KEAP1 C151 active site catalysis drives electrophilic signaling to upregulate cytoprotective enzyme expression
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Schnell, Matthew R.↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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A unified expression for estimating Poisson’s ratio from a hinged–hinged beam with a use for abnormality detection
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Luceadams, Matthew J. (ORCID:0000000333123595)↗
Nonlinear Molecular Electronic Spectroscopy via MCTDH Quantum Dynamics: From Exact to Approximate Expressions
Not Available
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs
Not provided.
Biochemistry & Molecular Biology↗
An Automated Model Test System for Systematic Development and Improvement of Gene Expression Models
Not provided.
Biochemistry & Molecular Biology↗
Tuning Cell-Free Composition Controls the Time Delay, Dynamics, and Productivity of TX-TL Expression
Not provided.
Biochemistry & Molecular Biology↗
The Neurospora crassa Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in Saccharomyces cerevisiae for Bidirectional Control of Gene Expression
Not provided.
Biochemistry & Molecular Biology↗
Tuning of Gene Expression in Clostridium phytofermentans Using Synthetic Promoters and CRISPRi
Not Available
59 BASIC BIOLOGICAL SCIENCES↗
Improving Protein Expression, Stability, and Function with ProteinMPNN
Not Available
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho
Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these two paradigms are unknown. We examined whether IF in the form of every-other-day feeding enhances cognition and adult hippocampal neurogenesis (AHN) when compared to a matched 10% daily CR intake and ad libitum conditions. After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention. IF increased the number of BrdU-labeled cells and neuroblasts in the hippocampus, and microarray analysis revealed that the longevity gene Klotho (Kl) was upregulated in the hippocampus by IF only. Furthermore, we found that downregulating Kl in human hippocampal progenitor cells led to decreased neurogenesis, whereas Kl overexpression increased neurogenesis. Finally, histological analysis of Kl knockout mice brains revealed that Kl is required for AHN, particularly in the dorsal hippocampus. These data suggest that IF is superior to 10% CR in enhancing memory and identifies Kl as a novel candidate molecule that regulates the effects of IF on cognition likely via AHN enhancement.
60 APPLIED LIFE SCIENCES↗