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At least 469 records · Page 26

Quantitative Analysis of Spaceflight Drug Stability Data to Support a Predictive Pharmaceutical Testing Strategy

To systematically quantify the time-dependent effect of spaceflight on active pharmaceutical ingredient (API) degradation, data were extracted from available published and unpublished spaceflight drug stability studies. Seven studies were identified that investigated the stability of individual medications following storage aboard crewed spacecraft. Medications stored for up to 2.4 years in low earth orbit (LEO) show limited change in API potency that, in all cases, falls within 10% of matched terrestrial controls, and within 5% of controls for the most drugs. This investigation shows that spaceflight is associated with a ~1.5-fold increase in the degradation rate relative to lot-matched terrestrial controls. Spaceflight is associated with an increased probability of drug failure over time; however, the incremental increase in degradation risk associated with spaceflight is minor compared to the baseline risk associated with terrestrial controls. Since most drugs across all NASA-supported studies were repackaged solid oral formulations that had been removed from protective manufacturer packaging, it is likely that prolonged exposure to atmospheric factors during both terrestrial and spaceflight treatments is a key contributor to degradation. Unique spaceflight environmental factors, particularly ionizing radiation and elevated CO2, may contribute to the additional cumulative effect of spaceflight. The results of this study show that the effect of spaceflight on drug stability is minor relative to the terrestrial baseline; however, the degradation rate and time-dependent failure of terrestrial controls highlights an extremely critical need to evaluate the effect of current repackaging methods and development of operationally appropriate methods to protected repackaged solid oral medications from environmental factors that mediate degradation.

J F Reichard↗

Tracking the Hunga Tonga-Hunga Ha’apai Eruption Stratospheric Aerosol and Trace Gas Plumes Using Machine Learning

The Hunga Tonga-Hunga Ha’apai (HTHH) submarine volcano had an explosive eruption phase on January 15, 2022, that thrusted ash, gases, and water vapor through the troposphere and into the stratosphere. The stratospheric volcanic plume included aerosol precursor gases such as SO2 and H2S as well as anomalously high water vapor concentrations due to the submarine oceanic origin. With these atmospheric constituents, the sulfuric gases and water vapor formed sulfate (SO4) particles via gas-to-particle reactions and these aerosols likely increased in size due to hygroscopic growth within anomalously humid regions. Strong easterlies and gravity waves propagated the volcanic impacts throughout the stratosphere. Orbital and suborbital passive sensor retrievals detected changes in the aerosol and trace gas characteristics within the atmospheric column for cloud-free regions over the southern hemisphere. While the CALIPSO lidar can detect aerosol layers in the stratosphere, passive sensors such as MODIS retrieved the total column aerosol abundance and characteristics. Previous studies used manual tracking methods to determine volcanic plume positions and compared them to ground observations. In this study, we examine the machine learning (ML) approaches including segmentation, object detection, and object tracking to identify and track aerosol and trace gas plumes using orbital and suborbital sensor data. This ML implementation strives to provide a more systematic approach to separate total column effects from those of the stratosphere. Similar ML tracking may be useful for stratospheric impact events observed historically by CALIPSO and in the future with EarthCare and the Atmosphere Observing System (AOS) lidar-capable missions.

Rhys Leahy↗

Systematic biases in radiometric diameter determinations

Radiometric diameter determinations are presently shown to often be significantly affected by the effect of rotation. This thermal effect of rotation depends not only on the object's thermal inertia, rotation rate, and pole orientation, but also on its temperature, since colder objects having constant rotation rate and thermal inertia will radiate less of their heat on the diurnal than on the nocturnal hemisphere. A disk-integrated beaming parameter of 0.72 is determined for the moon, and used to correct empirically for the roughness effects in thermophysical models; the standard thermal model is found to systematically underestimate cold object diameters, while overstating their albedos.

Spencer, John R.↗

Sensitivity of SLR baselines to errors in Earth orientation

The sensitivity of inter station distances derived from Satellite Laser Ranging (SLR) to errors in Earth orientation is discussed. An analysis experiment is performed which imposes a known polar motion error on all of the arcs used over this interval. The effect of the averaging of the errors over the tracking periods of individual sites is assessed. Baselines between stations that are supported by a global network of tracking stations are only marginally affected by errors in Earth orientation. The global network of stations retains its integrity even in the presence of systematic changes in the coordinate frame. The effect of these coordinate frame changes on the relative locations of the stations is minimal.

Smith, D. E.↗

Lunar and Planetary Science XXXV: Impact-Related Deposits

The session "Impact-Related Deposits" included:Evidence for a Lightning-Strike Origin of the Edeowie Glass; 57Fe M ssbauer Spectroscopy of Fulgurites: Implications for Chemical Reduction; Ca-Metasomatism in Crystalline Target Rocks from the Charlevoix Structure, Quebec, Canada: Evidence for Impact-related Hydrothermal Activity; Magnetic Investigations of Breccia Veins and Basement Rocks from Roter Kamm Crater and Surrounding Region, Namibia; Petrologic Complexities of the Manicouagan Melt Sheet: Implications for 40Ar-39Ar Geochronology; Laser Argon Dating of Melt Breccias from the Siljan Impact Structure, Sweden: Implications for Possible Relationship to Late Devonian Extinction Events; Lunar Impact Crater, India: Occurrence of a Basaltic Suevite?; Age of the Lunar Impact Crater, India: First Results from Fission Track Dating; The Fluidized Chicxulub Ejecta Blanket, Mexico: Implications for Mars; Low Velocity Ejection of Boulders from Small Lunar Craters: Ground Truth for Asteroid Surfaces; Ejecta and Secondary Crater Distributions of Tycho Crater: Effects of an Oblique Impact; Potassium Isotope Systematics of Crystalline Lunar Spherules from Apollo 16; Late Paleocene Spherules from the North Sea: Probable Sea Floor Precipitates: A Silverpit Provenance Unproven; A Lithological Investigation of Marine Strata from the Triassic-Jurassic Boundary Interval, Queen Charlotte Islands, British Columbia, Including a Search for Shocked Quartz; Triassic Cratered Cobbles: Shock Effects or Tectonic Pressure?; Regional Variations of Trace Element Composition Within the Australasian Tektite Strewn Field; Cretaceous-Tertiary Boundary Microtektite-bearing Sands and Tsunami Beds, Alabama Gulf Coastal Plain; Sand Lobes on Stewart Island as Probable Impact-Tsunami Deposits; Distal Impact Ejecta, Uppermost Eocene, Texas Coastal Plain; and Continental Impact Debris in the Eltanin Impact Layer.

Source record↗

Comparisons of Bispectral and Polarimetric Retrievals of Marine Boundary Layer Cloud Microphysics: Case Studies Using a LES- Satellite Retrieval Simulator

Many passive remote-sensing techniques have been developed to retrieve cloud microphysical properties from satellite-based sensors, with the most common approaches being the bispectral and polarimetric techniques. These two vastly different retrieval techniques have been implemented for a variety of polar-orbiting and geostationary satellite platforms, providing global climatological data sets. Prior instrument comparison studies have shown that there are systematic differences between the droplet size retrieval products (effective radius) of bispectral (e.g., MODIS, Moderate Resolution Imaging Spectroradiometer) and polarimetric (e.g., POLDER, Polarization and Directionality of Earth's Reflectances) instruments. However, intercomparisons of airborne bispectral and polarimetric instruments have yielded results that do not appear to be systematically biased relative to one another. Diagnosing this discrepancy is complicated, because it is often difficult for instrument intercomparison studies to isolate differences between retrieval technique sensitivities and specific instrumental differences such as calibration and atmospheric correction. In addition to these technical differences the polarimetric retrieval is also sensitive to the dispersion of the droplet size distribution (effective variance), which could influence the interpretation of the droplet size retrieval. To avoid these instrument-dependent complications, this study makes use of a cloud remote-sensing retrieval simulator. Created by coupling a large-eddy simulation (LES) cloud model with a 1-D radiative transfer model, the simulator serves as a test bed for understanding differences between bispectral and polarimetric retrievals. With the help of this simulator we can not only compare the two techniques to one another (retrieval intercomparison) but also validate retrievals directly against the LES cloud properties. Using the satellite retrieval simulator, we are able to verify that at high spatial resolution (50m) the bispectral and polarimetric retrievals are highly correlated with one another within expected observational uncertainties. The relatively small systematic biases at high spatial resolution can be attributed to different sensitivity limitations of the two retrievals. In contrast, a systematic difference between the two retrievals emerges at coarser resolution. This bias largely stems from differences related to sensitivity of the two retrievals to unresolved inhomogeneities in effective variance and optical thickness. The influence of coarse angular resolution is found to increase uncertainty in the polarimetric retrieval but generally maintains a constant mean value.

Miller, Daniel J.↗

Comparisons of Bispectral and Polarimetric Retrievals of Marine Boundary Layer Cloud Microphysics: Case Studies Using a LES-Satellite Retrieval Simulator

Many passive remote-sensing techniques have been developed to retrieve cloud microphysical properties from satellite-based sensors, with the most common approaches being the bispectral and polarimetric techniques. These two vastly different retrieval techniques have been implemented for a variety of polar-orbiting and geostationary satellite platforms, providing global climatological data sets. Prior instrument comparison studies have shown that there are systematic differences between the droplet size retrieval products (effective radius) of bispectral (e.g., MODIS, Moderate Resolution Imaging Spectroradiometer) and polarimetric (e.g., POLDER, Polarization and Directionality of Earth's Reflectances) instruments. However, intercomparisons of airborne bispectral and polarimetric instruments have yielded results that do not appear to be systematically biased relative to one another. Diagnosing this discrepancy is complicated, because it is often difficult for instrument intercomparison studies to isolate differences between retrieval technique sensitivities and specific instrumental differences such as calibration and atmospheric correction. In addition to these technical differences the polarimetric retrieval is also sensitive to the dispersion of the droplet size distribution (effective variance), which could influence the interpretation of the droplet size retrieval. To avoid these instrument-dependent complications, this study makes use of a cloud remote-sensing retrieval simulator. Created by coupling a large-eddy simulation (LES) cloud model with a 1-D radiative transfer model, the simulator serves as a test bed for understanding differences between bispectral and polarimetric retrievals. With the help of this simulator we can not only compare the two techniques to one another (retrieval intercomparison) but also validate retrievals directly against the LES cloud properties. Using the satellite retrieval simulator, we are able to verify that at high spatial resolution (50 m) the bispectral and polarimetric retrievals are highly correlated with one another within expected observational uncertainties. The relatively small systematic biases at high spatial resolution can be attributed to different sensitivity limitations of the two retrievals. In contrast, a systematic difference between the two retrievals emerges at coarser resolution. This bias largely stems from differences related to sensitivity of the two retrievals to unresolved inhomogeneities in effective variance and optical thickness. The influence of coarse angular resolution is found to increase uncertainty in the polarimetric retrieval but generally maintains a constant mean value.

Miller, Daniel J.↗

Boron Abundances in A and B-type Stars

Boron abundances in A- and B-type stars may be a successful way to track evolutionary effects in these hot stars. The light elements - Li, Be, and B - are tracers of exposure to temperatures more moderate than those in which the H-burning CN-cycle operates. Thus, any exposure of surface stellar layers to deeper layers will affect these light element abundances. Li and Be are used in this role in investigations of evolutionary processes in cool stars, but are not observable in hotter stars. An investigation of boron, however, is possible through the B II 1362 A resonance line. We have gathered high resolution spectra from the IUE database of A- and B-type stars near 10 solar mass for which nitrogen abundances have been determined. The B II 1362 A line is blended throughout; the temperature range of this program, requiring spectrum syntheses to recover the boron abundances. For no star could we synthesize the 1362 A region using the meteoritic/solar boron abundance of log e (B) = 2.88; a lower boron abundance was necessary which may reflect evolutionary effects (e.g., mass loss or mixing near the main-sequence), the natal composition of the star forming regions, or a systematic error in the analyses (e.g., non-LTE effects). Regardless of the initial boron abundance, and despite the possibility of non-LTE effects, it seems clear that boron is severely depleted in some stars. It may be that the nitrogen and boron abundances are anticorrelated, as would be expected from mixing between the H-burning and outer stellar layers. If, as we suspect, a residue of boron is present in the A-type supergiants, we may exclude a scenario in which mixing occurs continuously between the surface and the deep layers operating the CN-cycle. Further exploitation of the B II 1362 A line as an indicator of the evolutionary status of A- and B-type stars will require a larger stellar sample to be observed with higher signal-to-noise as attainable with the Hubble Space Telescope.

Lambert, David L.↗

Prediction of Unsteady Transitional Layers in Turbomachinery Using Navier Stokes Equations

The objective of the research reported in this presentation is to develop computational techniques for the prediction of unsteady transitional flows associated with the rotor stator interaction in turbomachinery. Three low-Reynolds number turbulence models are incorporated in two unsteady Navier-Stokes codes (one is pressure based and the other is time marching with Runge-Kutta time stepping) and evaluated for accuracy in predicting the onset and the end of unsteady transitional patches due to wake passing. The best model is then used for modification and improvement for the leading edge effect. An existing steady Navier-Stokes code was modified to include pseudo-time stepping, which provided acceleration from 5 to 25 times that of the original code. A systematic validation procedure was implemented to assess the effects of the grid, artificial dissipation, physical, and the pseudo-time step for an accurate prediction of transitional flows resulting from the rotor-stator interaction. The ability of the Navier-Stokes code to predict the unsteady transitional flow on a turbomachinery blade is demonstrated. The unsteady pressure and velocity fields are in good agreement with the experimental data and the prediction from the Euler/boundary layer approach. The numerical solver was able to capture all zones (wake induced transitional strip, wake induced turbulent strip, calmed region, etc.) associated with wake induced transition in a compressor cascade. Another significant step is the assessment of k-epsilon turbulence models, including the leading edge modifications. Best results were obtained from the FLB model. The LB model predicted earlier inception of the transition and shorter transition length. Modification of the k-epsilon model was found to be essential for an accurate prediction of the unsteady transitional flow in a compressor cascade. The CH model failed to predict the unsteady transitional flow. Predicted boundary layer was turbulent from the leading edge, even with the modification of the k-epsilon model near the stagnation point. A comparison of the instantaneous shape factor, the skin friction coefficient, and the momentum thickness indicates that the Navier-Stokes predictions are reasonably good. Interaction between the upstream wake and stator wake results in shedding of unsteady vortices from the trailing edge and increased dissipation in the stator wake and, as a consequence, increased rate of decay of the stator wake. The procedure developed at Penn State should aid the designers of turbomachinery in allowing for the unsteady transitional flows due to rotor-stator interaction.

Lakshminarayana, B.↗

Gamma-effects on 2-dimensional transonic aerodynamics

Nonlifting 10% biconvex airfoils are mounted in a 30 x 40 cm Ludwieg-tube-driven transonic test-section and the flow field recorded with a holographic interferometer. Nitrogen, argon, and carbon dioxide are used as the principal test gases. Experiments are conducted with Reynolds number based on chord of (0.5-3.5) x 10 to the 6th with Mach numbers of 0.70, 0.75, and 0.80. Supporting calculations use inviscid transonic small-disturbance and full-potential computer codes coupled with simple integral boundary-layer modeling. Systematic studies show that significant gamma-effects can occur due to shock-induced separation.

Tuzla, K.↗

Fine-cut bluntness effects on the hypersonic static stability of a 10 degree cone

A systematic wind-tunnel investigation has been performed on a series of spherically blunted 10-degree cones to determine Mach number and angle-of-attack effects on the hypersonic static stability. The cones, which range in nose-to-base radius ratios from 0 to 0.5, have been tested from -4 to 20 degrees angle of attack at Mach numbers of 6 and 10 in air and 20 in helium. Relatively large excursions in the center-of-pressure location were observed for small changes in cone nose bluntness. The movement of the center of pressure was also noted to become more pronounced as Mach number increased; increases in angle of attack tended to lessen the magnitude of these excursions. Computational predictions of basic aerodynamic coefficients as well as the center-of-pressure locations using both viscous and inviscid theory compare very well with the experimental data.

Bryan, M. D.↗

Analyses of On-orbit Determinations of the Clouds and the Earth Radiant Energy System (CERES) Thermistor Bolometer Sensor Zero-radiance Effects

The Clouds and Earth's Radiant Energy System (CERES) missions were designed to measure broadband earth-reflected shortwave solar (0.3 micrometers to less than 5.0 micrometers) and earth-emitted longwave (5.0 micrometers to greater than 100 micrometers) radiances as well as earth-emitted narrow-band radiances in the water vapor window region between 8 micrometers and 12 micrometers. However, the CERES scanning thermistor bolometer sensor zero-radiance offsets were found to vary as much as 1.0 Wm (exp -2) sr (exp -1) with the scan angle measurement geometry due to gravitational forces and systematic electronic noise. To minimize the gravitational effects, the Tropical Rainfall Measuring Mission (TRMM) Spacecraft CERES sensors' offsets were derived on-orbit as functions of scan elevation and azimuth angles from the January 7-8, 1998 radiometric observations of deep cold space, representative of a 3 K blackbody. In this paper, the TRMM/CERES six orbit data base of on-orbit derived offsets is presented and analyzed to define the sampling requirements for the CERES sensors located on the Earth Science Enterprise (ESE) Terra Spacecraft and on the Earth Observing System (EOS) Afternoon (PM-1) Spacecraft, scheduled for launches in 1999 and 2000, respectively. Analyses of the TRMM/CERES shortwave sensor earth radiance measurements indicate that offsets can be determined on-orbit at the plus or minus 0.02 Wm (exp -2) sr (exp -1) precision level. Offset measuring techniques and sampling requirements are discussed for the TRMM and ESE missions. Ground, pre-launch Terra CERES cross-track scan offsets are presented and described which were measured as a function of scan angle.

Lee, Robert B., III↗

Assessing Coulomb Collision Contributions to Photoelectron Deceleration above Earth’s Polar Caps

NASA’s Endurance rocket mission resolved a subtle energy shift in photoelectrons escaping from Earth’s polar caps, from which the first successful measurement of Earth’s ambipolar electrostatic field was made. Preflight models predicted that coulomb collisions with thermal electrons could add an extra energy shift of up to 1 eV. However, no such additional shift was reported in the initial analysis. Here, we identify a previously unreported effect related to the spacecraft wake, which introduced a systematic +0.25eV energy shift that countered and masked the shift from coulomb collisions. After applying an in-flight calibration for this wake effect, we find a total photopeak energy shift consistent with the combined influence of the ambipolar field and the subtler -0.37eV coulomb shift, predicted by the fully kinetic STET model. Further analysis of these recalibrated measurements yields an ambipolar field estimate in close agreement with the initial analysis.

Glyn A Collinson↗

Modification Of Gear Teeth To Reduce Vibrations

Computer simulations yield data useful in designing for low noise. Effects of modifications in shape of gear teeth upon static transmission error and dynamic loading of gears now analyzed systematically. Design curves generated by conducting numerical simulations of dynamic effects at successive incremental modifications of gear systems operated at various applied loads. Modifications that result in minimum dynamic effect determined from design curves.

Townsend, Dennis P.↗

MISR Level 1B1 Radiance Data (MI1B1_V1)

The results of two types of processing are included in this product. First, the Radiance Scaling operation converts the camera's digital number output to a measure of energy incident on the front optical surface. The measurement is expressed in units called radiance (energy per unit area, wavelength, and solid angle) as defined by the International Standard (SI). Second, Radiance Conditioning modifies the radiances to remove instrument-dependent effects. Specifically, image sharpening is applied, and focal-plane scattering is removed. Additionally, all radiances are adjusted to remove slight spectral sensitivity differences among the 1504 detector elements of each spectral band and each camera. The Radiometric Product contains spectral radiances for all MISR channels (four spectral bands and nine cameras). Each radiance value represents the incident radiance averaged over the sensor's total band response. Processing includes both radiance scaling and conditioning steps. Radiance scaling converts the Level 1A data from digital counts to radiances using coefficients derived in combination with the On-Board Calibrator (OBC) and vicarious calibrations. The OBC contains Spectralon calibration panels which are deployed monthly and reflect sunlight into the cameras. The OBC detector standards then measure this reflected light to provide the calibration. Vicarious field campaigns are conducted less frequently but provide an independent methodology useful for reducing systematic errors. Radiance conditioning removes undesirable instrument effects. Image enhancement is provided by deconvolving the scene with the sensor's point-spread-function. Additionally, in-band scaling adjusts the reported radiances to correspond to a nominal band response profile. This frees the Level 2 software from the need to correct for detector element non-uniformities. No out-of-band correction is done for this product, nor are the data geometrically corrected or resampled at this point. In summary, the Level 1B1 Product contains the Data Numbers (DNs) radiometrically-scaled to radiances with no geometric resampling. [Location=GLOBAL] [Temporal_Coverage: Start_Date=2000-02-24; Stop_Date=] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=275 m for red band only; Longitude_Resolution=275 m for red band only; Horizontal_Resolution_Range=250 meters - < 500 meters; Temporal_Resolution=about 15 orbits/day; Temporal_Resolution_Range=Daily - < Weekly, about 15 orbits/day, Daily - < Weekly].

EOSDIS↗

MISR Level 1B1 Radiance Data (MI1B1_V2)

The results of two types of processing are included in this product. First, the Radiance Scaling operation converts the camera's digital number output to a measure of energy incident on the front optical surface. The measurement is expressed in units called radiance (energy per unit area, wavelength, and solid angle) as defined by the International Standard (SI). Second, Radiance Conditioning modifies the radiances to remove instrument-dependent effects. Specifically, image sharpening is applied, and focal-plane scattering is removed. Additionally, all radiances are adjusted to remove slight spectral sensitivity differences among the 1504 detector elements of each spectral band and each camera. The Radiometric Product contains spectral radiances for all MISR channels (four spectral bands and nine cameras). Each radiance value represents the incident radiance averaged over the sensor's total band response. Processing includes both radiance scaling and conditioning steps. Radiance scaling converts the Level 1A data from digital counts to radiances using coefficients derived in combination with the On-Board Calibrator (OBC) and vicarious calibrations. The OBC contains Spectralon calibration panels which are deployed monthly and reflect sunlight into the cameras. The OBC detector standards then measure this reflected light to provide the calibration. Vicarious field campaigns are conducted less frequently but provide an independent methodology useful for reducing systematic errors. Radiance conditioning removes undesirable instrument effects. Image enhancement is provided by deconvolving the scene with the sensor's point-spread-function. Additionally, in-band scaling adjusts the reported radiances to correspond to a nominal band response profile. This frees the Level 2 software from the need to correct for detector element non-uniformities. No out-of-band correction is done for this product, nor are the data geometrically corrected or resampled at this point. In summary, the Level 1B1 Product contains the Data Numbers (DNs) radiometrically-scaled to radiances with no geometric resampling. [Temporal_Coverage: Start_Date=2000-02-24; Stop_Date=] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180] [Data_Resolution: Latitude_Resolution=1.1 km; Longitude_Resolution=1.1 km; Temporal_Resolution=about 15 orbits/day; Temporal_Resolution_Range=about 15 orbits/day].

AM-1↗

On the theory of silicon spectra in O and B stars

Results of a previous calculation of a grid of predicted line profiles for 36 multiplets of Si II, III, and IV over a range of model atmospheres corresponding roughly to B0-B5 in spectral type and III-IV in luminosity class are analyzed and applied to observed spectra. The overall properties of the grid of Si line equivalent widths are reviewed, the diagnostic capability of this grid is discussed, and some results are presented for the parameters of 11 B stars derived from observed Si lines. The general fit of the predictions to the observations is evaluated, and test calculations are performed to examine the effect of varying a number of important parameters. Some systematic trends in the computational results are noted which can be expressed as phenomenological 'laws'. Special attention is given to problems arising from non-LTE effects as well as to the self-consistency of analytical results obtained from unblanketed models. It is found that the Si line calculations yield good agreement in two tests for main-sequence stars between B0 and B2, but both tests give somewhat negative results for spectral types later than B2.

Kamp, L. W.↗