Structure-mining: screening structure models by automated fitting to the atomic pair distribution function over large numbers of models
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Abstract not provided.
Asymptotic fixed point theorems and periodic systems of functional-differential equations
Describing functions to analyze feedback control systems containing nonlinearities of dead zone and backlash
Testing complex land surface models has often proceeded by asking the question: does the model prediction agree with the observation? This approach has yet led to high-performance terrestrial models that meet the challenges of climate and ecological studies. Here we test the Community Land Model (CLM) by asking the question: does the model behave like an ecosystem? We pursue its answer by testing CLM in the ecosystem functional space (EFS) at the Missouri Ozark AmeriFlux (MOFLUX) forest site in the Central U.S., focusing on carbon and water flux responses to precipitation regimes and associated stresses. In the observed EFS, precipitation regimes and associated water and heat stresses controlled seasonal and interannual variations of net ecosystem exchange (NEE) of CO 2 and evapotranspiration in this deciduous forest ecosystem. Such controls were exerted more strongly by precipitation variability than by the total precipitation amount per se. A few simply constructed climate variability indices captured these controls, suggesting a high degree of potential predictability. While the interannual fluctuation in NEE was large, a net carbon sink was maintained even during an extreme drought year. Although CLM predicted seasonal and interanual variations in evapotranspiration reasonably well, its predictions of net carbon uptake were too small across the observed range of climate variability. Also, the model systematically underestimated the sensitivities of NEE and evapotranspiration to climate variability and overestimated the coupling strength between carbon and water fluxes. Its suspected that the modeled and observed trajectories of ecosystem fluxes did not overlap in the EFS and the model did not behave like the ecosystem it attempted to simulate. A definitive conclusion will require comprehensive parameter and structural sensitivity tests in a rigorous mathematical framework. We also suggest that future model improvements should focus on better representation and parameterization of process responses to environmental stresses and on more complete and robust representations of carbon-specific processes so that adequate responses to climate variability and a proper degree of coupling between carbon and water exchanges are captured.
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Abstract not provided
Cross-sections of associated production of a Higgs boson decaying into bottomquark pairs and an electroweak gauge boson, W or Z , decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the ‘simplified template cross-section’ framework. The results are found using 79.8 fb ₋1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons.
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The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. In this paper, we identified snake-specific sequence changes within an otherwise highly conserved long-range limb enhancer of Sonic hedgehog (Shh). Transgenic mouse reporter assays revealed that the in vivo activity pattern of the enhancer is conserved across a wide range of vertebrates, including fish, but not in snakes. Genomic substitution of the mouse enhancer with its human or fish ortholog results in normal limb development. In contrast, replacement with snake orthologs caused severe limb reduction. Synthetic restoration of a single transcription factor binding site lost in the snake lineage reinstated full in vivo function to the snake enhancer. Our results demonstrate changes in a regulatory sequence associated with a major body plan transition and highlight the role of enhancers in morphological evolution.