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At least 487 records · Page 27

Human papillomavirus–associated anal squamous cell carcinoma: sociodemographic, geographic, and county-level economic trends in incidence rates—United States, 2001-2019

Abstract Background Incidence of anal squamous cell carcinoma is increasing, but vaccination against human papillomavirus (HPV) and removal of precancerous anal lesions could prevent new cases. The overall HPV-associated cancer incidence is reported to be higher in rural populations and in counties with lower economic status. We assessed these differences specifically for HPV-associated anal squamous cell carcinoma and described the geographic, county-level economic, and sociodemographic variations in incidence rates and trends. Methods We analyzed data from the US Cancer Statistics to assess age-standardized incidence rates of HPV-associated squamous cell carcinomas among adults aged 18 years and older from 2001 to 2019. We calculated rate ratios and 95% confidence intervals to examine differences in incidence rates. We also quantified changes in incidence rates over time using joinpoint regression. Results From 2001 to 2019, 72 421 new cases of HPV-associated anal squamous cell carcinoma were diagnosed among women (2.8 per 100 000) and 37 147 among men (1.7 per 100 000). Age-standardized incidence rates were higher in the South compared with other census regions and in counties ranked in the bottom 25% and 25%-75% economically than in the top 25%. The overall incidence rate increased in women but remained stable in men during 2009-2019. Incidence rates increased in adults aged 50 years and older but decreased among those aged 40-44 years from 2001 to 2019 in women and from 2007 to 2019 in men. Conclusions There were inequities in HPV-associated anal squamous cell carcinoma incidence by geographic and county-level economic characteristics. Failure to improve vaccine and treatment equity may widen existing disparities.

Oncology↗

Oneida Indian Nation Community-Scale Clean Energy Deployment Combined Heat and Power Project. Tribal Renewable Energy (Final Technical Report)

This document reports on the Oneida Indian Nation's to upgrade and improve the operation of the Nation’s Central Utility Plant (CUP) so that previously wasted energy could be captured and utilized to produce electricity. The final technical report contains an overview of the project and the project objectives, which are increased energy efficiency, reduced dependency on fossil fuels, and lower energy costs while maintaining sound environmental stewardship of natural resources. The report describes the specific activities and milestones accomplished, a summary of the current status of the project, including objectives and results achieved, and a description of project management, challenges and lessons learned.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

IER 500: AWE-LLNL Measurement Campaign at DAF [Slides]

Presentation Hosted at Device Assembly Facility (DAF). Joint collaboration by Atomic Weapons Establishment (AWE) and Lawrence Livermore National Laboratory (LLNL). Multiple measurements were recorded through a two-week period with 12 unique objects measured. LLNL deployed Machine learning software program for diagnostic assessments. Current status notes the dedicated DAF team LLNL maintains. Additionally, LLNL is compiling a report on the AWE-LLNL measurements and designing security benchmark experiments. The presentation concludes with future work envisioned.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

An Overview of the Molten Salt Thermal Properties Database–Thermophysical, Version 2.1.1 (MSTDB-TP v.2.1.1)

The current status of the Molten Salt Thermodynamic Database- Thermal Physical (MSTDB-TP) is reported. Building off of MSTDB-TP and through the direction of the Roadmap for thermal property measurement of Molten Salt Reactor systems, MSTDB-TP 2.1.1 has now been released containing a total 448 salt entries (data from 140+independent studies) compared to the original commit of 62, containing thermophysical properties including density, viscosity, thermal conductivity, and heat capacity. Along with the new database release, further advancement of Saline, a C++application programming interface (API), and a graphical user interface (GUI) has facilitated increased user/developer interaction with the database. Furthermore, estimation techniques, first principles calculations (Ab-Initio) and interpolation/extrapolation methods (Redlich-Kister/Muggianu), have shown great promise in the future of thermophysical property determination for filling out compositional spaces and investigating experimentally difficult salts (hazardous/expensive). This report describes the database composition, development and advancement of database tools, and the strategy of advancing and implementing estimation data into future iterations of the database for MSTDB-TP.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Integration of the NCRC Database and Other INL Databases

The Nuclear Computational Resource Center provides a portal by which industry professionals, educational staff, students, national laboratory employees, and others may request access to certain engineering software tools. As the tools provided through the Nuclear Computational Resource Center portal are not open-source and freely available, a set of approvals are necessary before access is granted. All code recipients must be associated with an institution that has a license with Idaho National Laboratory for the code requested. Information about these licenses is controlled by Idaho National Laboratory’s Technology Deployment organization and housed in a Technology Deployment database. Those requesting code access who are not citizens of the United States must also have a security plan, mandated by Idaho National Laboratory policy. Security plans are managed by the International Access Program and are stored in an International Access Program database known as IFacts. Granting access to software thus depends on information stored in the Technology Deployment database and IFacts. In the past, no connection between the Nuclear Computational Resource Center portal and these databases existed, making checking the status of license agreements and security plans time consuming and error prone. This report demonstrates that the Nuclear Computational Resource Center portal now connects to both the Technology Deployment database and IFacts, greatly improving the ease of use of the Nuclear Computational Resource Center system for administrators, which leads to a better overall experience for those requesting code access.

99 GENERAL AND MISCELLANEOUS↗

Enhanced Hanford Low-Activity Waste Glass Property Data Development: Phase 2

The U.S. Department of Energy’s (DOE) Office of River Protection (ORP) requested Pacific Northwest National Laboratory (PNNL) to support the River Protection Project vitrification in an effort to support operations upon completion of startup activities (DOE 2012). This work was performed under the PNNL project titled “ORP Glass Support Work.” One task of this project—Enhanced Hanford Waste Glass Models—is the subject of this report. A previous task focused on generating property-composition data and models for the Hanford site low-activity waste (LAW) glasses with lower waste loadings, which are relevant to the commissioning of the LAW vitrification facility. The current task has the long-term objective of expanding the Hanford site LAW glass database and property composition models for the balance of the Hanford site tank waste treatment and immobilization mission. During the balance of the mission, LAW glasses with higher waste loadings will be produced. This report presents the glass compositions and glass property data developed in Phase 2 of the enhanced Hanford LAW glass property data development effort. When this effort is complete, enhanced LAW glass property models will be developed. Section 1.1 summarizes the status of the LAW glass composition regions and waste loading constraints prior to the data development effort documented in this report. Section 1.2 summarizes the LAW Phase 2 glass composition region and test matrix. Section 1.3 documents the quality assurance program used in performing the work discussed in this report.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Status Update on the Development of Transducers and Bonding Techniques for Enabling Acoustic Measurements of Damage in Microreactor Components

This report provides an overview of potential sensors and sensor-bonding techniques to enable the online acoustic interrogation of microreactor components and enhance structural health monitoring capabilities. The report focuses primarily on optical fiber–based acoustic sensors and describes initial experimental progress toward the deployment of these sensors for microreactor applications. The general approach is to monitor the resonant frequencies of microreactor components and search for evidence of structural defects that could indicate imminent failure. If properly identified, then the components could be repaired during the next reactor outage to prevent costly unplanned shutdowns. The ability to monitor the structural health of components could also reduce the need for time-consuming visual inspections and reduce staffing to improve microreactor economic viability. Increased sensor density is also one of the first steps to moving toward eventual semiautonomous operation. The expected microreactor conditions in which acoustic sensors must survive are characterized, including temperatures, neutron fluences, thermomechanical strains, and vibrational frequencies. Optical fiber–based acoustic sensors are identified as an attractive candidate for acoustic monitoring because of their high accuracy, immunity to electromagnetic interference, and resiliency in high-temperature, high-radiation environments. Optical fiber–based intrinsic sensors, such as type-II fiber-Bragg gratings and Fabry-Pérot Cavities (FPCs), are particularly attractive for a microreactor environment because of their high temperature stability, and FPCs also enable higher frequency interrogation with a lower sensitivity to radiation-induced drift. This report describes multiple interrogation systems, but the best interrogation system for a given situation will depend on the specific microreactor application, including the desired acoustic vibrational amplitudes, modes, and resonant frequencies. Initial experiments included fabricating three FPCs, tack-welding these FPCs to stainless-steel pipes or rods and performing room-temperature acoustic sensing tests to capture the vibrational frequency content. Peaks were identified in the measured frequency spectra and compared with the theoretical fundamental frequencies obtained from Euler-Bernoulli beam theory. Two of the three FPCs measured vibrational frequencies that generally matched those obtained from theory. Future work will include similar testing on pipes or other microreactor components with intentional flaws to evaluate the ability to determine changes in resonant frequencies. Finally, these tests will be repeated at high temperatures, potentially with an applied thermomechanical stress, to include environmental conditions similar to those for a microreactor application.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Status and Trends in the U.S. Voluntary Green Power Market (2021 Data)

Voluntary green power, for the purposes of this report, refers to renewable energy procurement by retail electricity customers above state renewable energy mandates. In this report, we present data and key trends for voluntary green power markets, except for a small portion of voluntary purchasing where no data are available. In 2021, about 8 million retail electricity customers procured about 244 million megawatt-hours (MWh) of voluntary green power (Figure ES-1), representing about 27% of all U.S. renewable energy sales, about 39% of non-hydro renewable energy sales, and about 6% of all U.S. retail electricity sales. Most of the remainder of U.S. renewable energy sales reflects renewable energy procured by load-serving entities to comply with state renewable energy mandates, also known as compliance-based procurement.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Status and Trends in the U.S. Voluntary Green Power Market: 2022 Data

Voluntary green power, for the purposes of this report, refers to renewable energy procurement by retail electricity customers above what is otherwise provided by load-serving entities. This report is part of an annual series of reports synthesizing trends in the United States voluntary green power market. In 2022, about 9.6 million retail electricity customers procured about 272 million megawatt-hours (MWh) of voluntary green power, representing about 38% of non-hydro renewable energy sales and about 6% of all U.S. retail electricity sales. Most of the remainder of U.S. renewable energy sales reflects renewable energy procured by load-serving entities to comply with state renewable energy mandates, also known as compliance-based procurement.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Fuels Irradiation and Physics Database (FIPD) Development and Data Qualification FY24 Updates

The DOE-NE Advanced Reactor Technologies program has supported efforts to recover and preserve metallic fuel data generated throughout the past fast reactor R&D programs. Those efforts are currently focused on establishing databases for information from the experiments conducted during the Integral Fast Reactor program including data generated at EBR-II, FFTF, and TREAT reactors, as well as out of pile transient testing data. These databases are essential for future-licensing activities of metallic fuel based advanced fast reactors. This report describes the Metallic Fuels Irradiation & Physics Database (FIPD) development, content updates, data qualification status, and user support in FY24. Future plans are also provided.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Design of the Electron–Ion Collider

The Electron–Ion Collider (EIC) is under construction at Brookhaven National Laboratory partnering with Jefferson Laboratory. The collider is designed for collisions of 70% polarized electrons and ions with luminosi ties up to $L$ = 1 × 10 34 cm -2 sec -1 at the center-of-mass energies up to 140 GeV. The report summarizes the requirements, describes the design of the collider, and presents the present status of the project.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

A cross-sectional study of the nasal and fecal microbiota of sows from different health status within six commercial swine farms

Cull sows are a unique population on swine farms, often representing poor producing or compromised animals, and even though recent studies have reported that the microbiome is associated with susceptibility to diseases, the microbiome of the cull sow population has not been explored. The main objective of this study was to investigate whether there were differences in fecal and upper respiratory tract microbiota composition for groups of sows of different health status (healthy, cull, and compromised/ clinical sows) and from different farms (1 to 6). Six swine farms were visited once. Thirty individual fecal samples and nasal swabs were obtained at each farm and pooled by five across health status and farm. Samples underwent 16S rRNA gene amplicon sequencing and nasal and fecal microbiota were analyzed using QIIME2 v.2021.4. Overall, the diversity of the nasal microbiota was lower than the fecal microbiota (p < 0.01). No significant differences were found in fecal or nasal alpha diversity by sow’s health status or by farm. Furthermore, there were significant differences in nasal microbial composition by farm and health status (PERMANOVA, p < 0.05), and in fecal microbiota by farm (PERMANOVA, p < 0.05), but not by health status. Lastly, at the L7 level, there was one differentially abundant taxa across farms for each nasal and fecal pooled samples. This study provided baseline information for nasal and fecal microbiota of sows under field conditions, and results suggest that farm of origin can affect microbial diversity and composition. Furthermore, sow’s health status may have an impact on the nasal microbiota composition.

59 BASIC BIOLOGICAL SCIENCES↗

Status and Trends in the Voluntary Market (2019 Data)

Green power refers to renewable electricity voluntarily purchased by retail electricity customers. Renewable energy sources for green power include solar, wind, biomass, geothermal, and small-scale hydropower. This report summarizes data on the various ways in which voluntary purchasers - including residential, commercial, and institutional customers - purchase green power. We summarize key historic trends in U.S. voluntary green power markets and the current status of green power sales through seven products: utility green pricing programs, utility renewable contracts, competitive suppliers, unbundled renewable energy certificates, community choice aggregations, power purchase agreements, and community solar.

42 ENGINEERING↗

Status and Trends in the Voluntary Market (2020 Data)

Green power refers to renewable electricity voluntarily purchased by retail electricity customers. Renewable energy sources for green power include solar, wind, biomass, geothermal, and small-scale hydropower. This report summarizes data on the various ways in which voluntary purchasers - including residential, commercial, and institutional customers - purchase green power. We summarize key historic trends in U.S. voluntary green power markets and the current status of green power sales through seven products: utility green pricing programs, utility renewable contracts, competitive suppliers, unbundled renewable energy certificates, community choice aggregations, and power purchase agreements. It includes discussion of how the voluntary market may impact the grid.

community choice aggregation↗

Status and Trends in the Voluntary Market (2021 Data)

Green power refers to renewable electricity voluntarily purchased by retail electricity customers. Renewable energy sources for green power include solar, wind, biomass, geothermal, and small-scale hydropower. This report summarizes data on the various ways in which voluntary purchasers including residential, commercial, and institutional customers purchase green power. We summarize key historic trends in U.S. voluntary green power markets and the current status of green power sales through seven products: utility green pricing programs, utility renewable contracts, competitive suppliers, unbundled renewable energy certificates, community choice aggregations, and power purchase agreements. It includes discussion of how the voluntary market may impact the grid.

ENERGY PLANNING, POLICY, AND ECONOMY↗

Rechargeable alkaline zinc–manganese oxide batteries for grid storage: Mechanisms, challenges and developments

Rechargeable alkaline Zn–MnO 2 (RAM) batteries are a promising candidate for grid-scale energy storage owing to their high theoretical energy density rivaling lithium-ion systems (~400 Wh/L), relatively safe aqueous electrolyte, established supply chain, and projected costs below $100/kWh at scale. In practice, however, many fundamental chemical and physical processes at both electrodes make it difficult to achieve commercially competitive energy density and cycle life. In this paper, we present a detailed and timely analysis of the constituent materials, current commercial status, electrode processes, and performance-limiting factors of RAM batteries. We also examine recently reported strategies in RAM and related systems to address these issues through additives and modifications to the electrode materials and electrolyte, special ion-selective separators and/or coatings, and unconventional cycling protocols. We conclude with a critical summary of these developments and discussion of how future studies should be focused toward the goal of energy-dense, scalable, and cost-effective RAM systems.

25 ENERGY STORAGE↗

Risk-Informed MultiPphysics BestEestimate Plus Uncertainties (BEPU) Application Development of RELAP5-3D Perturbation Model

The United States nuclear industry is facing a strong challenge to ensure maximum safety while enhancing economic benefit. Safety is a key parameter to all aspects related to light water reactor (LWR) nuclear power plants (NPPs), especially cost savings. Since the goal is to extend the lifetimes of these NPPs, the traditional deterministic safety concept may not guarantee a current economic asset. The Light Water Reactor Sustainability (LWRS) Program has been promoting a wide range of research and development (R&D) in this field to maximize the safety, economics, and performance of these NPPs through improved scientific understanding. One of the best practices to achieve this goal is to identify and optimize safety margins, which can lead to cost reduction. To do this, under the LWRS framework, the Risk-Informed Systems Analysis (RISA) Pathway will focus on the optimization of safety margin and minimization of uncertainties to ensure both safety and economics at the highest level. The RISA Pathway will provide enhanced capabilities for analyzing and characterizing LWR systems performance by developing and demonstrating methods, tools, and data to enable risk-informed margins management (RIMM). The goals of the RISA Pathway are twofold: (1) deploy the risk-informed tools and methods that enable better representation of safety margins and factors that contribute to cost and safety; and (2) conduct advanced risk assessment applications with industry to support margin management strategies that enable more cost-effective plant operation. The tools and methods provided by the RISA Pathway will support effective margin management for both active and passive safety systems, structures, and components (SSC) of an NPP. The tools and methods used in the RISA Pathway should have high confidence and highest technical maturity for and implementation to industry at its current setting. They should also have a capability to support risk-informed decision making for both probabilistic and deterministic elements of safety. The RISA Pathway will, therefore, perform a comprehensive assessment of verification and validation (V&V) status of RISA Toolkit to enhance credibility RISA Toolkit which be used by industry. This report summarizes RELAP5-3D development activities for best estimated and uncertainty (BEPU) capability to support ongoing RISA Pathway pilot projects for risk informed uncertainty quantification applications. Work scope includes (1) development of initial perturbation model for selected closure laws and (2) testing of suitable probability distribution functions (PDF) for the selected correlations. Developed BEPU modules are tested with selected separate effect cases and compared with conventional thermal-hydraulics model.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗