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NASA NTRS2019

Simulated Weightlessness Alters Cardiomyocyte Structure and Transcriptional Regulation of Mediators Related to Immunity and Cardiovascular Disease

Spaceflight and the ensuing fluid shifts, together with an overall reduction in physical activity, lead to acute and latent effects on the cardiovascular system. This current study makes use of the rodent hindlimb unloading (HU) model to determine how factors such as sex, age, and duration of exposure impact cardiac responses to weightlessness. We hypothesize that extended exposure to simulated weightlessness and the ensuing recovery alters cardiac structure and expression of select genes, including those involved in redox signaling which together, negatively impact long-term cardiac tissue health. To begin to test this hypothesis, male and female rats underwent HU at various durations up to 90 days, with a subset reambulated after 90 days of HU. Physiological stress or contractility changes lead to alterations in ventricular cardiomyocyte size and ventricular wall thickness to adapt to greater functional demand and mitigate mechanical stress to ventricular tissue; under certain conditions, these changes also may mark progression to cardiac failure. Hence, left ventricular cardiomyocyte size (cardiomyocyte cross sectional area, CSA) was quantified to determine if HU leads to structural adaptation responses in cardiac tissue and if age and sex had any impact on this outcome. Cardiomyocyte CSA of older males (9 months) were altered by HU in a time-dependent manner, where HU led to decreases in CSA at 14 days and increases at 90 days. In contrast, younger males (3 months) did not show any changes at day 14 of HU. CSA of females (3 months) was increased in response to short-term HU (14 days) suggesting sex-dependence of structural changes. In older HU males, cardiomyocyte CSA was comparable to controls after 90 days of re-ambulation. Levels of the DNA oxidative damage marker, 8-hydroxydeoxyguanosine (8-OHdG) were greater in left ventricular tissue of females that underwent HU compared to sex-matched controls, while there were no such differences in older or younger males. To gain insight into the signals that drive cardiac adaptations to HU, global transcriptomic analysis (RNAseq) was performed on left ventricular tissue of older males that underwent 14 days of HU. Short-term simulated weightlessness led to differential expression of genes involved in immune and pro-inflammatory signaling. A subset of these genes play a role in autoimmune and cardiovascular disease and are targets of current drugs used to treat bradycardia, hypertension, atherosclerosis and rheumatoid arthritis, amongst others. Oxidative damage/redox signaling pathways were not enriched at the timepoint tested in older males. Since young females displayed greater oxidative damage to DNA, activation of oxidative stress responses at earlier or later time points cannot be ruled out. In summary, simulated weightlessness in adult rats caused changes in cardiomyocyte structure in a sex and age-dependent manner, and the transcriptional regulation of key mediators of immunity and cardiovascular disease, meriting further study to define cardiac risks for interplanetary travel of human crew. Our findings also confirm the value of the rat HU model for cardiac health and countermeasure research.

Tahimic, Candice↗

NASA NTRS1977

Storage of solid propellants in space

A test program is described which determines the extent of physical property changes that result from extended space exposure. Primary emphasis was placed on determining the effects of space vacuum. Solid propellants were stored and their physical properties tested in a vacuum and in a dry environment. The storage caused significantly greater increases in the propellants' modulus and maximum tensile strength than occurred in parallel ambient stored samples. The data indicate that the loss of trace amounts of residual moisture from cured propellant is the apparent cause of the observed propellant property changes. Therefore, initial screening tests were carried out under dry storage conditions. Upon completion of the dry storage tests, appropriate propellant samples are exposed to an actual space environment using the Long Duration Exposure Facility (LDEF).

Udlock, D. E.↗

NASA NTRS1992

A comparison of shuttle vernier engine plume contamination with CONTAM 3.4 code predictions

In 1985, using the CONTAM 3.2 code, it was predicted that the shuttle Primary Reaction Control System (PRCS) and Vernier Reaction Control System (VRCS) engines could be potential contamination sources to sensitive surfaces located within the shuttle payload bay. Spaceflight test data on these engines is quite limited. Shuttle mission STS-32, the Long Duration Exposure Facility retrieval mission, was instrumented with an experiment that provided the design engineer with evidence that contaminant species from the VRCS engines can enter the payload bay. More recently, the most recent version of the analysis code, CONTAM 3.4, has re-examined the contamination potential of these engines.

Maag, Carl R.↗

NASA NTRS1996

Sorption cooling of astrophysics science instruments

The current status of continuous and periodic operation sorption cryocooler development for astrophysics missions requiring refrigeration to 4 K and below, is reviewed. These coolers are suited for the cooling of detectors in planned astrophysics missions such as the exploration of neighboring planetary systems planet finder array (ExNPS PFA). The cooler requirements imposed by these missions include a ten-year life, zero vibration, zero electromagnetic interference and electromagnetic charging operation, and the ability to scale designs to provide low refrigeration capability with low power consumption. Spaceflight test results are summarized for the brilliant eyes 10 K sorption cryocooler experiment. This experiment successfully validated flight cooler performance and provided characterization of all sorption cooler design parameters which may have shown sensitivity to microgravity effects. Ground test results from a continuous 25 K cooler planned for use in a long duration airborne balloon experiment are presented. A NASA program to develop 30 K, 10 K and 4 K vibration-free coolers for astrophysics missions is outlined.

Wade, Lawrence A.↗

NASA NTRS2010

International Space Station as a Platform for Exploration Beyond Low Earth Orbit

The International Space Station (ISS) has established a new model for the achievement of the most difficult engineering goals in space: international collaboration at the program level with competition at the level of technology. This strategic shift in management approach provides long term program stability while still allowing for the flexible evolution of technology needs and capabilities. Both commercial and government sponsored technology developments are well supported in this management model. ISS also provides a physical platform for development and demonstration of the systems needed for missions beyond low earth orbit. These new systems at the leading edge of technology require operational exercise in the unforgiving environment of space before they can be trusted for long duration missions. Systems and resources needed for expeditions can be aggregated and thoroughly tested at ISS before departure thus providing wide operational flexibility and the best assurance of mission success. We will describe representative mission profiles showing how ISS can support exploration missions to the Moon, Mars, asteroids and other potential destinations. Example missions would include humans to lunar surface and return, and humans to Mars orbit as well as Mars surface and return. ISS benefits include: international access from all major launch sites; an assembly location with crew and tools that could help prepare departing expeditions that involve more than one launch; a parking place for reusable vehicles; and the potential to add a propellant depot.

Raftery, Michael↗

NASA NTRS2014

Recent Advances in Water Analysis with Gas Chromatograph Mass Spectrometers

We report on progress made in developing a water sampling system for detection and analysis of volatile organic compounds in water with a gas chromatograph mass spectrometer (GCMS). Two approaches are described herein. The first approach uses a custom water pre-concentrator for performing trap and purge of VOCs from water. The second approach uses a custom micro-volume, split-splitless injector that is compatible with air and water. These water sampling systems will enable a single GC-based instrument to analyze air and water samples for VOC content. As reduced mass, volume, and power is crucial for long-duration, manned space-exploration, these water sampling systems will demonstrate the ability of a GCMS to monitor both air and water quality of the astronaut environment, thereby reducing the amount of required instrumentation for long duration habitation. Laboratory prototypes of these water sampling systems have been constructed and tested with a quadrupole ion trap mass spectrometer as well as a thermal conductivity detector. Presented herein are details of these water sampling system with preliminary test results.

quadrupole ion trap↗

NASA NTRS2018

Justification of Crew Function and Function Capability for Long Duration Deep Space Habitation

There are currently no established standards or guidelines that define the functions to be present in habitats for use beyond Low Earth Orbit (LEO), or for the capabilities of those functions. There is limited human experience with long duration space habitation, none of which is beyond LEO. There is significantly less experience with even short duration human habitation beyond LEO. Studies since the Apollo program that have proposed long duration habitats have applied inconsistent functionality, yet these functions have substantial implications for spacecraft mass and volume. There are also numerous aspects of human space flight beyond LEO that have implications for these functions. This paper develops a method for design teams to identify and justify the functions and capabilities to include in long duration habitats intended for use beyond LEO. Finally, human-in-the-loop testing methods are recommended for use in the early spacecraft design stages to ensure that the habitat will successfully provide the intended functions and capabilities.

Howard, Robert L.↗

NASA NTRSDate not supplied

How To Train Your Dragon (and Vice Versa) – Human Spaceflight Research and The First Commercial Crews

The International Space Station has been an orbiting laboratory for human spaceflight research for over 20 years. NASA’s human research implementation teams have worked to develop, refine, and execute pre-, in-, and post-flight sessions to collect critical research data that will enable future spaceflight missions. The teams have worked closely with the spaceflight vehicle teams, including those for Soyuz and the now retired Space Shuttle vehicles, to successfully conduct this research. As NASA has transitioned to commercial vehicles for transport of crews to the ISS, the implementation teams have expanded their scope to include the SpaceX and upcoming Boeing vehicles. This session will focus on the unique implementation needs for the first available commercial platform, SpaceX. We will identify implementation adjustments made to accommodate the SpaceX Dragon system, including crew training and preflight baseline data collection, inflight operations tied to landing, and postflight planning and crew testing, as well as offer lessons learned from the past three SpaceX long-duration crew missions. Representatives from the Flight Operations Directorate, including the Astronaut Office and the vehicle recovery team, will also provide their perspectives on this new system, and how it affects their work with the human research community. A panel discussion with dedicated time for Q&A will follow.

Pasha Morshedi↗

NASA NTRS2003

Mathematical Modeling of Food Supply for Long Term Space Missions Using Advanced Life Support

A habitat for long duration missions which utilizes Advanced Life Support (ALS), the Bioregenerative Planetary Life Support Systems Test Complex (BIO-Plex), is currently being built at JSC. In this system all consumables will be recycled and reused. In support of this effort, a menu is being planned utilizing ALS crops that will meet nutritional and psychological requirements. The need exists in the food system to identify specific physical quantities that define life support systems from an analysis and modeling perspective. Once these quantities are defined, they need to be fed into a mathematical model that takes into consideration other systems in the BIO-Plex. This model, if successful, will be used to understand the impacts of changes in the food system on the other systems and vice versa. The Equivalent System Mass (ESM) metric has been used to describe systems and subsystems, including the food system options, in terms of the single parameter, mass. There is concern that this approach might not adequately address the important issues of food quality and psychological impact on crew morale of a supply of fiesh food items. In fact, the mass of food can also depend on the quality of the food. This summer faculty fellow project will involve creating an appropriate mathematical model for the food plan developed by the Food Processing System for BIO-Plex. The desired outcome of this work will be a quantitative model that can be applied to the various options of supplying food on long-term space missions.

Cruthirds, John E.↗

NASA NTRS2009

Phase Change Material Heat Exchanger Life Test

Low Lunar Orbit (LLO) poses unique thermal challenges for the orbiting space craft, particularly regarding the performance of the radiators. The IR environment of the space craft varies drastically from the light side to the dark side of the moon. The result is a situation where a radiator sized for the maximal heat load in the most adverse situation is subject to freezing on the dark side of the orbit. One solution to this problem is to implement Phase Change Material (PCM) Heat Exchangers. PCM Heat Exchangers act as a "thermal capacitor," storing thermal energy when there is too much being produced by the space craft to reject to space, and then feeding that energy back into the thermal loop when conditions are more favorable. Because they do not use an expendable resource, such as the feed water used by sublimators and evaporators, PCM Heat Exchangers are ideal for long duration LLO missions. In order to validate the performance of PCM Heat Exchangers, a life test is being conducted on four n-Pentadecane, carbon filament heat exchangers. Fluid loop performance, repeatability, and measurement of performance degradation over 2500 melt-freeze cycles will be performed.

Lillibridge, Sean↗

NASA NTRS2012

Data Acquisition, Management, and Analysis in Support of the Audiology and Hearing Conservation and the Orbital Debris Program Office

My internship at Johnson Space Center, Houston TX comprised of working simultaneously in the Space Life Science Directorate (Clinical Services Branch, SD3) in Audiology and Hearing Conservation and in the Astromaterials Research and Exploration Sciences Directorate in the Orbital Debris Program Office (KX). The purpose of the project done to support the Audiology and Hearing Conservation Clinic (AuHCon) is to organize and analyze auditory test data that has been obtained from tests conducted onboard the International Space Station (ISS) and in Johnson Space Center's clinic. Astronauts undergo a special type of auditory test called an On-Orbit Hearing Assessment (OOHA), which monitors hearing function while crewmembers are exposed to noise and microgravity during long-duration spaceflight. Data needed to be formatted to assist the Audiologist in studying, analyzing and reporting OOHA results from all ISS missions, with comparison to conventional preflight and post-flight audiometric test results of crewmembers. Orbital debris is the #1 threat to manned spacecraft; therefore NASA is investing in different measurement techniques to acquire information on orbital debris. These measurements are taken with telescopes in different parts of the world to acquire brightness variations over time, from which size, rotation rates and material information can be determined for orbital debris. Currently many assumptions are taken to resolve size and material from observed brightness, therefore a laboratory (Optical Measurement Center) is used to simulate the space environment and acquire information of known targets suited to best model the orbital debris population. In the Orbital Debris Program Office (ODPO) telescopic data were acquired and analyzed to better assess the orbital debris population.

Dicken, Todd↗

NASA NTRS2018

Advanced Stirling Convertor Control Unit Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

Future NASA missions could include long-duration flyby, orbital, lander, or rover applications where generating power from sunlight may be limited. Radioisotope power systems (RPSs) provide a dependable power source for missions where inadequate sunlight or operational requirements make other power systems impractical. Over the past 16 years, NASA Glenn Research Center has been supporting the development of RPSs. The advanced Stirling radioisotope generator (ASRG) utilized a pair of advanced Stirling convertors (ASCs). Although flight development of the ASRG has been canceled, much of the technology and hardware continued development and testing to guide future activities. Specifically, a controller for the convertor(s) is an integral part of a Stirling-based RPS. For the ASRG design, the controller maintains stable operation of the convertors, regulates the alternating current produced by the linear alternator of the convertor, provides a specified direct-current output voltage for the spacecraft, and synchronizes the piston motion of the two convertors to minimize vibration as well as manage and maintain operation with a stable piston amplitude and hot-end temperature. It not only provides power to the spacecraft but also must regulate convertor operation to avoid damage to internal components and maintain safe thermal conditions after fueling. Lockheed Martin Coherent Technologies, Inc., has designed, developed, and tested an ASC control unit engineering development unit (ACU EDU) to support this effort. GRC used the ACU EDU as part of its nonnuclear representation of a RPS that also consists of a Dual advanced Stirling convertor simulator (DASCS), and associated support equipment to perform a test in the Radioisotope Power Systems System Integration Laboratory (RSIL). The RSIL was designed and built with flexibility to evaluate hardware utilizing RPS technology. The RSIL provides insight into the electrical interactions between as many as three radioisotope power generators, associated control strategies, and typical electric system loads. The first phase of testing included a DASCS that was developed by Johns Hopkins University Applied Physics Laboratory and simulates the operation and electrical behavior of a pair of ASCs in real time via a combination of hardware and software. Testing included the following spacecraft electrical energy storage configurations: capacitor, battery, and supercapacitor. Testing of the DASCS and ACU in each energy storage configuration included simulation of a typical mission profile and transient voltage and current data during load turnon and turnoff. Testing for these devices also included the initiation of several system faults such as short circuits, electrical bus overvoltage, undervoltage, and a "dead bus" recovery to restore normal power operations. The goal of this testing was to verify operation of the ACU(s) when connected to a spacecraft electrical bus. The results of these tests are presented here.

General↗

NASA NTRS2024

Advanced Lightweight TUFROC Thermal Protection System for Space Plane Applications

Toughened Uni-piece Fibrous Reinforced Oxidation-resistant Composite (TUFROC) represents the state of the art in low-cost, reusable spacecraft Thermal Protection Systems (TPS) with high temperature capability and is flight proven on the USAF X-37B. The two-piece design takes advantage of a low-conductivity porous silica substrate combined with high-temperature-capable carbon cap and surface treatments. NASA has updated the chemical composition of the surface treatments resulting in improved high-heating capability and reusability. The new system, called Advanced TUFROC, experiences a lower surface temperature (by ~80 K) at identical aerothermal heating conditions compared to the original formulation, now called Standard TUFROC. The reduced heating is attributed to the lower catalytic efficiency of the new formulation, which results in reduced exothermic atom recombination rates at the surface. Multiple arc-jet test campaigns demonstrate that Advanced TUFROC has the ability to withstand long and repeated exposures at 1866 K or a shorter duration exposure at 1980 K without recession or damage to TPS. Furthermore, an improved arc-jet article design for assessing 3-dimensional flow over a wing leading edge has been developed and tested. This article allows for assessment of heating at a tile gap under flight-relevant conditions at significantly reduced article fabrication and arc-jet facility configuration costs compared to prior work.

TUFROC↗

NASA NTRS2014

Materials International Space Station Experiment (MISSE): Overview, Accomplishments and Future Needs

Materials and devices used on the exterior of spacecraft in low Earth orbit (LEO) are subjected to environmental threats that can cause degradation in material properties, possibly threatening spacecraft mission success. These threats include: atomic oxygen (AO), ultraviolet and x-ray radiation, charged particle radiation, temperature extremes and thermal cycling, micrometeoroid and debris impacts, and contamination. Space environmental threats vary greatly based on spacecraft materials, thicknesses and stress levels, and the mission environment and duration. For more than a decade the Materials International Space Station Experiment (MISSE) has enabled the study of the long duration environmental durability of spacecraft materials in the LEO environment. The overall objective of MISSE is to test the stability and durability of materials and devices in the space environment in order to gain valuable knowledge on the performance of materials in space, as well as to enable lifetime predictions of new materials that may be used in future space flight. MISSE is a series of materials flight experiments, which are attached to the exterior of the International Space Station (ISS). Individual experiments were loaded onto suitcase-like trays, called Passive Experiment Containers (PECs). The PECs were transported to the ISS in the Space Shuttle cargo bay and attached to, and removed from, the ISS during extravehicular activities (EVAs). The PECs were retrieved after one or more years of space exposure and returned to Earth enabling post-flight experiment evaluation. MISSE is a multi-organization project with participants from the National Aeronautics and Space Administration (NASA), the Department of Defense (DoD), industry and academia. MISSE has provided a platform for environmental durability studies for thousands of samples and numerous devices, and it has produced many tangible impacts. Ten PECs (and one smaller tray) have been flown, representing MISSE 1 through MISSE 8, yielding long-duration space environmental performance and durability data that enable material validation, processing recertification and space qualification; improved predictions of materials and component lifetimes in space; model verification and development; and correlation factors between space-exposure and ground-facilities enabling more accurate in-space performance predictions based on ground-laboratory testing. A few of the many experiment results and observations, and their impacts, are provided. Those highlighted include examples on improved understanding of atomic oxygen scattering mechanisms, LEO coating durability results, and polymer erosion yields and their impacts on spacecraft design. The MISSE 2 Atomic Oxygen Scattering Chamber Experiment discovered that the peak flux of scattered AO was determined to be 45 deg from normal incidence, not the model predicted cosine dependence. In addition, the erosion yield (E(sub y)) of Kapton H for AO scattered off oxidized-Al is 22% of the E(sub y) of direct AO impingement. These results were used to help determine the degradation mechanism of a cesium iodide detector within the Hubble Space Telescope Cosmic Origins Spectrograph Experiment. The MISSE 6 Indium Tin Oxide (ITO) Degradation Experiment measured surface electrical resistance of ram and wake ITO coated samples. The data confirmed that ITO is a stable AO protective coating, and the results validated the durability of ITO conductive coatings for solar arrays for the Atmosphere-Space Transition 2 Explorer program. The MISSE 2, 6 and 7 Polymer Experiments have provided LEO AO Ey data on over 120 polymer and composites samples. The flight E(sub y) values were found to range from 3.05 x 10(exp -26) cu cm/atom for the AO resistant polymer CORIN to 9.14 x 10(exp -26) cu cm/atom for polyoxymethylene (POM). In addition, flying the same polymers on different missions has advanced the understanding of the AO E(sub y) dependency on solar exposure for polymers containing fluorine. The MISSE polymer results are highly requested and have impacted spacecraft design for WorldView-2 & -3, the Global Precipitation Measurement-Microwave Imager, and other spacecraft. The flight data has enabled the development of an Atomic Oxygen Erosion Predictive Tool that allows the erosion prediction of new and non-flown polymers. The data has also been used to develop a new NASA Technical Standards Handbook "Spacecraft Polymers Atomic Oxygen Durability Handbook." Many intangible benefits have also been derived from MISSE. For example, over 40 students have collaborated on Glenn's MISSE experiments, which have resulted in greater than $80K in student scholarships and awards in national and international science fairs. Students have also given presentations and won poster competition awards at international space conferences.

Flight Experiment↗

NASA NTRS2012

Microbial Monitoring of Pathogens by Comparing Multiple Real-Time PCR Platforms for Potential Space Applications

The International Space Station (ISS) is a closed environment wi~h rotations of crew and equipment each introducing their own microbial flora making it necessary to monitor the air, surfaces, and water for microbial contamination. Current microbial monitoring includes labor and time intensive methods to enumerate total bacterial and fungal cells with limited characterization during in-flight testing. Although this culture-based method has been sufficient for monitoring the ISS, future long duration missions will need to perform more comprehensive characterization in-flight, since sample return and ground characterization may not be available. A workshop was held in 2011 at the Johnson Space Center to discuss alternative methodologies and technologies suitable for microbial monitoring for these longterm exploration missions where molecular-based methodologies, such as polymerase chain reaction (PCR), were recommended. In response, a multi-center (Marshall Space Flight Center, Johnson Space Center, Jet Propulsion Laboratory, and Kennedy Space Center) collaborative research effort was initiated to explore novel commercial-off-the-shelf hardware options for spaceflight environmental monitoring. The goal was to evaluate quantitative/semi-quantitative PCR approaches to space applications for low cost in-flight rapid identification of microorganisms affecting crew safety. The initial phase of this project identified commercially available platforms that could be minimally modified to perform nominally in microgravity followed by proof-of-concept testing on the highest qualifying candidates with a universally available test organism, Salmonella enterica. The platforms evaluated during proof-of-concept testing included the iCubate 2.0(TradeMark) (iCubate, Huntsville, AL), RAZOR EX (BioFire Diagnostics; Salt Lake City, Utah) and SmartCycler(TradeMark) (Cepheid; Sunnyvale, CA). The analysis identified two potential technologies (iCubate 2.0 and RAZOR EX) that were able to perform sample-to-answer testing with cell sample concentrations between SO to 400 cells. In addition, the commercial systems were evaluated for initial flight safety and readiness, sample concentration needs were reviewed, and a competitive procurement of commercially available platforms was initiated.

Birmele, Michele↗

NASA NTRS2013

Acoustic and Thermal Testing of an Integrated Multilayer Insulation and Broad Area Cooling Shield System

A Multilayer Insulation (MLI) and Broad Area Cooling (BAC) shield thermal control system shows promise for long-duration storage of cryogenic propellant. The NASA Cryogenic Propellant Storage and Transfer (CPST) project is investigating the thermal and structural performance of this tank-applied integrated system. The MLI/BAC Shield Acoustic and Thermal Test was performed to evaluate the MLI/BAC shield's structural performance by subjecting it to worst-case launch acoustic loads. Identical thermal tests using Liquid Nitrogen (LN2) were performed before and after the acoustic test. The data from these tests was compared to determine if any degradation occurred in the thermal performance of the system as a result of exposure to the acoustic loads. The thermal test series consisted of two primary components: a passive boil-off test to evaluate the MLI performance and an active cooling test to evaluate the integrated MLI/BAC shield system with chilled vapor circulating through the BAC shield tubes. The acoustic test used loads closely matching the worst-case envelope of all launch vehicles currently under consideration for CPST. Acoustic test results yielded reasonable responses for the given load. The thermal test matrix was completed prior to the acoustic test and successfully repeated after the acoustic test. Data was compared and yielded near identical results, indicating that the MLI/BAC shield configuration tested in this series is an option for structurally implementing this thermal control system concept.

Wood, J. J.↗

NASA NTRS2013

Acoustic and Thermal Testing of an Integrated Multilayer Insulation and Broad Area Cooling Shield System

Wood, Jessica J.↗

NASA NTRS2018

Potential Advantages of Conducting Short Duration Visits to the Martian Surface

Recent NASA concepts for human missions to Mars, including the Evolvable Mars Campaign and Design Reference Architecture 5.0, have focused on the conduct of missions with long duration stays on the Martian surface. The decision to focus on long duration missions (typically to a single site) is driven by a desire to increase the perceived sustainability of the human Mars campaign, predicated on the assumption that sustainability is best achieved by maximizing the level of activity on the surface, providing for continuous growth in operations, and promoting pioneering of Mars. However, executing a series of long duration missions to a single site is not the only option for human exploration of Mars that has been proposed. Other architectures have been evaluated that focus on missions with short duration surface stays, with each mission visiting a separate site on the surface. This type of architecture is less efficient in that elements are not typically reused from one mission to the next but requires a far less complex surface architecture. There are potentially valid arguments to be made that a short duration, multiple site approach could result in different types of advantages when compared to the long duration, single site approach to Mars exploration, particularly for initial human missions to Mars. These arguments revolve around four areas: Achieved Value, Risk Mitigation, Developmental Affordability, and Operational Affordability & Flexibility. The question of Achieved Value relates to the prioritization of goals for Martian exploration. As discussed, goals related to pioneering and expanding human presence are often referenced as justifications for the long duration approach. However, there are other competing goals, including science and exploration. While there is not a clear consensus among planetary scientists, many have argued that the value of being able to visit multiple sites could outweigh the value of continually visiting a single site. Risk Mitigation is a major concern for initial human missions to Mars. There are a number of hazards related to operating on the Martian surface that are not well characterized. It may be desirable to conduct a series of short duration missions to better understand the nature of these risks prior to committing to a long duration mission. Developmental Affordability relates to the ability of NASA and its partners to develop and deploy the proposed architecture. Any human missions to Mars will be among the most complex endeavors ever undertaken. The capabilities that must be developed to enable any human Mars missions are extremely challenging. The total design, development, test, and evaluation (DDT&E) budget required to develop just the essential capabilities alone will be substantial. If additional surface capabilities are required to support long duration surface stays, the development effort could be unaffordable. Operational Affordability & Flexibility relates to the continued costs to execute the Mars campaign. Long duration missions, even with some amount of in-situ resource utilization, require a significant level of resupply for every mission. This requires additional launches and in-space transportation assets, increasing the operational complexity and total operational cost. This paper will explore each of the four potential advantages of short duration missions in detail. The authors will present comparisons between proposed long duration and short duration architectures through an evaluation of relevant performance, cost, and risk metrics.

Stromgren, Chel↗