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The spacecraft ISEE-3 will be sent to encounter the Giacobini-Zinner comet in September 1985 during the period of intense Halley observations. This mission provides a unique opportunity for comparative study of important dynamical processes at both short and long term comets.
In this work we study the properties of dissipatively stabilized steady states of noisy quantum algorithms, exploring the extent to which they can be well approximated as thermal distributions, and proposing methods to extract the effective temperature T. We study an algorithm called the relaxational quantum eigensolver (RQE), which is one of a family of algorithms that attempt to find ground states and balance error in noisy quantum devices. In RQE, we weakly couple a second register of auxiliary ‘shadow’ qubits to the primary system in Trotterized evolution, thus engineering an approximate zero-temperature bath by periodically resetting the auxiliary qubits during the algorithm’s runtime. Balancing the infinite temperature bath of random gate error, RQE returns states with an average energy equal to a constant fraction of the ground state. We probe the steady states of this algorithm for a range of base error rates, using several methods for estimating both T and deviations from thermal behavior. In particular, we both confirm that the steady states of these systems are often well-approximated by thermal distributions, and show that the same resources used for cooling can be adopted for thermometry, yielding a fairly reliable measure of the temperature. These methods could be readily implemented in near-term quantum hardware, and for stabilizing and probing Hamiltonians where simulating approximate thermal states is hard for classical computers.
At the start of FY2021, the PAIN portable neutron radiography project had approximately $26K of carryover funding from the FY2020 NA-22 DNN R&D PAIN budget that was used during the period October 1-15, 2020. During this period, the carryover funding was used to continue work on qualification of the Adelphi Technology DD108.2i neutron generator prior to returning for the DT upgrade, and further develop the neutron radiography modeling and simulation effort. This project is also being funded through NA-84 for FY2021.
As the complexity and expected life-span of modern space systems continue to increase, the need for real-time data monitoring and failure analysis becomes more critical to their successful operation. The DEcision Support SYstem (DESSY) is a joint effort by the Intelligent Systems Branch/ER2 and the Remote Manipulator System (RMS) Section/DF44 to develop an expert system for the monitoring of the Payload Deployment and Retrieval System (PDRS). DESSY users, the RMS flight controllers, are provided with user interface enhancements and automated monitoring of system state (physical orientation) and status (operational health). Currently, a DESSY prototype for the Manipulator Positioning Mechanism (MPM) and Manipulator Retention Latches (MRL) of the PDRS has been developed and successfully demonstrated during the STS-49 and STS-46 missions. Expert systems for monitoring real-time operations must not only accurately represent domain knowledge, but also address the challenges of using unfiltered real-time data as input. This paper describes the methods and design strategies developed to overcome problems with real-time data in the NASA Mission Control Center. Types of data problems addressed are as follows: (1) loss of data; (2) erratic data; and (3) data lags and irregularities during state transition. Methods used to handle data problems include rule disabling for ignoring data when data quality is uncertain, context-sensitive bounded pattern recognition for minimizing incorrect conclusions based on bad data, and graceful recovery through system correction when reliable data returns. This combination of methods with an object-based modular DESSY design assures a robust program capable of lengthy periods of uninterrupted use in operations.
Transgenic animals, with the integrated target gene, provide a unique approach for measuring and characterizing mutations in any tissue of the animal. We are using the plasmid-based lacZ transgenic mice with different p53 genetic background to examine radiation-induced genetic damage resulting from exposure to heavy particle radiation. We measured lacZ mutation frequencies (MF) in the brain and spleen tissues at various times after exposing animals to an acute dose of 1 Gy of 1GeV/amu iron particles. MF in the spleen of p53+/+ animals increased up to 2.6-fold above spontaneous levels at 8 weeks post irradiation. In contrast, brain MF from the same animals increased 1.7-fold above controls in the same period. In the p53-/- animals, brain MF increased to 2.2-fold above spontaneous levels at 1 week after treatment, but returned to control levels thereafter. Radiation also induced alterations in the spectrum of mutants in both tissues, accompanied by changes in the frequency of mutants with deletions extending past the transgene into mouse genomic DNA. Our results indicate that the accumulation of transgene MF after radiation exposure is dependant on the tissue examined as well as the p53 genetic background of the animals.
Collagenase is synthesized and secreted by rat osteoblastic cells in response to PTH. We have previously demonstrated that this effect involves a substantial increase in collagenase mRNA via transcription. Northern blots and nuclear run-on assays were performed to further investigate the induction of collagenase by PTH in the rat osteoblastic cell line UMR 106-01. Detectable amounts of collagenase mRNA were not apparent until 2 h of PTH treatment, showed the greatest abundance at 4 h, and declined to approximately 30% of maximum by 8 h. The changes in the rate of transcription of the collagenase gene in response to PTH paralleled and preceded the changes in the steady state mRNA levels. After an initial lag period of about 1 h, collagenase transcription rates increased from very low levels to a maximal response at 2 h, returning to about 50% of maximum by 10 h. The increased transcriptional rate of the collagenase gene was found to be dependent on the concentration of PTH, with a half-maximal response at approximately 7 x 10(-10) M rat PTH-(1-34) and a maximal effect with a dose of 10(-8) M. The PTH-mediated induction of collagenase transcriptional activity was completely abolished by cycloheximide, while transcription of the beta-actin gene was unaffected by the translation inhibitor. These data suggest that a protein factor(s) is required for PTH-mediated transcriptional induction of collagenase. Since PTH increases intracellular levels of several potential second messengers, agents that mimic these substances were employed to determine which signal transduction pathway is predominant in the PTH-mediated stimulation of collagenase transcription.(ABSTRACT TRUNCATED AT 250 WORDS).
The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (hereafter JSC curation) is the past, present, and future home of all of NASA's astromaterials sample collections. JSC curation currently houses all or part of nine different sample collections: (1) Apollo samples (1969), (2) Lunar samples (1972), (3) Antarctic meteorites (1976), (4) Cosmic Dust particles (1981), (5) Microparticle Impact Collection (1985), (6) Genesis solar wind atoms (2004); (7) Stardust comet Wild-2 particles (2006), (8) Stardust interstellar particles (2006), and (9) Hayabusa asteroid Itokawa particles (2010). Each sample collection is housed in a dedicated clean room, or suite of clean rooms, that is tailored to the requirements of that sample collection. Our primary goals are to maintain the long-term integrity of the samples and ensure that the samples are distributed for scientific study in a fair, timely, and responsible manner, thus maximizing the return on each sample. Part of the curation process is planning for the future, and we also perform fundamental research in advanced curation initiatives. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of sample collections, or getting new results from existing sample collections [2]. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, and curation of organically- and biologically-sensitive samples. As part of these advanced curation efforts we are augmenting our analytical facilities as well. A micro X-Ray computed tomography (micro-XCT) laboratory dedicated to the study of astromaterials will be coming online this spring within the JSC Curation office, and we plan to add additional facilities that will enable nondestructive (or minimally-destructive) analyses of astromaterials in the near future (micro-XRF, confocal imaging Raman Spectroscopy). These facilities will be available to: (1) develop sample handling and storage techniques for future sample return missions; (2) be utilized by PET for future sample return missions; (3) be used for retroactive PET (Positron Emission Tomography)-style analyses of our existing collections; and (4) for periodic assessments of the existing sample collections. Here we describe the new micro-XCT system, as well as some of the ongoing or anticipated applications of the instrument.
The Astromaterials Acquisition and Curation Office at NASA's Johnson Space Center (hereafter JSC curation) is the past, present, and future home of all of NASA's astromaterials sample collections. JSC curation currently houses all or part of nine different sample collections: (1) Apollo samples (1969), (2) Lunar samples (1972), (3) Antarctic meteorites (1976), (4) Cosmic Dust particles (1981), (5) Microparticle Impact Collection (1985), (6) Genesis solar wind atoms (2004); (7) Stardust comet Wild-2 particles (2006), (8) Stardust interstellar particles (2006), and (9) Hayabusa asteroid Itokawa particles (2010). Each sample collection is housed in a dedicated clean room, or suite of clean rooms, that is tailored to the requirements of that sample collection. Our primary goals are to maintain the long-term integrity of the samples and ensure that the samples are distributed for scientific study in a fair, timely, and responsible manner, thus maximizing the return on each sample. Part of the curation process is planning for the future, and we also perform fundamental research in advanced curation initiatives. Advanced Curation is tasked with developing procedures, technology, and data sets necessary for curating new types of sample collections, or getting new results from existing sample collections [2]. We are (and have been) planning for future curation, including cold curation, extended curation of ices and volatiles, curation of samples with special chemical considerations such as perchlorate-rich samples, and curation of organically- and biologically-sensitive samples. As part of these advanced curation efforts we are augmenting our analytical facilities as well. A micro X-Ray computed tomography (micro-XCT) laboratory dedicated to the study of astromaterials will be coming online this spring within the JSC Curation office, and we plan to add additional facilities that will enable nondestructive (or minimally-destructive) analyses of astromaterials in the near future (micro-XRF, confocal imaging Raman Spectroscopy). These facilities will be available to: (1) develop sample handling and storage techniques for future sample return missions; (2) be utilized by PET for future sample return missions; (3) be used for retroactive PET (Positron Emission Tomography)-style analyses of our existing collections; and (4) for periodic assessments of the existing sample collections. Here we describe the new micro-XCT system, as well as some of the ongoing or anticipated applications of the instrument.
The key goal of the Spaceflight Standard Measures project is to ensure that a set of measures, representing the Human Research Program’s key risks and acquired with minimal impact on time and resources, is consistently captured from crewmembers through the end of the International Space Station (ISS) Program. Data collected under the Spaceflight Standard Measures project include assessments of sleep/wake cycles, cognition, immune status and function, general blood and urine chemistry (urine is collected only before flight and after landing), microbiome composition (gastrointestinal tract, saliva, and body surface), cardiovascular structure and function (carotid intima-media thickness, orthostatic responses), sensorimotor function, and team processes. Data is collected once or twice before the flight (180 and 90 days before launch), twice during the 6-month missions (fight day 30 and 30 days before return to Earth) with the exception of actigraphy, which is recorded continuously during the mission, and during two-week periods before and after the mission. In this presentation, we will review the data collected to date on twelve ISS crew members. These data are placed in the NASA Life Sciences Data Archive and are available for occupational surveillance (using non-identifiable data) Institutional Review Board-approved data sharing requests, and retrospective data requests. This data repository enables high-level monitoring of the effectiveness of countermeasures and meaningful interpretation of health and performance outcomes for various mission durations. The knowledge gained from this project informs and supports future hypothesis-driven research that will enable the success of planetary missions.
As the future of spaceflight focuses on human exploration beyond low Earth orbit (BLEO), space biology experiments using model organisms are becoming increasingly important. NASA’s Artemis missions seek to build technologies that enable extended crewed flights into deep space, a region not travelled by humans for over 50 years. From the Apollo missions and ground experiments, it is known that BLEO galactic cosmic radiation can cause damage to DNA and proteins, as well as an increased risk of cancer to astronauts. NASA’s latest biosensor technology, the Lunar Explorer Instrument for space biology applications (LEIA), builds upon the viable and cost-effective platform of CubeSats to take biology experiments back to the Moon. Stationed on the lunar South Pole, LEIA will collect valuable in-situ radiation data, and use yeast to study the response to combined partial gravity and radiation stressors, as well as provide a proof-of-concept of on-demand bio nutrient production as a countermeasure for future crewed missions. Directly enhancing the abilities of the BioSentinel CubeSat mission, the main components of LEIA are the two radiation sensors and the 4U BioSensor, composed of 16-microfluidic cards housing dried yeast cells. The payload is fully contained and autonomous, directly sending data back to Earth without the need for sample return. In addition, the thermal environment of the BioSensor is optimized to keep cells alive for the pre-launch period and duration of the Artemis III mission, while also running on limited power supply. This talk highlights how the development of flexible instruments, like LEIA, enables human exploration into deep space. The technology developed with LEIA can be used as a stepping-stone for establishing a sustained lunar surface habitation and beyond, as humans continue to venture into space.
Different types of materials are being considered for fuel, cladding, and structures in existing and advanced nuclear reactors. These materials can undergo significant dimensional and physical changes during irradiation. Currently in the US, such changes are measured with the ‘cook and look’ method (i.e. repeatedly irradiating a specimen for a specified period of time and then removing it from the reactor for evaluation). The time and labor to remove, examine, and return irradiated samples for each measurement makes this approach expensive. In addition, such techniques provide limited data, and handling may disturb the phenomena of interest. Therefore, in-pile detection of changes in geometry is sorely needed to understand real-time behavior during irradiation testing of fuels and materials in high flux US Material and Test Reactors (MTRs). This paper presents development results of an advanced Linear Variable Differential Transformer (LVDT)-based test rig capable of detecting real-time changes in diameter or length of fuel rods or other material samples during irradiation in US MTRs. This test rig is being developed at the Idaho National Laboratory (INL), and will provide experimenters with a unique capability to measure dimensional changes associated with fuel and clad swelling, pellet-clad interaction, and crud buildup. This novel LVDT design uses the MTR’s loop pressure to drive the test specimen at a constant rate. This leads to a simplified construction, that is, the use of fewer components than other diameter gauge test rigs. This simplified design only requires three pressure boundary penetrations. Further, a key component of this test rig is a leak tight hydraulic ram capable of actuating under low differential pressure, and is able to survive the high irradiation tests at Pressurized Water Reactor (PWR) conditions. The sensor has been proven on a benchtop scale, and shows repeatability and reliability. Measurement accuracies of ±3 µm for diameter and ±90 µm for length have been achieved.
According to article 6 of the German Atomic Energy Act (AtG), storage of Spent Nuclear Fuel requires a license. The competent licensing authority in this field is the Federal Office for Safety of Nuclear Waste Management (BfE). According to the Act for selecting a repository site for heat-generating radioactive waste (HAW) (Site Selection Act - StandAG) dating from 2017, BfE has been assigned the task of developing, conducting, and evaluating public participation procedures in the process of site search and selection for a deep geological repository for radioactive waste and SNF. Article 6 AtG applies to interim storage of SNF. If the legally defined licensing conditions by article 6 (2) AtG are met, the storage license applied for has to be granted. For on-site facilities, interim storage has been limited to 40 years. The licensing procedures for interim storage of SNF are carried out in accordance with the general administrative procedural rules. In certain cases due to the Environmental Impact Assessment Act (EIA Act), an EIA has to be carried out. In these cases, a formalized licensing procedure including an involvement of the public is conducted. The Nuclear Licensing Procedure Ordinance (AtVfV) originating from 1977 and reformulated in 1995 defines formalized rules for the public participation procedure which have to be followed strictly. These include a public hearing. The risen objections are evaluated by the licensing authority and taken account of in the licensing decision. The process of repository site selection defined by the StandAG exceeds these formalized procedures significantly: The objective of this process is to achieve a broad social consensus about the site selection procedure and about a repository site that will offer the best possible safety for one million years. Therefore, the process has to be particularly transparent, and involvement of the public - including newly developed forms of public involvement - is an essential part of it. BfE as competent authority in both the fields of repository site search and selection and licensing of interim storage of SNF has recently developed new strategies of involving the public concerning interim storage of SNF. Supplementing the standard licensing procedures, BfE presently informs and involves the public about topical issues regarding the present state and recent developments in the field of interim storage of SNF. Current central topics are for example the return of HAW and MAW from reprocessing of SNF in France and UK as well as perspective longer interim storage periods on the interface with final disposal. Regarding longer interim storage, host communities of interim storage facilities are concerned that interim storage might be extended indefinitely. Additionally, there is a strong fear of transports of radioactive waste and SNF from one place to another. (authors)
The sources of molecular deposits on a Temperature-Controlled Quartz Crystal Microbalance (TQCM) attached to the shuttle bay wall at some distance from the payload and pointing out of the bay have been investigated. Explored as possible sources are: (1) the outgassing of the shuttle tiles treated with the water proofing di-methyl-ethoxy-silane (DMES) compound, scattered back by the ambient molecules into the bay; (2) The ambient scattered return flux of the outgassing, from the RTV 560 silicone which is used as the adhesive for the tiles; (3) the ambient scattered return flux of the payload outgassing; (4) the return C, flux from outgassing source originating near, below, or adjacent to the package containing the TQCM; and (5) the self-scattering of venting plumes and outgassing above the monitor package depositing on the TQCM. In all of these sources, the magnitudes of the outgassing, of the leakage rates, and venting had to be estimated in the absence of data. The resulting analyses which can be useful for similar investigations, indicates that the outgassin- from the tiles, the RTV, the payloads, or the shuttle may not have been the sources of the deposit (about 1 micro g/cm(sup 2) during a the period from bay door opening and payload release from the bay). It appears more probable that the origin is the self- and/or ambient-scattered return fluxes originating near, below, or internal to the monitor package.
The OSIRIS-REx spacecraft launched on September 8, 2016, on a seven-year journey to return samples from asteroid (101955) Bennu. This presentation summarizes the scientific results from the Approach and Preliminary Survey phases. Bennu observations are set to begin on August 17, 2018,when the asteroid is bright enough for detection by the PolyCam. PolyCam and MapCam collect data to survey the asteroid environment for any hazards and characterize the asteroid point-source photometric properties. Resolved images acquired during final approach, starting in late October 2018, allow the creation of a shape model using stereophotoclinometry (SPC), needed by both the navigation team and science planners. The OVIRS and OTES spectrometers characterize the point- source spectral properties over a full rotation period, providing a first look at any features and thermophysical properties. TAGSAM is released from the launch container and deployed into the sampling configuration then returned to the stow position.Preliminary Survey follows the Approach Phase in early December 2018. This phase consists of a series of hyperbolic trajectories that cross over the North and South poles and the equator of Bennu at a close-approach distance of 7 km. Images from these Preliminary Survey passes provide data to complete the 75-cm resolution SPC global shape model and solve for the rotation state. Once the shape model is complete, the asteroid coordinate system is defined for co-registration of all data products. These higher-resolution images also constrain the photometric properties and allow for an initial assessment of the geology. In Preliminary Survey the team also obtains the first OLA data, providing a measure of the surface topography. OVIRS and OTES collect data as "ride-along" instruments, with the spacecraft pointing driven by imaging constraints. These data provide a first look at the spectral variation across the surface of Bennu. Radio science measurements, combined with altimetry and imagery, determine Bennu's mass, a prerequisite to placing the spacecraft into orbit in late December 2018. Together, data from the Approach and Preliminary Survey phases set the stage for the extensive mapping planned for 2019. These dates are the baseline plan. Any contingency or unexpected discovery may change this mission profile.
The Collisions Into Dust Experimental (COLLIDE-2) was the second flight of the COLLIDE payload. The payload performs six low-velocity impact experiments to study the collisions that are prevalent in planetary ring systems and in the early stages of planet formation. Each impact experiment is into a target of granular material, and the impacts occur at speeds between 1 and 100 cm/s in microgravity and in a vacuum. The experiments are recorded on digital videotape which is later analyzed. During the period of performance a plan was developed to address some of the technical issues that prevented the first flight of COLLIDE from being a complete success, and also to maximize the scientific return based on the science results from the first flight. The experiment was modified following a series of reviews of the design plan, and underwent extensive testing. The data from the experiment show that the primary goal of identifying transition regimes for low-velocity impacts based on cratering versus accretion was achieved. Following a brief period of storage, the experiment flew regimes for low-velocity impacts based on cratering versus accretion was achieved. as a Hitchhiker payload on the MACH-1 Hitchhiker bridge on STS-108 in December 2001. These data have been analyzed and submitted for publication. That manuscript is attached to this report. The experiment was retrieved in January 2002, and all six impact experiments functioned nominally. Preliminary results were reported at the Lunar and Planetary Science Conference.
Astronauts returning from space flight experience locomotor dysfunction following their return to Earth. Our laboratory is currently developing a gait adaptability training program that is designed to facilitate recovery of locomotor function following a return to a gravitational environment. The training program exploits the ability of the sensorimotor system to generalize from exposure to multiple adaptive challenges during training so that the gait control system essentially learns to learn and therefore can reorganize more rapidly when faced with a novel adaptive challenge. Evidence for the potential efficacy of an adaptive generalization gait training program can be obtained from numerous studies in the motor learning literature which have demonstrated that systematically varying the conditions of training enhances the ability of the performer to learn and retain a novel motor task. These variable practice training approaches have been used in applied contexts to improve motor skills required in a number of different sports. The central nervous system (CNS) can produce voluntary movement in an almost infinite number of ways. For example, locomotion can be achieved with many different combinations of joint angles, muscle activation patterns and forces. The CNS can exploit these degrees of freedom to enhance motor response adaptability during periods of adaptive flux like that encountered during a change in gravitational environment. Ultimately, the functional goal of an adaptive generalization countermeasure is not necessarily to immediately return movement patterns back to normal. Rather the training regimen should facilitate the reorganization of available sensory and motor subsystems to achieve safe and effective locomotion as soon as possible after long duration space flight. Indeed, this approach has been proposed as a basic feature underlying effective neurological rehabilitation. We have previously confirmed that subjects participating in an adaptive generalization training program using a variety of visuomotor distortions and throwing as the dependent measure can learn to enhance their ability to adapt to a novel sensorimotor environment (Roller et al., 2001). Importantly, this increased adaptability was retained even one month after completion of the training period. Adaptive generalization has been observed in a variety of other tasks requiring sensorimotor transformations including manual control tasks and reaching (Bock et al., 2001, Seidler, 2003) and obstacle avoidance during walking (Lam and Dietz, 2004). Taken together, the evidence suggests that a training regimen exposing crewmembers to variation in locomotor conditions, with repeated transitions among states, may enhance their ability to learn how to reassemble appropriate locomotor patterns upon return from microgravity. We believe exposure to this type of training will extend crewmembers locomotor behavioral repertoires, facilitating the return of functional mobility after long duration space flight. In other words, our proposed training protocol will compel subjects to develop new behavioral solutions under varying sensorimotor demands. Over time subjects will learn to create appropriate locomotor solution more rapidly enabling acquisition of mobility sooner after long-duration space flight. A gait adaptability training program can be superimposed on nominal treadmill exercise activities thus ensuring that no additional crew time is required to perform this type of training regimen and that it can be implemented with current in-flight exercise systems available on the International Space Station.
Attention is given to a personnel-carrying space vehicle concept developed to minimize the cost of access to LEO. The RUPC could provide alternate access to Space Station Freedom (SSF) for six passengers per flight. It can also bring and return small amounts of cargo, up to and including one SSF double rack. These capabilities are ideal for utilization flights during man-tended operations at SSF and for crew rotation during permanently manned periods. The RUPC is a reusable conical reentry vehicle and disposable adapter with propulsion and power subsystems. Avionics subsystem benefit from advanced low-power high-performance microelectronics developed for both the civilian and military space sectors. The RUPC core cabin concept has growth potential for other applications, including assured crew return, ground-launched crew rescue, delivery and retrieval of SSF cargo, and crew cabin for flights to the moon.
The Stardust spacecraft carried the first spaceborne collector specifically designed to capture and return a sample of contemporary interstellar dust to terrestrial laboratories for analysis [1]. The collector was exposed to the interstellar dust stream in two periods in 2000 and 2002 with a total exposure of approximately 1.8 10(exp 6) square meters sec. Approximately 85% of the collector consisted of aerogel, and the remainder consisted of Al foils. The Stardust Interstellar Preliminary Examination (ISPE) was a consortiumbased effort to characterize the collection in sufficient detail to enable future investigators to make informed sample requests. Among the questions to be answered were these: How many impacts are consistent in their characteristics with interstellar dust, with interplanetary dust, and with secondary ejecta from impacts on the spacecraft? Are the materials amorphous or crystalline? Are organics detectable? An additional goal of the ISPE was to develop or refine the techniques for preparation, analysis, and curation of these tiny samples, expected to be approximately 1 picogram or smaller, roughly three orders of magnitude smaller in mass than the samples in other small particle collections in NASA's collections - the cometary samples returned by Stardust, and the collection of Interplanetary Dust Particles collected in the stratosphere.