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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRSDate not supplied

Elevating the Quality of Space Omics Sequencing Data: Innovations and Methodologies from NASA GeneLab Sample Processing Laboratory

NASA’s GeneLab, part of the NASA Open Science Data Repository, is a space-related database that hosts a diverse range of transcriptomics, proteomics, epigenomics and genomics data. The NASA GeneLab Sample Processing Laboratory (SPL) generates omics data from biological experiments conducted aboard the International Space Station, Space Shuttle and space related ground experiments, this omics data then hosted on the GeneLab repository. Samples generated such experiments pose numerous technical challenges such as small experimental sample size, variance in dissection times, limited tissue preservation methods, prolonged storage time, and more. GeneLab SPL team had developed specialized expertise in nucleic acid extraction, library preparation and sequencing of such biological samples via extensive training and years of experience. In order to ensure data accuracy and consistency across experiments, SPL has developed standardized protocols for each species and tissue type. These protocols in conjunction with quality control metrics and data standards are crucial in generating of high-quality data. SPL protocols and standards have been developed in collaboration with the scientific community and had been made publicly available on the GeneLab portal, guaranteeing comparability of datasets across spaceflight experiments. To ensure reliability of data generation, SPL leverages cutting-edge innovations in laboratory automation for sample processing. By leveraging these state-of-the-art platforms, SPL achieves high levels of data reproducibility while significantly minimizing sources of bias and variability, especially across experiments with large numbers of samples. Over the past few years, the space biology investigator community has accessed SPL-generated data from the Open Science Data Repository for a myriad of data re-analysis and re-use studies. We observe a trend that in-house SPL-generated data consistently outperforms outsourced sequencing data in terms of technical standards, quality control metrics, timeliness of data delivery, and sequencing and reagent efficiency. Superior data generation has and will continue to enable discoveries in disease, diagnostic tools, and the biological effects of long duration spaceflight.

GeneLab↗
NASA NTRS1974

Vectorcardiographic results from Skylab medical experiment M092: Lower body negative pressure

Vectorcardiograms were recorded via a modified Frank lead system from all crewmen of the three Skylab missions in conjuction with the Lower Body Negative Pressure - M092 Experiment. Data were analyzed by a specially developed computer program (VECTAN). Design of the test sequences allowed direct comparisons of supine resting, Earth based (reference) vectorcardiograms with those taken during lower body negative pressure stress and those obtained at rest in orbit, as well as combinations of these conditions. Results revealed several statistically significant space flight related changes; namely, increased testing and lower body negative pressure stressed heart rates, modestly increased PR interval and corrected QTC interval, and greatly increased P and QPS loop maximal amplitudes. In addition, orientation changes in the QRS maximum vector and the J-vector at rest in space seem quite consistent among crewmen and different from those caused by the application of lower body negative pressure. No clinical abnormalities were observed. Etiology of these findings is conjectured to be, at least in part, related to fluid mass shifts occurring in weightlessness and attendant alterations in cardiovascular dynamics and myocardial autonomic control mechanisms.

Hoffler, G. W.↗
NASA NTRS1979

Analysis of multiple pulse NMR in solids. III

The paper introduces principles which greatly simplify the process of designing and analyzing compound pulse cycles. These principles are demonstrated by applying them to the design and analysis of several cycles, including a 52-pulse cycle; this pulse cycle combines six different REV-8 cycles and has substantially more resolving power than previously available techniques. Also, a new 24-pulse cycle is introduced which combines three different REV-8 cycles and has a resolving ability equivalent to that of the 52-pulse cycle. The principle of pulse-cycle decoupling provides a method for systematically combining pulse groups into compound cycles in order to achieve enhanced performance. This method is illustrated by a logical development from the two-pulse solid echo sequence to the WAHUHA (Waugh et al., 1968), the REV-8, and the new 24-pulse and 52-pulse cycles, along with the 14-pulse and 12-pulse cycles. Proton chemical shift tensor components for several organic solids, measured by using the 52-pulse cycle, are reported without detailed discussion.

Burum, D. P.↗
NASA NTRS1982

A Markov chain model for reliability growth and decay

A mathematical model is developed to describe a complex system undergoing a sequence of trials in which there is interaction between the internal states of the system and the outcomes of the trials. For example, the model might describe a system undergoing testing that is redesigned after each failure. The basic assumptions for the model are that the state of the system after a trial depends probabilistically only on the state before the trial and on the outcome of the trial and that the outcome of a trial depends probabilistically only on the state of the system before the trial. It is shown that under these basic assumptions, the successive states form a Markov chain and the successive states and outcomes jointly form a Markov chain. General results are obtained for the transition probabilities, steady-state distributions, etc. A special case studied in detail describes a system that has two possible state ('repaired' and 'unrepaired') undergoing trials that have three possible outcomes ('inherent failure', 'assignable-cause' 'failure' and 'success'). For this model, the reliability function is computed explicitly and an optimal repair policy is obtained.

Siegrist, K.↗
NASA NTRS1982

A non-catastrophist explanation for the iridium anomaly at the Cretaceous/Tertiary boundary

The iridium (Ir) anomaly at the Cretaceous/Tertiary (C/T) boundary can be explained by dissolution of normal pelagic limestones producing an insoluble clay residue containing Ir-rich meteoritic material. Further concentration of Ir and other trace metals in the clay can be explained by deposition under reducing conditions. Clay-mineral analyses indicate that the boundary clay is similar to locally derived clays in the limestones above and below the boundary, and contains no detectable exotic components. This supports a terrestrial origin for the boundary clay. The genesis of the boundary clay is attributed to changes in ocean chemistry (pH and oxygenation), leading to an interval of widespread dissolution of carbonate sequences in the oceans, and culminating in the development of submarine pyritic hardgrounds and a disconformity of global extent.

Rampino, M. R.↗
NASA NTRS1984

VLSI Architectures for the Multiplication of Integers Modulo a Fermat Number

Multiplication is central in the implementation of Fermat number transforms and other residue number algorithms. There is need for a good multiplication algorithm that can be realized easily on a very large scale integration (VLSI) chip. The Leibowitz multiplier is modified to realize multiplication in the ring of integers modulo a Fermat number. This new algorithm requires only a sequence of cyclic shifts and additions. The designs developed for this new multiplier are regular, simple, expandable, and, therefore, suitable for VLSI implementation.

Chang, J. J.↗
NASA NTRS1986

Digital Pseudonoise Generator

Architecture developed for noise generator based on pseudorandom number sequence. Concept involves no additions or multiplications; outputs of set of feedback shift registers combined, bit-by-bit, in accordance with desired probability distribution. Digital, pseudorandom number output fed to digital-to-analog converter to generate pseudonoise signal suitable for testing broadband amplifiers.

Knoebel, A.↗
NASA NTRS1989

Passive navigation using image irradiance tracking

Rotorcraft operating at low altitudes require navigational schemes for locating the terrain and obstacles. Due to the covert nature of missions to be accomplished, a passive navigation scheme is desirable. This paper describes the development of a passive navigation scheme combining image sequences from a vehicle mounted camera with vehicle motion variables. Geometric properties of perspective projection together with an image irradiance tracking scheme at each pixel are used to determine the range to various objects within the field-of-view. Derivation of the numerical algorithm and simulation results are given. Other applications of the proposed approach include navigation for autonomous planetary rovers and telerobots.

Menon, P. K. A.↗
NASA NTRS1990

A superelement methodology for coupled loads analysis of Space Station Freedom

A technique for calculating the effects of on-orbit loads on the structural dynamics of the International Space Station is developed on the basis of MSC/NASTRAN superelement solution sequences. The complexity of the Space Station program with its multiple configurations, international partners, and contractors is stressed, and the impact of this complexity on the dynamic-load analysis process is indicated. The MSC/NASTRAN-based approach is outlined, and its application to two versions of the Permanent Manned Capability configuration is described in detail, including component mode synthesis, GFSC/FLAME coupled-loads analysis (with components from the system FEM model or from the Work Package), and ISI/MATRIX-X generation of closed-loop forcing functions. The results of these sample analyses are presented in extensive tables and graphs and briefly characterized.

Del Basso, Steve↗
NASA NTRS1992

A variational approach to three-dimensional elasticity solutions of laminated composite plates

The displacements in a laminated composite are represented as products of two sets of unknown functions, one of which is only a function of the thickness coordinate and the other is a function of the in-plane coordinates (i.e., separation of variables approach), and the minimization of the total potential energy is reduced to a sequence of iterative linear problems. Analytical solutions are developed for cross-ply and angle-ply laminated composite rectangular plates. The solution for simply-supported cross-ply plates under sinusoidal transverse load reduces to that of Pagano. Numerical results for stresses and is placements for antisymmetric angle-ply laminates are presented. The three-dimensional elasticity solutions developed are important because they can be used to study the behavior of composite laminates, in addition to serving as reference for approximate solutions by numerical methods and two-dimensional theories.

Savoia, M.↗
NASA NTRS1994

Accuracy assessment of the large-scale dynamic ocean topography from TOPEX/POSEIDON altimetry

The quality of TOPEX/POSEIDON determinations of the global scale dynamic ocean topography have been assessed by determining mean topography solutions for successive 10-day repeat cycles and by examining the temporal changes in the sea surface topography to identify known features. The assessment is based on the analysis of TOPEX altimeter data cycles 1 through 36. Important errors in the tide model used to correct the altimeter data have been identified. The errors were reduced significantly by use of a new tide model derived with the TOPEX/POSEIDON measurements. Maps of the global 1-year mean topography, produced using four of the most accurate of the marine geoid, show that the largest error in the dynamic ocean topography show expected features, such as the known annual hemispherical sea surface rise and fall and the seasonal variability due to monsoon influence in the Indian Ocean. Changes in the sequence of 10-day topography maps show the development and propagation of an equatorial Kelvin wave in the Pacific beginning in December 1992 with a propagation velocity of approximately 3 m/s. The observations are consistent with observed changes in the equatorial trade winds, and with tide gauge and other in situ observations of the strengthening of the El Nino. Comparison of TOPEX-determine sea surface height at points near oceanic tide gauges shows agreement at the 4 cm root-mean-square (RMS) level over the tropical Pacific. The results show that the TOPEX altimeter data set can be used to map the ocean surface with a temporal resolution of 10 days and an accuracy which is insonsistent with traditional in situ methods for the determination of sea level variations.

Tapley, B. D.↗
NASA NTRS1995

Potential theoretic methods for far field sound radiation calculations

In the area of computational acoustics, procedures which accurately predict the far-field sound radiation are much sought after. A systematic development of such procedures are found in a sequence of papers by Atassi. The method presented here is an alternate approach to predicting far field sound based on simple layer potential theoretic methods. The main advantages of this method are: it requires only a simple free space Green's function, it can accommodate arbitrary shapes of Kirchoff surfaces, and is readily extendable to three-dimensional problems. Moreover, the procedure presented here, though tested for unsteady lifting airfoil problems, can easily be adapted to other areas of interest, such as jet noise radiation problems. Results are presented for lifting airfoil problems and comparisons are made with the results reported by Atassi. Direct comparisons are also made for the flat plate case.

Hariharan, S. I.↗
NASA NTRS2003

IFR Operations at Non-Towered, Non-Radar Airports: Can we do Better Than One-at-a-Time?

This paper describes a new concept for operations in non-radar terminal airspace around small, nontowered airports. Currently, air traffic operations in instrument meteorological conditions (IMC) at airfields without control towers and radar service are severely constrained by what is known as the one-in/one-out paradigm. Under these conditions only one operation (either arrival or departure) is allowed to occur at a time. Since these operations can take over 15 minutes to complete, capacity at these airports is severely restricted in IMC. The proposed concept is an attempt to break this current paradigm by applying emerging airborne and ground-based technologies to enable simultaneous operations by multiple aircraft in nonradar terminal airspace around small non-towered airports in IMC. The general philosophy underlying this concept of operations is the establishment of a newly defined area surrounding these airports called a Self-Controlled Area (SCA). Aircraft operating within the SCA are required to have a specified minimum level of equipage. Within the SCA, pilots are responsible for separating themselves from other similarly equipped aircraft through the use of new onboard systems and procedures. This concept also takes advantage of newly developed automation at the airport, which provides appropriate sequencing information to the pilots for safe and improved operations. Such operations would enhance the opportunity for point-to-point air taxi or charter operations into smaller airfields that are closer to a traveler s origin and destination. A description of this concept of operations and a simulation environment used for evaluation is provided in this paper.

Jones, K.↗
NASA NTRS1988

Pulmonary function in microgravity: Spacelab 4 and beyond

This paper refers principally to the composition gradient of gases within the lung in various conditions of gravity, as revealed by exhaled breath. A rapid gas analyzer-based system has been developed for tests in Spacelab 4. The test sequence and expected results are presented.

Flight Experiment↗
NASA NTRS1997

Gravity and the orientation of cell division

A novel culture system for mammalian cells was used to investigate division orientations in populations of Chinese hamster ovary cells and the influence of gravity on the positioning of division axes. The cells were tethered to adhesive sites, smaller in diameter than a newborn cell, distributed over a nonadhesive substrate positioned vertically. The cells grew and divided while attached to the sites, and the angles and directions of elongation during anaphase, projected in the vertical plane, were found to be random with respect to gravity. However, consecutive divisions of individual cells were generally along the same axis or at 90 degrees to the previous division, with equal probability. Thus, successive divisions were restricted to orthogonal planes, but the choice of plane appeared to be random, unlike the ordered sequence of cleavage orientations seen during early embryo development.

Non-NASA Center↗
NASA NTRS2006

From Prime to Extended Mission: Evolution of the MER Tactical Uplink Process

To support a 90-day surface mission for two robotic rovers, the Mars Exploration Rover mission designed and implemented an intensive tactical operations process, enabling daily commanding of each rover. Using a combination of new processes, custom software tools, a Mars-time staffing schedule, and seven-day-a-week operations, the MER team was able to compress the traditional weeks-long command-turnaround for a deep space robotic mission to about 18 hours. However, the pace of this process was never intended to be continued indefinitely. Even before the end of the three-month prime mission, MER operations began evolving towards greater sustainability. A combination of continued software tool development, increasing team experience, and availability of reusable sequences first reduced the mean process duration to approximately 11 hours. The number of workshifts required to perform the process dropped, and the team returned to a modified 'Earth-time' schedule. Additional process and tool adaptation eventually provided the option of planning multiple Martian days of activity within a single workshift, making 5-day-a-week operations possible. The vast majority of the science team returned to their home institutions, continuing to participate fully in the tactical operations process remotely. MER has continued to operate for over two Earth-years as many of its key personnel have moved on to other projects, the operations team and budget have shrunk, and the rovers have begun to exhibit symptoms of aging.

mission operations↗
NASA NTRS2006

From Prime to Extended Mission: Evolution of the MER Tactical Uplink Process

To support a 90-day surface mission for two robotic rovers, the Mars Exploration Rover mission designed and implemented an intensive tactical operations process, enabling daily commanding of each rover. Using a combination of new processes, custom software tools, a Mars-time staffing schedule, and seven-day-a-week operations, the MER team was able to compress the traditional weeks-long command-turnaround for a deep space robotic mission to about 18 hours. However, there was never an intention of maintaining the pace of this process indefinitely. Even before the end of the three-month prime mission, MER operations began evolving towards greater sustainability. A combination of continued software tool development, increasing team experience, and availability of reusable sequences first reduced the mean process duration to approximately 11 hours. The number of workshifts required to perform the process dropped, and the team returned to a modified 'Earth-time' schedule. Additional process and tool adaptation eventually provided the option of planning multiple Martian days of activity within a single workshift, making 5- day-a-week operations possible. The vast majority of the science team returned to their home institutions, continuing to participate fully in the tactical operations process remotely. MER has continued to operate for over two Earth-years as many of its key personnel have moved on to other projects, the operations team and budget have shrunk, and the rovers have begun to exhibit symptoms of aging.

Mars exploration↗
NASA NTRS2017

A Simulation Based Investigation of High Latency Space Systems Operations

This study was the first in a series of planned tests to use physics-based subsystem simulations to investigate the interactions between a spacecraft's crew and a ground-based mission control center for vehicle subsystem operations across long communication delays. The simulation models the life support system of a deep space habitat. It contains models of an environmental control and life support system, an electrical power system, an active thermal control systems, and crew metabolic functions. The simulation has three interfaces: 1) a real-time crew interface that can be use to monitor and control the subsystems; 2) a mission control center interface with data transport delays up to 15 minute each way; and 3) a real-time simulation test conductor interface used to insert subsystem malfunctions and observe the interactions between the crew, ground, and simulated vehicle. The study was conducted at the 21st NASA Extreme Environment Mission Operations (NEEMO) mission. The NEEMO crew and ground support team performed a number of relevant deep space mission scenarios that included both nominal activities and activities with system malfunctions. While this initial test sequence was focused on test infrastructure and procedures development, the data collected in the study already indicate that long communication delays have notable impacts on the operation of deep space systems. For future human missions beyond cis-lunar, NASA will need to design systems and support tools to meet these challenges. These will be used to train the crew to handle critical malfunctions on their own, to predict malfunctions and assist with vehicle operations. Subsequent more detailed and involved studies will be conducted to continue advancing NASA's understanding of space systems operations across long communications delays.

Li, Zu Qun↗