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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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DOE OSTI2026

Uncertainty Quantification (UQ) for AI fact Sheet

UQ is traditionally defined as quantitative characterization and estimation of uncertainties in both computational and real-world applications. It tries to determine how likely certain outcomes are if some aspects of the system are not exactly known.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2026

Pairing Simulation with Uncertainty Quantification for Exploding Wire Tests

In a 2025 SAND report by Carnes et al., it was observed that experimental and model results were not in agreement, especially peak voltage, and time of peak, for gold, with observed disagreements of up to 40%. In this work, we investigate whether other sources of uncertainty in the model can explain this disagreement between experiment and model.

Mendoza, Hector Javier [Sandia National Laboratori↗
DOE OSTI2024

Quantification of heterogeneity in human CD8 + T cell responses to vaccine antigens: an HLA-guided perspective

Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease, e.g., Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health strategies and counter-measure development missions. Here, we propose coverage metrics to quantify vaccine-induced CD8 + T cell-mediated immune protection, as well as metrics to characterize immuno-dominant epitopes, in light of human genetic heterogeneity and viral evolution. Proof-of-principle of our approach and methods are demonstrated for Ebola virus, SARS-CoV-2, and Burkholderia pseudomallei (vaccine) proteins.

60 APPLIED LIFE SCIENCES↗