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Realistic simulation of reduced-dose CT with noise modeling and sinogram synthesis using DICOM CT images

Purpose: Reducing the patient dose while maintaining the diagnostic image quality during CT exams is the subject of a growing number of studies, in which simulations of reduced-dose CT with patient data have been used as an effective technique when exploring the potential of various dose reduction techniques. Difficulties in accessing raw sinogram data, however, have restricted the use of this technique to a limited number of institutions. Here, we present a novel reduced-dose CT simulation technique which provides realistic low-dose images without the requirement of raw sinogram data. Methods: Two key characteristics of CT systems, the noise equivalent quanta (NEQ) and the algorithmic modulation transfer function (MTF), were measured for various combinations of object attenuation and tube currents by analyzing the noise power spectrum (NPS) of CT images obtained with a set of phantoms. Those measurements were used to develop a comprehensive CT noise model covering the reduced x-ray photon flux, object attenuation, system noise, and bow-tie filter, which was then employed to generate a simulated noise sinogram for the reduced-dose condition with the use of a synthetic sinogram generated from a reference CT image. The simulated noise sinogram was filtered with the algorithmic MTF and back-projected to create a noise CT image, which was then added to the reference CT image, finally providing a simulated reduced-dose CT image. The simulation performance was evaluated in terms of the degree of NPS similarity, the noise magnitude, the bow-tie filter effect, and the streak noise pattern at photon starvation sites with the set of phantom images. Results: The simulation results showed good agreement with actual low-dose CT images in terms of their visual appearance and in a quantitative evaluation test. The magnitude and shape of the NPS curves of the simulated low-dose images agreed well with those of real low-dose images, showing discrepancies of less than +/−3.2% in terms of the noise power at the peak height and +/−1.2% in terms of the spatial frequency at the peak height. The magnitudes of the noise measured for 12 different combinations the phantom size, tube current, and reconstruction kernel for the simulated and real low-dose images were very similar, with differences of 0.1 to 4.7%. Thep value for a statistical testing of the difference in the noise magnitude ranged from 0.99 to 0.11, showing that there was no difference statistically between the noise magnitudes of the real and simulated low-dose images using our method. The strength and pattern of the streak noise in an anthropomorphic phantom was also consistent with expectations. Conclusions: A novel reduced-dose CT simulation technique was developed which uses only CT images while not requiring raw sinogram data. Our method can provide realistic simulation results under reduced-dose conditions both in terms of the noise magnitude and the textual appearance. This technique has the potential to promote clinical research for patient dose reductions.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

First Annual Report on Pulsed Thermal Tomography Nondestructive Evaluation of Additively Manufactured Reactor Materials and Components: Pulsed Thermal Tomography Nondestructive Examination of Additively Manufactured Reactor Materials and Components

Additive manufacturing (AM, or 3D printing) for commercial nuclear energy applications is an emerging method for cost-efficient manufacturing aimed at replacing aging nuclear reactor parts and reducing costs for new construction. Because of the geometry of metallic structures of interest for nuclear applications, which consist of planar primitives with no symmetry of revolution, limited options are available for nondestructive evaluation (NDE), either during or post manufacturing. Known material flaws in AM include low-density regions consisting of non-sintered powder, which have to be detected to ensure the safety of long-term performance nuclear reactor components. As a solution to NDE of AM, we are developing pulsed thermal tomography (PTT) models and depth inversion algorithms for 3D imaging. PTT has many advantages because the method is non-contact and allows for in-service, NDE of AM nuclear reactor parts. By analyzing transients of surface temperature response due to internal thermal resistances, one can obtain 3D reconstructions of material effusivity using a unique inversion algorithm developed at Argonne. This report provides results of preliminary performance evaluation of PTT capability in detection of flaws in metallic structures, as well imaging complex geometry AM structures. Performance of PTT was investigated through modeling and experiments, Computer models of PTT were developed using COMSOL Heat Transfer module. Defects were modeled as cylindrical flat bottom holes (FBH), which is a common model of calibrated material flaws in thermal tomography experiments. Materials considered in this study include stainless steel 316 (SS316), stainless steel 304 (SS304), and Inconel 718. Theoretical analyses were conducted to validate inversion of simulated PTT data with COMSOL for a plate. Subsequently, 3D reconstructions were performed on COMSOL simulations for FBH, revealing a decrease in spatial resolution over depth due to thermal diffusion. The results of this study show that the performance of the inversion algorithm for detecting smaller defects depends strongly on the depth of the defect as well as the incident heat flux. The size of detectable defect was estimated by fitting a Gaussian function to surface temperature profile. The criteria for detectability was taken as 20mK noise equivalent temperature difference (NETD), which is currently the sensitivity limit of high-performance infrared cameras. It was determined through computer simulations that the smallest detectable FBH in SS316 has a 50µm diameter and is located 0.5mm below the plate surface. Preliminary experimental studies were performed to evaluate PTT performance in detecting calibrated flaws using metallic specimens with AM defects simulated as drilled-in FBH’s. High strength Stainless Steel 316 and Inconel 718 alloys were considered, as well as lower grade Stainless Steel 304, Nickel 200, and Hastelloy C276. Specimens investigated in this report consisted of approximately 1/4in-thick plates made out of these alloys using conventional manufacturing methods. The diameters of FBH’s varied from 1mm to 8mm, and their depths below the plate flat surface varied between 1mm and 6mm. The size of the smallest FBH was limited to 1mm because conventional mechanical drills were used for creating the holes. PTT imaging results have shown that 1mm-diameter FBH located 1mm and 2mm below the surface were detectable. Larger size FBH were detectable at greater depth. For example, 6mm-diameter FBH could be detected at 8mm depth. Image contrast varied slightly between the specimens, with the best reconstructions obtained in SS316 and C276 plates. Finally, PTT capability in imaging several AM structures fabricated from Inconel 718 (IN718) powder feedstock was investigated. The AM structures have complex geometry, but do not have calibrated internal defects. The objective is to determine PTT settings, such as the total integration time, for imaging of representative AM structures. A new FLIR X8500sc IR camera with higher spatial resolution (1280x1024 at 181Hz frame rate) was integrated into the PTT laboratory setup. Software tools were developed to ensure compatibility of new camera files with legacy effusivity reconstruction codes. The new camera was used to obtain 3-D reconstructions of AM IN718 nozzle plate and a particle filter plate. It was shown that PTT can scan through 2/3in-thick Inconel 718 plates in approximately 15s. Several modes of 3-D data visualization were explored, including using ImageJ and MATLAB software packages. The results demonstrate the capability of PTT in 3-D imaging of complex geometry AM structures. Intermediate results demonstrated in this report will be developed further to investigate detection of flaws in AM specimens.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Enhancing Regional Seismic Velocity Models With Higher‐Resolution Local Results Using Sparse Dictionary Learning

Abstract We use sparse dictionary learning to develop transformations between seismic velocity models of different resolution and spatial extent. Starting with data in the common region of both models, the method can enhance a regional lower‐resolution model to match the style and resolution of local higher‐resolution results while preserving its regional coverage. The method is demonstrated by applying it to two‐dimensional V S and three‐dimensional V P and V S regional and local velocity models in southern California. The enhanced reconstructed regional results exhibit clear visual improvements, especially in the reconstructed V P / V S ratios, and better correlations with geological features. Moreover, the reconstructed regional V P , V S models outperform the original ones in comparison of simulated earthquake waveforms to observations. The improved fitting to observed waveforms extends beyond the domain of the overlapping region. The developed dictionary learning approach provides physically interpretable results and offers a powerful tool for additional applications of data enhancement in earth sciences.

Geochemistry & Geophysics↗

Induced microearthquakes predict permeability creation in the brittle crust

Predicting the evolution of permeability accurately during stimulation at the reservoir scale and at the resolution of individual fractures is essential to characterize the fluid transport and the reactive/heat-transfer characteristics of reservoirs where stress exerts significant control. Here, we develop a hybrid machine learning (ML) model to visualize in situ permeability evolution for an intermediate-scale (~10 m) hydraulic stimulation experiment. This model includes an ML model that was trained using the well history of flow rate and wellhead pressure and MEQ data from the first three stimulation episodes to predict average permeability from the statistical features of the MEQs alone for later episodes. Moreover, a physics-inspired model is integrated to estimate in situ fracture permeability spatially. This method relates fracture permeability to fracture dilation and scales dilation to the equivalent MEQ magnitude, according to laboratory observations. The seismic data are then applied to define incremental changes in permeability in both space and time. Our results confirm the excellent agreement between the ground truth and model-predicted permeability evolution. The resulting permeability map defines and quantifies flow paths in the reservoir with the averaged permeability comparing favorably with the ground truth of permeability.

induced seismicity↗

Progress and Plans in Support of the Polar Community

Feedback provided by the Antarctic community has proven instrumental in positively influencing the direction of the GCMD's development. For example, in response to requests for a stand alone metadata authoring tool, a new shareable software package called docBUILDER solo will be released to the public in March 2006. This tool permits researchers to document their data during experiments and observational periods in the field. The international polar community has also played a key role in encouraging support for the foreign language character set in the metadata display and tools (10% of the records in the AMD hold foreign characters). In the upcoming release, the full ISO character set, which also includes mathematical symbols, will be supported. Additional upgrades include the ability for users to search for data sets based on pre-selected temporal and spatial resolution ranges. Data providers are strongly encouraged to populate the resolution fields for their data sets, although these fields are not currently required. In prior versions, browser incompatibilities often resulted in unreliable performance for users attempting to initiate a spatial search using a map based on Java applet technology. The GCMD will offer an integrated Google map and date search, replacing the applet technology and enhancing the geospatial and temporal searches. It is estimated that 30% of the records in the AMD have direct access to data. A growing number of these records can be accessed through data service links. Related data services are therefore becoming valuable assets in facilitating the use and visualization of data. Users will gain the ability to refine services using the same options as those available for data set searches. Data providers are encouraged to describe available data-related services through the directory. Future plans include offering web services through a SOAP interface and extending semantic queries for the polar regions through the use of ontologies. The Open Archives Initiative's (OAI) Protocol for Metadata Harvesting (PMH) has been successfully tested with several organizations and appears to be a prime candidate for sharing metadata within the community. The GCMD anticipates contributing to the design of the data management system for the International Polar Year and to the ongoing efforts in the years to come. Further enhancements will be discussed at the meeting.

Olsen, Lola M.↗

Four-Dimensional Imaging of ZnO-Coated Alumina Aerogels by Scanning Transmission X-ray Microscopy and Ptychographic Tomography

Functional porous materials are of mounting significance in energy conversion and catalysis. Improved analysis is needed to guide optimization. Four-dimensional (4D) imaging [chemical mapping in three-dimensional (3D) by spectro-tomography] of an Al 2 O 3 aerogel coated with ZnO by atomic layer deposition was performed using soft X-ray ptychography at the Zn L-edge. A two-dimensional spatial resolution of 14(2) nm was achieved. Visualizations of the 3D chemical structure are provided. The degree of ZnO coverage of the surface of the Al 2 O 3 aerogel framework in two different samples was estimated and found to be both thicker and less homogeneous than expected. Other analyses of the 4D results, including the degree of contact between Al 2 O 3 and ZnO, were extracted from the reconstructed 3D data. This pioneering soft X-ray spectro-ptycho-tomography research will anchor further studies of functional porous materials.

36 MATERIALS SCIENCE↗

Large-scale mapping of the Galaxy by IRAS

The Infrared Astronomical Satellite (IRAS), launched Jan. 25, 1983, has conducted a high-sensitivity, high-resolution all-sky photometric survey at wavelengths of 12, 25, 60, and 100 microns in the infrared. One of the data products to be developed from the survey is a map of the entire Milky Way within latitude limits of 10 degrees at a resolution of 4 arcmin. The dc-coupled, extremely stable detector system permits mapping with reliable information at all spatial scales larger than the map resolution. The extremely high sensitivity of the IRAS instrument for the detection of interstellar material in the survey mode is illustrated in terms of visual extinction and dust and gas column densities.

Gautier, T. N., III↗

NASA SPoRT GOES-R Proving Ground Activities

The NASA Short-term Prediction Research and Transition (SPoRT) program is a partner with the GOES-R Proving Ground (PG) helping prepare forecasters understand the unique products to come from the GOES-R instrument suite. SPoRT is working collaboratively with other members of the GOES-R PG team and Algorithm Working Group (AWG) scientists to develop and disseminate a suite of proxy products that address specific forecast problems for the WFOs, Regional and National Support Centers, and other NOAA users. These products draw on SPoRT s expertise with the transition and evaluation of products into operations from the MODIS instrument and the North Alabama Lightning Mapping Array (NALMA). The MODIS instrument serves as an excellent proxy for the Advanced Baseline Imager (ABI) that will be aboard GOES-R. SPoRT has transitioned and evaluated several multi-channel MODIS products. The true and false color products are being used in natural hazard detection by several SPoRT partners to provide better observation of land features, such as fires, smoke plumes, and snow cover. Additionally, many of SPoRT s partners are coastal offices and already benefit from the MODIS sea surface temperature composite. This, along with other surface feature observations will be developed into ABI proxy products for diagnostic use in the forecast process as well as assimilation into forecast models. In addition to the MODIS instrument, the NALMA has proven very valuable to WFOs with access to these total lightning data. These data provide situational awareness and enhanced warning decision making to improve lead times for severe thunderstorm and tornado warnings. One effort by SPoRT scientists includes a lightning threat product to create short-term model forecasts of lightning activity. Additionally, SPoRT is working with the AWG to create GLM proxy data from several of the ground based total lightning networks, such as the NALMA. The evaluation will focus on the vastly improved spatial coverage of the GLM, but with the trade-off of lower resolution compared to the NALMA. In addition to the above tasks, SPoRT will make these data available in the NWS next generation display software, AWIPS II. This has already been successfully completed for the two basic GLM proxies. SPoRT will use these products to train forecasters on the capabilities of GOES-R and foster feedback to develop additional products, visualizations, and requirements beneficial to end users needs. These developments and feedback will be made available to the GOES-R Proving Ground for the upcoming 2010 Spring Program in Norman, Oklahoma.

Stano, Geoffrey T.↗

Amorphous and Crystalline H20 Ice at Rhea's Inktomi Crater

We present the analysis of Cassini spectral data from spectral mapping of Saturnian icy moons Dione and Rhea, to investigate possible effects of impact crater formation on the relative abundances of crystalline and amorphous water ice in the moons' ice crusts. Both moons display morphologically young ray craters as well as older craters. Possible changes in ice properties due to crater formation are conjectured to be more visible in younger craters, and as such Rhea's well imaged ray crater Inktomi is analysed, as are older craters for comparison. We used data from Cassini's Visual and Infrared Mapping Spectrometer (VIMS). For each pixel in the VIMS maps, spectral data were extracted in the near-infrared range (1.75 micrometers less than lambda less than 2.45 micrometers). Analysis was begun by fitting a single Gaussian to the peak in absorption at 2.0 micrometers, which was then subtracted from the data, leaving residuals with a minimum on either side of the original 2.0-micrometers band. The spectra of the individual spatial pixels were then clustered by the differences between these minima, which are sensitive to changes in both ice grain size and crystallinity. This yielded preliminary maps which approximated the physical characteristics of the landscape and were used to identify candidates for further analysis. Spectra were then clustered by the properties of the 1.5-micrometers band, to divide the map into regions based on inferred grain size. For each region, the predicted differences in minima from the Gaussian residuals, over a range of crystallinities, were calculated based on the found grain sizes. This model was used to find the crystallinity of each pixel via grain size and characteristics of the residual function. Preliminary results show a greater degree of crystallization of young crater interiors, particularly in Rhea's ray crater Inktomi, where ice showed crystalline ice abundances between 33 percent and 61 percent. These patterns in ice crystallization are possibly attributable to increased heat generated during crater formation.

Saturn Satellites↗

Virtual Diagnostics Interface (ViDI) for Planning Laser-Based Wind Tunnel Experiments

Virtual Diagnostics Interface (ViDI), originally introduced by Richard Schwartz in 2004 and described again by Alderfer, et. al., in 2007, is an interactive 3D software tool developed at NASA Langley Research Center to serve three main purposes: assist in pre-test planning, enhance post-test image analysis and visualization, and serve as a central location for data storage and distribution.1,2 ViDI is composed of custom-developed software and Autodesk® 3ds Max® as it incorporates Computer Aided Design (CAD) models with the results obtained from optical diagnostics.3 This software tool has proven useful in the field of optical diagnostics where pre-test planning of beam paths, optical elements, and test articles must be carried out to avoid interference, ensure spatial resolution is sufficient, and the camera Field of View (FoV) is adequate for the field of interest. Typically, practical considerations such as the distance a camera is from the region of interest, the angles at which the camera is oriented and issues such as the size of the camera and its sensor and size and focal length lens as well as the path of the laser need to be taken into account to predict a successful measurement. An example application of ViDI is shown in Fig.1 where an experiment to investigate flow separation over the wing of the High Lift Common Research Model (HL-CRM) is currently being planned in the National Transonic Facility (NTF) at NASA Langley Research Center.

virtual diagnostics interface↗

No more active galactic nuclei in clumpy disks than in smooth galaxies at z ∼ 2 in CANDELS/3D-HST

We use CANDELS imaging, 3D-HST spectroscopy, and Chandra X-ray data to investigate if active galactic nuclei (AGNs) are preferentially fueled by violent disk instabilities funneling gas into galaxy centers at 1.3 < z < 2.4. We select galaxies undergoing gravitational instabilities using the number of clumps and degree of patchiness as proxies. The CANDELS visual classification system is used to identify 44 clumpy disk galaxies, along with mass-matched comparison samples of smooth and intermediate morphology galaxies. We note that despite being mass-matched and having similar star formation rates, the smoother galaxies tend to be smaller disks with more prominent bulges compared to the clumpy galaxies. The lack of smooth extended disks is probably a general feature of the z ∼ 2 galaxy population, and means we cannot directly compare with the clumpy and smooth extended disks observed at lower redshift. We find that z ∼ 2 clumpy galaxies have slightly enhanced AGN fractions selected by integrated line ratios (in the mass-excitation method), but the spatially resolved line ratios indicate this is likely due to extended phenomena rather than nuclear AGNs. Meanwhile, the X-ray data show that clumpy, smooth, and intermediate galaxies have nearly indistinguishable AGN fractions derived from both individual detections and stacked non-detections. The data demonstrate that AGN fueling modes at z ∼ 1.85—whether violent disk instabilities or secular processes—are as efficient in smooth galaxies as they are in clumpy galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

TU-AB-204-00: Advances in Cone-Beam CT and Emerging Applications

This symposium highlights advanced cone-beam CT (CBCT) technologies in four areas of emerging application in diagnostic imaging and image-guided interventions. Each area includes research that extends the spatial, temporal, and/or contrast resolution characteristics of CBCT beyond conventional limits through advances in scanner technology, acquisition protocols, and 3D image reconstruction techniques. Dr. G. Chen (University of Wisconsin) will present on the topic: Advances in C-arm CBCT for Brain Perfusion Imaging. Stroke is a leading cause of death and disability, and a fraction of people having an acute ischemic stroke are suitable candidates for endovascular therapy. Critical factors that affect both the likelihood of successful revascularization and good clinical outcome are: 1) the time between stroke onset and revascularization; and 2) the ability to distinguish patients who have a small volume of irreversibly injured brain (ischemic core) and a large volume of ischemic but salvageable brain (penumbra) from patients with a large ischemic core and little or no penumbra. Therefore, “time is brain” in the care of the stroke patients. C-arm CBCT systems widely available in angiography suites have the potential to generate non-contrast-enhanced CBCT images to exclude the presence of hemorrhage, time-resolved CBCT angiography to evaluate the site of occlusion and collaterals, and CBCT perfusion parametric images to assess the extent of the ischemic core and penumbra, thereby fulfilling the imaging requirements of a “one-stop-shop” in the angiography suite to reduce the time between onset and revascularization therapy. The challenges and opportunities to advance CBCT technology to fully enable the one-stop-shop C-arm CBCT platform for brain imaging will be discussed. Dr. R. Fahrig (Stanford University) will present on the topic: Advances in C-arm CBCT for Cardiac Interventions. With the goal of providing functional information during cardiac interventions, significant effort has been expended to improve the quantitative accuracy of C-arm CBCT reconstructions. The challenge is to improve image quality while providing very short turnaround between data acquisition and volume data visualization. Corrections for x-ray scatter, view aliasing and patient motion that require no more than 2 iterations keep processing time short while reducing artifact. Fast, multi-sweep acquisitions can be used to permit assessment of left ventricular function, and visualization of radiofrequency lesions created to treat arrhythmias. Workflows for each imaging goal have been developed and validated against gold standard clinical CT or histology. The challenges, opportunities, and limitations of the new functional C-arm CBCT imaging techniques will be discussed. Dr. W. Zbijewski (Johns Hopkins University) will present on the topic: Advances in CBCT for Orthopaedics and Bone Health Imaging. Cone-beam CT is particularly well suited for imaging of musculoskeletal extremities. Owing to the high spatial resolution of flat-panel detectors, CBCT can surpass conventional CT in imaging tasks involving bone visualization, quantitative analysis of subchondral trabecular structure, and visualization and monitoring of subtle fractures that are common in orthopedic radiology. A dedicated CBCT platform has been developed that offers flexibility in system design and provides not only a compact configuration with improved logistics for extremities imaging but also enables novel diagnostic capabilities such as imaging of weight-bearing lower extremities in a natural stance. The design, development and clinical performance of dedicated extremities CBCT systems will be presented. Advanced capabilities for quantitative volumetric assessment of joint space morphology, dual-energy image-based quantification of bone composition, and in-vivo analysis of bone microarchitecture will be discussed, along with emerging applications in the diagnosis of arthritis and osteoporosis and assessment of novel therapies. Finally, Dr. J. Boone (UC Davis) will present on the topic: Advances in CBCT for Breast Imaging. Breast CT has been studied as an imaging tool for diagnostic breast evaluation and for potential breast cancer screening. The breast CT application lends itself to CBCT because of the small dimensions of the breast, the tapered shape of the breast towards higher cone angle, and the fact that there are no bones in the breast. The performance of various generations of breast CT scanners developed in recent years will be discussed, focusing on advances in spatial resolution and image noise characteristics. The results will also demonstrate the results of clinical trials using both computer and human observers. Learning Objectives: Understand the challenges, key technological advances, and emerging opportunities of CBCT in: Brain perfusion imaging, including assessment of ischemic stroke Cardiac imaging for functional assessment in cardiac interventions Orthopedics imaging for evaluation of musculoskeletal trauma, arthritis, and osteoporosis Breast imaging for screening and diagnosis of breast cancer. Work presented in this symposium includes research support by: Siemens Healthcare (Dr. Chen); NIH and Siemens Healthcare (Dr. Fahrig); NIH and Carestream Health (Dr. Zbijewski); and NIH (Dr. Boone)

60 APPLIED LIFE SCIENCES↗

Visualizing feedstock siting in biomass production: Tradeoffs between economic and water quality objectives

New domestic, renewable energy resources must be considered to increase energy security in the U.S. Ethanol production through second-generation (cellulosic) feedstocks will help the U.S. meet the legislative Renewable Fuel Standard, which mandates 36 billion gallons of renewable fuels by 2022. Yet, conversion of cropland to meet the cellulosic feedstock production goals may have unforeseen environmental consequences. Here, using Soil Water Assessment Tool (SWAT) outputs and National Agricultural Statistics Service (USDA NASS) economic data, we conducted a spatial optimization of bioenergy feedstock introduction into the Arkansas White-Red River Basin based on water quality and economic objectives, subject to constraints on total land conversion. Results displayed tradeoffs between bioenergy yield for three crops (switchgrass, sorghum and poplar) and land rent objectives. Optimal solutions tended to prioritize conversion of land in eastern AWR subbasins where yield and water quality objective improvements were greatest. A small number of subbasins contributed to basin-wide water quality improvements, whereas subbasins contributing to economic benefits were more spatially dispersed, indicating that water quality responses are more likely to constrain feedstock placement. Biomass production targets can be met vianumerous spatial arrangements, whereas marginal improvement in water quality objectives can best be achieved by selectively siting perennial feedstocks in the eastern half of the region.

09 BIOMASS FUELS↗

Development of low temperature fuel cell holders for Operando x-ray micro and nano computed tomography to visualize water distribution

Abstract Synchrotron x-ray imaging techniques, like x-ray computed tomography (CT) and radiography have proven instrumental in expanding the communities knowledge of complex transport and reaction kinetics in electrochemical devices such as fuel cells and electrolyzers. This work presents the development of novel x-ray CT imaging techniques for operando visualization of water within low temperature fuel cells at spatial resolutions spanning the micro and nano scales. The design of operando sample holders, for both micro x-ray CT and nano CT experiments is described in depth, and prototypes of these sample holders were evaluated across a set of requirements, the most important of which are x-ray transmissibility, electrical conductivity and mechanical stability. Water segmentation from micro x-ray CT data was enabled by an image subtraction method, where the image without water is subtracted from the one with water. Through iterative experimentations, the operando nano CT cell was developed to optimize mechanical compression, electric conductivity and gas flow. While three-dimensional fuel cell reconstructions were shown possible, there remain challenges to overcome at typical lower energies (8 keV) due to beam damage, whereas it is not as significant for higher energies (>17.5 keV).

Kulkarni, Devashish↗

Spatially resolved reflectivities of Saturn - 3000-6000 A

Absolute reflectivity reductions are presented for spectrophotometric observations of seven spatially-resolved regions on the disk of Saturn in the 3000-6000 A region. An asymmetry is found between northern and southern hemisphere data, in the equivalent width of the CH4, 5430-A band and in the continuum reflectivity. In addition, the spectra are found not to include the 4700 A reflectivity peak found by Bergstralh et al (1981), and to exhibit general agreement with the Podolack and Danielson (1977) model. The blue and visual spectral region continuum reflectivity of a planetary atmosphere provides constraints for determining aerosol particle single-scattering albedo and vertical distribution, which are in turn important to an understanding of planetary energy balance, atmospheric dynamics, and planetary molecular absorption spectrum interpretation.

Cochran, W. D.↗

Facilitating Navigation Through Large Archives

Automated Visual Access (AVA) is a computer program that effectively makes a large collection of information visible in a manner that enables a user to quickly and efficiently locate information resources, with minimal need for conventional keyword searches and perusal of complex hierarchical directory systems. AVA includes three key components: (1) a taxonomy that comprises a collection of words and phrases, clustered according to meaning, that are used to classify information resources; (2) a statistical indexing and scoring engine; and (3) a component that generates a graphical user interface that uses the scoring data to generate a visual map of resources and topics. The top level of an AVA display is a pictorial representation of an information archive. The user enters the depicted archive by either clicking on a depiction of subject area cluster, selecting a topic from a list, or entering a query into a text box. The resulting display enables the user to view candidate information entities at various levels of detail. Resources are grouped spatially by topic with greatest generality at the top layer and increasing detail with depth. The user can zoom in or out of specific sites or into greater or lesser content detail.

Shelton, Robert O.↗

Imaging LIDAR through Fog and Dust for Maritime Surveillance

This work supports Airborne Intelligence, Surveillance, and Reconnaissance (ISR) for tactical situational awareness in challenging environments with modified imaging LIDAR (light detection and ranging). LIDAR produces an irradiance-based scene with high, three-dimensional, spatial resolution; differentiating reflecting surfaces and surface textures not just for target detection, but also target recognition. LIDAR is generally prevented from working through all weather; as the traditional source wavelengths are scattered and/or absorbed by fog, clouds, and dust known as degraded visual environments (DVEs). This work identifies and quantifies improved optical wavelength regimes and polarization strategies that should open this otherwise denied operating window for LIDAR. We demonstrate modified imaging LIDAR's utility and ability to produce images in environments that have been challenging for traditional LIDAR (fog, dust) systems. We utilize a state-of-the-art Geiger mode avalanche photodiode (GMAPD) 32X32 detecting array for imaging with an integrated fast timing circuit ROIC per imaging detector pixel. This GMAPD is equivalent to 1024 radar receivers and produces a 3-D point cloud scene for each <lnsec laser interrogation pulse. Through this work, we have demonstrated Sandia's first imaging LIDAR system. We developed significant software to scan the GMAPD array, control data acquisition, and stitch an arbitrary number of images for greater lateral spatial resolution. We designed and built an optical system to evaluate performance, in the laboratory and in field tests, and relate to the performance at tactically important distances. Our use of this system is to study and characterize techniques that extend the range of useful imaging through fog for applications in a maritime environment. We quantify, with simulations, broad wavelength regimes and illuminating polarizations that have benefit in propagating through fog. In particular, we identify circular polarization over broad wavebands as a superior persisting signal technique in extending the useful range of active LIDAR in forward-scattering environments. Finally, we characterize the performance of our LIDAR system and confirm our theoretical predictions in the field and directly evaluate this system as a function of polarization in Sandia's medium-range Fog Tunnel Facility. This technology has potential impacts in improved ISR in maritime environments, but with further development could be revolutionary in tactical ISR by providing real-time three-dimensional full motion video (3D FMV) in DVEs.

47 OTHER INSTRUMENTATION↗

TU-H-206-01: An Automated Approach for Identifying Geometric Distortions in Gamma Cameras

Purpose: To develop a clinically-deployable, automated process for detecting artifacts in routine nuclear medicine (NM) quality assurance (QA) bar phantom images. Methods: An artifact detection algorithm was created to analyze bar phantom images as part of an ongoing QA program. A low noise, high resolution reference image was acquired from an x-ray of the bar phantom with a Philips Digital Diagnost system utilizing image stitching. NM bar images, acquired for 5 million counts over a 512×512 matrix, were registered to the template image by maximizing mutual information (MI). The MI index was used as an initial test for artifacts; low values indicate an overall presence of distortions regardless of their spatial location. Images with low MI scores were further analyzed for bar linearity, periodicity, alignment, and compression to locate differences with respect to the template. Findings from each test were spatially correlated and locations failing multiple tests were flagged as potential artifacts requiring additional visual analysis. The algorithm was initially deployed for GE Discovery 670 and Infinia Hawkeye gamma cameras. Results: The algorithm successfully identified clinically relevant artifacts from both systems previously unnoticed by technologists performing the QA. Average MI indices for artifact-free images are 0.55. Images with MI indices < 0.50 have shown 100% sensitivity and specificity for artifact detection when compared with a thorough visual analysis. Correlation of geometric tests confirms the ability to spatially locate the most likely image regions containing an artifact regardless of initial phantom orientation. Conclusion: The algorithm shows the potential to detect gamma camera artifacts that may be missed by routine technologist inspections. Detection and subsequent correction of artifacts ensures maximum image quality and may help to identify failing hardware before it impacts clinical workflow. Going forward, the algorithm is being deployed to monitor data from all gamma cameras within our health system.

60 APPLIED LIFE SCIENCES↗