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At least 487 records · Page 27

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DOE OSTI2023

Case report: Fatal Legionella infection diagnosed via by metagenomic next-generation sequencing in a patient with chronic myeloid leukemia

Legionella is an aerobic, gram-negative, intracellular pathogen and is an important cause of community-acquired pneumonia. Legionella pneumophila is the most common causative agent of Legionella pneumonia. Clinical diagnosis of Legionella pneumonia is challenging due to the lack of specific clinical manifestations and the low positive rates of conventional pathogen detection methods. In this study, we report a case of a patient with chronic myeloid leukemia who developed rigors and high fever after chemotherapy and immunotherapy. Chest computed tomography revealed consolidation in the left lower lobe of the lung and ground-glass opacities in both lower lobes. Multiple blood cultures showed Escherichia coli , Staphylococcus aureus , Bacillus licheniformis , and positive results in the β-D-glucan test (G test). The patient was treated with various sensitive antimicrobial agents, including meropenem plus fluconazole, meropenem plus carpofungin, and vancomycin. Unfortunately, the patient’s condition gradually worsened and eventually resulted in death. On the following day of death, metagenomic next-generation sequencing (mNGS) of 1whole blood revealed L. pneumophila pneumonia with concurrent bloodstream infection (blood mNGS reads 114,302). These findings suggest that when conventional empirical antimicrobial therapy proves ineffective for critically ill patients with pneumonia, the possibility of combined Legionella infection must be considered, and mNGS can provide a diagnostic tool in such cases.

Bu, Chunhong↗

DOE OSTI2020

Next-Generation Intensity-Duration-Frequency Curves for Climate-Resilient Infrastructure Design: Advances and Opportunities

National and international security communities (e.g., U.S. Department of Defense) have shown increasing attention for innovating critical infrastructure and installations due to recurring high-profile flooding events in recent years. The standard infrastructure design approach relies on local precipitation-based intensity-duration-frequency (PREC-IDF) curves that do not account for snow process and assume stationary climate, leading to high failure risk and increased maintenance costs. This paper reviews the recently developed next-generation IDF (NG-IDF) curves that explicitly account for the mechanisms of extreme water available for runoff including rainfall, snowmelt, and rain-on-snow under nonstationary climate. The NG-IDF curve is an enhancement to the PREC-IDF curve and provides a consistent design approach across rain- to snow-dominated regions, which can benefit engineers and planners responsible for designing climate-resilient facilities, federal emergency agencies responsible for the flood insurance program, and local jurisdictions responsible for developing design manuals and approving subsequent infrastructure designs. Further, we discuss the recent advances in climate and hydrologic science communities that have not been translated into actional information in the engineering community. To bridge the gap, we advocate that building climate-resilient infrastructure goes beyond the traditional local design scale where engineers rely on recipe-based methods only; the future hydrologic design is a multi-scale problem and requires closer collaboration between climate scientists, hydrologists, and civil engineers.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2020

Advancing How We Learn from Biodesign to Mitigate Risks with Next-Generation Genome Engineering

In the last decade, the unprecedented simplicity and flexibility of the CRISPR-Cas system has made it the dominant transformative tool in gene and genome editing. However, this democratized technology is both a boon and a bane, for which we have yet to understand the full potential to investigate and rewrite genomes (also named “genome biodesign”). Rapid CRISPR advances in a range of applications in basic research, agriculture, and clinical applications pose new risks and raise several biosecurity concerns. In such a fast-moving field of research, we emphasize the importance of properly communicating the quality and accuracy of results and recommend new reporting requirements for results derived from next-generation genome engineering.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2020

The Nucleosynthetic Yields of Core-collapse Supernovae: Prospects for the Next Generation of Gamma-Ray Astronomy

Though the neutrino-driven convection model for the core-collapse explosion mechanism has received strong support in recent years, there are still many uncertainties in the explosion parameters—such as explosion energy, remnant mass, and end-of-life stellar abundances as initial conditions. Using a broad set of spherically symmetric core-collapse simulations we examine the effects of these key parameters on explosive nucleosynthesis and final explosion yields. The post-bounce temperature and density evolution of zero-age main-sequence 15, 20, and 25 solar mass progenitors are post-processed through the Nucleosynthesis Grid nuclear network to obtain detailed explosive yields. In particular, this study focuses on radio isotopes that are of particular interest to the next generation of gamma-ray astronomical observations: 43 K, 47 Ca, 44 Sc, 47 Sc, 48 V, 48 Cr, 51 Cr, 52 Mn, 59 Fe, 56 Co, 57 Co, and 57 Ni. Furthermore, these nuclides may be key in advancing our understanding of the inner workings of core-collapse supernovae by probing the parameters of the explosion engine. We find that the isotopes that are strong indicators of explosion energy are 43 K, 47 Ca, 44 Sc, 47 Sc, and 59 Fe, those that are dependent on the progenitor structure are 48 V, 51 Cr, and 57 Co, and those that probe neither are 48 Cr, 52 Mn, 57 Ni, and 56 Co. We discuss the prospects of observing these radionuclides in supernova remnants.

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2020

Constraining Properties of the Next Nearby Core-collapse Supernova with Multimessenger Signals

With the advent of modern neutrino and gravitational wave (GW) detectors, the promise of multimessenger detections of the next galactic core-collapse supernova (CCSN) has become very real. Such detections will give insight into the CCSN mechanism and the structure of the progenitor star, and may resolve longstanding questions in fundamental physics. In order to properly interpret these detections, a thorough understanding of the landscape of possible CCSN events, and their multimessenger signals, is needed. We present detailed predictions of neutrino and GW signals from 1D simulations of stellar core collapse, spanning the landscape of core-collapse progenitors from 9 to 120 M ⊙ . In order to achieve explosions in 1D, we use the Supernova Turbulence In Reduced-dimensionality model, which includes the effects of turbulence and convection in 1D supernova simulations to mimic the 3D explosion mechanism. We study the GW emission from the 1D simulations using an astroseismology analysis of the protoneutron star. We find that the neutrino and GW signals are strongly correlated with the structure of the progenitor star and remnant compact object. Using these correlations, future detections of the first few seconds of neutrino and GW emission from a galactic CCSN may be able to provide constraints on stellar evolution independent of preexplosion imaging and the mass of the compact object remnant prior to fallback accretion.

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2022

SALT3-NIR: Taking the Open-source Type Ia Supernova Model to Longer Wavelengths for Next-generation Cosmological Measurements

Abstract A large fraction of Type Ia supernova (SN Ia) observations over the next decade will be in the near-infrared (NIR), at wavelengths beyond the reach of the current standard light-curve model for SN Ia cosmology, SALT3 (∼2800–8700 Å central filter wavelength). To harness this new SN Ia sample and reduce future light-curve standardization systematic uncertainties, we train SALT3 at NIR wavelengths (SALT3-NIR) up to 2 μ m with the open-source model-training software SALTshaker , which can easily accommodate future observations. Using simulated data, we show that the training process constrains the NIR model to ∼2%–3% across the phase range (−20 to 50 days). We find that Hubble residual (HR) scatter is smaller using the NIR alone or optical+NIR compared to optical alone, by up to ∼30% depending on filter choice (95% confidence). There is significant correlation between NIR light-curve stretch measurements and luminosity, with stretch and color corrections often improving HR scatter by up to ∼20%. For SN Ia observations expected from the Roman Space Telescope, SALT3-NIR increases the amount of usable data in the SALT framework by ∼20% at redshift z ≲ 0.4 and by ∼50% at z ≲ 0.15. The SALT3-NIR model is part of the open-source SNCosmo and SNANA SN Ia cosmology packages.

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2025

Transforming Windows from Energy Liabilities to Zero-Energy Assets: Next-Generation Solutions for Buildings

Windows have traditionally contributed to a building's HVAC load, but they can also become a source of net energy gain or even operate as zero-energy components. For heating applications, highly insulating windows can harness more solar heat than the energy lost through them, transforming windows from energy liabilities to assets. Dynamic glazings provide further benefits by regulating solar heat gain, reducing cooling loads in summer and heating demands in winter. This simulation study focuses on developing the next generation of zero-energy windows (ZEW) for residential new construction. Through annual energy simulations across climate zones 1-8, ZEW performance benchmarks were established based on current code-level buildings, and we've identified the regions where meeting ZEW standards are most achievable. This work evaluates both static and dynamic window technologies, assessing their effects on annual energy use and cost. Key findings demonstrate that ZEW performance is achievable across diverse climate zones, with specific regional requirements. Most climate zones from 3-8 can achieve ZEW with specific configurations, while some warm climates (1-2) appear challenging for ZEW implementation. Climate zones 4-6 consistently allow for zero energy window implementation, offering multiple pathways through either static or dynamic window technologies. Colder climate zones (7-8) ZEW products allow for higher SHGC values while requiring low U-values.

Yu, Lili↗

NASA NTRS1977

Patterns of broad-beam antennas of different polarizations next to simple Hangar models

Broad-beam antennas of different polarizations radiating next to simple hangar models are investigated. Expressions that represent the elevation-plane patterns of slots in and 1/4 wavelength monopoles on a finite rectangular ground plane upon which a rectangular scattering object was placed were derived using geometrical theory of diffraction. These expressions were obtained by superposing the infinite ground plane solutions, reflected field solutions from the scattering object and diffracted field solutions in their respective regions of validity. Patterns for a 1/2 wavelength slot and 1/4 wavelength electric monopole are verified experimentally for a number of source locations. Data pertaining to the polarization question in regard to the multipath problem are presented.

Cockrell, C. R.↗

NASA NTRS1979

Developing the next phase in NASA's satellite communications program

Since 1973, NASA has conducted hundreds of user experiments and demonstrations using the Applications Technology Satellites ATS-1, -3, and -6, and the Communications Technology Satellite CTS. Now, projections show that the commercial demand will continue to increase, soon exceeding the current technology's capacity. The next phase in NASA's satellite communication program include 30/20 GHz Ka-band technology, extending the current work in advanced multibeam antennas; a narrow-band system and technology study that could lead to mobile and transportable communication developments; and studies of future uses of technology in communications.

Dement, D. K.↗

NASA NTRS1980

Planetary spacecraft pointing and control - The next 20 years

Pointing and control systems recommended for NASA planetary exploration missions of the next twenty years are discussed. The functional and operational requirements and design constraints imposed on the driving control system by the mission and science goals of the spacecraft are examined. Criteria for the selection of a pointing and control system type (spin, dual-spin, three-axis active or momentum bias) are outlined, including payload functional characteristics, orbital characteristics, vehicle configuration and mission duration, and candidate system types proposed for preliminary survey, detailed remote observation, deep space close scrutiny, near-sun close scrutiny and sample return missions are indicated. Trends in control system design are discussed, and key enabling technology areas that will require additional or new development are considered, with particular emphasis on laser and fiber optics gyros, CCD arrays and DMA signal/power transmission, bearings and motor technologies, directed at three-axis active and dual-spin implementations.

Mcglinchey, L. F.↗

NASA NTRS1983

An advanced control system for a next generation transport aircraft

The use of modern control theory to develop a high-authority stability and control system for the next generation transport aircraft is described with examples taken from work performed on an advanced pitch active control system (PACS). The PACS was configured to have short-period and phugoid modes frequency and damping characteristics within the shaded S-plane areas, column force gradients with set bounds and with constant slope, and a blended normal-acceleration/pitch rate time history response to a step command. Details of the control law, feedback loop, and modal control syntheses are explored, as are compensation for the feedback gain, the deletion of the velocity signal, and the feed-forward compensation. Scheduling of the primary and secondary gains are discussed, together with control law mechanization, flying qualities analyses, and application on the L-1011 aircraft.

Rising, J. J.↗

NASA NTRS1984

The next generation of reentry vehicles: NASA's view

The term reentry vehicle is used in the broad sense. The vehicles addressed include not only those that return from orbit to the Earth's surface, but also aeroassisted orbit transfer vehicles that use aerodynamic forces generated during atmospheric passes to achieve orbital changes with a smaller expenditure of energy than is required for an all-propulsion vehicle. Advanced reusable launch vehicles with special emphasis on system concepts and the influence of advanced technology on entry vehicle configuration are considered. Three categories of orbital transfer vehicles discussed: synergetic plane-change vehicles, planetary aerocapture vehicles, and LEO to GEO orbital transfer vehicles. While the orbital transfer and planetary vehicles are quite different from conventional winged Earth entry vehicles, synergetic plane change and high cross-range Earth entry vehicles have many similarities. Finally, a possible scenario for the development of the next generation of reentry vehicles is presented.

Walberg, G. D.↗

NASA NTRS1984

A next generation microdensitometer?

Motivations for construction of a next generation microdensitometer (NGM) are presented and their effect on the NGM design is discussed. A prototype of such an engine has been constructed at KPNO. Its design and performance is reviewed.

Monet, D. G.↗

NASA NTRS1982

The next generation microwave sounder for weather satellites

Microwave sounders are multichannel microwave radiometers for measuring atmospheric temperature (or humidity) profiles. These devices are also known as microwave spectrometers because a sounder typically has a number of channels measuring the spectral shape of an absorption line. Each channel of the sounder responds essentially to a given layer of the atmosphere. The characteristics of currently employed microwave sounders on satellites are briefly examined, and new features expected in connection with the introduction of the next generation sounders are discussed. There will probably be an increase in the number of oxygen channels with the objective to extend the weighting function height coverage into the stratosphere and to improve the temperature retrieval accuracy. Other features are to be related to better surface resolution, auxiliary channels, and water vapor sounding.

Shiue, J. C.↗

NASA NTRS1982

Observational parameters for remote sensing in the next decade

The spectral and spatial requirements for remote sensing in the next decade are presented. The requirements presented were obtained through extensive literature research and discussions with leading members of the various remote sensing research communities. In the 0.35-2.5 micron region of the spectrum, numerous bands will be needed at bandwidths as narrow as 10-20 nanometers. There is also growing interest in the thermal infrared (8-14 microns). Spatial resolution (instantaneous field of view) of 5 to 10 meters will be of great benefit to many fields of remote sensing.

Vane, G.↗

NASA NTRS1984

Space simulation in the next 20 years

This is a brief overview of logically expected advancements in the area of space simulation over the next twenty years. Current NASA Space Shuttle simulations will be upgraded to support more complex payload and on-orbit tasks. This includes the ability to integrate various remote ground facilities with a real time space mission simulator and an expanded use of efficient part-task simulations. Software compatibilities between simulators will increase and each simulator will have a more combined training and engineering role. Software development processors will be increasingly internetted to an integrated data processing system.

Knorre, M. J.↗

NASA NTRS1984

Space station - The next logical step

NASA has been charged with the development, over the next decade, of a permanently manned space station in low earth orbit. The space station system will comprise a manned base and associated unmanned platforms; while one of the platforms will be in polar orbit, another (or several) platforms will, like the manned base, have an orbital inclination of 28.5 deg. Because it is permanent, the space station will have to be semiautonomous from its mission control center. NASA will take a number of steps to foster the commercial utilization of the space station, and one of the design goals of the project is the definition of astronaut facilities that are very 'customer friendly'. Reliance on a single, program-wide contractor has been deemed undesirable; several major aerospace manufacturers will instead distribute responsibility among themselves for the various modules constituting the craft.

Beggs, J. M.↗

NASA NTRS1984

Planetary cartography in the next decade (1984 - 1994)

The cartographic products required to support science and planetary exploration during the next 10 years were assessed. Only major map series or first order maps needed to characterize the surface physiography of a planet or satellite were considered. Included in these considerations are maps needed as bases for plotting geologic, geophysical, and atmospheric phenomena and for planning future planetary exploration. These products consist of three types of maps: controlled photomosaics, shaded relief maps, and topographic contour maps.

Source record↗