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At least 415 records · Page 23

Adiabatic charged particle motion in rapidly rotating magnetospheres

Some aspects of adiabatic drift theory are investigated in the regime where the E x B drift velocity is comparable with or larger than the gyro velocity. Particles undergo five drifts in addition to the E x B gradient, and line curvature drifts have three more terms in the parallel equation of motion. The case of the rapidly rotating rigid magnetic field configuration is found to be an exception due to the corotating particle with a nearly periodic motion. The guiding center drift velocity and parallel differential equation of motion are obtained, and the drift velocity in the rotating frame is found to consist of the expected field gradient and line curvature drift, plus centrifugal and coriolis force induced drifts. It is shown that the second invariant is conserved in the rotating frame by the four drifts, so that a particle slowly drifts around on its drift shell and returns to its original field line. Thus, there is no long term energy change, and any energy change is periodic on the bounce and drift time scale.

Northrop, T. G.↗

Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

ABSTRACT To test how osteoporosis drugs affect bone matrix maturation during cortical bone remodeling, 72 pregnant rats were switched from a 0.4% to a 0.01% calcium diet at parturition for a 23‐day lactation period. At weaning, eight dams were sacrificed to establish baseline values, while the remaining dams were returned to 0.4% calcium and treated with vehicle (saline), sodium fluoride (NaF), zoledronic acid (ZA), or sclerostin antibody (Scl‐Ab) for either 7 or 28 days (eight animals per group per time point). Femora were examined by μCT, dynamic histomorphometry, Fourier transform infrared imaging, and three‐point bending of notched specimens. Cortical porosity decreased in all groups from baseline to day 28. Intracortical mineralizing surface (MS/BS) and mineral apposition rate (MAR), as well as the mineral‐to‐matrix ratio were unaffected by treatment, but intracortical crystallinity was increased in the ZA group at day 10 compared with vehicle. Cortical area increased in all groups over 28 days mainly because of an addition of bone at the endocortical surface. Endocortical MS/BS did not vary among the groups, but endocortical MAR was suppressed in the NaF group at day 2 and elevated in the Scl‐Ab group at day 4 compared with vehicle. Endocortical mineral‐to‐matrix ratio was increased at days 5 and 10 following NaF treatment and endocortical crystallinity was increased at day 5 following ZA treatment compared with vehicle. Fracture toughness did not differ among the groups. Thus, the treatments affected matrix maturation more strongly at the endocortical then intracortical envelope. In this model of induced remodeling, the bone formation phase is synchronized at multiple sites, facilitating study of the effects of drugs or other bone‐targeting agents on matrix maturation independent of their effects on the initiation of remodeling. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

59 BASIC BIOLOGICAL SCIENCES↗

Climate Conditions During a Rift Valley Fever Post-epizootic Period in Free State, South Africa, 2014–2019

Rift Valley fever virus (RVFV) activity in Southern Africa tends to occur during periods of sustained elevated rainfall, cooler than normal conditions, and abundant vegetation cover creating ideal conditions for the increase and propagation of populations of RVFV mosquito vectors. These climatic and ecological conditions are modulated by large-scale tropical-wide El Niño–Southern Oscillation (ENSO) phenomena. The aim of this 5-year study was to investigate climatic conditions during Rift Valley fever “post-epizootic” period in Free State province of the Republic of South Africa, which historically experienced the largest RVF outbreaks in this country. We collected satellite-derived rainfall, land surface temperature (LST), and normalized difference vegetation index (NDVI) data since 2014 to understand broad environmental conditions in the years following a period of sustained and widespread large RVF outbreaks (2008–2011) in the region. We found this post-epizootic/interepizootic period to be characterized by below-normal rainfall (~-500 mm), above LSTs (~+12°C), depressed NDVI (60% below normal), and severe drought as manifested particularly during the 2015–2016 growing season. Such conditions reduce the patchwork of appropriate habitats available for emergence of RVFV vectors and diminish chances of RVFV activity. However, the 2016–2017 growing season saw a marked return to somewhat wetter conditions without any reported RVFV transmission. In general, the aggregate vector collections during this 5-year period follow patterns observed in climate measurements. During the 2017–2018 growing season, late and seasonally above average rainfall resulted in a focal RVF outbreak in one location in the study region. This unanticipated event is an indicator of cryptic RVF activity during post-epizootic period and may be a harbinger of RVFV activity in the coming years.

climate variability↗

Environmental Variation and Cohort Effects in an Antarctic Predator

Understanding the potential influence of environmental variation experienced by animals during early stages of development on their subsequent demographic performance can contribute to our understanding of population processes and aid in predicting impacts of global climate change on ecosystem functioning. Using data from 4,178 tagged female Weddell seal pups born into 20 different cohorts, and 30 years of observations of the tagged seals, we evaluated the hypothesis that environmental conditions experienced by young seals, either indirectly through maternal effects and/or directly during the initial period of juvenile nutritional independence, have long-term effects on individual demographic performance. We documented an approximately 3-fold difference in the proportion of each cohort that returned to the pupping colonies and produced a pup within the first 10 years after birth. We found only weak evidence for a correlation between annual environmental conditions during the juvenile-independence period and cohort recruitment probability. Instead, the data strongly supported an association between cohort recruitment probability and the regional extent of sea ice experienced by the mother during the winter the pup was in utero. We suggest that inter-annual variation in winter sea-ice extent influences the foraging success of pregnant seals by moderating the regional abundance of competing predators that cannot occupy areas of consolidated sea ice, and by directly influencing the abundance of mid-trophic prey species that are sea-ice obligates. We hypothesize that this environmentally-induced variation in maternal nutrition dictates the extent of maternal energetic investment in offspring, resulting in cohort variation in mean size of pups at weaning which, in turn, contributes to an individual?s phenotype and its ultimate fitness. These linkages between sea ice and trophic dynamics, combined with demonstrated and predicted changes in the duration and extent of sea ice associated with climate change, suggest significant alterations in Antarctic marine ecosystems in the future.

Garrott, Robert A.↗

Assessing Government and Industry Roles to Accelerate Commercialization of Advanced Reactors and Supporting Fuel Cycles

Recent growth in private sector interest and investment in advanced reactor designs signals a new period in the greater than six decade pursuit of commercial nuclear technology. This nuclear entrepreneurship is primarily centered in the North America; meanwhile, national programs in China, France, India, Russia, and South Korea also feature active efforts to design, construct, operate and export advanced reactors .The business case for most private ventures calls for an aggressive commercialization timeline-tied to expectations for returns on investment. Finally, strategic energy portfolio projections and utility resource planning point to the 2030 - 2050 window as the period of greatest need for dispatchable, energy intensive, low-carbon generation options to address retirement of baseload capacity, increased penetration of renewables and economy-scale decarbonization. However, lead times for commercialization range from 30 to 50 years based on more traditional government-centric timelines. Fuel development and fuel cycle infrastructure deployment represent parallel timelines that directly influence the timeline for commercialization of many advanced reactor concepts. While multi-decade development periods appear to be commonplace for new nuclear projects, such timelines were not always the norm-three separate countries set out to develop civilian commercial power from fundamental nuclear principles, in just over a decade, on average. The US led light-water reactor (LWR) development in the 1950's, the UK pioneered a gas-cooled reactor (GCR) concept in the same time period, and Canada forged the path to commercializing the heavy-water reactor (HWR) starting in the mid-1950's and into the mid-1960's. The necessary fuel cycle facilities to support the commercial reactor design also did not appear suddenly, but were a collaborative effort between government and private partners. In this paper, the efforts of these three governments and their private industry partnerships in reactor and fuel cycle development are explored, and a select sample of representative milestones for each is presented, with the roles that each group played. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Combined Optical and Radio-Frequency Perspectives on a Hybrid Cloud-To-Ground Lightning Flash Observed by the FORTE Satellite

In this work, we use the coincident optical and radio-frequency (RF) measurements taken by the Fast On-orbit Recording of Transient Events (FORTE) satellite to shed light on common optical signatures recorded by NASA and NOAA lightning imagers during Cloud-to-Ground (CG) lightning. We build flash cluster data for FORTE using the same techniques as the NASA/NOAA instruments to document the optical/RF evolution of an oceanic hybrid -CG flash. The flash began with strong Very High Frequency (VHF)-band emission from a Narrow Bipolar Event (NBE) that initiated a period of normal bilevel intracloud (IC) activity in two vertical layers (8 and 12 km) that lasted for 490 ms. VHF waveforms show step leader activity ahead of the return stroke. All impulsive VHF sources after the stroke come from the lower (8 km) layer. K-changes are noted following the return stroke, but no subsequent strokes are detected. The optical flash began 136 ms after the NBE RF pulse. Twenty-two of the 33 optical groups were dim and occurred during the in-cloud phase of the flash. This activity included both isolated pulses and sustained periods of illumination over tens of milliseconds. Initial cloud pulses accounted for 23% of the total optical radiance from the flash. Illumination during the return stroke contributed 58% of the total radiance, and the K-changes and cloud pulses after the stroke supplied the remaining 19%. These results highlight the benefit of having RF alongside optical lightning measurements for clarifying signatures in the optical data and providing information on their physical origins.

54 ENVIRONMENTAL SCIENCES↗

The effect of Mars surface and Phobos propellant production on Earth launch mass

Fuel and oxidizer produced on the surface of Mars and on the Martian Moon Phobos can reduce the cumulative mass of fuel and oxidizer which must be launched to low Earth orbit for Mars exploration missions. A scenario in which ten conjunction class trajectory missions over a twenty year period land a surface base and propellant production facilities on the Martian surface and on Phobos was examined. Production of oxygen on Phobos provides the greatest benefit. If all the propellant for Mars operations and Earth return is produced at Phobos and on Mars, a 30% reduction in cumulative low Earth orbit mass can be achieved at the end of the 20 year period.

Gus R Babb↗

Space Flight Handbooks. Volume 3- Planetary Flight Handbook: Supplementary Trajectory Data: Venus to Earth and Mars to Earth - Part 2

Parts 2 and 3 present tabulations of trajectory data for scheduling flights to and from Venus and Mars during the period 1960-2000. Part 2 contains information for outbound flights to these planets; Part 3 contains information for trajectories returning from the planets to Earth. Each Part contains data for single-plane transfers, as well as for broken-plane transfers which employ a midcourse plane-change to eliminate the high speed "ridges." The mathematical analyses employed for all calculations are described in Part 1 of this handbook. To facilitate the construction of round-trip trajectories, the date at the target planet is held fixed while the trip duration is varied in 10-day increments from zero days to the length of that planet's synodic period with Earth. Dates of arrival at the target planet are presented in the extreme right-hand column of Part 2, and dates of departure from the target planet are presented in the extreme left-hand column of Part 3. Thus, by holding Part 2 directly to the left of Part 3, the analyst may easily and rapidly scan all trip possibilities which involve any desired stopover time at the target planet. Within approximately 200 days of each conjunction or opposition, data are presented in 10-day increments at the target planet. Only those trips are listed for which the hyperbolic excess speeds at either or both ends of the trajectory do not exceed 0.6 EMOS (Earth Mean Orbital Speed). For the remaining mission regions, the requirements are so smoothly varying that a 50-day interval in dates at the target planet may be employed; the 10-day interval in trip times is, however, preserved here. In these regions, only those trips are listed for which either or both speeds do not exceed 0.3 EMOS.

INTERPLANETARY FLIGHT↗

Space Flight Handbooks. Volume 3- Planetary Flight Handbook: Supplementary Trajectory Data: Venus to Earth and Mars to Earth - Part 3

Parts 2 and 3 present tabulations of trajectory data for scheduling flights to and from Venus and Mars during the period 1960-2000. Part 2 contains information for outbound flights to these planets; Part 3 contains information for trajectories returning from the planets to Earth. Each Part contains data for single-plane transfers, as well as for broken-plane transfers which employ a midcourse plane-change to eliminate the high speed "ridges." The mathematical analyses employed for all calculations are described in Part 1 of this handbook. To facilitate the construction of round-trip trajectories, the date at the target planet is held fixed while the trip duration is varied in 10-day increments from zero days to the length of that planet's synodic period with Earth. Dates of arrival at the target planet are presented in the extreme right-hand column of Part 2, and dates of departure from the target planet are presented in the extreme left-hand column of Part 3. Thus, by holding Part 2 directly to the left of Part 3, the analyst may easily and rapidly scan all trip possibilities which involve any desired stopover time at the target planet. Within approximately 200 days of each conjunction or opposition, data are presented in 10-day increments at the target planet. Only those trips are listed for which the hyperbolic excess speeds at either or both ends of the trajectory do not exceed 0.6 EMOS (Earth Mean Orbital Speed). For the remaining mission regions, the requirements are so smoothly varying that a 50-day interval in dates at the target planet may be employed; the 10-day interval in trip times is, however, preserved here. In these regions, only those trips are listed for which either or both speeds do not exceed 0.3 EMOS.

Source record↗

A transcriptional relationship with a natural product disrupts mitochondrial biogenesis

Discovery of new compound leads and oncology targets to treat cancer will require overcoming resistance to traditional therapies such as BRAF and mitogen-activated protein kinase inhibitors (MAPKi). In addition, potent new therapies will benefit from selective localization at the cancer site rather than general cell toxicity which can lead to undesired side effects. This selectivity can be gained by identifying new compound leads that are “prodrugs”, that is they are activated by mechanisms selective to cancer cells leading to strong pharmacological activity (Zhang, 2017). Continuing discovery of anticancer agents that overcome resistance and take advantage of cancer cell mechanisms will be greatly augmented by returning to the potent well of natural products; in fact, an analysis of a 70-year period ending in 2014 showed that nearly 50% of approved anticancer drugs are or are derived from natural products (Newman, 2016). Discovery of new agents with high potency and selectivity will require natural product research focused on discovering biologically active compounds with unique structures and mechanisms of action that utilize target cell functions.

Wright, Aaron T.↗

Nonadiabatic strong-field photoionization revisited: Detailed analysis

We develop a theoretical framework to interpret “bump-like” enhancements in the energy distribution of electrons emitted from cesium atoms subjected to intense infrared laser fields, as observed in a recent experiment. These emissions, detected at energies approaching twice the ponderomotive energy (2⁢𝑈 p ), indicate a mechanism where electrons are nonadiabatically ejected with substantial inward velocity following ionization. The bump-like features arise from returning trajectories that scatter off the residual ion. We interpret these experimental results classically using a periodically driven version of the Bohr model and quantum mechanically through Keldysh's adiabaticity parameter (𝛾 K ) and Reiss's continuum-state intensity parameter 𝒵 in a Coulomb-corrected version of the strong-field approximation (SFA) that incorporates “complex” electronic trajectories. Notably, our theoretical analysis shows that these emissions are independent of the specific short-range form of the atomic potential.

74 ATOMIC AND MOLECULAR PHYSICS↗

Evaluation of a Surface Spill Operation to Return Adult Steelhead Overshoots Downstream of McNary Dam

This study, funded by the U.S. Army Corps of Engineers (USACE), was conducted by the Pacific Northwest National Laboratory to evaluate the efficacy of operating one Top Spill Weir (TSW) at McNary Dam outside the normal TSW operation dates for juvenile salmon passage. Of interest is whether the TSW is an effective downstream passage route for adult steelhead overshoots. Overshoots are fish which, having passed upstream at McNary Dam, must pass downstream to return to their natal stream to spawn. This report covers Fall (2019) and Spring (2020) study periods. The study design arranged the available 24 hours of TSW spill per week into weekly blocks with sub-blocks differentiated into day and night operations with TSW discharge periods of 4- and 8-hours duration. Hydroacoustic techniques were used to sample adult fish passage at the TSW and at turbine units 1 and 10. The experimental design contrasted TSW spill periods of differing duration and at different times of the day. The small number of fish detected passing the TSW, and the smaller number of fish detected passing the turbine units, were best suited to an ad hoc, exploratory approach to evaluating the effect of TSW spill. It is worthwhile to note that the operations data obtained for the fall study period had a greater than expected number of gaps and apparent anomalies that we believe were a result of how the data were aggregated. These problems are not particularly problematic for the present study, because the available data still provide a good indication of whether the TSW was operating at each point in time. TSW flows in both fall and spring data sets were able to be cleaned up using the established relationship between forebay elevation and TSW discharge rate. Additional cleanup of operations data would be needed, however, if more quantitative evaluation of dam-wide flow and passage relationships were needed. This study contrasted TSW spill periods of differing duration and at different times of the day. The small number of fish detected passing the TSW, and the smaller number of fish detected passing the turbine units were best suited to an ad hoc, exploratory approach to evaluating the effect of TSW spill. Spring adult steelhead passage numbers estimated using hydroacoustics were notably lower than during the fall study period, and that was consistent with our analysis of PIT tagged fish likely to be in the vicinity during each study period. Detections of fish in BlueView sampling areas upstream of the TSW and powerhouse were not correlated with detections of fish passing hydroacoustic sampling areas, which suggests that fish approaching the face of the dam can move around the forebay before passing. Other fish detected in the forebay in large numbers, such as shad, were able to be filtered out of steelhead passage counts and did not appear to be influencing hydroacoustic passage rate estimates. A pulse of passage at the initial TSW opening was weakly evident, but trends across 4- and 8-hour operational periods did not show a distinct decline in passage over time as TSW operation continued. Our findings do not indicate a reason to choose one 8-hour period over two 4-hour periods, or vice versa. This suggests that the duration of spill periods can be chosen based on operational or other considerations. Passage rates were consistently higher during the daytime TSW discharge periods, relative to nighttime TSW discharge periods. The experimental design of the current study used start times near dawn for day periods and near dusk for night periods.

59 BASIC BIOLOGICAL SCIENCES↗

PHAT. XIX. The Ancient Star Formation History of the M31 Disk

We map the star formation history across M31 by fitting stellar evolution models to color–magnitude diagrams of each 83″ × 83″ (0.3 × 1.4 kpc, deprojected) region of the Panchromatic Hubble Andromeda Treasury (PHAT) survey outside of the innermost 6{sup ′}×12{sup ′} portion. We find that most of the star formation occurred prior to ∼8 Gyr ago, followed by a relatively quiescent period until ∼4 Gyr ago, a subsequent star formation episode about 2 Gyr ago, and a return to relative quiescence. There appears to be little, if any, structure visible for populations with ages older than 2 Gyr, suggesting significant mixing since that epoch. Finally, assuming a Kroupa initial mass function from 0.1 to 100 M {sub ⊙}, we find that the total amount of star formation over the past 14 Gyr in the area over which we have fit models is 5 × 10{sup 10} M {sub ⊙}. Fitting the radial distribution of this star formation and assuming azimuthal symmetry, (1.5 ± 0.2) × 10{sup 11} M {sub ⊙} of stars has formed in the M31 disk as a whole, (9 ± 2) × 10{sup 10} M {sub ⊙} of which has likely survived to the present after accounting for evolutionary effects. This mass is about one-fifth of the total dynamical mass of M31.

79 ASTRONOMY AND ASTROPHYSICS↗

Reversal of bedrest-induced orthostatic intolerance by lower body negative pressure and saline

Six healthy male volunteers underwent two 1-week periods of bedrest, each preceded and followed by 2-week control and recovery periods. The daily metabolic diet contained 150 mEq of sodium. Following one 7-day bedrest period, each man was subjected to LBNP at a level of -30 mm Hg for 4 hr while consuming 1000 ml of beef bouillon containing 154 mEq of sodium. After the other bedrest period, each man simply consumed the bouillon without LBNP treatment during 4 hr of continued bedrest. Measurements of plasma volume and orthostatic tolerance were made before and after each treatment period. After combined LBNP and saline therapy, plasma volume and response to LBNP testing showed a return to pre-bedrest levels. Saline consumption alone had a lesser effect. With continuation of bedrest in three subjects, the beneficial effects of these measures appeared to be largely gone after 18 hr.

Hyatt, K. H.↗

Definition of an entry research vehicle

Within the last year, there has been a growing interest in technology which would support the development of vehicles which can maneuver in the atmosphere while returning from orbit and vehicles which can fly in the atmosphere at hypersonic speeds for sustained periods of time. This rebirth of interest in hypersonics is partly a result of a developing awareness of the potential benefits which can be derived from vehicles with capability to operate between the limits of existing aircraft and spacecraft. Examples of the types of maneuvers which are projected for this new class of vehicles are presented. Challenges provided by the considered maneuvers are summarized, taking into account a synergetic or atmospheric plane change. The plane change maneuver will require a Thermal Protection System (TPS). Attention is given to the definition of a Shuttle launched entry research vehicle experiment. Details regarding the synergetic plane change are considered along with the maneuvering entry, vehicle heating, and experiments and instrumentation.

Freeman, D. C.↗

Dust jets in comet Halley observed by Giotto and from the ground

A hypothesis for the short-lived, intermittent discrete sources of dust on the nucleus surface of comet Halley has been confirmed by closeup imaging by a camera aboard the Giotto probe. A previous conclusion for the nonexistence of jet emission from the dark side of the nucleus, reached on the basis of analysis of ground-based data, is also confirmed. Attention is given to such issues as possible spin vector variations for comet Halley over the 76-year period, the survival of dust sources, and the positions of the prime meridian at the two returns to the sun.

Sekanina, Z.↗

Aerothermodynamic heating environment and thermal protection materials comparison for manned Mars-earth return vehicles

The aerothermodynamic environment during the earth return portion of a specific manned Mars mission is studied. Particular attention is given to the earlier smaller crew return capsule and its thermal protection system requirements. Data are presented on the stagnation region of a generic Mars return capsule. Insulation material thicknesses required to maintain allowable structural temperatures throughout a prolonged heat soak period are estimated.

Henline, William D.↗

Final results of the Space Exposed Experiment Developed for Students (SEEDS) P-0004-2

Space Exposed Experiment Developed for Students (SEEDS), resulted in the distribution of over 132,000 SEED kits in 1990. The kits contained Rutger's tomato seeds that had flown on the Long Duration Exposure Facility (LDEF) as well as seeds that had been stored in a climate controlled warehouse for the same period of time. Students compared germination and growth rate characteristics of the two seeds groups and returned data to NASA for analysis. The scientific information gained was valuable as students shared the excitement of taking part in a national project. Of greater importance was the subsequent interest generated in science education.

Grigsby, Doris K.↗