,960 vs. 59,456) and ASV’s (amplicon sequence variants) (60 vs 64.5) than the one hour samples, but these differences are not statistically significant. The most abundant ASV in every sample mapped to the genus Cupravidus. ASV’s mapping to the genuses Bacillus, Schlegelella, Thermus, and Staphylococcus were also common. Discussion and Future Work: Alpha diversity statistics like Shannon Entropy and Faith Phylogenetic Diversity are used to describe the diversity of organisms in a single sample. If a longer sampling time was biasing the data, we would expect to see a change in these diversity statistics vs. sample time. However, we did not observe this in our data. The median Shannon entropy was slightly higher for the overnight samples (3.773 vs 3.611) as was the Faith Phylogenetic Diversity (4.042 vs 3.596), but both values were within a standard deviation of each other for the two sampling times (Fig. 1). It is unlikely, that the longer sampling time is introducing bias into our data. We do observe a significant decrease in diversity when comparing the air samples by lab. The Genesis lab (ISO 4 equivalent) has a lower median number of ASV’s (45.5) than the other labs (62). Median values for Shannon Entropy (3.717 vs. 3.430) and Faith Phylogenetic Diversity (3.796 vs. 3.548) are also lower for Genesis, but those values are with one standard deviation of each other for the different sampling times. This is consistent with previous culture-based results suggesting that the environment in cleanrooms tends to select for a core group of organisms capable of surviving under dry, low nutrient, conditions. The presence of the ASV’s mapping to Cupravidus and Thermus in our sequencing blanks and controls suggests that several of the most common organisms in our samples represent contaminants from the reagents used to perform the DNA extractions and sequencing. Further work is needed to identify these contaminants, remove them from our data and recalculate the diversity statistics. This is a systematic error. Therefore, we do not expect removing the sequencing contaminants to change our conclusions. Longer air sample collection times appear to result in slightly higher diversity and do not bias the results towards “hardy” bacteria like spore-formers. Based on these preliminary results we conclude that sampling at least 3,000 liters of air is sufficient to capture the microbial diversity of cleanrooms, and that air samples can also be collected overnight without negatively impacting diversity. These results allow us to be flexible when designing microbial monitoring plans so that they do not interfere with routine lab activity. References: 1. Regberg, A. B. et al. 49th Lunar and Planetary Science Conference (2018). 2. The United States Pharmacopeial Convention. USP General Chapter <1116> (2013). 3. Regberg, A. B., et al. 54th Lunar and Planetary Science Conference (2023). 4. Regberg, A. B. et al. 53rd Lunar and Planetary Science Conference ( 2022). 5. Davis, R. E.,et al. 50th Lunar and Planetary Science Conference (2019). 6. Qiagen. MagAttract® PowerMicrobiome® DNA/RNA EP Kit Handbook. (2018). 7. Walters, W. et al. mSystems 1, (2015). 8. Callahan, B. J. et al. Nat. Methods 13, 581–583 (2016). 9. Hall, M. & Beiko, R. G. Microbiome Analysis: Methods and Protocols113–129 (Springer, 2018). 10. Philipson, C. et al. Bio-Protoc. 7, e2622 (2017).

A. B. Regberg↗

NASA NTRSDate not supplied

Evaluation of Initial and Mid-Term Air Traffic Procedures for Urban Air Mobility Operations

Urban air mobility (UAM) operations are expected to expand in scale over the next several years as novel aircraft types, including electric vertical takeoff and landing aircraft, are certified and begin operations. These new aircraft may increase safety, decrease noise, and lower operating costs compared with helicopters, allowing them to operate in ways existing aircraft do not. It is vital that these expanded operations are compatible with and do not disrupt existing operations or the air traffic management system. To study the ways in which scaled UAM operations can best integrate in the national airspace system, NASA and Joby Aviation partnered to conduct a high-fidelity air traffic controller-in-the-loop study. Building on air traffic procedures used to manage high tempo operations in other parts of the airspace, new procedures, routes, and communications protocols were developed and tested by retired controllers in NASA’s Future Flight Central tower simulation facility. In addition, new cooperative airspace constructs in the form of corridors were developed to understand their potential contributions to even greater scales of operation. The controllers managed traffic scenarios in the Dallas-Fort Worth and Dallas Love Field airports consisting of fleets of up to 100 UAM aircraft operating alongside traditional traffic . Metrics for air traffic controller workload, duration of communications, departure delays, and other measures of allowable aircraft throughput were collected. The analysis indicates that using today’s procedures for initial UAM operations under nominal conditions could enable up to 40 operations per hour to an airport’s central terminal area if that involved crossing a runway and up to 55operations per hour if reaching the central terminal did not involve crossing a runway. Operations at these tempos did not delay or otherwise interfere with simulated runway traffic and were rated acceptable by the air traffic controllers. The new corridor constructs dramatically lowered controller workload in certain circumstances, suggesting they may be effective in further increasing the allowable scale of operations.

Urban Air Mobility↗

NASA NTRSDate not supplied

Evaluation of Initial and Mid-Term Air Traffic Procedures for Urban Air Mobility

Urban air mobility (UAM) operations are expected to expand in scale over the next several years as novel aircraft types, including electric vertical takeoff and landing aircraft, are certified and begin operations. These new aircraft may increase safety, decrease noise, and lower operating costs compared with helicopters, allowing them to operate in ways existing aircraft do not. It is vital that these expanded operations are compatible with and do not disrupt existing operations or the air traffic management system. To study the ways in which scaled UAM operations can best integrate in the national airspace system, NASA and Joby Aviation partnered to conduct a high-fidelity air traffic controller-in-the-loop study. Building on air traffic procedures used to manage high tempo operations in other parts of the airspace, new procedures, routes, and communications protocols were developed and tested by retired controllers in NASA’s Future Flight Central tower simulation facility. In addition, new cooperative airspace constructs in the form of corridors were developed to understand their potential contributions to even greater scales of operation. The controllers managed traffic scenarios in the Dallas-Fort Worth and Dallas Love Field airports consisting of fleets of up to 100 UAM aircraft operating alongside traditional traffic. Metrics for air traffic controller workload, duration of communications, departure delays, and other measures of allowable aircraft throughput were collected. The analysis indicates that using today’s procedures for initial UAM operations under nominal conditions could enable up to 40 operations per hour to an airport’s central terminal area if that involved crossing a runway and up to 55 operations per hour if reaching the central terminal did not involve crossing a runway. Operations at these tempos did not delay or otherwise interfere with simulated runway traffic and were rated acceptable by the air traffic controllers. The new corridor constructs dramatically lowered controller workload in certain circumstances, suggesting they may be effective in further increasing the allowable scale of operations.

Advanced Air Mobility↗

NASA NTRS2006

VOIP over Space Networks

This viewgraph presentation reviews Voice over Internet Protocol (VOIP) over a space networking environment. The topics include: 1) Drivers for VOIP in Space; 2) Challenges in the Space Networking Environment: Long Latencies, Path errors, Simplex paths, Asymmetric paths, QoS requirements, Team-based operations, and Overhead concerns; 3) Possible VOIPOSN approaches; 4) Study of BER, code type and voice frame length on PESQ-MOS; 5) Codec Latency Trade Space; and 6) Testbed.

Internet Protocol (IP)↗

NASA NTRS1996

Design of Plant Gas Exchange Experiments in a Variable Pressure Growth Chamber

Sustainable human presence in extreme environments such as lunar and martian bases will require bioregenerative components to human life support systems where plants are used for generation of oxygen, food, and water. Reduced atmospheric pressures will be used to minimize mass and engineering requirements. Few studies have assessed the metabolic and developmental responses of plants to reduced pressure and varied oxygen atmospheres. The first tests of hypobaric pressures on plant gas exchange and biomass production at the Johnson Space Center will be initiated in January 1996 in the Variable Pressure Growth Chamber (VPGC), a large, closed plant growth chamber rated for 10.2 psi. Experiments were designed and protocols detailed for two complete growouts each of lettuce and wheat to generate a general database for human life support requirements and to answer questions about plant growth processes in reduced pressure and varied oxygen environments. The central objective of crop growth studies in the VPGC is to determine the influence of reduced pressure and reduced oxygen on the rates of photosynthesis, dark respiration, evapotranspiration and biomass production of lettuce and wheat. Due to the constraint of one experimental unit, internal controls, called pressure transients, will be used to evaluate rates of CO2 uptake, O2 evolution, and H2O generation. Pressure transients will give interpretive power to the results of repeated growouts at both reduced and ambient pressures. Other experiments involve the generation of response functions to partial pressures of O2 and CO2 and to light intensity. Protocol for determining and calculating rates of gas exchange have been detailed. In order to build these databases and implement the necessary treatment combinations in short time periods, specific requirements for gas injections and removals have been defined. A set of system capability checks will include determination of leakage rates conducted prior to the actual crop growouts. Schedules of experimental events for lettuce and wheat are outlined and include replications in time of diurnal routines, pressure transients, variable pO2, pO2/pCO2 ratio, and light intensity responses.

Corey, Kenneth A.↗

NASA NTRS1982

Study of outgassing and decomposition of space shuttle heat protection tiles, fillers and adhesive

The purpose of this project was to determine the chemicals desorbing from the space shuttle heat protection tiles. The original protocol for this project involved direct insertion probe mass spectrometry (DIPMS) analysis of the outgassing products from the tiles. However, this method proved unsatisfactory due to the large number of compounds desorbing from the tiles. A purge and trap technique was then employed to collect and separate the chemicals desorbing from the tiles. The maximum temperature in this analysis was 180 C which is the gas chromatograph fused silica capillary column's temperature limit. The desorption was also carried out at atmospheric pressure with helium as the purge gas. A description of the modified protocol is given. All compounds are tentatively identified.

Proctor, B. L.↗

NASA NTRS1986

A second generation experiment in fault-tolerant software

The primary goal was to determine whether the application of fault tolerance to software increases its reliability if the cost of production is the same as for an equivalent nonfault tolerance version derived from the same requirements specification. Software development protocols are discussed. The feasibility of adapting to software design fault tolerance the technique of N-fold Modular Redundancy with majority voting was studied.

Knight, J. C.↗

NASA NTRS2000

Mapping Environmental Contaminants at Ray Mine, AZ

Airborne Visible and InfraRed Imaging Spectrometer (AVIRIS) data was collected over Ray Mine as part of a demonstration project for the Environmental Protection Agency (EPA) through the Advanced Measurement Initiative (AMI). The overall goal of AMI is to accelerate adoption and application of advanced measurement technologies for cost effective environmental monitoring. The site was selected to demonstrate the benefit to EPA in using advanced remote sensing technologies for the detection of environmental contaminants due to the mineral extraction industry. The role of the Jet Propulsion Laboratory in this pilot study is to provide data as well as performing calibration, data analysis, and validation of the AVIRIS results. EPA is also interested in developing protocols that use commercial software to perform such work on other high priority EPA sites. Reflectance retrieval was performed using outputs generated by the MODTRAN radiative transfer model and field spectra collected for the purpose of calibration. We are presenting advanced applications of the ENVI software package using n-Dimensional Partial Unmixing to identify image-derived endmembers that best match target materials reference spectra from multiple spectral libraries. Upon identification of the image endmembers the Mixture Tuned Match Filter algorithm was applied to map the endmembers within each scene. Using this technique it was possible to map four different mineral classes that are associated with mine generated acid waste.

McCubbin, Ian↗

NASA NTRS2011

Identification of Cardiometabolic Vulnerabilities Caused by Effects of Synergistic Stressors that are Commonly Encountered During Space Missions

Microgravity is a physiologically challenging state even when at rest. Astronauts experience additional physical and mental stresses, such as prolonged exertion, sleep loss and circadian misalignment, that could impact cardiovascular function. The main goals of this four year NASA project are to characterize the independent and synergistic effects on cardiovascular and immune function of: (1) circadian misalignment; (2) sleep loss; and (3) varied physical and mental stressors, mimicking some of the synergistic stressors experienced by astronauts. Sixteen healthy volunteers, aged 35-55 years, will be studied with standardized behavioral stressors occurring across all circadian phases, both with and without accruing sleep loss, achieved via two 11-day "forced desynchrony" protocols performed in each subject (randomized, within-subject design), where wake periods are advanced 4-h each "day" (i.e. recurring 20-h "days"). One protocol permits 8.33 h sleep opportunity per 20-h "day" (=10 h sleep per 24-h), and the other permits 5 h sleep per 20-h "day" (=6 h sleep per 24-h; matching the reported sleep duration of astronauts). In both protocols, subjects will perform a standardized stress battery including a cognitively challenging task; bicycle exercise, and passive 60deg head up tilt. Outcome variables include blood pressure, heart rate, arrhythmia frequency, cardiac vagal tone (from heart rate variability), sympathetic activity (catecholamines), and endothelial function. Additional measures of cardiac function (echocardiography), responses to a passive 80deg head up tilt, maximal oxygen uptake, and immune function will be assessed at the beginning and at the end of each protocol (i.e., without and with sleep loss, and before and after circadian misalignment). We hope to identify the relative impact on cardiovascular risk markers of varied behavioural stressors while subjects experience circadian misalignment and sleep loss, mimicking some of the synergistic stressors experienced by astronauts. Supported by NASANNX1 OAR 1 OG.

Ruger, M.↗

NASA NTRS2016

Ambulation During Periods of Supersaturation Increase Decompression Stress in Spacewalk Simulations

Musculoskeletal activity accelerates inert gas elimination during oxygen breathing prior to decompression (prebreathe), but may also promote bubble formation (nucleation) and increase the risk of decompression sickness (DCS). The timing, pattern and intensity of musculoskeletal activity and the level of tissue supersaturation are likely critical to the net effect. Understanding the relationships is important to evaluate exercise prebreathe protocols and quantify decompression risk in gravity and microgravity environments. The NASA Prebreathe Reduction Program (PRP) combined oxygen prebreathe and exercise preceding a low pressure (4.3 psia; altitude equivalent of 30,300 ft [9,235 m]) simulation exposure of non-ambulatory subjects (a microgravity analog) to produce two protocols now used by astronauts preparing for extravehicular activity. One protocol included both upright cycling and non-cycling exercise (CEVIS: 'cycle ergometer vibration isolation system') and one protocol relied on non-cycling exercise only (ISLE: 'in-suit light exercise'). CEVIS trial data serve as control data for the current study to investigate the influence of ambulation exercise in 1G environments on bubble formation and the subsequent risk of DCS.

Pollock, N. W.↗

NASA NTRS2021

Towards the Development of a Multi-Agent Cognitive Networking System for the Lunar Environment

This paper details the development of a multi-agent cognitive system intended to optimize networking performance in the lunar environment. NASA’s current concept of the future of lunar communication, LunaNet [1], outlines a complex network of networks. Challenges such as scalability, interoperability and reliability must first be addressed to successfully fulfill this vision. Machine intelligence can greatly reduce the reliance on human operators and enable efficient operations for tasks such as scheduling and network management. The application of machine learning, artificial intelligence, and other automated decision-making techniques can be used to allow network nodes to intelligently sense and adapt to changes in the environment such as link disruptions, new nodes joining the network, and support for a diverse range of protocols. Cognitive networking seeks to evolve these technologies into an autonomous system with improved science data return, reliability, and scalability. In this paper, we study three main areas a means to further develop cognitive networking capabilities: networking and flight software development, analysis of wireless data for modeling and simulation, and development of algorithms for a multi-agent system.

Cognitive Networking↗