Search NASA⌕ Search

SEARCH · Search NASA

Results for “MASS REDUCTION”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25

International Space Station Operational Experience and Its Impacts on Future Mission Supportability

Operational experience gained on the International Space Station (ISS) has enabled significant improvements in failure rate estimates for various Orbital Replacement Units (ORUs). These improved estimates, in turn, allow more efficient and accurate spare parts allocations for future missions, enabling significant reductions in both logistics mass and risk. This paper examines the value of ISS experience to date in terms of its impact on supportability for future missions. A supportability model is presented that assesses the spares required as a function of mission endurance and risk, taking into account uncertainty in failure rate estimates. Changes in ISS Environmental Control and Life Support (ECLSS) ORU failure rate estimates are described and discussed, both in terms of the overall population of ORUs and the evolution of failure rate estimates over time for a particular item. The value of those updated failure rate estimates is assessed by calculating the estimated spares mass requirements for two cases, using the initial, pre-ISS estimates and using the estimates informed by on-orbit experience. Hidden risk resulting from underestimated failure rates is also assessed. These results indicate that, for a 1,200-day Mars mission, ISS experience has enabled a 3.9 t to 6.0 t reduction in ECLSS spares mass required and uncovered failure rate underestimates that would have resulted in an order of magnitude increase in risk had they not been discovered and corrected. The implications of these results for system development and mission planning are discussed, including approaches to accelerate the rate of failure rate refinement and the risks associated with making changes or introducing new systems. Overall, test time is a critical factor that must be carefully considered in system development, and new systems must budget appropriate time for testing in a relevant environment or accept higher risk and logistics requirements on future missions.

Owens, Andrew C.↗

Prediction and rational correlation of thermophoretically reduced particle mass transfer to hot surfaces across laminar or turbulent forced-convection gas boundary layers

A formulation previously developed to predict and correlate the thermophoretically-augmented submicron particle mass transfer rate to cold surfaces is found to account for the thermophoretically reduced particle mass transfer rate to overheated surfaces such that thermophoresis brings about a 10-decade reduction below the convective mass transfer rate expected by pure Brownian diffusion and convection alone. Thermophoretic blowing is shown to produce effects on particle concentration boundary-layer (BL) structure and wall mass transfer rates similar to those produced by real blowing through a porous wall. The applicability of the correlations to developing BL-situations is demonstrated by a numerical example relevant to wet-steam technology.

Gokoglu, Suleyman A.↗

ARCUS Vertical-Axis Wind Turbine (Final Scientific/Technical Report)

While land-based wind energy has become economically competitive with traditional energy generation sources in the U.S., offshore wind is not. For floating offshore wind this difference is even more substantial where the levelized cost of energy (LCOE) is projected to be around 3-5 times more expensive than land-based wind. The turbine capital costs represent around 50% of the LCOE for land-based wind sites, but the increased system costs for floating offshore wind reduce this to 20%. The platform and mooring costs are the single largest contributor to the LCOE for floating offshore wind where their mass must counteract the overturning moment caused by the turbine’s thrust force. Despite the high costs of the platform and relatively low cost of the turbine, current offshore wind turbines are designed essentially the same as for land-based sites. Reducing the LCOE is the greatest challenge to realize the benefits of sustained development of floating offshore wind in the U.S. Reducing the complicated system costs of floating offshore wind will enable the industry to continue to grow and outpace current projections if reduced cost curves can be reached. The ideal wind energy system would remove all mass and cost that is not directly capturing energy from the wind. For floating offshore wind energy systems, this objective is even more significant as increased mass above the water level must be supported by larger and more expensive floating platforms. For this reason, vertical-axis wind turbines (VAWTs) are ideal for floating offshore sites and have several advantages over horizontal-axis wind turbines (HAWTs) at this scale. Large VAWTs offer opportunities for improved energy capture over HAWTs as single units and with reduced wind plant aerodynamic losses through enhanced wake recovery. Additionally, the platform-level placement of the VAWT drivetrain greatly reduces the demands placed on the floating platform and its mass and cost. The ARCUS vertical-axis wind turbine concept (U.S. 11,421,650 B2) is an iteration beyond traditional Darrieus-type VAWTs that replaces the rigid tower with blades that are bent into shape and held in place with tensioned center supports, like a bow. The ARCUS design has been shown to further decrease the VAWT rotor mass properties, with a 50% reduction over traditional Darrieus VAWTs quantified in the ATLANTIS program. The ARCUS VAWT’s efficient use of material for the rotor and turbine support structures combined with its lowered center of gravity enables a tension-leg platform (TLP) with simplified installation procedures. TLPs have been an emerging platform architecture in the Oil and Gas industry and demonstrated to have the lowest hull mass requirements while maintaining stability with minimal roll and pitch deflections in operation. A 22 MW ARCUS turbine has been designed with a three-column TLP that enables quayside integration of the turbine while maintaining system stability during tow-out and installation and having optimal mass and cost properties. A comprehensive analysis shows the optimal ARCUS TLP system design minimizes LCOE through efficient material usage and increased energy capture to yield a competitive LCOE estimate of $\$$55/MWh. A comparison with a reference HAWT, having the same swept area, quantifies the advantages that helped to produce this improved LCOE for the ARCUS concept: (1) 30% reduction in total turbine mass, (2) 70% reduction in turbine center of gravity, and (3) 45% increase in energy production over what is optimal for a HAWT. Intellectual property has been generated through the ATLANTIS program providing opportunities to further reduce the LCOE and improve the performance of the ARCUS turbine and TLP system, expanding the list of innovations to support commercial development of the ARCUS concept.

17 WIND ENERGY↗

Design and preliminary tests of a blade tip air mass injection system for vortex modification and possible noise reduction on a full-scale helicopter rotor

Full-scale tests were conducted on the Langley helicopter rotor test facility as part of a study to evaluate the effectiveness of a turbulent blade tip air mass injection system in alleviating the impulsive noise (blade slap) caused by blade-vortex interaction. Although blade-slap conditions could not be induced during these tests, qualitative results from flow visualization studies using smoke showed that the differential velocity between the jet velocity and the rotor tip speed was a primary parameter controlling the vortex modification.

Pegg, R. J.↗

Data Reduction and Analysis of Pioneer Venus Orbital Ion Mass Spectrometer

Research was carried out on developing a flow field interaction model for both the dayside and nightside ionosphere of Venus. Specific topics related to the dayside ionosphere included: (1) wave particle mechanisms at the ionopause, (2) structure and dynamics of the Venus ionopause and Ionosphere, and (3) flows and fields in the Venus Ionosphere. The structure and dynamics of ion troughs was also studied in the nightside ionosphere of Venus.

Cloutier, Paul A.↗

Strategies to overcome mass transfer limitations of hydrogen during anaerobic gaseous fermentations: A comprehensive review

Fermentation of gaseous substrates such as carbon dioxide (CO 2 ) has emerged as a sustainable approach for transforming greenhouse gas emissions into renewable fuels and biochemicals. CO 2 fermentations are catalyzed by hydrogenotrophic methanogens and homoacetogens, these anaerobic microorganisms selectively reduce CO 2 using hydrogen (H 2 ) as electron donor. However, H 2 possesses low solubility in liquid media leading to slow mass transport, limiting the reaction rates of CO 2 reduction. Solving the problems of mass transport of H 2 could boost the advance of technologies for valorizing industrial CO 2 -rich streams, like biogas or syngas. The application could further be extended to combustion flue gases or even atmospheric CO 2 . In this work, an overview of strategies for overcoming H 2 mass transport limitations during methanogenic and acetogenic fermentation of H 2 and CO 2 is presented. Here, the potential for using these strategies in future full-scale facilities and the knowledge gaps for these applications are discussed in detail.

09 BIOMASS FUELS↗

Water Interplays during Dysprosium Electrodeposition in Pyrrolidinium Ionic Liquid: Deconvoluting the Pros and Cons for Rare Earth Metallization

The electrochemical production of rare earth metals (REMs) in ionic liquids (ILs) has received much attention as a promising, sustainable and replacement to the molten salt electrolysis. Water additives have been recently suggested as a strategy to overcome the limitations of the ionic liquid process, but without complete assessment of its overall viability for the REMs production. In this regard, a full investigation of water impact on dysprosium (Dy) electrodeposition in pyrrolidinium triflate (BMPyOTf) ionic liquid was carried out. Water introduction was revealed to involve an interplay of implications on the electrodeposition process, including coordination, speciation, reduction pathways, interfacial dynamics, nucleation and metal stability and purity. In highly dry conditions, the reduction occurs at very negative potentials (-3.3V) in a consecutive pathway, resulting in negligible metal electrodeposition (low rate and efficiency) at the electrode surface. Initial water introduction (<30% molar fraction) leads to partitioning of the Dy complex between water and IL coordinated speciation, giving rise to an additional wave at more positive potentials (-2.4V). Probing and quantification of the heterogeneous Dy speciation by spectroscopic analyses enabled the uncovering of the reduction mechanism and accurate evaluation of the mass transport properties. While lowering the reduction thermodynamics, water addition also improved the nucleation, deposition rate and faradaic efficiency. In spite of these benefits, stripping voltammetric analysis also indicated substantial chemical reactivity of the deposited Dy metal with water additives and/or electrolyte components, under extended timescales. Surface characterization of the obtained product confirmed limited Dy metal stability (mostly oxidized/fluorinated) and purity (~60%) in the studied system. Moreover, high water introduction (>30% molar fraction) was shown to trigger a fast hydrogen evolution reaction (HER), downgrading the robustness of system efficiency. We report the overall impact of water additives seems to engender both promoting and mitigating effects on the Dy electrodeposition process, making the case for more innovative strategies to be sought.

36 MATERIALS SCIENCE↗

On the fragmentation of protogalactic clouds

After its initial collapse, a protogalactic cloud is expected to be shock heated to its virial temperature of about 1 million K. This temperature lies near a very unstable region of the cooling curve, so that density enhancements will be expected to grow rapidly as the protogalaxy cools to lower temperatures. In this contribution, the dynamical effects on the growth of perturbations are examined. It is shown that perturbations with large initial amplitudes lead to the formation of H2, which results in rapid cooling to 100 K, and the formation of population III stars. Perturbations with small initial amplitudes, however, do not cool significantly ahead of the background, do not develop strong contrasts with the background, and so cannot induce the formtion of H2. They thus remain near 10,000 K, forming a population of protoclusters with masses of about 10 to the 7th solar masses, somewhat larger than typical globular cluster masses. Contamination by metals from a primordial generation of stars may lead to cooling and a significant reduction of the Jeans mass. Photodissociation induced by a background source of hard photons can also prevent cooling below 10,000 K, enhancing the formation of protoclusters relative to stars.

Murray, Stephen D.↗

Metallurgical Analysis of the High Flux Isotope Reactor (HFIR) Carrier Lifting Bails (Rev.1)

The dissolution rates of the aluminum alloys in the High Flux Isotope Reactor (HFIR) element carriers and the Material Test Reactor (MTR) L-bundles in the H-Canyon facility have been identified as the possible cause of extended dissolutions that result in significant time and financial expenditures. A study, carried out by Savannah River National Laboratory (SRNL) to determine relationships between the dissolution rates and the metallurgical properties of the aluminum alloy materials of construction of the HFIR carriers and the L-bundles, considered the dissolution rates of aluminum alloy (AA) series 1100, 6061, and 6063. The study determined that the aluminum alloy compositions played a principal role in the dissolution rate of the carrier/bundle components. Higher dissolution rates were correlated with lower concentrations of the minor element additions in the alloys and with specific element concentrations. Aluminum alloys 1100 and 6063 were found to have similar dissolution rates that were approximately two orders of magnitude (100X) greater than those of AA6061. Based on the results of the dissolution behavior study, a Technical Assistance Request (TAR) was first issued to determine if the replacement of AA6061-T6 with AA6063-T6 is feasible for the HFIR carrier lifting bails. A Technical Task Request was then issued to consider AA6063-T5 as well as other alloys to improve possible supply chain issues. The metallurgical properties of the L-bundle (specifically the end caps) were not evaluated in this report because L-Bundle drawings already allow for the use of AA6063-T6 in all structural components. The HFIR carriers are composed of thin-walled components with significant surface areas that allow for relatively quick overall dissolution times. Conversely, the carrier lifting bails and the supporting constituents are composed of solid bars and thick plate regions with relatively small surface areas that experience longer overall dissolution times. While the MTR L-bundle design includes allowances for the materials of construction to be either AA6061-T6 or AA6063-T6, the HFIR carriers are specified to be constructed fully with AA6061-T6 alloy. This report analyzes the recommendations of the dissolution behavior study to replace the materials of construction of the HFIR carrier lifting bails. The analysis considers the operational requirements of the lifting bail and its supporting structures. To decrease dissolution times, the analysis considers direct replacement of the material as well as reductions in the thicknesses of the components to decrease the mass of the elements. Material reductions are considered on options for using either AA6061 and/or AA6063. The calculations are based on specifications from the American Society of Mechanical Engineer (ASME) and The Aluminum Association, Inc. design codes. The analysis finds that direct replacement of the lifting bail material of construction with AA6063-T6, and AA6063-T5 as well as reductions in the dimensions of the lifting bail components are acceptable. Note that this study considers the structural suitability of the alloys. It does not consider their dissolution rates in the dissolvers.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Training custom light curve models of SN Ia subpopulations selected according to host galaxy properties

ABSTRACT Type Ia supernova (SN Ia) cosmology analyses include a luminosity step function in their distance standardization process to account for an observed yet unexplained difference in the post-standardization luminosities of SNe Ia originating from different host galaxy populations [e.g. high-mass ($M \gtrsim 10^{10} \, {\rm M}_{\odot }$) versus low-mass galaxies]. We present a novel method for including host-mass correlations in the SALT3 (Spectral Adaptive Light curve Template 3) light curve model used for standardizing SN Ia distances. We split the SALT3 training sample according to host-mass, training independent models for the low- and high-host-mass samples. Our models indicate that there are different average Si ii spectral feature strengths between the two populations, and that the average spectral energy distribution of SNe from low-mass galaxies is bluer than the high-mass counterpart. We then use our trained models to perform an SN cosmology analysis on the 3-yr spectroscopically confirmed Dark Energy Survey SN sample, treating SNe from low- and high-mass host galaxies as separate populations throughout. We find that our mass-split models reduce the Hubble residual scatter in the sample, albeit at a low statistical significance. We do find a reduction in the mass-correlated luminosity step but conclude that this arises from the model-dependent re-definition of the fiducial SN absolute magnitude rather than the models themselves. Our results stress the importance of adopting a standard definition of the SN parameters (x0, x1, c) in order to extract the most value out of the light curve modelling tools that are currently available and to correctly interpret results that are fit with different models.

Taylor, G. (ORCID:0000000157563259)↗

History of the mass of Mercury

A historical investigation reveals that Newcomb omitted to complete the calculation for the mass of mercury which would have given 8,405,291(-1), but instead arbitrarily adopted a value of 6,000,000(-1). This baseless figure 6000000(-1) became generally accepted and adopted in subsequent attempts to improve the mass. That only small changes have emerged is likely to be no more than a consequence of relying on a least squares process. Reduction of the Mercury mass to 9,000,000(-1) would alter theoretical angular positions of Venus by less than inherent observational errors, but the theoretical distances would be changed by amounts probably capable of detection by radar means.

Lyttleton, R. A.↗

Multi-Pass Quadrupole Mass Analyzer

Analysis of the composition of planetary atmospheres is one of the most important and fundamental measurements in planetary robotic exploration. Quadrupole mass analyzers (QMAs) are the primary tool used to execute these investigations, but reductions in size of these instruments has sacrificed mass resolving power so that the best present-day QMA devices are still large, expensive, and do not deliver performance of laboratory instruments. An ultra-high-resolution QMA was developed to resolve N2 +/CO+ by trapping ions in a linear trap quadrupole filter. Because N2 and CO are resolved, gas chromatography columns used to separate species before analysis are eliminated, greatly simplifying gas analysis instrumentation. For highest performance, the ion trap mode is used. High-resolution (or narrow-band) mass selection is carried out in the central region, but near the DC electrodes at each end, RF/DC field settings are adjusted to allow broadband ion passage. This is to prevent ion loss during ion reflection at each end. Ions are created inside the trap so that low-energy particles are selected by low-voltage settings on the end electrodes. This is beneficial to good mass resolution since low-energy particles traverse many cycles of the RF filtering fields. Through Monte Carlo simulations, it is shown that ions are reflected at each end many tens of times, each time being sent back through the central section of the quadrupole where ultrahigh mass filtering is carried out. An analyzer was produced with electrical length orders of magnitude longer than its physical length. Since the selector fields are sized as in conventional devices, the loss of sensitivity inherent in miniaturizing quadrupole instruments is avoided. The no-loss, multi-pass QMA architecture will improve mass resolution of planetary QMA instruments while reducing demands on the RF electronics for high-voltage/high-frequency production since ion transit time is no longer limited to a single pass. The QMA-based instrument will thus give way to substantial reductions of the mass of flight instruments.

Prestage, John D.↗

Time course changes in [Ca2+]i, force, and protein content in hindlimb-suspended mouse soleus muscles

BACKGROUND: Exposure to reduced gravitational forces during spaceflight is associated with significant reductions in skeletal muscle mass and strength. The purpose of this study was to test the hypothesis that increases in resting cytosolic free calcium concentration ([Ca2+]i) would precede reductions in protein content and maximal isometric tetanic force (Po) in mouse soleus muscle after initiation of hindlimb suspension. METHODS: Female ICR mice (n = 42) were hindlimb suspended for 1, 2, 3, 5, or 7 d; weight-matched mice were used as controls. Following the hindlimb suspension, the left soleus muscle was used to determine Po in vitro and the right soleus muscle was used to determine protein content and [Ca2+]i via confocal laser scanning microscopy. RESULTS: Compared with controls, [Ca2+]i was elevated by 38% at 2 d, and 117% at 7 d. Compared with controls, soleus muscle total and myofibrillar protein contents were reduced 27-29% and 30-34%, respectively, at 5-7 d after initiation of hindlimb suspension. Compared with controls, soleus muscle Po was decreased by 24% at 3 d, and 38% at 7 d. CONCLUSION: It appears that resting cytosolic Ca2+ homeostasis is disturbed soon after the initiation of hindlimb suspension, and these elevations in [Ca2+]i may play a role in initiating soleus muscle atrophy.

Non-NASA Center↗

Noise transmission through flat rectangular panels into a closed cavity

Five panels backed by a closed cavity were studied experimentally and analytically to determine the noise transmission characteristics of the coupled panel-cavity system. The closed cavity was studied both with and without fiber-glass lining to provide either an absorbent or a reverberant acoustic space. The effects on noise reduction of cavity absorption, measurement location within the cavity, panel mass, and panel stiffness were examined. Results indicated that both measurement location and absorption in the cavity have significant effects on the noise reduction. Increasing panel mass improves the noise reduction at almost all frequencies, and increasing panel stiffness improves nose reduction below the fundamental resonance frequency. A simple, one dimensional analytical model was developed which provided good agreement with the experimental results.

Barton, C. K.↗

On The Development of Additive Construction Technologies for Application to Development of Lunar/Martian Surface Structures Using In-Situ Materials

For long-duration missions on other planetary bodies, the use of in-situ materials will become increasingly critical. As man's presence on these bodies expands, so must the breadth of the structures required to accommodate them including habitats, laboratories, berms, radiation shielding for natural radiation and surface reactors, garages, solar storm shelters, greenhouses, etc. Planetary surface structure manufacturing and assembly technologies that incorporate in-situ resources provide options for autonomous, affordable, pre-positioned environments with radiation shielding features and protection from micrometeorites, exhaust plume debris, and other hazards. This is important because gamma and particle radiation constitute a serious but reducible threat to long-term survival of human beings, electronics, and other materials in space environments. Also, it is anticipated that surface structures will constitute the primary mass element of lunar or Martian launch requirements. The ability to use in-situ materials to construct these structures will provide a benefit in the reduction of up-mass that would otherwise make long-term Moon or Mars structures cost prohibitive. The ability to fabricate structures in situ brings with it the ability to repair these structures, which allows for self-sufficiency necessary for long-duration habitation. Previously, under the auspices of the MSFC In Situ Fabrication and Repair (ISFR) project and more recently, under the joint MSFC/KSC Additive Construction with Mobile Emplacement (ACME) project, the MSFC Surface Structures Group has been developing materials and construction technologies to support future planetary habitats with in situ resources. One such technology, known as Contour Crafting (additive construction), is shown in Figure 1, along with a typical structure fabricated using this technology. This paper will present the results to date of these efforts, including development of novel nozzle concepts for advanced layer deposition using the Contour Crafting process. This process, conceived initially for rapid development of cementitious structures on Earth, also lends itself exceptionally well to the automated fabrication of planetary surface structures using minimally processed regolith as aggregate, and imported binder material or binders developed from in situ materials. This process has been used successfully in the fabrication of construction elements using lunar regolith simulant and Mars regolith simulant, both with various binder materials. These binder materials have resulted from extensive evaluation and include both "imported" binder materials that might be launched from Earth as well as some binder materials that can theoretically also be derived from existing regolith materials. They were chosen to 1) reduce penetrating radiation as much as possible, primarily with hydrogen-bearing polymers, 2) attempt to provide an air-tight structure, 3) sufficiently mix and adsorb to regolith grains for strength, 4) maximize tolerance to day-night thermal cycling, 5) possibly increase electrical conductivity to dissipate any accumulated static charge, and 6) ease their application on planetary surfaces (specifically, the accommodation of reduced atmosphere and lack of heat sinks). Some of these materials have been tested with respect to radiation mitigation, micrometeorite resistance, and resistance to larger, slower-traveling pieces of regolith impinging on the surface, simulating nearby launch and landing activities. Conceptual designs for a Continuous Feedstock Delivery/Mixing System (CFDMS) will also be presented and future planned activities will be discussed as well.

Werkheiser, Niki↗

Numerical Investigation of Rotorcraft Fuselage Drag Reduction Using Active Flow Control

The effectiveness of unsteady zero-net-mass-flux jets for fuselage drag reduction was evaluated numerically on a generic rotorcraft fuselage in forward flight with a rotor. Previous efforts have shown significant fuselage drag reduction using flow control for an isolated fuselage by experiment and numerical simulation. This work will evaluate a flow control strategy, that was originally developed on an isolated fuselage, in a more relevant environment that includes the effects of a rotor. Evaluation of different slot heights and jet velocity ratios were performed. Direct comparisons between an isolated fuselage and rotor/fuselage simulations were made showing similar flow control performance at a -3deg fuselage angle-of-attack condition. However, this was not the case for a -5deg angle-of-attack condition where the performance between the isolated fuselage and rotor/fuselage were different. The fuselage flow control resulted in a 17% drag reduction for a peak C(sub mu) of 0.0069 in a forward flight simulation where mu = 0:35 and CT/sigma = 0:08. The CFD flow control results also predicted a favorable 22% reduction of the fuselage download at this same condition, which can have beneficial compounding effects on the overall performance of the vehicle. This numerical investigation was performed in order to provide guidance for a future 1/3 scale wind tunnel experiment to be performed at the NASA 14-by 22-Foot Subsonic Tunnel.

Allan, Brian G.↗

Logistics Reduction Technologies for Exploration Missions

Human exploration missions under study are limited by the launch mass capacity of existing and planned launch vehicles. The logistical mass of crew items is typically considered separate from the vehicle structure, habitat outfitting, and life support systems. Although mass is typically the focus of exploration missions, due to its strong impact on launch vehicle and habitable volume for the crew, logistics volume also needs to be considered. NASA's Advanced Exploration Systems (AES) Logistics Reduction and Repurposing (LRR) Project is developing six logistics technologies guided by a systems engineering cradle-to-grave approach to enable after-use crew items to augment vehicle systems. Specifically, AES LRR is investigating the direct reduction of clothing mass, the repurposing of logistical packaging, the use of autonomous logistics management technologies, the processing of spent crew items to benefit radiation shielding and water recovery, and the conversion of trash to propulsion gases. Reduction of mass has a corresponding and significant impact to logistical volume. The reduction of logistical volume can reduce the overall pressurized vehicle mass directly, or indirectly benefit the mission by allowing for an increase in habitable volume during the mission. The systematic implementation of these types of technologies will increase launch mass efficiency by enabling items to be used for secondary purposes and improve the habitability of the vehicle as mission durations increase. Early studies have shown that the use of advanced logistics technologies can save approximately 20 m(sup 3) of volume during transit alone for a six-person Mars conjunction class mission.

Broyan, James L., Jr.↗

Effects of 2.0-g 1.75-g and 1.5-g Hypergravity on Pregnancy Outcome in Rats (Rattus norvegicus)

In 1995, ten pregnant female rats were launched on the Space Shuttle (STS-70) on Gestational day(G) 11 of their 22-day pregnancy as part of the NASA/NIH.Rodent (R)2 Experiment. Following landing on G20, fetuses were harvested from half of the dams, while the remaining five dams underwent birth. Spaceflight did not interrupt pregnancy, alter litter sizes, or affect body weights or gender ratios of the fetuses or neonates. In the present study we used the NASA/NIH.R2 experimental paradigm to analyze the effects of hypergravity on pregnancy outcome. On G10, time-bred Sprague-Dawley rat dams were assigned to either G20 or Birth conditions, then further assigned to Hypergravity (HG) 2.0-g, HG 1.75-g, HG 1.5-g, Rotational Control (RC, 1.03), or Stationary Control (SC, 1.0-g) treatments. Dams were exposed to continuous centrifugation from G11 through G20, with brief daily stops for animal health checks and maintenance. For both the G20 and Birth dams, comparable litter sizes and litter gender ratios were observed across gravity conditions. However, centrifugation-exposed (HG and RC) fetuses and neonates showed significantly lower body masses (p less than 0.05) relative to SC offspring. HG 2.0-g offspring weighed significantly less than those in all other gravity conditions (p less than 0.05). The observed reductions in offspring body mass at 1.5-g and 1.75-g, can be attributed to the rotational component of centrifugation, rather than to increased gravitational load, whereas 2.0-g hypergravity exposure further exacerbated the gravity centrifugation effect on offspring body mass. Pregnant dams exposed to centrifugation weighed significantly less than SC dams (p less than 0.05), suggesting that centrifugation effects on maternal body mass may contribute to reduced size of the developing offspring. These findings are consistent with previous reports of non-pregnant adult animals suggesting that, whereas spaceflight has virtually no effect on body mass, centrifugation is associated with changes in body weight regulation.

Mills, Nicole A.↗