Search NASA⌕ Search

SEARCH · Search NASA

Results for “Targeting”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 451 records · Page 25
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Targeted materials discovery using Bayesian algorithm execution

Rapid discovery and synthesis of future materials requires intelligent data acquisition strategies to navigate large design spaces. A popular strategy is Bayesian optimization, which aims to find candidates that maximize material properties; however, materials design often requires finding specific subsets of the design space which meet more complex or specialized goals. We present a framework that captures experimental goals through straightforward user-defined filtering algorithms. These algorithms are automatically translated into one of three intelligent, parameter-free, sequential data collection strategies (SwitchBAX, InfoBAX, and MeanBAX), bypassing the time-consuming and difficult process of task-specific acquisition function design. Our framework is tailored for typical discrete search spaces involving multiple measured physical properties and short time-horizon decision making. We demonstrate this approach on datasets for TiO 2 nanoparticle synthesis and magnetic materials characterization, and show that our methods are significantly more efficient than state-of-the-art approaches. Overall, our framework provides a practical solution for navigating the complexities of materials design, and helps lay groundwork for the accelerated development of advanced materials.

42 ENGINEERING↗
DOE OSTI2024

Feasibility of peak temperature targets in light of institutional constraints

Despite faster-than-expected progress in clean energy technology deployment, global annual CO 2 emissions have increased from 2020 to 2023. The feasibility of limiting warming to 1.5 °C is therefore questioned. Here we present a model intercomparison study that accounts for emissions trends until 2023 and compares cost-effective scenarios to alternative scenarios with institutional, geophysical and technological feasibility constraints and enablers informed by previous literature. Our results show that the most ambitious mitigation trajectories with updated climate information still manage to limit peak warming to below 1.6 °C (‘low overshoot’) with around 50% likelihood. However, feasibility constraints, especially in the institutional dimension, decrease this maximum likelihood considerably to 5–45%. Accelerated energy demand transformation can reduce costs for staying below 2 °C but have only a limited impact on further increasing the likelihood of limiting warming to 1.6 °C. Our study helps to establish a new benchmark of mitigation scenarios that goes beyond the dominant cost-effective scenario design.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2025

Scalable fabrication of an array-type fixed-target device for automated room temperature X-ray protein crystallography

X-ray crystallography is one of the leading tools to analyze the 3-D structure, and therefore, function of proteins and other biological macromolecules. Traditional methods of mounting individual crystals for X-ray diffraction analysis can be tedious and result in damage to fragile protein crystals. Furthermore, the advent of multi-crystal and serial crystallography methods explicitly require the mounting of larger numbers of crystals. To address this need, we have developed a device that facilitates the straightforward mounting of protein crystals for diffraction analysis, and that can be easily manufactured at scale. Inspired by grid-style devices that have been reported in the literature, we have developed an X-ray compatible microfluidic device that can be used to trap protein crystals in an array configuration, while also providing excellent optical transparency, a low X-ray background, and compatibility with the robotic sample handling and environmental controls used at synchrotron macromolecular crystallography beamlines. At the Stanford Synchrotron Radiation Lightsource (SSRL), these capabilities allow for fully remote-access data collection at controlled humidity conditions. Furthermore, we have demonstrated continuous manufacturing of these devices via roll-to-roll fabrication to enable cost-effective and efficient large-scale production.

chemical engineering↗
DOE OSTI2024

Constraints on fifth forces and ultralight dark matter from OSIRIS-REx target asteroid Bennu

It is important to test the possible existence of fifth forces, as ultralight bosons that would mediate these are predicted to exist in several well-motivated extensions of the Standard Model. Recent work indicated asteroids as promising probes, but applications to real data are lacking so far. Here we use the OSIRIS-REx mission and ground-based tracking data for the asteroid Bennu to derive constraints on fifth forces. Our limits are strongest for mediator masses m ~ (10 -18 -10 -17 ) eV, where we currently achieve the tightest bounds. These can be translated to a wide class of models leading to Yukawa-type fifth forces, and we demonstrate how they apply to U(1) B dark photons and baryon-coupled scalars. Our results demonstrate the potential of asteroid tracking in probing well-motivated extensions of the Standard Model and ultralight bosons near the fuzzy dark matter range.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

Benchmarking greenhouse gas emissions from US wastewater treatment for targeted reduction

Here, in this study, to assess the national climate impact of wastewater treatment and inform decarbonization, we assembled a comprehensive greenhouse gas inventory of 15,863 facilities in the contiguous USA. Considering location and treatment configurations, we modelled on-site CH 4 , N 2 O and CO 2 production and emissions associated with energy, chemical inputs and solids disposal. Using Monte Carlo simulations, we estimated median national emissions at 47 million tonnes of CO 2 equivalent per year, with on-site process CH 4 and N 2 O emissions exceeding current government estimates by 41%. Treatment configurations with anaerobic digesters are responsible for 16 million tonnes of CO 2 equivalent per year of fugitive methane, outweighing benefits achieved through on-site electricity generation. Systems designed for nutrient removal have the highest greenhouse gas emissions intensity, attributable to energy requirements and N 2 O production, demonstrating current trade-offs between meeting water quality and climate objectives. We analysed key sensitivities and included a geospatial analysis to highlight the scale and distribution of opportunities for reducing life cycle greenhouse gas emissions.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2025

A bipartite bacterial virulence factor targets the complement system and neutrophil activation

Abstract The complement system and neutrophils constitute the two main pillars of the host innate immune defense against infection by bacterial pathogens. Here, we identify T-Mac, a novel virulence factor of the periodontal pathogen Treponema denticola that allows bacteria to evade both defense systems. We show that T-Mac is expressed as a pre-protein that is cleaved into two functional units. The N-terminal fragment has two immunoglobulin-like domains and binds with high affinity to the major neutrophil chemokine receptors FPR1 and CXCR1, blocking N -formyl-Met-Leu-Phe- and IL-8-induced neutrophil chemotaxis and activation. The C-terminal fragment functions as a cysteine protease with a unique proteolytic activity and structure, which degrades several components of the complement system, such as C3 and C3b. Murine infection studies further reveal a critical T-Mac role in tissue damage and inflammation caused by bacterial infection. Collectively, these results disclose a novel innate immunity-evasion strategy, and open avenues for investigating the role of cysteine proteases and immunoglobulin-like domains of gram-positive and -negative bacterial pathogens.

Kurniyati, Kurni↗
DOE OSTI2024

Development of a high performance MagLIF target platform using high aspect ratio coated liners and low-mix laser preheat

We report on a series of Magnetized Liner Inertial Fusion (MagLIF) experiments conducted on the Z pulsed power facility that utilized high aspect ratio (ratio of outer radius to wall thickness) liners with dielectric coatings and low-mix laser preheat configurations. The liners consisted of an aspect ratio of 10.6 beryllium tube coated with 75 μm of epoxy on the outside that have been shown to maintain a better implosion stability than uncoated beryllium and have demonstrated consistent stagnation performances in previous experiments [Ampleford et al., Phys. Plasmas 31, 022703 (2024)]. Two-dimensional HYDRA simulations were used to design three different “co-injection” laser configurations, whereby a second laser is used to provide an early prepulse before the main pulse, to reduce LEH foil mix while increasing the fuel density and coupled energy. The laser preheat energy for each configuration was constrained using dedicated laser experiments before being applied to the integrated MagLIF experiments on Z. The DD neutron yield for experiments using co-injection preheat configurations is found to increase with the specific preheat energy in line with simulations. The highest neutron yield achieved in this study of 1.1 × 10 13 matches the highest reported in a MagLIF experiment to date and is a factor 3.5 times higher than similar experiments using preheat with no phase plate smoothing. We attempt to assess the effects of mix and morphology to explain the improved performance; however, neither factor is found to be conclusive within the uncertainty of the measurements.

Harvey-Thompson, A. J.↗
DOE OSTI2025

Effect of self-generated magnetic fields on x-ray emission in Kr-filled targets at the National Ignition Facility

We examine the effects of self-generated magnetic fields in a Kr gas pipe x-ray source platform. X-ray emission from Kr plasma is dependent on the plasma conditions, as the ionization state is largely a function of temperature. Magnetic fields are known to limit heat conduction, which increases temperature. We show that the emission in simulations of the gas pipe x-ray source is dependent on how self-generated magnetic fields are modeled. The inclusion of self-generated magnetic fields in simulations more accurately captures the emission of lower energy x-ray emission (L-shell), bringing results closer to experiments. The modeled x-ray emission and self-generated magnetic fields are shown to be particularly sensitive to the inclusion of the Nernst effect in simulations. Severely limiting the Nernst effect leads to a hotter Kr plasma, which can account for the discrepancy seen in earlier studies. By modifying the Nernst effect multiplier, we can achieve better experimental agreement in x-ray emission from gas pipes; the value of the multiplier that leads to the best agreement is dependent on the laser power of the drive. Currently, the suppression factor of the Nernst effect needed for high power drives (PL>200 TW) is more restrictive than what is currently put forward by non-local models.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2025

Rippled shock propagation in a laser-driven target at multimegabar pressures

The evolution of non-uniform shocks produced by modulated laser irradiation or surface perturbations is relevant to studies of inertial confinement fusion and material properties at high-energy-density conditions. We present results from an experiment conducted at the OMEGA EP laser facility, where a 300 GPa shock was driven into a fused silica sample with pre-fabricated single-mode surface modulations. Using time-resolved optical velocimetry, we captured the continuous evolution of rippled shock motion, enabling a comprehensive mapping of the spatial amplitude history from formation to phase reversal in a single experiment. Initially, the ablation-driven shock inherits a fraction of the surface modulation amplitude from the sample, which subsequently grows before decaying, ultimately leading to the flattening of the rippled shock and a phase reversal. We find that two-dimensional inviscid hydrodynamic simulation of the experiment is able to qualitatively capture many aspects of the rippled shock evolution but over-predicts the initial amplitude growth. This experimental platform, capable of accommodating varying ripple wavelengths, lays the groundwork for a potential viscometry method at extreme pressures, where viscous effects manifest as differences in shock flattening times between rippled shocks of two distinct wavelengths propagating through the sample.

36 MATERIALS SCIENCE↗
DOE OSTI2024

Quantum computation of stopping power for inertial fusion target design

Stopping power is the rate at which a material absorbs the kinetic energy of a charged particle passing through it—one of many properties needed over a wide range of thermodynamic conditions in modeling inertial fusion implosions. First-principles stopping calculations are classically challenging because they involve the dynamics of large electronic systems far from equilibrium, with accuracies that are particularly difficult to constrain and assess in the warm-dense conditions preceding ignition. Here, we describe a protocol for using a fault-tolerant quantum computer to calculate stopping power from a first-quantized representation of the electrons and projectile. Our approach builds upon the electronic structure block encodings of Su et al. [ PRX Quant. 2 , 040332 (2021)], adapting and optimizing those algorithms to estimate observables of interest from the non-Born–Oppenheimer dynamics of multiple particle species at finite temperature. We also work out the constant factors associated with an implementation of a high-order Trotter approach to simulating a grid representation of these systems. Ultimately, we report logical qubit requirements and leading-order Toffoli costs for computing the stopping power of various projectile/target combinations relevant to interpreting and designing inertial fusion experiments. We estimate that scientifically interesting and classically intractable stopping power calculations can be quantum simulated with roughly the same number of logical qubits and about one hundred times more Toffoli gates than is required for state-of-the-art quantum simulations of industrially relevant molecules such as FeMoco or P450.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2024

Targeted engineering of camelina and pennycress seeds for ultrahigh accumulation of acetyl-TAG

Acetyl-TAG (3-acetyl-1,2-diacylglycerol), unique triacylglycerols (TAG) possessing an acetate group at the sn -3 position, exhibit valuable properties, such as reduced viscosity and freezing points. Previous attempts to engineer acetyl-TAG production in oilseed crops did not achieve the high levels found in naturally producing Euonymus seeds. Here, we demonstrate the successful generation of camelina and pennycress transgenic lines accumulating nearly pure acetyl-TAG at 93 mol% and 98 mol%, respectively. These ultrahigh acetyl-TAG synthesizing lines were created using gene-edited FATTY ACID ELONGASE1 ( FAE1 ) mutant lines as an improved genetic background to increase levels of acetyl-CoA available for acetyl-TAG synthesis mediated by the expression of EfDAcT, a high-activity diacylglycerol acetyltransferase isolated from Euonymus fortunei . Combining EfDAcT expression with suppression of the competing TAG-synthesizing enzyme DGAT1 further enhanced acetyl-TAG accumulation. These ultrahigh levels of acetyl-TAG exceed those in earlier engineered oilseeds and are equivalent or greater than those in Euonymus seeds. Imaging of lipid localization in transgenic seeds revealed that the low amounts of residual TAG were mostly confined to the embryonic axis. Similar spatial distributions of specific TAG and acetyl-TAG molecular species, as well as their probable diacylglycerol (DAG) precursors, provide additional evidence that acetyl-TAG and TAG are both synthesized from the same tissue-specific DAG pools. Remarkably, this ultrahigh production of acetyl-TAG in transgenic seeds exhibited minimal negative effects on seed properties, highlighting the potential for production of designer oils required for economical biofuel industries.

09 BIOMASS FUELS↗