PERIOD 2 regulates low-dose radioprotection via PER2/pGSK3β/β-catenin/Per2 loop
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In this work, ferritic-martensitic (F/M) HT9 along with fully ferritic HT9 specimens were irradiated using self-ions to 600 peak displacement-per-atom (dpa) at 450 °C. To investigate and minimize the carbon contamination effect on void swelling, two identical F/M HT9 specimens were prepared: one without a coating and the other one with a tungsten and silver coating on the surface prior to irradiation. The specimen without a coating showed carbide formation in the matrix, resulting from carbon contamination during irradiation, with no voids observed. The coated sample did not form matrix carbides, and voids were observed within the irradiated region. The same coating was applied to the ferritic HT9, and void swelling results of both the F/M HT9 and the ferritic HT9 alloys were compared after irradiation. The F/M HT9 exhibited a maximum of 2.6% swelling, while the ferritic HT9 showed a maximum of 0.8% swelling at a 400–500 nm depth, equivalent to 334 local dpa. The results were correlated with the instability of carbides in the ferritic HT9 under irradiation. Carbides in the F/M HT9 and the ferritic HT9 are both M23C6, but the matrix carbides in the ferritic HT9 were less stable under the irradiation, compared to the ones on the grain boundaries in the F/M HT9. The study shows the impact of chemistry on the void swelling which overpowers the microstructural factors such as grain size and phase.
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Every country that has made nuclear weapons has used uranium enrichment to do so. Despite the centrality of this technology to international security, there is still no reliable physical marker of past enrichment in the open literature that can be used to perform forensic verification of historically produced weapons on gas centrifuges. We show that the extremely low radioactivity from uranium alpha emissions during enrichment leaves detectable and irreversible calorimetric signatures in the common enrichment gasket material PTFE, allowing for historical reconstruction of past enrichment activities at a sensitivity better than one weapon’s quantity of highly enriched uranium. Fast scanning calorimetry also enables the measurement of recrystallization enthalpies of sequentially microtomed slices, confirming the magnitude and the type of radiation exposure while also providing detection of tampering and a method for analyzing field samples useful for treaty verification. Furthermore, this work opens the door for common items to be turned into precise dosimeters to detect the past presence of radioactivity, nuclear materials, and related activities with high confidence.
Glycemic control is a strong predictor of long-term cardiovascular risk in patients with diabetes mellitus, and poor glycemic control influences long-term risk of cardiovascular disease even decades after optimal medical management. This phenomenon, termed glycemic memory, has been proposed to occur due to stable programs of cardiac and endothelial cell gene expression. This transcriptional remodeling has been shown to occur in the vascular endothelium through a yet undefined mechanism of cellular reprogramming.