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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 451 records · Page 25
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?

The search for efficient antimicrobial therapies that can alleviate suffering caused by infections from resistant bacteria is more urgent than ever before. Infections caused by multi-resistant pathogens represent a significant and increasing burden to healthcare and society and researcher are investigating new classes of bioactive compounds to slow down this development. Antimicrobial peptides from the innate immune system represent one promising class that offers a potential solution to the antibiotic resistance problem due to their mode of action on the microbial membranes. However, challenges associated with pharmacokinetics, bioavailability and off-target toxicity are slowing down the advancement and use of innate defensive peptides. Improving the therapeutic properties of these peptides is a strategy for reducing the clinical limitations and synthetic mimics of antimicrobial peptides are emerging as a promising class of molecules for a variety of antimicrobial applications. These compounds can be made significantly shorter while maintaining, or even improving antimicrobial properties, and several downsized synthetic mimics are now in clinical development for a range of infectious diseases. A variety of strategies can be employed to prepare these small compounds and this review describes the different compounds developed to date by adhering to a minimum pharmacophore based on an amphiphilic balance between cationic charge and hydrophobicity. These compounds can be made as small as dipeptides, circumventing the need for large compounds with elaborate three-dimensional structures to generate simplified and potent antimicrobial mimics for a range of medical applications. This review highlights key and recent development in the field of small antimicrobial peptide mimics as a promising class of antimicrobials, illustrating just how small you can go.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Resilience in an Evolving Electrical Grid

Fundamental shifts in the structure and generation profile of electrical grids are occurring amidst increased demand for resilience. These two simultaneous trends create the need for new planning and operational practices for modern grids that account for the compounding uncertainties inherent in both resilience assessment and increasing contribution of variable inverter-based renewable energy sources. This work reviews the research work addressing the changing generation profile, state-of-the-art practices to address resilience, and research works at the intersection of these two topics in regards to electrical grids. The contribution of this work is to highlight the ongoing research in power system resilience and integration of variable inverter-based renewable energy sources in electrical grids, and to identify areas of current and further study at this intersection. Areas of research identified at this intersection include cyber-physical analysis of solar, wind, and distributed energy resources, microgrids, network evolution and observability, substation automation and self-healing, and probabilistic planning and operation methods.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2021

Towards Reconstruction of Complex Flow Fields Using Unit Flows

Many complex turbulent flows in nature and engineering can be qualitatively regarded as being constituted of multiple simpler unit flows. The objective of this work is to characterize the coherent structures in such complex flows as a combination of constituent unitary flow structures for the purpose of reduced-order representation. While turbulence is clearly a non-linear phenomenon, we aim to establish the degree to which the optimally weighted superposition of unitary flow structures can represent the complex flow structures. The rationale for investigating such superposition stems from the fact that the large-scale coherent structures are generated by underlying flow instabilities that may be reasonably described using linear analysis. Clearly, the degree of validity of superposition will depend on the flow under consideration. In this work, we take the first step toward establishing a procedure for investigating superposition. Experimental data of single and triple tandem jets in crossflow are used to demonstrate the procedure. A composite triple tandem jet flow field is generated from optimal superposition of single jet data and compared against ‘true’ triple jet data. Direct comparisons between the true and composite fields are made for spatial, temporal, and kinetic energy content. The large-scale features (obtained from proper orthogonal decomposition or POD) of true and composite tandem jet wakes exhibit nearly 70% agreement in terms of modal eigenvector correlation. Corresponding eigenvalues reveal that the kinetic energy of the flow is also emulated with only a slight overprediction. Temporal frequency features are also examined in an effort to completely characterize POD modes. The proposed method serves as a foundation for more rigorous and robust dimensional reduction in complex flows based on unit flow modes.

Kristo, Paul J.↗
NASA NTRS1967

Heat generation in a viscoelastic solid.

Temperature distributions and heat generation in viscoelastic isotropic solid resulting from mechanical deformations determined by energy equation

ENERGY EQUATION↗
NASA NTRS1974

The Apollo Lunar Sounder radar system

The objectives of the Apollo 17 Lunar Sounder Experiment (ALSE) were to detect subsurface geologic structures, to generate a continuous lunar profile, and to image the moon at radar wavelengths. A three-wavelength synthetic-aperture radar (SAR) operating at 60, 20, and 2 m wavelengths was designed to attain these objectives. The design choices reflected a balance of scientific requirements versus Apollo mission and hardware constraints. The radar data from the lunar mission were recorded on photographic film in a conventional SAR format, and were returned to earth for processing. A combination of optical and digital processing and exploitation techniques was applied to the scientific interpretation of the data. Some preliminary results from the lunar mission have been obtained.

Porcello, L. J.↗
NASA NTRS1980

Surface relief structures for multiple beam LO generation

Linear and binary holograms for use in heterodyne detection with 10.6 micron imaging arrays are described. The devices match the amplitude and phase of the local oscillator to the received signal and thus maximize the system signal to noise ratio and resolution and minimize heat generation on the focal plane. In both the linear and binary approaches, the holographic surface-relief pattern is coded to generate a set of local oscillator beams when the relief pattern is illuminated by a single planewave. Each beam of this set has the same amplitude shape distribution as, and is collinear with, each single element wavefront illuminating array.

Veldkamp, W. B.↗
NASA NTRS1982

Lightning protection of wind turbines

Possible damages to wind turbine components due to lightning strikes are discussed and means to prevent the damage are presented. A low resistance path to the ground is noted to be essential for any turbine system, including metal paths on nonmetal blades to conduct the strike. Surge arrestors are necessary to protect against overvoltages both from utility lines in normal operation and against lightning damage to control equipment and contactors in the generator. MOS structures are susceptible to static discharge injury, as are other semiconductor devices, and must be protected by the presence of static protection circuitry. It is recommended that the electronics be analyzed for the circuit transient response to a lightning waveform, to induced and dc current injection, that input/output leads be shielded, everything be grounded, and lightning-resistant components be chosen early in the design phase.

Dodd, C. W.↗
NASA NTRS1983

Advanced 3-V semiconductor technology assessment

Components required for extensions of currently planned space communications systems are discussed for large antennas, crosslink systems, single sideband systems, Aerostat systems, and digital signal processing. Systems using advanced modulation concepts and new concepts in communications satellites are included. The current status and trends in materials technology are examined with emphasis on bulk growth of semi-insulating GaAs and InP, epitaxial growth, and ion implantation. Microwave solid state discrete active devices, multigigabit rate GaAs digital integrated circuits, microwave integrated circuits, and the exploratory development of GaInAs devices, heterojunction devices, and quasi-ballistic devices is considered. Competing technologies such as RF power generation, filter structures, and microwave circuit fabrication are discussed. The fundamental limits of semiconductor devices and problems in implementation are explored.

Nowogrodzki, M.↗
NASA NTRS1985

Estimating the weight of generally configured dual wing systems

Formulas available for the weight estimation of monoplane wings cannot be said to be appropriate for the estimation of generally configured dual wing systems. In the present paper a method is described which simultaneously generates a structural weight estimate and a fully stressed, quasi-optimal structure for a model of a dual wing system. The method is fast and inexpensive. It is ideally suited to preliminary design. To illustrate the method, a dual wing system and a conventional wing system are sized. Numerical computation is shown to be suitably fast for both cases and, for both cases, convergence to a final configuration is shown to be quite rapid. To illustrate the validity of the method, a conventional wing is sized and its weight obtained by the present method is compared to its weight determined by a reputable weight estimation formula. The results are shown to be very close.

Cronin, D. L.↗
NASA NTRS1986

Advanced data structures for the interpretation of image and cartographic data in geo-based information systems

A growing need to usse geographic information systems (GIS) to improve the flexibility and overall performance of very large, heterogeneous data bases was examined. The Vaster structure and the Topological Grid structure were compared to test whether such hybrid structures represent an improvement in performance. The use of artificial intelligence in a geographic/earth sciences data base context is being explored. The architecture of the Knowledge Based GIS (KBGIS) has a dual object/spatial data base and a three tier hierarchial search subsystem. Quadtree Spatial Spectra (QTSS) are derived, based on the quadtree data structure, to generate and represent spatial distribution information for large volumes of spatial data.

Peuquet, D. J.↗
NASA NTRS1987

A Modal-Parameter Extraction Procedure

Procedure accommodates multiple input excitations. Improved modalparameter extraction procedure applicable to linear, time-invariant systems derived in 92-page report. Algorithm allows multiple noncoherent input excitations applied to structure and generates consistent set of modal parameters. Procedure extension of simultaneous frequency-domain (SFD) techniques achieved through investigation of two automatic methods for reducing effective problem size while minimizing amount of user interaction. In several sample runs, independentcoordinate reduction method shown more accurate method for small sample size. Principle-component method used to estimate number of modes active in given frequency range.

Kurdila, A. H.↗
NASA NTRS1984

IDEAS: A multidisciplinary computer-aided conceptual design system for spacecraft

During the conceptual development of advanced aerospace vehicles, many compromises must be considered to balance economy and performance of the total system. Subsystem tradeoffs may need to be made in order to satisfy system-sensitive attributes. Due to the increasingly complex nature of aerospace systems, these trade studies have become more difficult and time-consuming to complete and involve interactions of ever-larger numbers of subsystems, components, and performance parameters. The current advances of computer-aided synthesis, modeling and analysis techniques have greatly helped in the evaluation of competing design concepts. Langley Research Center's Space Systems Division is currently engaged in trade studies for a variety of systems which include advanced ground-launched space transportation systems, space-based orbital transfer vehicles, large space antenna concepts and space stations. The need for engineering analysis tools to aid in the rapid synthesis and evaluation of spacecraft has led to the development of the Interactive Design and Evaluation of Advanced Spacecraft (IDEAS) computer-aided design system. The ADEAS system has been used to perform trade studies of competing technologies and requirements in order to pinpoint possible beneficial areas for research and development. IDEAS is presented as a multidisciplinary tool for the analysis of advanced space systems. Capabilities range from model generation and structural and thermal analysis to subsystem synthesis and performance analysis.

Ferebee, M. J., Jr.↗
NASA NTRS1988

The effect of acoustic forcing on trailing edge separation and near wake development of an airfoil

An experimental study was conducted to investigate the effect of acoustic forcing on flow fields near the trailing edge of a symmetric airfoil at zero angle of attack. At low chord Reynolds numbers, the boundary layers separate from the surfaces in the rear part of the airfoil and create recirculation regions near the trailing edge. It is shown that with the introduction of acoustic forcing through a slot in the vicinity of the separation point, periodic large-scale structures are generated in the trailing edge region. Significant reduction of trailing edge separation is achieved. It is also found that the most effective forcing frequency to control trailing edge separation is the wake vortex shedding frequency. As a result of forcing, applied only on the upper surface, the upper boundary layer is accelerated and the flow over the lower surface decelerated. Consequently, an asymmetric wake is formed. The results presented indicate that the development of the near wake varies with forcing conditions.

Huang, L. S.↗
NASA NTRS1988

Finite element Euler computations in three dimensions

A two-step explicit FEM solution algorithm for the three-dimensional compressible Euler and Navier-Stokes equations based on unstructured triangular and tetrahedral grids is described and demonstrated. The method represents an extension and refinement of the algorithms presented by Loehner et al. (1984 and 1985), Peraire et al. (1987), and Morgan et al. (1987). The formulation and numerical implementation are outlined; the mesh generation, data structures, and adaptive remeshing are explained; and results for a two-dimensional airfoil, a three-dimensional engine air intake, a B747 in landing configuration, and a generic fighter aircraft are presented in extensive graphics and discussed in detail.

Peraire, Jaime↗
NASA NTRS1989

End-effector-joint conjugates for robotic assembly of large truss structures in space: A second generation

Attachment of strut to node can be accomplished with a variety of mechanisms. All require extensive standoff elements (called scars) added to the nodes. These increase packaging volume for the nodes by as much as 300 percent. First generation designs also tend to be either heavy or expensive due to complex parts. Screws thread mechanisms are discussed simplest and most easily manufactured of alternatives. Torque and rotational motion must be transmitted across the strut to end-effector interface accomplishing the joining process and establishing a specific preload. Four drive mechanisms are considered: worm, helical, bevel, and differential gears.

Brewer, William V.↗