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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 451 records · Page 25
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Ultrathick Boron Carbide Coatings for Nuclear Fusion Targets

Boron carbide is an attractive ablator for next-generation inertial confinement fusion (ICF) targets. Here we describe several aspects of our ongoing systematic studies of the deposition and processing of B 4 C coatings for ICF targets. We show that residual compressive stress in films can be reduced and the deposition rate increased by N-doping. Further, we also demonstrate successful Si substrate etching and surface polishing and discuss remaining challenges and offer potential solutions to the buildup of particulates in the deposition chamber during prolonged coating runs, control of nodular growth defects, and lateral nonuniformity of film properties for deposition conditions with relatively low target-to-substrate distances.

36 MATERIALS SCIENCE↗
DOE OSTI2023

Segmenting the target audience for transportation demand management programs: An investigation between mode shift and individual characteristics

Understanding the characteristics of travelers and situations that are more likely to switch from single occupancy vehicles (SOV) to more sustainable mobility options can help transportation agencies develop better behavior change strategies. Existing mode shift programs, however, rarely identify their target audience, which could make the programs less effective. Here, to investigate the demographics and trip characteristics of those who are more likely to shift from SOV to carpooling, public transit, and micromobility (e.g. walking, biking), a matrix decomposition audience segmentation method is proposed and applied on travel survey data. The results of this research show that for short-distance leisure or social trips, young and middle-income people are more likely to shift to these mobility options from SOV. This study provides a comprehensive and profound understanding of the characteristics of the target audience that can inform policies to create more targeted behavior change strategies to reach their sustainability goals.

42 ENGINEERING↗
DOE OSTI2023

Novel SOLPS-ITER simulations of X-point target and snowflake divertors

Abstract The design and understanding of alternative divertor configurations may be crucial for achieving acceptable steady-state heat and particle material loads for magnetic confinement fusion reactors. Multiple X-point alternative divertor geometries such as snowflakes and X-point targets have great potential in reducing power loads, but have not yet been simulated widely in codes with kinetic neutrals. This paper discusses recent changes made to the SOLPS-ITER code to allow for the simulation of X-point target and low-field side snowflake divertor geometries. Snowflake simulations using this method are presented, in addition to the first SOLPS-ITER simulation of the X-point target. Analysis of these results show reasonable consistency with the simple modelling and theoretical predictions, supporting the validity of the methodology implemented.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2024

Multilayer film coating for laser ion source target for increase of low charge state production

The use of Laser Ion Source for accelerator facilities has the advantage to tune the characteristic of the produced beams by changing the laser parameters using the same primary target. The advantageous and innovative opportunity to manipulate the characteristic of charge state distributions by the use of composed target, may open new possibilities for the ion sources. In this experiment we characterize and study the plasma produced by the laser ablation of coated targets at constant laser parameters. The performed investigation has the double purpose to have a better understanding of penetration depth of laser in composed materials and understand how to tune the charge states by adding coating films. Finally, the obtained results showed that for particular thickness of coating, the low charge states were produced with higher yield than in the case of pure material.

43 PARTICLE ACCELERATORS↗
DOE OSTI2022

Optimal band selection for target detection with a LWIR multispectral imager

Multispectral imaging can offer many benefits in cost, complexity, resolution, size, weight, and power, relative to hyperspectral imaging. When designing a multispectral system, spectral bandpasses can be selected using optimization algorithms configured to maximally separate target detection scores between target and background regions. A hyperspectral image (HSI) can serve as the source of data from which band groupings can be tested for optimality. The output of an adaptive cosine estimator target detection algorithm is used in an objective function. Three optimization algorithms are compared: particle swarm, dual annealing, and differential evolution. A global optimum is also found using a brute force approach on the Livermore Computing Syrah supercomputer. Three materials are investigated: calcite, gypsum, and limestone. This is done for 3-, 4-, and 5-band systems. The data originate from a longwave infrared HSI of a material display board. The optimization algorithms were run 30 times for every scenario. Performance statistics (maximum, minimum, mean, standard deviation, and median) based on the separation values are given. Additional characterization was performed using receiver operator characteristic (ROC) curves and the area under the ROC curve. While good performance was obtained for the three optimization algorithms, the dual annealing algorithm produced the highest and most consistent detection separation scores on average.

47 OTHER INSTRUMENTATION↗
DOE OSTI2023

Targeted metagenomic assessment reflects critical colonization in battlefield injuries

Current diagnostics and clinical management strategies for combat wounds are based on decisions made by expert clinicians. However, even in the hands of experienced surgeons, wounds from combat injuries can exhibit failed healing and complications related to limitations in the rapid and comprehensive generation of diagnostic information. Previous studies have demonstrated the possible use of genomic sequencing approaches to detect microbial signatures involved in combat casualty care. While effective, whole metagenome sequencing is limited by the depth required to confidently detect all relevant signatures. To address this, we developed a targeted capture sequencing panel to detect microbial signatures relevant to wound healing. These targets include known microbial nosocomial pathogens, wound colonizers, and genes involved in virulence and antimicrobial resistance. A bioinformatics pipeline was built to identify genomic regions of interest and over 8,000 oligonucleotide probes were designed for capture. The panel was synthesized and validated using control reference genomes in human background and on wound-effluent samples from a cohort of combat-injured U.S. service members. Our panel was sensitive against wound-colonizing species, Acinetobacter baumannii and Pseudomonas aeruginosa, and was specific in detecting corresponding virulence and antimicrobial-resistance genes as well as other pathogenic species present in microflora mixtures. Random forest feature permutation confirmed the prevalence of Acinetobacter and Pseudomonas in critically colonized wounds and wounds that failed to heal, respectively. Our results demonstrate the capability of targeted sequencing tools and analysis platforms to profile and deliver information on pathogenic factors influencing wound progression, thereby guiding therapeutic intervention.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

Cascade Models in Simulation of Extended Heavy Targets Irradiated by Accelerated Proton and Deuteron Beams

The paper presents a survey of the main numerical models used for simulation of interaction of accelerated particle beams with target nuclei. These models form the core of the software for simulation of various experiments and experimental facilities both for scientific and applied purposes. The beam and target parameters considered in detail in this study (protons and deuterons with energies from 0.66 to 4 AGeV and bulk U targets) cover the range of interest in development of new concepts of nuclear power production aided by accelerated particle beams.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

Gas jet targets for direct reaction studies

The study of direct reactions is of broad interest in nuclear physics, providing constraint to models of nuclear structure evolution and data to better understand the creation of the elements. In many cases, however, the data of interest are hindered by backgrounds and poor resolution from contaminants in either the beam, the target, or both. The use of a gas jet can overcome some of these issues through clever engineering, providing a reaction target that is chemically pure and thin enough to significantly reduce the impact on experimental resolution. This Perspective will discuss the effort to design, construct, and operate gas jet targets for direct reaction studies in the rare isotope era.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2026

In Vitro Selection of Antibodies Targeting Yersinia pestis Membrane Lipids Using Nanodisc-Based Antigen Presentation

Proteins are the most common targets for antibody discovery and vaccine development, but their sequence variability can limit the breadth of resulting antigens. Lipids represent an alternative class of antigens due to their structural conservation and roles in host–pathogen interactions. Here, we describe the development and optimization of an in vitro antibody selection workflow using lipid-containing nanodiscs as antigen presentation platforms to enable phage and yeast display selections under conditions adapted for these non-protein targets. Lipopolysaccharide (LPS) nanodiscs were first used as a model system to evaluate selection strategies, including competitive and subtractive approaches to reduce non-specific binders, yielding peptide and single-chain variable fragment (scFv) binders that were affinity matured to improve binding signals. The same approach was subsequently used to select scFv antibodies that recognize lipid nanodiscs prepared from Yersinia pestis membrane lipid extracts. These antibodies show binding to lipid nanodiscs derived from Y. pestis, with evidence of selectivity relative to control nanodiscs. Overall, this work establishes a workflow for antibody selection against lipid-containing nanodisc antigens and highlights practical considerations associated with these targets. The approach may be useful for generating affinity reagents to membrane-associated lipids, although further characterization is required to define antigen specificity and functional activity.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Summary Analysis of Different Offshore Wind Capacity Density Drivers in Proposed U.S. Projects and Impacts on Progress Towards State and Federal Deployment Targets

Understanding the density of offshore wind development - or the "capacity density" - is important for state and federal offshore wind planning efforts and to track progress towards policy goals. NREL has traditionally assumed a capacity density of 3 megawatts per square kilometer (MW/km2) when estimating the U.S. project pipeline (Musial et al. 2022), but capacity densities for existing European offshore wind farms ranged from 2-19 MW/km2 (Borrmann et al. 2018). We track the expected capacity densities of the proposed U.S. projects in the East Coast and make an analysis by state and by developer to identify what are the capacity density norms in the industry and whether the state in which the development efforts are taking place has some impact on capacity density. We also analyze the effects of the area occupied by station keeping systems on capacity density for lease areas dedicated to floating projects and provide a list of main capacity density drivers. This summary analysis sets a baseline to study how different capacity density drivers could impact the progress towards state and federal deployment targets. Given the currently delineated Renewable Energy Areas in the Outer Continental Shelf (OCS) and the basis from the summary analysis, we estimate the expected offshore wind deployment over time federally and by state and compare it to the state and federal deployment targets. The proposed analysis helps identify gaps and needs to meet state and federal targets, which provides sufficient information to propose strategic supply chain and policy planning with the objective of meeting deployment goals.

capacity density↗
DOE OSTI2020

3D Hybrid Nanofiber Aerogels Combining with Nanoparticles Made of a Biocleavable and Targeting Polycation and MiR‐26a for Bone Repair

Abstract The healing of large bone defects represents a clinical challenge, often requiring some form of grafting. 3D nanofiber aerogels could be a promising bone graft due to their biomimetic morphology and controlled porous structures and composition. miR‐26a has been reported to induce the differentiation of bone marrow‐derived mesenchymal stem cells (BMSCs) and facilitate bone formation. Introducing miR‐26a with a suitable polymeric vector targeting BMSCs could improve and enhance the functions of 3D nanofiber aerogels for bone regeneration. Herein, the comb‐shaped polycation (HA–SS–PGEA) is first developed, carrying a targeting component, biocleavable groups, and short ethanolamine (EA)‐decorated poly(glycidyl methacrylate) (PGMA) (abbreviated as PGEA) arms as miR‐26a delivery vector. Thereafter, the cytotoxicity and transfection efficiency of this polycation and cellular response to miR‐26a‐incorporated nanoparticles (NPs) are assessed in vitro. HA–SS–PGEA exhibits a stronger ability to transport miR‐26a and exert its functions than the gold standard polyethyleneimine (PEI) and low‐molecular‐weight linear PGEA. The efficacy of HA–SS–PGEA/miR‐26a NPs loaded 3D hybrid nanofiber aerogels showing a positive effect on the cranial bone defect healing is finally examined. Together, the combination of 3D nanofiber aerogels and functional NPs consisting of a biodegradable and targeting polycation and therapeutic miRNA could be a promising approach for bone regeneration.

Li, Ruiquan↗
DOE OSTI2022

Targeting Gut Bacteria Using Inulin‐Conjugated Mesoporous Silica Nanoparticles

Abstract To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin‐conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.

36 MATERIALS SCIENCE↗
DOE OSTI2021

Target space entanglement in Matrix Models

We study target space entanglement in gauged multi-matrix models as models of entanglement between groups of D-branes separated by a planar entangling surface, paying close attention to the implementation of gauge invariance. We open with a review of target space entanglement between identical particles, which shares some important features (specifically a gauged permutation symmetry) with our main problem. For our matrix models, we implement a gauge fixing well-adapted to the entangling surface. In this gauge, we map the matrix model problem to that of entanglement of a U(1) gauge theory on a complete or all-to-all lattice. Matrix elements corresponding to open strings stretching across the entangling surface in the target space lead to interesting contributions to the entanglement entropy.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2022

Exploring rapid chemical separations of Sc-47 produced from photonuclear reactions on natural vanadium targets

Scandium-47 ( 47 Sc) production via bremsstrahlung irradiation of natural vanadium targets offers significant advantages for producing high purity 47 Sc; this work evaluates several rapid dissolution and chemical separation techniques for recovering high purity 47 Sc from irradiated vanadium. Here, techniques developed are combined into a simple, gram-scale, semi-automated target processing system that enables 47 Sc recovery from irradiated vanadium targets with chemical yields as high as 93 ± 3% and 47 Sc/V separation factors of 6 ± 3 ·10 11 within 90 min total processing times. Future research into H 2 O 2 resistant separation techniques and their applicability for direct process coupling to chelation are recommended.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2020

SuperCam Calibration Targets: Design and Development

Abstract SuperCam is a highly integrated remote-sensing instrumental suite for NASA’s Mars 2020 mission. It consists of a co-aligned combination of Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), Visible and Infrared Spectroscopy (VISIR), together with sound recording (MIC) and high-magnification imaging techniques (RMI). They provide information on the mineralogy, geochemistry and mineral context around the Perseverance Rover. The calibration of this complex suite is a major challenge. Not only does each technique require its own standards or references, their combination also introduces new requirements to obtain optimal scientific output. Elemental composition, molecular vibrational features, fluorescence, morphology and texture provide a full picture of the sample with spectral information that needs to be co-aligned, correlated, and individually calibrated. The resulting hardware includes different kinds of targets, each one covering different needs of the instrument. Standards for imaging calibration, geological samples for mineral identification and chemometric calculations or spectral references to calibrate and evaluate the health of the instrument, are all included in the SuperCam Calibration Target (SCCT). The system also includes a specifically designed assembly in which the samples are mounted. This hardware allows the targets to survive the harsh environmental conditions of the launch, cruise, landing and operation on Mars during the whole mission. Here we summarize the design, development, integration, verification and functional testing of the SCCT. This work includes some key results obtained to verify the scientific outcome of the SuperCam system.

Manrique, J. A. (ORCID:0000000220532819)↗
DOE OSTI2024

Can Wholesale Electricity Markets Achieve Resource Adequacy and High Clean Energy Generation Targets in the Presence of Self-Interested Actors?

Wholesale electricity markets are intended to incentivize system generation investments and operations outcomes that meet evolving system needs. In this work, we evaluate the effectiveness of wholesale market structures, rules and policies in achieving system resource adequacy (RA) and clean energy targets in the presence of self-interested generation investors using the Electricity Markets and Investment Suite Agent-based Simulation (EMIS-AS) model. Results highlight that both capacity markets and operating reserve demand curves (ORDCs) can help achieve a reliable system but with different RA compliance timelines and distribution of generation technologies. Structures with capacity markets tend to favor more capital-intensive peaking technologies while reducing wind and solar build-outs due to suppressed energy and clean energy market prices, particularly in the absence of strong clean energy targets. Conversely, ORDCs improve the commitment of available generation units, but this comes at the expense of higher system costs and renewable generation curtailment. We also find that well-calibrated static capacity demand curves can yield similar reliability and total cost compared to capacity market demand curves informed dynamically by resource adequacy while also yielding stable annual capacity prices. Different approaches to formulating ORDC curves can also yield key trade-offs, namely that a more efficient treatment of storage chronology results in lower ORDC curves and prices, yielding less investment and cost but at the expense of reliability. Finally, the effectiveness of wholesale electricity markets in practically achieving very high clean energy generation targets highly depends on the cost-competitiveness of clean energy technologies that can support critical balancing needs across multiple timescales.

capacity expansion↗
DOE OSTI2021

Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

An effective HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs). Broad and potent VRC01-class bNAbs have been isolated from multiple infected individuals, suggesting that they could be reproducibly elicited by vaccination. Several HIV-1 envelope-derived germline-targeting immunogens have been designed to engage naive VRC01-class precursor B cells. However, they also present off-target epitopes that could hinder development of VRC01-class bNAbs. We characterize a panel of anti-idiotypic monoclonal antibodies (ai-mAbs) raised against inferred-germline (iGL) VRC01-class antibodies. By leveraging binding, structural, and B cell sorting data, we engineered a bispecific molecule derived from two aimAbs; one specific for VRC01-class heavy chains and one specific for VRC01-class light chains. The bispecific molecule preferentially activates iGL-VRC01 B cells in vitro and induces specific antibody responses in a murine adoptive transfer model with a diverse polyclonal B cell repertoire. This molecule represents an alternative non-envelope-derived germline-targeting immunogen that can selectively activate VRC01-class precursors in vivo.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes

Zika virus (ZIKV) is an emerging pathogen that causes devastating congenital defects. The overlapping epidemiology and immunologic cross-reactivity between ZIKV and dengue virus (DENV) pose complex challenges to vaccine design, given the potential for antibody-dependent enhancement of disease. Therefore, classification of ZIKV-specific antibody targets is of notable value. From a ZIKV-infected rhesus macaque, we identify ZIKV-reactive B cells and isolate potent neutralizing monoclonal antibodies (mAbs) with no cross-reactivity to DENV. We group these mAbs into four distinct antigenic groups targeting ZIKV-specific cross-protomer epitopes on the envelope glycoprotein. Co-crystal structures of representative mAbs in complex with ZIKV envelope glycoprotein reveal envelope-dimer epitope and unique dimer-dimer epitope targeting. All four specificities are serologically identified in convalescent humans following ZIKV infection, and representative mAbs from all four groups protect against ZIKV replication in mice. These results provide key insights into ZIKV-specific antigenicity and have implications for ZIKV vaccine, diagnostic, and therapeutic development.

59 BASIC BIOLOGICAL SCIENCES↗