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All sourcesNASA NTRSDOE OSTI
NASA NTRS2016

Metabolomic and Genomic Markers of Atherosclerosis as Related to Oxidative Stress, Inflammation, and Vascular Function in Twin Astronauts

Background: Future human space travel will consist primarily of long-duration missions onboard the International Space Station (ISS) or exploration-class missions to Mars, its moons, or nearby asteroids. Astronauts participating in long-duration missions may be at an increased risk of oxidative stress and inflammatory damage due to radiation, psychological stress, altered physical activity, nutritional insufficiency, and hyperoxia during extravehicular activity. By studying one identical twin during his 1-year ISS mission and one ground-based twin, this work extends a current NASA-funded investigation to determine whether these spaceflight factors contribute to an accelerated progression of atherosclerosis. This study of twins affords a unique opportunity to examine the spaceflight-related atherosclerosis risk independent of the confounding factors associated with different genotypes. Purpose: The purpose of this investigation is to determine whether biomarkers of oxidative and inflammatory stress are elevated during and after long-duration spaceflight and determine if a relation exists between levels of these biomarkers and structural and functional indices of atherosclerotic risk measured in the carotid and brachial arteries. These physiological and biochemical data will be extended by using an exploratory approach to investigate the relationship between intermediate phenotypes and risk factors for atherosclerosis and the metabolomic signature from plasma and urine samples. Since metabolites are often the indirect products of gene expression, we will simultaneously assess gene expression and DNA methylation in leukocytes. Hypothesis: We predict that the space-flown twin will experience elevated biomarkers of oxidative stress and inflammatory damage, altered arterial structure and function, accelerated telomere shortening, dysregulation of genes associated with oxidative stress and inflammation, and a metabolic profile shift that is associated with elevated atherosclerosis risk factors. Conversely, these will not be observed in the ground-based twin. Methods: We will measure blood and urine biomarkers of oxidative stress and inflammation as well as arterial structure and function (carotid intima-medial thickness and brachial artery flow-mediated dilation) in one twin astronaut before, during, and after long-duration spaceflight and in his twin serving as a ground-based control. Furthermore, we will measure metabolomics (targeted and untargeted approaches) and genomic markers (DNA methylation, mRNA gene expression, telomere length) to elucidate the molecular mechanisms involved. A panel of biomarkers of oxidative and inflammatory stress will be measured in venous blood samples and 24-hour (in-flight) and 48-hour (pre- and post-flight) urine pools twice before flight, early (flight days 15 and 60) and late (2 weeks before landing) during the mission, and early in the post-flight recovery phase (approximately 3-5 days after landing). Arterial structure, assessed from measures of intima-media thickness, will be measured at the same times. Arterial function will be assessed using brachial flow-mediated dilation, a well-validated measure used to assess endothelium-dependent vasodilation and a sensitive predictor of atherosclerotic risk, only before and after spaceflight. Discussion: Pre- and in-flight data collection is in progress for the space-flown twin, and similar data have been obtained from the ground-based twin. Blood and urine samples will be batch processed when received from ISS after the conclusion of the 1-year mission. Results from these individual subjects will be compared to the larger complement of subjects participating in the companion study currently ongoing in ISS astronauts.

Lee, Stuart M. C.↗
NASA NTRS2017

Metabolomic and Genomic Markers of Atherosclerosis as Related to Oxidative Stress, Inflammation, and Vascular Function in Twin Astronauts

BACKGROUND: Future human space travel will consist primarily of long-duration missions onboard the International Space Station (ISS) or exploration-class missions to Mars, its moons, or nearby asteroids. Astronauts participating in long-duration missions may be at an increased risk of oxidative stress and inflammatory damage due to radiation, psychological stress, altered physical activity, nutritional insufficiency, and hyperoxia during extravehicular activity. By studying one identical twin during his 1-year ISS mission and his ground-based twin, this work extends a current NASA-funded investigation to determine whether these spaceflight factors contribute to an accelerated progression of atherosclerosis. This study of twins affords a unique opportunity to examine spaceflight-related atherosclerosis risk that is independent of the confounding factors associated with different genotypes. PURPOSE: The purpose of this investigation was to determine whether biomarkers of oxidative and inflammatory stress are elevated during and after long-duration spaceflight and determine if a relation exists between levels of these biomarkers and structural and functional indices of atherosclerotic risk measured in the carotid and brachial arteries. These physiological and biochemical data will be extended by using an exploratory approach to investigate the relationship between intermediate phenotypes and risk factors for atherosclerosis and the metabolomic signature from plasma and urine samples. Since metabolites are often the indirect products of gene expression, we simultaneously assessed gene expression and DNA methylation in leukocytes. HYPOTHESIS: We predict that, compared to the ground-based twin, the space-flown twin will experience elevated biomarkers of oxidative stress and inflammatory damage, altered arterial structure and function, accelerated telomere shortening, dysregulation of genes associated with oxidative stress and inflammation, and a metabolic profile shift that is associated with elevated atherosclerosis risk factors. METHODS: In the space-flown twin, a panel of biomarkers of oxidative and inflammatory stress were measured in venous blood samples and in 24-h (in-flight) and 48-h (pre- and post-flight) urine pools collected twice before flight, six times during the mission (~FD15, 75, 180, 240, 300, 335), and early in the post-flight recovery phase (3-5 days after landing). We also measured metabolomic (targeted and untargeted approaches) and genomic markers (DNA methylation, mRNA gene expression, telomere length) in these samples. Arterial structure, assessed from measures of intima-media thickness, also were measured using standard clinical ultrasound at the same time points. Arterial function was assessed using brachial flow-mediated dilation, a well-validated measure used to assess endothelium-dependent vasodilation and a sensitive predictor of atherosclerotic risk, only before and after spaceflight. All of the same measures were obtained in the ground-based twin, but less frequently. DISCUSSION: All data collection has been completed for both the space-flown twin and the ground-based twin. Vascular structure and function measures have been analyzed, blood and urine samples have been batch-processed. Results from these individuals will be compared to each other, to data from other Twin Study investigations, and to the larger complement of subjects participating in the companion study currently ongoing in ISS astronauts.

Lee, Stuart M. C.↗
NASA NTRS2004

A Novel Inter Core-Cladding Lithium Niobate Thin Film Coated Fiber Modulator/Sensor

A fiber modulator/sensor has been fabricated by depositing a lithium niobate sol-gel thin film between the core and cladding of a fiber preform. The preform is then drawn into 125 micron fiber. The proposed design of lithium niobate cylinder fibers can enhance the existing methodology for detecting sound waves under water utilizing the acoustooptic properties of lithium niobate. Upon application of a stress or strain, light propagating inside the core, according to the principle of total internal reflection, escapes, into the cladding because of the photoelastic boundary layer of lithium niobate. Test results of the lithium niobate fiber reveal a reduction in the 1550 nm, 4mW source with applied tension. The source power from an ordinary quartz fiber under the same stress condition remained invariant to applied tension.

Jamison, Tracee L.↗
NASA NTRS1992

Structural Tailoring of Advanced Turboprops (STAT). Theoretical manual

This manual describes the theories in the Structural Tailoring of Advanced Turboprops (STAT) computer program, which was developed to perform numerical optimizations on highly swept propfan blades. The optimization procedure seeks to minimize an objective function, defined as either direct operating cost or aeroelastic differences between a blade and its scaled model, by tuning internal and external geometry variables that must satisfy realistic blade design constraints. The STAT analyses include an aerodynamic efficiency evaluation, a finite element stress and vibration analysis, an acoustic analysis, a flutter analysis, and a once-per-revolution (1-p) forced response life prediction capability. The STAT constraints include blade stresses, blade resonances, flutter, tip displacements, and a 1-P forced response life fraction. The STAT variables include all blade internal and external geometry parameters needed to define a composite material blade. The STAT objective function is dependent upon a blade baseline definition which the user supplies to describe a current blade design for cost optimization or for the tailoring of an aeroelastic scale model.

Brown, K. W.↗
NASA NTRS1994

Thermocryogenic buckling and stress analyses of a partially filled cryogenic tank subjected to cylindrical strip heating

Thermocryogenic buckling and stress analyses were conducted on a horizontally oriented cryogenic tank using the finite element method. The tank is a finite-length circular cylindrical shell with its two ends capped with hemispherical shells. The tank is subjected to cylindrical strip heating in the region above the liquid-cryogen fill level and to cryogenic cooling below the fill level (i.e., under thermocryogenic loading). The effects of cryogen fill level on the buckling temperature and thermocryogenic stress field were investigated in detail. Both the buckling temperature and stress magnitudes were relatively insensitive to the cryogen fill level. The buckling temperature, however, was quite sensitive to the radius-to-thickness ratio. A mechanical stress analysis of the tank also was conducted when the tank was under: (1) cryogen liquid pressure loading; (2) internal pressure loading; and (3) tank-wall inertia loading. Deformed shapes of the cryogenic tanks under different loading conditions were shown, and high-stress domains were mapped on the tank wall for the strain-gage installations. The accuracies of solutions from different finite element models were compared.

Ko, William L.↗
NASA NTRS1994

Thermally induced damage in composite space structure: Predictive methodology and experimental correlation

A general analysis method is presented to predict matrix cracks in all plies of a composite laminate, and resulting degraded laminate properties, as functions of temperature or thermal cycles. A shear lag solution of the stresses in the vicinity of cracks and a fracture mechanics crack formation criteria are used to predict cracks. Damage is modeled incrementally, which allows the inclusion of the effects of temperature dependent material properties and softening of the laminate due to previous cracking. The analysis is incorporated into an easy-to-use computer program. The analysis is correlated with experimentally measured crack densities in a variety of laminates exposed to monotonically decreasing temperatures. Crack densities are measured at the edges of specimens by microscopic inspection, and throughout the specimen volumes by x-ray and sanding down of the edges. Correlation between the analytical results and the crack densities in the interiors of the specimens was quite good. Crack densities measured at specimen edges did not agree with internal crack densities (or analyses) in some cases. A free-edge stress analysis clarified the reasons for these discrepancies.

Park, Cecelia↗
NASA NTRS1984

Evolution of assumed stress hybrid finite element

Early versions of the assumed stress hybrid finite elements were based on the a priori satisifaction of stress equilibrium conditions. In the new version such conditions are relaxed but are introduced through additional internal displacement functions as Lagrange multipliers. A rational procedure is to choose the displacement terms such that the resulting strains are now of complete polynomials up to the same degree as that of the assumed stresses. Several example problems indicate that optimal element properties are resulted by this method.

Pian, T. H. H.↗
NASA NTRS1971

Moonquakes.

Although the average rate of seismic energy release within the moon appears to be far below that of the earth, over 100 events believed to be moonquakes have been recorded by the two seismic stations installed on the lunar surface during Apollo missions 12 and 14. With few exceptions, the moonquakes occur at monthly intervals near times of perigee and apogee and show correlations with the longer-term (7-month) lunar gravity variations. The repeating moonquakes are believed to occur at not less than 10 different locations. However, a single focal zone accounts for 80 per cent of the total seismic energy detected. This active zone appears to be 600 kilometers south-southwest of the Apollo 12 and 14 sites and deep within the moon. Each focal zone must be small (less than 10 kilometers in linear dimension) and fixed in location over a 14-month period. Cumulative strain at each location is inferred. Thus, the moonquakes appear to be releasing internal strain of unknown origin, the release being triggered by tidal stresses.

Latham, G.↗
NASA NTRS1981

On the formation of protostellar disks

An analysis is presented of the hydrodynamic aspects of the growth of protostellar disks from the accretion of a rotating gas cloud. Streamline equations for the flow onto the disk are derived, including the special case where the disk is very thin. For the radial structure of the disk, detailed equations of conservation of mass, momentum, angular momentum, and energy are given. Exact solutions are found for the case of no internal viscosity. For the more general case where there is viscous stress, hypotheses are formulated with the objective of discovering the main qualitative characteristics of a turbulent system and to estimate the magnitude of the turbulent stress. Solutions are also found for boundary conditions, and the large and small viscosity limits. The relation of energy balance to disk thermal structure is detailed. Finally, trends in the collapse of the dust cloud are discussed in the light of the solutions given.

Cassen, P.↗
NASA NTRS1982

Advances in nondestructive evaluation technology

Research at NASA Langley's Materials Characterization Instrumentation Section has followed the philosophy of improving the science base of nondestructive evaluation and advancing the state of the art of quantitative interpretability of physical measurements of materials. Details of several R&D programs choosen to highlight the last several years are given. Applications of these technologies are presented in the area of stress measurement, characterization of metal heat treatment, and evaluation of material internal structure. A second focus of the program is on quantitative transducers/measurements that have resulted in better data in irregular inhomogeneous materials such as composites. Examples are presented of new capabilities resulting from these advances that include fatigue and impact damage evaluation.

Joseph S. Heyman↗
NASA NTRS1983

Preliminary scramjet design for hypersonic airbreathing missile application

A conceptual design study of a scramjet engine was conducted for a hypersonic surface to air missile (HYSAM). The definition of the engine was based upon the requirements of accelerating the HYSAM from Mach 4 at 20,000 feet to Mach 6 at 100,000 feet and the cruise conditions at Mach 6. The resulting external and internal environmental conditions were used by various engineering disciplines performing design, stress and heat transfer analysis. A detailed structural analysis was conducted along with an indepth thermal analysis. Structurally all the components within the system exhibit positive margins of safety. A feasible concept was defined which uses state-of-the-art materials and existing TMC technology. The engine basically consists of a three dimensional carbon/carbon combustor/nozzle secured to an FS-85 columbium inlet. The carbon/carbon liner is sheathed with carbon felt insulation to thermally protect the FS-85 structure and skin. The thermal analysis of the engine indicates that a thermally viable configuration exists.

Carlson, C. H.↗
NASA NTRS1984

Literature survey on oxidations and fatigue lives at elevated temperatures

Nickel-base superalloys are the most complex and the most widely used for high temperature applications such as aircraft engine components. The desirable properties of nickel-base superalloys at high temperatures are tensile strength, thermomechanical fatigue resistance, low thermal expansion, as well as oxidation resistance. At elevated temperature, fatigue cracks are often initiated by grain boundary oxidation, and fatigue cracks often propagate along grain boundaries, where the oxidation rate is higher. Oxidation takes place at the interface between metal and gas. Properties of the metal substrate, the gaseous environment, as well as the oxides formed all interact to make the oxidation behavior of nickel-base superalloys extremely complicated. The important topics include general oxidation, selective oxidation, internal oxidation, grain boundary oxidation, multilayer oxide structure, accelerated oxidation under stress, stress-generation during oxidation, composition and substrate microstructural changes due to prolonged oxidation, fatigue crack initiation at oxidized grain boundaries and the oxidation accelerated fatigue crack propagation along grain boundaries.

Liu, H. W.↗
NASA NTRS1924

Recent researches in airship construction III : a new type of nonrigid airship

The author describes experiments in designing nonrigid airships. A nonrigid airship of 32,000 cubic meters, the PL 27 withstood all stresses with 20 kg/m(exp 2) hull pressure during its life of two years. The moment of resistance is known, as also the stresses in the envelope for the given hull pressure. The mean internal pressure necessary to give the airship the requisite rigidity and to prevent buckling was also investigated.

AIRSHIPS - CONSTRUCTION↗
NASA NTRS1991

Regional tectonic analysis of Venus as part of the Pioneer Venus guest investigator project

Over the past year, much of the tectonic analysis of Venus we have done has centered on global properties of the planet, in order to understand fundamental aspects of the dynamics of the mantle and lithosphere of Venus. We have developed convection models of the Earth and Venus. These models assume whole mantle internally-heated convection. The viscosity is temperature, volatile-content, and stress dependent. An initial temperature and volatile content is assumed, and the thermal evolution is tracked for 4.6 billion years. During this time, heating occurs by decay of radiogenic elements in the mantle, and degassing and regassing of volatiles takes place at the surface. For a model assuming plate tectonics as the primary heat loss mechanism, representing the Earth through most of it's history and perhaps Venus' earlier history, degassing of the mantle was found to occur rapidly (approximately 200 My) over a large range of parameters. Even for parameters chosen to represent extreme cases of an initially cool planet, low radiogenic heating, and large initial volatile complement, the mantle water content was degassed to an equilibrium value in about 2 By. These values may be applicable to the early Venus, if a large, Moon-forming impact on Earth resulted in efficient heating and loss of water, leaving Venus with a comparably greater volatile budget and less vigorous early convection. It may therefore be impossible to retain large amounts of water in the interior of Venus until the planet cools down enough for the 'cold-trap' effect to take place. This effect traps crust forming melts within the mantle due to a cusp in the solidus, causing these melts to refreeze at depth into a dense eclogite phase, which will inhibit ascent of this material to the surface. This effect, however, requires a hydrous mantle, so early loss of water might prevent it from taking place. Since without plate tectonics there is no mechanism for regassing volatiles into the mantle, as occurs on Earth at subduction zones, this means the interior of Venus would at present be almost completely dry. We have also calculated argon degassing, and mantle flow velocities. viscosities, and cooling rates in these models, and these values can provide constraints on present day mantle dynamics.

Williams, David R.↗
NASA NTRS2002

Glenn-HT: The NASA Glenn Research Center General Multi-Block Navier Stokes Heat Transfer Code

For the last several years, Glenn-HT, a three-dimensional (3D) Computational Fluid Dynamics (CFD) computer code for the analysis of gas turbine flow and convective heat transfer has been evolving at the NASA Glenn Research Center. The code is unique in the ability to give a highly detailed representation of the flow field very close to solid surfaces in order to get accurate representation of fluid beat transfer and viscous shear stresses. The code has been validated and used extensively for both internal cooling passage flow and for hot gas path flows, including detailed film cooling calculations and complex tip clearance gap flow and heat transfer. In its current form, this code has a multiblock grid capability and has been validated for a number of turbine configurations. The code has been developed and used primarily as a research tool, but it can be useful for detailed design analysis. In this presentation, the code is described and examples of its validation and use for complex flow calculations are presented, emphasizing the applicability to turbomachinery.

Gaugler, Raymond E.↗
NASA NTRS2001

Glenn-HT: The NASA Glenn Research Center General Multi-Block Navier-Stokes Heat Transfer Code

For the last several years, Glenn-HT, a three-dimensional (3D) Computational Fluid Dynamics (CFD) computer code for the analysis of gas turbine flow and convective heat transfer has been evolving at the NASA Glenn Research Center. The code is unique in the ability to give a highly detailed representation of the flow field very close to solid surfaces in order to get accurate representation of fluid heat transfer and viscous shear stresses. The code has been validated and used extensively for both internal cooling passage flow and for hot gas path flows, including detailed film cooling calculations and complex tip clearance gap flow and heat transfer. In its current form, this code has a multiblock grid capability and has been validated for a number of turbine configurations. The code has been developed and used primarily as a research tool, but it can be useful for detailed design analysis. In this paper, the code is described and examples of its validation and use for complex flow calculations are presented, emphasizing the applicability to turbomachinery for space launch vehicle propulsion systems.

Gaugler, Raymond E.↗
NASA NTRS2002

Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins

Mechanical stresses modulate cell function by either activating or tuning signal transduction pathways. Mechanotransduction, the process by which cells convert mechanical stimuli into a chemical response, occurs both in cells specialized for sensing mechanical cues and in parenchymal cells whose primary function is not mechanosensory. However, common among the various responses to mechanical stress is the importance of direct or indirect connections between the internal cytoskeleton, the extracellular matrix (ECM), and traditional signal transducing molecules. In many instances, these elements converge at focal adhesions, sites of structural attachment between the cytoskeleton and ECM that are anchored by cell surface integrin receptors. Alenghat and Ingber discuss the accumulating evidence for the central role of cytoskeleton, ECM, and integrin-anchored focal adhesions in several mechanotransduction pathways.

Review, Tutorial↗