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At least 487 records · Page 27

Multiple emission components in the Cygnus cocoon detected from Fermi -LAT observations

Star-forming regions may play an important role in the life cycle of Galactic cosmic rays (CRs), notably as home to specific acceleration mechanisms and transport conditions. Gamma-ray observations of Cygnus X have revealed the presence of an excess of hard-spectrum gamma-ray emission, possibly related to a cocoon of freshly accelerated particles. We seek an improved description of the gamma-ray emission from the cocoon using ~13 yr of observations with the Fermi-Large Area Telescope (LAT) and use it to further constrain the processes and objects responsible for the young CR population. We developed an emission model for a large region of interest, including a description of interstellar emission from the background population of CRs and recent models for other gamma-ray sources in the field. Thus, we performed an improved spectro-morphological characterisation of the residual emission including the cocoon. The best-fit model for the cocoon includes two main emission components: an extended component FCES G78.74+1.56, described by a 2D Gaussian of extension r 68 = 4.4° ± 0.1° -0.1° +0.1° and a smooth broken power law spectrum with spectral indices 1.67 ± 0.05 -0.01 +0.02 and 2.12 ± 0.02 -0.01 +0.00 below and above 3.0 ± 0.6 -0.2 +0.0 GeV, respectively; and a central component FCES G80.00+0.50, traced by the distribution of ionised gas within the borders of the photo-dissociation regions and with a power law spectrum of index 2.19 ± 0.03 -0.01 +0.00 that is significantly different from the spectrum of FCES G78.74+1.56. An additional extended emission component FCES G78.83+3.57, located on the edge of the central cavities in Cygnus X and with a spectrum compatible with that of FCES G80.00+0.50, is likely related to the cocoon. For the two brightest components FCES G80.00+0.50 and FCES G78.74+1.56, spectra and radial-azimuthal profiles of the emission can be accounted for in a diffusion-loss framework involving one single population of non-thermal particles with a flat injection spectrum. Particles span the full extent of FCES G78.74+1.56 as a result of diffusion from a central source, and give rise to source FCES G80.00+0.50 by interacting with ionised gas in the innermost region. For this simple diffusion-loss model, viable setups can be very different in terms of energetics, transport conditions, and timescales involved, and both hadronic and leptonic scenarios are possible. The solutions range from long-lasting particle acceleration, possibly in prominent star clusters such as Cyg OB2 and NGC 6910, to a more recent and short-lived release of particles within the last 10–100 kyr, likely from a supernova remnant. The observables extracted from our analysis can be used to perform detailed comparisons with advanced models of particle acceleration and transport in star-forming regions.

79 ASTRONOMY AND ASTROPHYSICS↗

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

We demonstrate a protocol for single-walled carbon nanotube functionalization using thermo-sensitive PEO-PPO-PEO triblock copolymers in an aqueous solution In a carbon nanotube/PEO105-PPO70-PEO105 (poloxamer 407) aqueous solution, the amphiphilic poloxamer 407 adsorbs onto the carbon nanotube surfaces and self-assembles into continuous layers, driven by intermolecular interactions between constituent molecules. The addition of 5-methylsalicylic acid changes the self-assembled structure from spherical-micellar to a cylindrical morphology. The fabricated poloxamer 407/carbon nanotube hybrid particles exhibit thermo-responsive structural features so that the density and thickness of poloxamer 407 layers are also reversibly controllable by varying temperature. The detailed structural properties of the poloxamer 407/carbon nanotube particles in suspension can be characterized by small-angle neutron scattering experiments and model fit analyses. The distinct curve shapes of the scattering intensities depending on temperature control or addition of aromatic additives are well described by a modified core-shell cylinder model consisting of a carbon nanotube core cylinder, a hydrophobic shell, and a hydrated polymer layer. In conclusion, this method can provide a simple but efficient way for the fabrication and in-situ characterization of carbon nanotube-based nano particles with a structure-tunable encapsulation.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Empirical model of global thermospheric temperature and composition based on data from the OGO-6 quadrupole mass spectrometer

An empirical global model for magnetically quiet conditions has been derived from longitudinally averaged N2, O, and He densities by means of an expansion in spherical harmonics. The data were obtained by the OGO-6 neutral mass spectrometer and cover the altitude range 400 to 600 km for the period 27 June 1969 to 13 May 1971. The accuracy of the analytical description is of the order of the experimental error for He and O and about three times experimental error for N2, thus providing a reasonable overall representation of the satellite observations. Two model schemes are used: one representing densities extrapolated to 450 km and one representing densities extrapolated to 120 km with exospheric temperatures inferred from N2 densities. Using the best fit model parameters the global thermospheric structure is presented in the form of a number of contour plots.

Hedin, A. E.↗

Predicting Lifetimes Of CMOS ASIC's From Test Data

Concise report discusses recent developments in use of semiempirical mathematical models to predict rates of failure and operating lifetimes of complementary metal oxide/semiconductor (CMOS) application-specific integrated circuits (ASIC's). Each model represents specific mechanism of failure. Once failure mechanisms and models relevant to given ASIC chosen, adjustable parameters in models fitted to life-test data acquired from representative integrated-circuit structures on test coupons fabricated along with ASIC's. Then design parameters of ASIC's incorporated into models, and models yield lifetimes.

Buehler, Martin G.↗

Complex Sources and Impacts on Remediation and Monitoring Approaches

Remedy selection, implementation, and coordination with tank farm activities for adjacent waste sites need to be facilitated by a technically defensible description of sources and their relative strength and temporal contributions to groundwater contamination. Detailed data describing contaminant source releases are typically not available, so source locations are highly uncertain. Furthermore, data on sources and model parameters are not readily available through direct measurements. Instead, source data are often derived by extrapolation from a few direct and/or indirect measurements, while model parameters are commonly estimated using inverse modeling or calibration methods. Because the conceptual model of sources will influence the mass and timing of the flux of contaminants to groundwater, uncertainty in the source terms should be considered. Even though a best-fit model can often be identified, it may not be the best representation of the sources given the sparse, uncertain nature of the data used for estimating source terms. To support future feasibility studies, a systematic approach is needed for identifying remediation and monitoring activities appropriate under conditions of uncertainty. In this study, an integrated assessment of alternative conceptual model elements has been examined using the B-Complex site in the Hanford Central Plateau to demonstrate how multiple sources in a waste management complex can be described to identify their relative contributions to groundwater. The heterogeneous structure of the system is modeled based on available field information on the lithological data for both the vadose zone and aquifer. The approach includes a simulation assessment and linkages to site data, with an uncertainty analysis applied to evaluate the effects of source term uncertainty on contaminant mass flux to groundwater. An integrated assessment of alternative conceptual model elements was evaluated to identify how parameter uncertainty impacts both temporal and spatial uncertainties associated with vadose zone source terms. Modeling scenarios identify important characteristics of remediation target zones to provide context for how surface barriers, in situ remedies, and water-table treatment zones can be designed to account for source dynamics. Ramifications for remediation and monitoring are discussed within the context of the source term uncertainty. The described approach facilitates systematically addressing alternative conceptual model questions in relation to remediation and monitoring and supports the remedial investigation/ feasibility study process and the remediation strategy development for the Hanford Central Plateau.

Rockhold, Mark L.↗

Complex Sources and Impacts on Remediation and Monitoring Approaches - 19058

Remedy selection, implementation, and coordination with tank farm activities for adjacent waste sites need to be facilitated by a technically defensible description of sources and their relative strength and temporal contributions to groundwater contamination. Detailed data describing contaminant source releases are typically not available, so source locations are highly uncertain. Furthermore, data on sources and model parameters are not readily available through direct measurements. Instead, source data are often derived by extrapolation from a few direct and/or indirect measurements, while model parameters are commonly estimated using inverse modeling or calibration methods. Because the conceptual model of sources will influence the mass and timing of the flux of contaminants to groundwater, uncertainty in the source terms should be considered. Even though a best-fit model can often be identified, it may not be the best representation of the sources given the sparse, uncertain nature of the data used for estimating source terms. To support future feasibility studies, a systematic approach is needed for identifying remediation and monitoring activities appropriate under conditions of uncertainty. In this study, an integrated assessment of alternative conceptual model elements has been examined using the B-Complex site in the Hanford Central Plateau to demonstrate how multiple sources in a waste management complex can be described to identify their relative contributions to groundwater. The heterogeneous structure of the system is modeled based on available field information on the lithological data for both the vadose zone and aquifer. The approach includes a simulation assessment and linkages to site data, with an uncertainty analysis applied to evaluate the effects of source term uncertainty on contaminant mass flux to groundwater. An integrated assessment of alternative conceptual model elements was evaluated to identify how parameter uncertainty impacts both temporal and spatial uncertainties associated with vadose zone source terms. Modeling scenarios identify important characteristics of remediation target zones to provide context for how surface barriers, in situ remedies, and water-table treatment zones can be designed to account for source dynamics. Ramifications for remediation and monitoring are discussed within the context of the source term uncertainty. The described approach facilitates systematically addressing alternative conceptual model questions in relation to remediation and monitoring and supports the remedial investigation/ feasibility study process and the remediation strategy development for the Hanford Central Plateau. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

The Pantheon+ Analysis: Forward Modeling the Dust and Intrinsic Color Distributions of Type Ia Supernovae, and Quantifying Their Impact on Cosmological Inferences

Abstract Recent studies have shown that the observed color distributions of Type Ia supernovae (SNe Ia) can be well described by a combination of a dust distribution and an intrinsic color distribution. Using the Pantheon+ sample of 1701 SN Ia, we apply a new forward-modeling fitting method (Dust2Dust) to measure the parent dust and color distributions, including their dependence on host-galaxy mass. At each fit step, the SN Ia selection efficiency is determined from a large simulated sample that is reweighted to reflect the proposed distributions. We use five separate metrics to describe the goodness of fit: distribution of fitted light-curve color c , cosmological residual trends with c , cosmological residual scatter with c , fitted color–luminosity relationship β SALT2 , and intrinsic scatter σ int . We present the results and the uncertainty in 12-dimensional space. Furthermore, we measure that the uncertainty on this modeling propagates to an upper threshold uncertainty in the equation of state of dark energy w of 0.014(1) for the Pantheon+ cosmology analysis and contributes negligible uncertainty to the Hubble constant H 0 . The Dust2Dust code is made publicly available at https://github.com/djbrout/dustdriver .

79 ASTRONOMY AND ASTROPHYSICS↗

Analyzing gamma-ray burst spectral data

The paper describes an improved method for calculating gamma-ray spectra of gamma-ray bursts. This method is independent of any assumed model for the incident spectrum. In many cases it makes it possible to perform chi-squared model fitting without detailed knowledge of the instrument response functions. The results of extensive calculations using simulated data and realistic response functions are presented; the Backus-Gilbert technique produces model-independent spectral estimates that are quantitatively accurate and easy to calculate.

Loredo, Thomas J.↗

Recovery of 29 Second Oscillations in Hubble Space Telescope Eclipse Observations of the Cataclysmic Variable UX Ursae Majoris

Low-amplitude (approximately 0.5%) 29 s oscillations have been detected in Hubble Space Telescope Faint Object Spectrograph eclipse observations of the nova-like cataclysmic variable UX UMa. These are the same dwarf nova-type oscillations that were originally discovered in this system in 1972. The 29 s oscillations are seen in one pair of eclipse sequences obtained with the FOS/PRISM in 1994 November but not in a similar pair obtained with the FOS/GI60L grating in August of the same year. The oscillations in the PRISM data are sinusoidal to within the small observational errors and undergo an approximately - 360' phase shift during eclipses (i.e., one cycle is lost). The amplitudes are highest at pre-eclipse orbital phases and exhibit a rather gradual eclipse whose shape is roughly similar to, although perhaps slightly narrower than, LTX UMa's overall light curve in the PRISM bandpass (2000-8000 A). Spectra of the oscillations have been constructed from pre-, mid, and post-eclipse data segments of the November observations. The spectra obtained from the out-of-eclipse segments are extremely blue, and only lower limits can be placed on the temperature of the source that dominates the modulated flux at these orbital phases. Lower limits derived from blackbody (stellar atmosphere) model fits to these data are >or equal to 95,000 K (> or equal to 85,000 K); the corresponding upper limits on the projected area of this source are all less than 2% of the white dwarf (WD) surface area. By contrast, oscillation spectra derived from mid- eclipse data segments are much redder. Fits to these spectra yield temperature estimates in the range 20,000 K approximately greater T and T approximately less than 30,000 K for both blackbody and stellar atmosphere models and corresponding projected areas of a few percent of the WD surface area. These estimates are subject to revision if the modulated emission is optically thin. We suggest that the ultimate source of the oscillations is a hot, compact region near disk center, but that a significant fraction of the observed, modulated flux is due to reprocessing of the light emitted by this source in the accretion disk atmosphere. The compact source is occulted at orbital phases near mid-eclipse, leaving only part of the more extended reprocessing region(s) to produce the weak oscillations that persist even at conjunction. The highly sinusoidal oscillation pulse shape does not permit the identification of the compact comonent in this model with emission produced by a rotating disturbance in the inner disk or in a classical, equatorial boundary layer. Instead, this component could arise in a bright spot on the surface of the WD, possibly associated with a magnetic pole. However, a standard intermediate polar model can also be ruled out since UX UMa's oscillation period has been seen to change on timescales much shorter than the minimum timescale required to spin up the WD by accretion torques. A model invoking magnetically controlled accretion onto differentially rotating WD surface layers may be viable, but needs more theoretical work.

Knigge, Christian↗

Post-Flight Back Pain Following International Space Station Missions: Evaluation of Spaceflight Risk Factors

INTRODUCTION Back pain during spaceflight has often been attributed to the lengthening of the spinal column due to the absence of gravity during both short and long-duration missions. Upon landing and re-adaptation to gravity, the spinal column reverts back to its original length thereby causing some individuals to experience pain and muscular spasms, while others experience no ill effects. With International Space Station (ISS) missions, cases of back pain and injury are more common post-flight, but little is known about the potential risk factors. Thus, the purpose of this project was to perform an initial evaluation of reported post-flight back pain and injury cases to relevant spaceflight risk factors in United States astronauts that have completed an ISS mission. METHODS All US astronauts who completed an ISS mission between Expeditions (EXP) 1 and 41 (2000-2015) were included in this evaluation. Forty-five astronauts (36 males and 9 females) completed 50 ISS missions during the study time period, as 5 astronauts completed 2 ISS missions. Researchers queried medical records of the 45 astronauts for occurrences of back pain and injury. A case was defined as any reported event of back pain or injury to the cervical, thoracic, lumbar, sacral, or coccyx spine regions. Data sources for the cases included the Flight Medicine Clinic's electronic medical record; Astronaut Strength, Conditioning and Rehabilitation electronic documentation; the Private Medical Conference tool; and the Space Medicine Operations Team records. Post-flight cases were classified as an early case if reported within 45 days of landing (R + 45) or a late case if reported from R + 46 to R + 365 days after landing (R + 1y). Risk factors in the astronaut population for back pain include age, sex, prior military service, and prior history of back pain. Additionally, spaceflight specific risk factors such as type of landing vehicle and onboard exercise countermeasures were included to evaluate their contribution to post-flight cases. Prior history of back pain included back pain recorded in the medical record within 3 years prior to launch. Landing vehicle was included in the model to discern if more astronauts experienced back pain or injury following a Shuttle or Soyuz landing. Onboard exercise countermeasures were noted for those astronauts who had a mission following 2009 deployment of the Advanced Resistive Exercise Device (aRED) (EXP 19 to 41). T-test and chi-squared tests were performed to evaluate the association between each individual risk factor and post-flight case. Logistic regression was used to evaluate the combined contribution of all the risk factors on post-flight cases. Separate models were calculated for cases reported by R + 45 and R + 1y. RESULTS During the study time period, there were 13 post-flight cases reported by R + 45 and an additional 5 reported by R + 1y. Most of these cases have been reported since EXP 19 with 10 cases by R + 45 and 4 by R + 1y. Individual risk factors of age, sex, landing vehicle, and prior military service were not significantly associated with post-flight cases identified at R + 45 or R + 1y (p greater than 0.05). Having back pain or injury within 3 years prior to launch significantly increased the likelihood of becoming a case by R + 1y (p = 0.041), but not at R+45 (p=0.204). Additionally, astronauts who experienced onboard exercise countermeasures that included aRED had a significantly increased risk of becoming a case at R + 45 (p = 0.024) and R + 1y (p=0.003). Multiple logistic regression evaluating all the risk factors for cases identified no significant risk factors at either the R + 45 or R + 1y time period (p greater than 0.05). Overall model fit was poor for both the R + 45 (R(exp 2) = 0.132) and R + 1y (R(exp 2) = 0.186) cases showing that there are risk factors not represented in our model. CONCLUSIONS Regardless of cause, post-flight cases are reported more often since aRED was deployed in 2009. This may reflect improved documentation or unidentified risk factors. No spaceflight risk factor explains the data fully. Post-flight cases are probably due to multi-faceted factors that are not easily elucidated in the medical data.

Laughlin, M. S.↗

SEC ‐ SAXS / MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes. While robust methods exist to study entirely folded or unfolded proteins, structure–function studies of combined, mixed folded/disordered proteins remain challenging. In this work, we employ orthogonal biophysical and computational techniques to provide structural characterization of mitosis‐competent human Cdt1. Thermal stability analyses shows that both folded winged helix domains1 are unstable. CD and NMR show that the N‐terminal and linker regions are intrinsically disordered. DLS shows that Cdt1 is monomeric and polydisperse, while SEC‐MALS confirms that it is monomeric at high concentrations, but without any apparent inter‐molecular self‐association. SEC‐SAXS enabled computational modeling of the protein structures. Using the program SASSIE, we performed rigid body Monte Carlo simulations to generate a conformational ensemble of structures. We observe that neither fully extended nor extremely compact Cdt1 conformations are consistent with SAXS. The best‐fit models have the N‐terminal and linker disordered regions extended into the solution and the two folded domains close to each other in apparent “folded over” conformations. We hypothesize the best‐fit Cdt1 conformations could be consistent with a function as a scaffold protein that may be sterically blocked without binding partners. Our study also provides a template for combining experimental and computational techniques to study mixed‐folded proteins.

Cell Biology↗

Generating multi-scale Li-ion battery cathode particles with radial grain architectures using stereological generative adversarial networks

Abstract Understanding structure-property relationships of Li-ion battery cathodes is crucial for optimizing rate-performance and cycle-life resilience. However, correlating the morphology of cathode particles, such as in LiNi0.8Mn0.1Co0.1O2 (NMC811), and their inner grain architecture with electrode performance is challenging, particularly, due to the significant length-scale difference between grain and particle sizes. Experimentally, it is not feasible to image such a high number of particles with full granular detail. A second challenge is that sufficiently high-resolution 3D imaging techniques remain expensive and are sparsely available at research institutions. Here, we present a stereological generative adversarial network-based model fitting approach to tackle this, that generates representative 3D information from 2D data, enabling characterization of materials in 3D using cost-effective 2D data. Once calibrated, this multi-scale model can rapidly generate virtual cathode particles that are statistically similar to experimental data, and thus is suitable for virtual characterization and materials testing through numerical simulations. A large dataset of simulated particles with inner grain architecture has been made publicly available.

25 ENERGY STORAGE↗

Hubble Space Telescope near-ultraviolet spectroscopy of bright CEMP-s stars

We present an elemental-abundance analysis, in the near-ultraviolet (NUV) spectral range, for the bright carbon-enhanced metal-poor (CEMP) stars HD 196944 (V=8.40, [Fe/H] = −2.41) and HD 201626 (V=8.16, [Fe/H] = −1.51), based on data acquired with the Space Telescope Imaging Spectrograph (STIS) on the Hubble Space Telescope. Both of these stars belong to the sub-class CEMP-s, and exhibit clear over-abundances of heavy elements associated with production by the slow neutron-capture process. HD 196944 has been well-studied in the optical region, but we add abundance results for six species (Ge, Nb, Mo, Lu, Pt, and Au) that are only accessible in the NUV. In addition, we provide the first determination of its orbital period, P = 1325 days. HD 201626 has only a limited number of abundance results based on previous optical work—here we add five new species from the NUV, including Pb. We compare these results with models of binary-system evolution and s-process element production in stars on the asymptotic giant branch, with the goal of explaining their origin and evolution. Our best-fitting models for HD 196944 (M{sub 1,i}=0.9M{sub ⊙}, M{sub 2,i}=0.86M{sub ⊙}, for [Fe/H] = −2.2), and HD 201626 (M{sub 1,i}=0.9M{sub ⊙}, M{sub 2,i}=0.76M{sub ⊙}, for [Fe/H] = −2.2; M{sub 1,i}=1.6M{sub ⊙}, M{sub 2,i}=0.59M{sub ⊙}, for [Fe/H] = −1.5) are consistent with the current accepted scenario for the formation of CEMP-s stars.

79 ASTRONOMY AND ASTROPHYSICS↗

Review of PBX 9502 Pop Plot data

Pop plot data (distance of run and time to detonation as a function of shock pressure) is a simple characterization of shock initiation of a high explosive. It is used, along with other data, to calibrate reactive burn models. For the insensitive TATB based explosive PBX 9502, there are data at 5 initial temperatures (77 K, -55 C, 23 C, 76 C, 130 C) and for several lots. Here we review the dependence of the Pop plot on temperature and the variation with lot. There is a significant increase in shock sensitivity with temperature.Since the Pop plot is important for modeling, fit parameters are interpolated to cover the temperature range –55 < T < 76 C. The scatter in the data and variation with lot is important for assessing the accuracy to which a model can be calibrated.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗

The 1973 solar occultation of the Crab Nebula pulsar

The mean electron density of the solar corona was determined by measuring the dispersion of radiofrequency pulses from pulsar NP 0532 during the June 1973 solar occultation. Trends continued which were noticed in 1971 as solar activity declined. Model fitting results suggest that the corona continued to become even more concentrated toward the equator in 1973 than in 1971. The number density of electrons in most regions decreased. The best model of the distribution of corona electrons is suggested to be one with zero density at the poles. K-corona isophotes and contours of equal path-integrated density are presented for several models. Electron density versus date and position in the corona are tabulated. It is seen that there is no simple relationship between the onset of major solar activity and density or scattering enhancements.

Weisberg, J. M.↗

Investigation of SiPM physics parameters down to cryogenic temperatures and for a bio-medical application

Silicon PhotoMultiplier (SiPM) detector has become a suitable visible light/photon detector for many applications like high energy physics and neutrino experiments, fluorescence detection, bio-photonics and medical imaging. The first part of my thesis was oriented to the studies of SiPM physics parameters as a function of temperature. Particularly, recent KETEK devices (year 2015) with different technological characteristics like p/n and n/p junctions, with and without trench technology, and different widths of epitaxial layer were studied in the temperature range from 308.15 K (+35°C) down to 238.15 K (-35°C). In addition, the Hamamatsu devices from 2011 production run as well as new devices from 2015 year, with improved technological characteristics inducing a reduced noise, were investigated in a wider temperature range from 318.15 K (+45°C) down to 98.15 K (-175°C). For these purposes, I participated to the design, installation, commissioning and calibration of a cryogenic experimental setup dedicated to electrical, optical and temperature studies of SiPM devices. Also, I have developed an automatic analysis procedure able to handle in a short time an impressive quantity of experimental data (i.e. tens of Gb/device) and to give a precise and fast information on main SiPM parameters and their temperature dependence. I have also developed a physical modeldescribing the DC I-V curves of SiPM detectors at different temperatures. The proposed model fits well the shape of IV curve in a very large currents range from 10⁻¹² A up to 10⁻⁵ A over the full working range of various devices. Consequently, the IV model can be used as a simple and fast method for determination of SiPM parameters like breakdown voltage VBD, the shape of Geiger triggering probability PGeiger as a function of Vbias as well as the Vbias working range. The comparison of these parameters with those calculated from AC measurements and analyzed by the automatic procedure showed a good agreement. The second part of my thesis was oriented to the study of SiPM devices and their physical parameters required to build a prototype of betasensitive intracerebral probe. Such probe is dedicated to measure the local concentration of radiolabeled molecules on awake and freely moving animal and to study new animal models of human disorders (neurodegenerative diseases, tumor growth, and neuropsychiatric disorders). It is composed of small size, low-noise SiPM device coupled to a scintillating fiber and readout by a dedicated miniaturized low-power consumption electronics. Three SiPM devices have been chosen as the most adapted for our application: two small KETEK devices of 0.5×0.5 mm² size (with and without optical trenches, specially developed by KETEK to fulfill our requirements) and a standard Hamamatsu device of 1.3×1.3 mm² size, all devices having 50 × 50 μm² μcell size. For each SiPM the gain G, dark count rate DCR and beta sensitivity were measured as a function of Vbias and temperature. The obtained results showed that the small field of view and newly developed structure of the KETEK devices allow a large decrease of the dark count rate DCR. However, this small field of view also leads to a reduced light collection due to the thickness of the epoxy protection resin on top of the SiPM and the acceptance angle of the fiber. Since the beta sensitivity represents a tradeoff between photon detection efficiency PDE and dark count rate DCR, KETEK SiPMs exhibit similar performances in comparison with the Hamamatsu device. Preliminary results demonstrate that the beta sensitivity of KETEK devices can be significantly improved by using focusing lens between the scintillating fiber and the SiPM or by reducing the thickness of its epoxy protection resin.

Nagai, Andrii↗

An Indication of Anisotropy in Arrival Directions of Ultra-high-energy Cosmic Rays through Comparison to the Flux Pattern of Extragalactic Gamma-Ray Sources

A new analysis of the dataset from the Pierre Auger Observatory provides evidence for anisotropy in the arrival directions of ultra-high-energy cosmic rays on an intermediate angular scale, which is indicative of excess arrivals from strong, nearby sources. The data consist of 5514 events above 20 EeV with zenith angles up to 80 deg recorded before 2017 April 30. Sky models have been created for two distinct populations of extragalactic gamma-ray emitters: active galactic nuclei from the second catalog of hard Fermi-LAT sources (2FHL) and starburst galaxies from a sample that was examined with Fermi-LAT. Flux-limited samples, which include all types of galaxies from the Swift-BAT and 2MASS surveys, have been investigated for comparison. The sky model of cosmic-ray density constructed using each catalog has two free parameters, the fraction of events correlating with astrophysical objects and an angular scale characterizing the clustering of cosmic rays around extragalactic sources. A maximum-likelihood ratio test is used to evaluate the best values of these parameters and to quantify the strength of each model by contrast with isotropy. It is found that the starburst model fits the data better than the hypothesis of isotropy with a statistical significance of 4.0 sigma, the highest value of the test statistic being for energies above 39 EeV. The three alternative models are favored against isotropy with 2.7-3.2 sigma significance. The origin of the indicated deviation from isotropy is examined and prospects for more sensitive future studies are discussed.

79 ASTRONOMY AND ASTROPHYSICS↗

Estimation of automobile-driver describing function from highway tests using the double steering wheel

The automobile-driver describing function for lateral position control was estimated for three subjects from frequency response analysis of straight road test results. The measurement procedure employed an instrumented full size sedan with known steering response characteristics, and equipped with a lateral lane position measuring device based on video detection of white stripe lane markings. Forcing functions were inserted through a servo driven double steering wheel coupling the driver to the steering system proper. Random appearing, Gaussian, and transient time functions were used. The quasi-linear models fitted to the random appearing input frequency response characterized the driver as compensating for lateral position error in a proportional, derivative, and integral manner. Similar parameters were fitted to the Gabor transformed frequency response of the driver to transient functions. A fourth term corresponding to response to lateral acceleration was determined by matching the time response histories of the model to the experimental results. The time histories show evidence of pulse-like nonlinear behavior during extended response to step transients which appear as high frequency remnant power.

Delp, P.↗