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At least 469 records · Page 26

Post-metamorphic fluid infiltration into granulites from the Adirondack Mountains, USA

Post-metamorphic effects in the anorthosites of the Adirondacks, New York were described. Calcite-chlorite-sericite assemblages occur as veins, in disseminated form and as clots, and document retrograde fluid infiltration. These features are associated with late-state CO2-rich fluid inclusions. Stable isotope analyses of calcites indicates that the retrograde fluids interacted with meta-igneous and supracrustal lithologies, but the precise timing of the retrogression is as yet unknown.

Morrison, J.↗

The Messy Aerosol Submodel MADE3 (v2.0b): Description and a Box Model Test

We introduce MADE3 (Modal Aerosol Dynamics model for Europe, adapted for global applications, 3rd generation), an aerosol dynamics submodel for application within the MESSy framework (Modular Earth Submodel System). MADE3 builds on the predecessor aerosol submodels MADE and MADE-in. Its main new features are the explicit representation of coarse particle interactions both with other particles and with condensable gases, and the inclusion of hydrochloric acid (HCl)chloride (Cl) partitioning between the gas and condensed phases. The aerosol size distribution is represented in the new submodel as a superposition of nine lognormal modes: one for fully soluble particles, one for insoluble particles, and one for mixed particles in each of three size ranges (Aitken, accumulation, and coarse mode size ranges). In order to assess the performance of MADE3 we compare it to its predecessor MADE and to the much more detailed particle-resolved aerosol model PartMC-MOSAIC in a box model simulation of an idealized marine boundary layer test case. MADE3 and MADE results are very similar, except in the coarse mode, where the aerosol is dominated by sea spray particles. Cl is reduced in MADE3 with respect to MADE due to the HClCl partitioning that leads to Cl removal from the sea spray aerosol in our test case. Additionally, aerosol nitrate concentration is higher in MADE3 due to the condensation of nitric acid on coarse particles. MADE3 and PartMC- MOSAIC show substantial differences in the fine particle size distributions (sizes about 2 micrometers) that could be relevant when simulating climate effects on a global scale. Nevertheless, the agreement between MADE3 and PartMC-MOSAIC is very good when it comes to coarse particle size distribution, and also in terms of aerosol composition. Considering these results and the well-established ability of MADE in reproducing observed aerosol loadings and composition, MADE3 seems suitable for application within a global model.

Mixing state↗

Recent Cross Section Work From NOvA

The NOvA experiment is an off-axis long-baseline neutrino oscillation experiment seeking to measure $\nu_{\mu}$ disappearance and $\nu_{e}$ appearance in a $\nu_{\mu}$ beam originating at Fermilab. In addition to measuring the unoscillated neutrino spectra for the purposes of predicting the oscillated neutrino spectrum in the far detector, the 293-ton near detector also enables high-statistics investigation into neutrino scattering in numerous reaction channels. We discuss the various near detector analyses currently in progress, including inclusive measurements of both electron and muon neutrino charged-current interactions and efforts to constrain the off-axis NuMI flux using the elastic scattering of neutrinos from atomic electrons.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

MEASUREMENT OF THE CHARGED-CURRENT INCLUSIVE ELECTRON NEUTRINO AND ELECTRON ANTINEUTRINO CROSS SECTION USING THE MICROBOONE DETECTOR IN THE NUMI BEAM

Detection of electron neutrino appearance is the process by which modern neutrino experiments seek to answer the open questions in neutrino physics: CP-violation in the neutrino sector, the neutrino mass ordering, and sterile neutrino oscillations. To date, only three measurements of electron neutrino cross sections have been performed. The analysis presented in this thesis describes the extraction of the first charged-current inclusive $\nu_e$ + $\bar{\nu}_e$ cross section on argon. This calculation was performed with data collected by the MicroBooNE liquid argon time projection chamber using neutrinos from the Neutrino Main Injector (NuMI) beam located at the Fermi National Accelerator Laboratory. Extraction of this cross section is enabled by the first fully-automated inclusive selection of $\nu_e$ + $\bar{\nu}_e$ charged-current interactions in a liquid argon time projection chamber, which provided the largest sample of $\nu_e$ + $\bar{\nu}_e$ charged-current interactions ever observed in liquid argon. The selection utilises the signature capabilities of liquid argon, such as distinguishing electron-like and photon-like electromagnetic showers using their charge-deposition profiles (dE/dx). The evaluation of systematic effects influencing the final cross section, including detector simulation and flux simulation uncertainties, which have been applied for the first time to a MicroBooNE analysis using neutrinos from the NuMI beam, is also presented. The total impact of all systematic and statistical effects results in a 38.44\% uncertainty on the flux integrated cross section, giving $\sigma_{\nu_{e}~+~\bar{\nu}_e} = 4.67 \pm 1.01 \textrm{(stat)} \pm 1.48 \textrm{(sys)} \times 10^{-39}$ cm$^{2}$ per nucleon as the final result, which is in agreement with theoretical predictions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Interactive effects of dietary fishmeal level and plant essential oils supplementation on European sea bass, Dicentrarchus labrax : Growth performance, nutrient utilization, and immunological response

Abstract The inclusion of phytogenics in fish feed is a promising strategy to compensate for the negative performance effects of replacing fishmeal (FM) with vegetable sources. The present work assessed the interactive effects of different dietary FM levels (22.5 and 10% of formulation) and the supplementation of a commercial blend of anise, citrus, and oregano essential oils (Digestarom PEP M.G.E 150) on European sea bass, Dicentrarchus labrax growth performance, nutrient utilization, gut morphology, antioxidant status, and immunological response over a 60‐day growth trial. Results showed decreased growth and protein efficiency ratio and increased feed conversion ratio with a low dietary FM level. In contrast, supplementation of the phytogenic product demonstrated improved performance and nutrient utilization together with increased protein and energy retention. Supplementation with the plant essential oils fully compensated for the negative intestinal changes observed in sea bass fed a low‐FM diet but showed little improvement in fish immunological response, except for the 30% increase in lysozyme activity observed in fish fed the low FM‐supplemented diet compared to those fed the standard high‐FM diet. Overall, this study supports the use of this phytogenic product in low‐FM diets as a possible tool to decrease feed costs associated with FM without compromising fish performance, nutrient utilization, and health.

Gonçalves, Rui A.↗

Electrostatically controlled surface boundary conditions in nematic liquid crystals and colloids

Differing from isotropic fluids, liquid crystals exhibit highly anisotropic interactions with surfaces, which define boundary conditions for the alignment of constituent rod-like molecules at interfaces with colloidal inclusions and confining substrates. We show that surface alignment of the nematic molecules can be controlled by harnessing the competing aligning effects of surface functionalization and electric field arising from surface charging and bulk counterions. The control of ionic content in the bulk and at surfaces allows for tuning orientations of shape-anisotropic particles like platelets within an aligned nematic host and for changing the orientation of director relative to confining substrates. The ensuing anisotropic elastic and electrostatic interactions enable colloidal crystals with reconfigurable symmetries and orientations of inclusions.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Parameterization-Induced Uncertainties and Impacts of Crop Management Harmonization in a Global Gridded Crop Model Ensemble

Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without investigating the causes of divergence in outputs. This study explores differences in maize yield estimates from five GGCMs based on the public domain field-scale model Environmental Policy Integrated Climate (EPIC) that participate in the AgMIP Global Gridded Crop Model Intercomparison initiative. Albeit using the same crop model, the GGCMs differ in model version, input data, management assumptions, parameterization, and selection of subroutines affecting crop yield estimates via cultivar distributions, soil attributes, and hydrology among others. The analyses reveal inter-annual yield variability and absolute yield levels in the EPIC-based GGCMs to be highly sensitive to soil parameterization and crop management. All GGCMs show an intermediate performance in reproducing reported yields with a higher skill if a static soil profile is assumed or sufficient plant nutrients are supplied. An in-depth comparison of setup domains for two EPIC-based GGCMs shows that GGCM performance and plant stress responses depend substantially on soil parameters and soil process parameterization, i.e. hydrology and nutrient turnover, indicating that these often neglected domains deserve more scrutiny. For agricultural impact assessments, employing a GGCM ensemble with its widely varying assumptions in setups appears the best solution for coping with uncertainties from lack of comprehensive global data on crop management, cultivar distributions and coefficients for agro-environmental processes. However, the underlying assumptions require systematic specifications to cover representative agricultural systems and environmental conditions. Furthermore, the interlinkage of parameter sensitivity from various domains such as soil parameters, nutrient turnover coefficients, and cultivar specifications highlights that global sensitivity analyses and calibration need to be performed in an integrated manner to avoid bias resulting from disregarded core model domains. Finally, relating evaluations of the EPIC-based GGCMs to a wider ensemble based on individual core models shows that structural differences outweigh in general differences in configurations of GGCMs based on the same model, and that the ensemble mean gains higher skill from the inclusion of structurally different GGCMs. Although the members of the wider ensemble herein do not consider crop-soil-management interactions, their sensitivity to nutrient supply indicates that findings for the EPIC-based sub-ensemble will likely become relevant for other GGCMs with the progressing inclusion of such processes.

Folberth, Christian↗

Comparative study of He 6 β -decay based on different similarity-renormalization-group evolved chiral interactions

We report on a study of the Gamow-Teller matrix element contributing to ${}^6$He $\beta$-decay with similarity renormalization group (SRG) versions of momentum- and configuration-space two-nucleon interactions. These interactions are derived from two different formulations of chiral effective field theory ($\chi$EFT) -- without and with the explicit inclusion of $\Delta$-isobars. We consider evolution parameters $\Lambda_{\rm SRG}$ in the range between 1.2 and 2.0 fm$^{-1}$ and, for the $\Delta$-less case, also the unevolved (bare) interaction. The axial current contains one- and two-body terms, consistently derived at tree level (no loops) in the two distinct $\chi$EFT formulations we have adopted here. The ${}^6$He and ${}^6$Li ground-state wave functions are obtained from hyperspherical-harmonics (HH) solutions of the nuclear many-body problem. In $A\,$=$\,6$ systems, the HH method is limited at present to treat only two-body interactions and non-SRG evolved currents. Our results exhibit a significant dependence on $\Lambda_{\text{SRG}}$ of the contributions associated with two-body currents, suggesting that a consistent SRG-evolution of these is needed in order to obtain reliable estimates. We also show that the contributions from one-pion-exchange currents depend strongly on the model (chiral) interactions and on the momentum- or configuration-space cutoffs used to regularize them. These results might prove helpful in clarifying the origin of the sign difference recently found in No-Core-Shell-Model and Quantum Monte Carlo calculations of the ${}^6$He Gamow-Teller matrix element.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Aerosol Complexity and Implications for Predictability and Short-Term Forecasting

There are clear NWP and climate impacts from including aerosol radiative and cloud interactions. Changes in dynamics and cloud fields affect aerosol lifecycle, plume height, long-range transport, overall forcing of the climate system, etc. Inclusion of aerosols in NWP systems has benefit to surface field biases (e.g., T2m, U10m). Including aerosol affects has impact on analysis increments and can have statistically significant impacts on, e.g., tropical cyclogenesis. Above points are made especially with respect to aerosol radiative interactions, but aerosol-cloud interaction is a bigger signal on the global system. Many of these impacts are realized even in models with relatively simple (bulk) aerosol schemes (approx.10 -20 tracers). Simple schemes though imply simple representation of aerosol absorption and importantly for aerosol-cloud interaction particle-size distribution. Even so, more complex schemes exhibit a lot of diversity between different models, with issues such as size selection both for emitted particles and for modes. Prospects for complex sectional schemes to tune modal (and even bulk) schemes toward better selection of size representation. I think this is a ripe topic for more research -Systematic documentation of benefits of no vs. climatological vs. interactive (direct and then direct+indirect) aerosols. Document aerosol impact on analysis increments, inclusion in NWP data assimilation operator -Further refinement of baseline assumptions in model design (e.g., absorption, particle size distribution). Did not get into model resolution and interplay of other physical processes with aerosols (e.g., moist physics, obviously important), chemistry

Predictability↗

Quasi-relativistic electron precipitation due to interactions with coherent VLF waves in the magnetosphere

The equations of motion for the cyclotron resonance interaction between coherent whistler mode waves and energetic particles are rederived with the inclusion of relativistic effects. The pitch angle scattering of the near-loss-cone quasi-relativistic electrons trapped in the magnetosphere is studied using a test particle method employing these relativistic equations, and the precipitated energy spectrum due to the wave-induced perturbations of a full distribution of particles is computed. Results show that the full width at half maximum peak width of the rms scattering pattern of the near-loss-cone particles would give an upper bound to the peak width of the associated precipitated energy spectrum under the conditions of moderate wave intensities in the low L shell region. In addition, it is found that the peak widths are within the upper limit values measured by recent satellite experiments. It is concluded that interactions of inner radiation belt particles with monochromatic waves could produce precipitated fluxes with relatively sharp spectral widths, and that therefore the L-dependent narrow peaks observed by low altitude satellite particle detectors could be caused by such interactions.

Chang, H. C.↗

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

We performed analyses of compounds in clinical development which have shown that ligand efficient-molecules with privileged physical properties and low dose are less likely to fail in the various stages of clinical testing, have fewer postapproval withdrawals, and are less likely to receive black box safety warnings. However, detailed side-by-side examination of molecular interactions and properties within single drug classes are lacking. As a class, VEGF receptor tyrosine kinase inhibitors (VEGFR TKIs) have changed the landscape of how cancer is treated, particularly in clear cell renal cell carcinoma, which is molecularly linked to the VEGF signaling axis. Despite the clear role of the molecular target, member molecules of this validated drug class exhibit distinct clinical efficacy and safety profiles in comparable renal cell carcinoma clinical studies. The first head-to-head randomized phase III comparative study between active VEGFR TKIs has confirmed significant differences in clinical performance [Rini BI, et al. (2011) Lancet 378:193–1939]. To elucidate how fundamental drug potency–efficiency is achieved and impacts differentiation within the VEGFR TKI class, we determined potencies, time dependence, selectivities, and X-ray structures of the drug–kinase complexes using a VEGFR2 TK construct inclusive of the important juxtamembrane domain. Collectively, the studies elucidate unique drug–kinase interactions that are dependent on distinct juxtamembrane domain conformations, resulting in significant potency and ligand efficiency differences. Finally, the identified structural trends are consistent with in vitro measurements, which translate well to clinical performance, underscoring a principle that may be broadly applicable to prospective drug design for optimal in vivo performance.

McTigue, Michele↗

Inclusive J/ψ production in Xe–Xe collisions at s NN = 5.44 TeV

J/ψ production is studied in Xe–Xe interactions at a centre-of-mass energy per nucleon pair of √ s NN=5.44 TeV, using the ALICE detector at the CERN LHC. The J/ψ meson is reconstructed via its decay into a muon pair, in the centre-of-mass rapidity interval 2.5 < y < 4 and down to zero transverse momentum. In this Letter, the nuclear modification factors R AA for inclusive J/ψ, measured in the centrality range 0–90% as well as in the centrality intervals 0–20% and 20–90% are presented. The R AA values are compared to previously published results for Pb–Pb collisions at √ s NN=5.02 TeV and to the calculation of a transport model. A good agreement is found between Xe–Xe and Pb–Pb results as well as between data and the model.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Next generation of the self-consistent and environment-dependent Hamiltonian: Applications to various boron allotropes from zero- to three-dimensional structures

An upgrade of the previous self-consistent and environment-dependent linear combination of atomic orbitals Hamiltonian (referred as SCED-LCAO) has been developed. This improved version of the semi-empirical SCED-LCAO Hamiltonian, in addition to the inclusion of self-consistent determination of charge redistribution, multi-center interactions, and modeling of electron-electron correlation, has taken into account the effect excited on the orbitals due to the atomic aggregation. This important upgrade has been subjected to a stringent test, the construction of the SCED-LCAO Hamiltonian for boron. It was shown that the Hamiltonian for boron has successfully characterized the electron deficiency of boron and captured the complex chemical bonding in various boron allotropes, including the planar and quasi-planar, the convex, the ring, the icosahedral, and the fullerene-like clusters, the two-dimensional monolayer sheets, and the bulk alpha boron, demonstrating its transferability, robustness, reliability, and predictive power. The molecular dynamics simulation scheme based on the Hamiltonian has been applied to explore the existence and the energetics of ∼230 compact boron clusters B{sub N} with N in the range from ∼100 to 768, including the random, the rhombohedral, and the spherical icosahedral structures. It was found that, energetically, clusters containing whole icosahedral B{sub 12} units are more stable for boron clusters of larger size (N > 200). The ease with which the simulations both at 0 K and finite temperatures were completed is a demonstration of the efficiency of the SCED-LCAO Hamiltonian.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

A 1D coupled transport/cold plasma wave model for parallel ponderomotive density modification near RF actuators

The plasma density profile close to RF actuators plays a vital role in the efficiency of power coupling from the antenna to the core plasma of fusion devices. Nonlinear interactions can be significant when considering the interaction of applied RF power and the tenuous SOL plasma, and the inclusion of this region in computational analysis is essential to providing robust predictive simulations of plasma response to RF application. Of particular interest is the observed density modification during RF operation. Here we present a self consistent description of the nonlinear ponderomotive force in the antenna near field region, via coupling a 1D field aligned transport model with a 1D cold plasma wave model. Results are presented, which show a parallel electric field of 300 Vm -1 drove a density reduction of ~ 20% over 25 RF periods.

Barnett, Rhea↗

Improved predictions of transcription factor binding sites using physicochemical features of DNA

Typical approaches for predicting transcription factor binding sites (TFBSs) involve use of a position-specific weight matrix (PWM) to statistically characterize the sequences of the known sites. Recently, an alternative physicochemical approach, called SiteSleuth, was proposed. In this approach, a linear support vector machine (SVM) classifier is trained to distinguish TFBSs from background sequences based on local chemical and structural features of DNA. SiteSleuth appears to generally perform better than PWM-based methods. Here, we improve the SiteSleuth approach by considering both new physicochemical features and algorithmic modifications. New features are derived from Gibbs energies of amino acid–DNA interactions and hydroxyl radical cleavage profiles of DNA. Algorithmic modifications consist of inclusion of a feature selection step, use of a nonlinear kernel in the SVM classifier, and use of a consensus-based post-processing step for predictions. We also considered SVM classification based on letter features alone to distinguish performance gains from use of SVM-based models versus use of physicochemical features. The accuracy of each of the variant methods considered was assessed by cross validation using data available in the RegulonDB database for 54 Escherichia coli TFs, as well as by experimental validation using published ChIP-chip data available for Fis and Lrp.

59 BASIC BIOLOGICAL SCIENCES↗

Absence of a charge diffusion pole at finite energies in an exactly solvable interacting flat-band model in $d$ dimensions

Motivated by recent bounds for charge diffusion in critical matter, we investigate the following question: What sets the scale for the velocity for diffusing degrees of freedom in a scale-invariant system? To make our statements precise, here we analyze the diffusion pole in an exactly solvable model for a Mott transition in the presence of a long-range interaction term. To achieve scale invariance, we limit our discussion to the flat-band regime. We find in this limit that the diffusion pole, which would normally obtain at finite energy, is pushed to zero energy, resulting in a vanishing of the diffusion constant. This occurs even in the presence of interactions in certain limits, indicating the robustness of this result to the inclusion of a scale in the problem. Consequently, scale invariance precludes any reasonable definition of the diffusion constant. Nonetheless, we do find that a scale can be defined, albeit irrelevant to diffusion, which is the product of the squared band velocity and the density of states.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Neutrino energy reconstruction from semi-inclusive samples

We study neutrino-nucleus charged-current reactions on finite nuclei for the situation in which an outgoing muon and a proton are detected in coincidence, {\it i.e.,} we focus on semi-inclusive cross sections. We limit our attention to one-body current interactions (quasielastic scattering) and assess the impact of different nuclear effects in the determination of the neutrino energy. We identify the regions in phase space where the neutrino energy can be reconstructed relatively well, and study whether the cross section in those regions is significant. Our results indicate that it is possible to filter more than 50\% of all events according to the muon and proton kinematics, so that for the DUNE and T2K fluxes the neutrino energy can be determined with an uncertainty of less than 1\% and 3\%, respectively. Furthermore, we find that the reconstructed neutrino energy does not depend strongly on how one treats the final-state interactions and is not much affected by the description of the initial state. On the other hand, the estimations of the uncertainty on the neutrino energy show important sensitivity to the modeling of the initial state.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Acoustic Power Transmission Through a Ducted Fan

For high-speed ducted fans, when the rotor flowfield is shock-free, the main contribution to the inlet radiated acoustic power comes from the portion of the rotor stator interaction sound field that is transmitted upstream through the rotor. As such, inclusion of the acoustic transmission is an essential ingredient in the prediction of the fan inlet noise when the fan tip relative speed is subsonic. This paper describes a linearized Euler based approach to computing the acoustic transmission of fan tones through the rotor. The approach is embodied in a code called LINFLUX was applied to a candidate subsonic fan called the Advanced Ducted Propulsor (ADP). The results from this study suggest that it is possible to make such prediction with sufficient fidelity to provide an indication of the acoustic transmission trends with the fan tip speed.

aeroacoustics↗