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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3

Biomimetic virus-based colorimetric sensors

The present invention provides, inter alia, a device comprising a colorimetric detection layer configured to undergo a color change upon interaction with a first analyte of interest. The detection layer comprises a first plurality of self-assembled fiber bundles. At least a fraction of the fiber bundles undergo a change from a first conformation to a second conformation upon interaction with the first analyte of interest, thereby undergoing a color change. The invention also provides a method for using the system to detect an analyte of interest.

36 MATERIALS SCIENCE↗

Biomimetic virus-based colorimetric sensors

The present invention provides, inter alia, a device comprising a colorimetric detection layer configured to undergo a color change upon interaction with a first analyte of interest. The detection layer comprises a first plurality of self-assembled fiber bundles. At least a fraction of the fiber bundles undergo a change from a first conformation to a second conformation upon interaction with the first analyte of interest, thereby undergoing a color change. The invention also provides a method for using the system to detect an analyte of interest.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

A comparative review of optical surface contamination assessment techniques

This paper will review the relative sensitivities and practicalities of the common surface analytical methods that are used to detect and identify unwelcome adsorbants on optical surfaces. The compared methods include visual inspection, simple reflectometry and transmissiometry, ellipsometry, infrared absorption and attenuated total reflectance spectroscopy (ATR), Auger electron spectroscopy (AES), scanning electron microscopy (SEM), secondary ion mass spectrometry (SIMS), and mass accretion determined by quartz crystal microbalance (QCM). The discussion is biased toward those methods that apply optical thin film analytical techniques to spacecraft optical contamination problems. Examples are cited from both ground based and in-orbit experiments.

Heaney, James B.↗

High-precision chemical quantum sensing in flowing monodisperse microdroplets

A method is presented for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. Using nanodiamonds (ND) with fluorescent nitrogen-vacancy (NV) centers as quantum sensors, rapidly flowing microdroplets containing analyte molecules are analyzed. A noise-suppressed mode of optically detected magnetic resonance is enabled by pairing controllable flow with microwave control of NV electronic spins, to detect analyte-induced signals of a few hundredths of a percent of the ND fluorescence. Using this method, paramagnetic ions in droplets are detected with low limit-of-detection using small analyte volumes, with exceptional measurement stability over >10 3 s. In addition, these droplets are used as microconfinement chambers by co-encapsulating ND quantum sensors with various analytes such as single cells, suggesting wide-ranging applications including single-cell metabolomics and real-time intracellular measurements from bioreactors. Important advances are enabled by this work, including portable chemical testing devices, amplification-free chemical assays, and chemical imaging tools for probing reactions within microenvironments.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Affordable Realtime Viral Detection: Demonstrated with SARS COV-2

The near real-time detection of airborne particles-of-interest is needed for avoiding current/future threats. The incorporation of imprinted particles into a micelle-based electrochemical cell produced a signal when brought into contact with particle analytes (such as SARS-COV-2), previously imprinted onto the structure. Nanoamp scales of signals were generated from what may’ve been individual virus-micelle interactions. The system showed selectivity when tested against similar size and morphology particles. The technology was compatible with airborne aerosol sampling techniques. Overall, the application of imprinted micelle technology could provide near real-time detection methods to a host of possible analytes of interest in the field.

47 OTHER INSTRUMENTATION↗

Chemical Detection and Identification Techniques for Exobiology Flight Experiments

Exobiology flight experiments require highly sensitive instrumentation for in situ analysis of the volatile chemical species that occur in the atmospheres and surfaces of various bodies within the solar system. The complex mixtures encountered place a heavy burden on the analytical Instrumentation to detect and identify all species present. The minimal resources available onboard for such missions mandate that the instruments provide maximum analytical capabilities with minimal requirements of volume, weight and consumables. Advances in technology may be achieved by increasing the amount of information acquired by a given technique with greater analytical capabilities and miniaturization of proven terrestrial technology. We describe here methods to develop analytical instruments for the detection and identification of a wide range of chemical species using Gas Chromatography. These efforts to expand the analytical capabilities of GC technology are focused on the development of detectors for the GC which provide sample identification independent of the GC retention time data. A novel new approach employs Penning Ionization Electron Spectroscopy (PIES).

Kojiro, Daniel R.↗

Air Conditioning Systems Fault Detection and Diagnosis-Based Sensing and Data-Driven Approaches

The air conditioning (AC) system is the primary building end-use contributor to the peak demand for energy. The energy consumed by this system has grown as fast as it has in the last few decades, not only in the residential section but also in the industry and transport sectors. Therefore, to combat energy crises, urgent actions on energy efficiency should be taken to support energy security. Consequently, the faults in AC system components increase energy consumption due to the degradation of the system’s performance and the losses in the energy conversion procedure. In this work, AC system fault detection and diagnosis (FDD) methods are investigated to propose analytic tools to identify faults and provide solutions to those problems. The analysis of existing work shows that data-driven approaches are more accurate for both soft and hard fault detection and diagnosis in AC systems. Therefore, the proposed methods are not accurate for simultaneous fault detection, while in some works, authors tested the method with several faults separately without investigating scenarios that combine more than one fault. Moreover, this study shows that integrating data-driven approaches requires deploying an optimal sensing and measurement architecture that can detect a maximum number of faults with minimally deployed sensors. The new sensing, information, and communication technologies are discussed for their integration in AC system monitoring in order to optimize system operation and detect faults.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Integration of SAR and DEM data: Geometrical considerations

General principles for integrating data from different sources are derived from the experience of registration of SAR images with digital elevation models (DEM) data. The integration consists of establishing geometrical relations between the data sets that allow us to accumulate information from both data sets for any given object point (e.g., elevation, slope, backscatter of ground cover, etc.). Since the geometries of the two data are completely different they cannot be compared on a pixel by pixel basis. The presented approach detects instances of higher level features in both data sets independently and performs the matching at the high level. Besides the efficiency of this general strategy it further allows the integration of additional knowledge sources: world knowledge and sensor characteristics are also useful sources of information. The SAR features layover and shadow can be detected easily in SAR images. An analytical method to find such regions also in a DEM needs in addition the parameters of the flight path of the SAR sensor and the range projection model. The generation of the SAR layover and shadow maps is summarized and new extensions to this method are proposed.

Kropatsch, Walter G.↗

Medical applications of artificial olfactometry

The present invention provides methods for detecting the presence of an analyte indicative of various medical conditions, including halitosis, periodontal disease and other diseases are also disclosed.

Lewis, Nathan S.↗

Separation at Crossing Waypoints Under Wind Uncertainty in Urban Air Mobility

To enable high-density operations in major metropolitan areas, urban air mobility networks are anticipated to have air traffic management with higher levels of autonomy. To ensure that this type of autonomy is feasible, one of the critical steps from a safety and efficiency perspective is understanding various factors that affect the spatial separation between airborne flights and ensure that these factors can be managed. In terms of separation assurance and scheduling, an important real-world concern is that future states of aircraft cannot be perfectly predicted. The focus of this research paper is to understand how these prediction errors affect separation and scheduling services and to explore mitigation strategies to handle these errors. In this research, we have simulated these types of uncertainty by adding wind-prediction errors to trajectory predictions for separation. With these wind-prediction errors, we decompose the problem into two separate questions. First, using both simulation and analytical methods, we look at conflict-detection-only scenarios to understand how the wind errors affect required minimum temporal separation between crossing flights to ensure a specific spatial separation. Next, we study how trajectory errors effect conflict resolution, and we explore different combinations of scheduling and separation assurance to mitigate the effects of uncertainty between crossing flights. The conflict resolution algorithm aims to minimize necessary temporal separation between crossing flights under uncertainty, still ensuring safety-critical spatial separation. In summary, this research suggests that the required minimum temporal separation at a crossing waypoint is dependent on factors such as inbound crossing angle, the relative angle between wind direction and bearing of each route, wind magnitude, wind magnitude uncertainty, nominal cruise airspeed of aircraft, and look-ahead time of the conflict detection algorithm. This research also suggests that different combinations of scheduling and separation have different qualitative results. Using a combination of strategic, flow-based scheduling, tactical scheduling at crossings, speed control near crossing points, and separation management leads to a system that is insensitive to trajectory prediction errors with high throughput and flexibility for aircraft away from shared resources.

urban air mobility↗

Separation at Crossing Waypoints Under Wind Uncertainty in Urban Air Mobility

To enable high-density operations in major metropolitan areas, urban air mobility networks are anticipated to have air traffic management with higher levels of autonomy. To ensure that this type of autonomy is feasible, one of the critical steps from a safety and efficiency perspective is understanding various factors that affect the spatial separation between airborne flights and ensure that these factors can be managed. In terms of separation assurance and scheduling, an important real-world concern is that future states of aircraft cannot be perfectly predicted. The focus of this research paper is to understand how these prediction errors affect separation and scheduling services and to explore mitigation strategies to handle these errors. In this research, we have simulated these types of uncertainty by adding wind-prediction errors to trajectory predictions for separation. With these wind-prediction errors, we decompose the problem into two separate questions. First, using both simulation and analytical methods, we look at conflict-detection-only scenarios to understand how the wind errors affect required minimum temporal separation between crossing flights to ensure a specific spatial separation. Next, we study how trajectory errors effect conflict resolution, and we explore different combinations of scheduling and separation assurance to mitigate the effects of uncertainty between crossing flights. The conflict resolution algorithm aims to minimize necessary temporal separation between crossing flights under uncertainty, still ensuring safety-critical spatial separation. In summary, this research suggests that the required minimum temporal separation at a crossing waypoint is dependent on factors such as inbound crossing angle, the relative angle between wind direction and bearing of each route, wind magnitude, wind magnitude uncertainty, nominal cruise airspeed of aircraft, and look-ahead time of the conflict detection algorithm. This research also suggests that different combinations of scheduling and separation have different qualitative results. Using a combination of strategic, flow-based scheduling, tactical scheduling at crossings, speed control near crossing points, and separation management leads to a system that is insensitive to trajectory prediction errors with high throughput and flexibility for aircraft away from shared resources.

urban air mobility↗

Detection of analytes using porous mass spectrometry surface

The disclosure herein includes compositions and methods for ionizing targets and methods for making the compositions. In some embodiments, the compositions can include a porous substrate that has been etched for a desired average pore size, a desired porosity, or both for detection of one or more targets of interest. Also disclosed herein are methods for using the composition to ionize targets.

36 MATERIALS SCIENCE↗

Sensitive Procedures for Determining the Permeation Resistance of Chlorinated Polyethylene Against Liquid Propellants

The permeation resistance of chlorinated polyethylene (CPE) used in totally encapsulating chemical protective suits against the aerospace fuels hydrazine, monomethylhydrazine, and uns-dimethylhydrazine was determined by measuring the breakthrough time (BT) and time-averaged vapor transmission rate (VTR) using procedures consistent with ASTM F 739 and ASTM F 1383. Two exposure scenarios were simulated: a 2 hour (h) fuel vapor exposure, and a liquid fuel "splash" followed by a 2 h vapor exposure. To simulate internal suit pressure during operation, a positive differential pressure of 0.3 in. water (75 Pa) on the collection side of the permeation apparatus was used. Using the available data, a model was developed to estimate propellant concentrations inside an air-line fed, totally encapsulating chemical protective suit. Concentrations were calculated under simulated conditions of fixed vapor transmission rate, variable breathing air flow rate, and variable splash exposure area. Calculations showed that the maximum allowable permeation rates of hydrazine fuels through CPE were of the order of 0.05 to 0.08 ng/sq cm min for encapsulating suits with low breathing air flow rates (of the order of 5 scfm or 140 L min-1). Above these permeation rates, the 10 parts-per-billion (ppb) threshold limit value time-weighted average could be exceeded. To evaluate suit performance at 10 ppb threshold-limiting value/time-weighted average level concentrations, use of a sensitive analytical method such as cation exchange high performance liquid chromatography with amperometric detection was found to be essential. The analytical detection limit determines the lowest measurable VTR, which in turn governed the lowest per meant concentration that could be calculated inside the totally encapsulating chemical protective suit.

Waller, Jess M.↗

Development of Direct Injection/Ionization Mass Spectrometry Methods for Whole Molecule Characterization

The objective of this work is to adapt ambient ionization mass spectrometry (AMS) techniques for the rapid analysis of intact uranium complexes, stable strontium, cerium, and explosive compounds. The methods used were “soft ionization” techniques, which facilitate the detection of whole molecule complexes. The soft ionization mass spectrometry (MS) techniques that were investigated include paper spray ionization (PSI), matrix-assisted ionization (MAI), electrospray ionization (ESI) and direct analysis in real time (DART). For the first time, PSI-MS methods were successfully developed for whole molecule uranium-containing analytes (uranyl acetate, uranyl nitrate, and uranyl-tributylphosphate complexes). This was also the first demonstration of uranium complex detection and characterization and one of the few examples of inorganic analysis using MAI techniques. Proof of concept experiments also putatively identified matrix-derived ions and ion complexes that have not previously been described in the literature. Additionally, PSI-MS on cotton swipe samples doped with a multi-element standard containing μg levels of U, Bi, Pb, Cd, Fe, and Zn were directly analyzed without purification, representing a major improvement over existing methods. Both PSI and MAI methods demonstrated limits of detection (LODs) in the 10 - 100’s ng for various uranyl species within a range of 10’s ppm - 100’s ppb, dependent on analytical method and analyte species. AMS methods were also developed for other inorganics, including Ce and Sr, and organic explosive residues to address specific challenges in environmental monitoring and forensics. Further refinement and qualification of the AMS techniques developed within this effort would lead to significant cost reduction and timeliness by facilitating the triage and queueing of samples for subsequent more sensitive and time-consuming analyses.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Search for and investigation of extraterrestrial forms of life

Correct combinations of remote, analytic, and functional methods and measuring devices for detecting extraterrestrial life are elaborated. Considered are techniques and instruments available both on earth and aboard spacecraft and artificial planetary satellites. Emphasis is placed on the abiogenetic synthesis of organic compounds formed in photosynthesis on Mars.

Rubin, A. B.↗

Failure detection and isolation experiments with the Langley Mini-Mast

A report is presented on experiments to demonstrate failure detection and isolation (FDI) using the flexible truss facility Mini-Mast at the NASA Langley Research Center. Two techniques are selected for study because they are applicable both to sensor and actuator failures and because they do not depend on hypotheses about the forms of possible failures. These two are the method of generalized parity relations and the failure detection filter. These methods utilize the concept of analytical redundancy and therefore their performance depends on the fidelity of the model of the dynamics of the system being monitored. Results are given for sensor FDI using generalized parity relations and input-output data collected during operation of the Mini-Mast. component failures are simulated in the data. The dependence of the performance of the methods on choices of the parameters in their implementation is explored.

Vander Velde, Wallace E.↗

Methods for isothermal molecular amplification with nanoparticle-based reactions

The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.

Gang, Oleg↗

Detection of Anatoxins in Human Urine by Liquid Chromatography Triple Quadrupole Mass Spectrometry and ELISA

Harmful cyanobacterial blooms are becoming more common and persistent around the world. When in bloom, various cyanobacterial strains can produce anatoxins in high concentrations, which, unlike other cyanobacterial toxins, may be present in clear water. Potential human and animal exposures to anatoxins occur mainly through unintentional ingestion of contaminated algal mats and water. To address this public health threat, we developed and validated an LC-MS/MS method to detect anatoxins in human urine to confirm exposures. Pooled urine was fortified with anatoxin-a and dihydroanatoxin at concentrations from 10.0 to 500 ng/mL to create calibrators and quality control samples. Samples were diluted with isotopically labeled anatoxin and solvent prior to LC-MS/MS analysis. This method can accurately quantitate anatoxin-a with inter- and intraday accuracies ranging from 98.5 to 103% and relative standard deviations < 15%, which is within analytical guidelines for mass spectrometry methods. Additionally, this method qualitatively detects a common degradation product of anatoxin, dihydroanatoxin, above 10 ng/mL. We also evaluated a commercial anatoxin-a ELISA kit for potential diagnostic use; however, numerous false positives were detected from unexposed individual human urine samples. In conclusion, we have developed a method to detect anatoxins precisely and accurately in urine samples, addressing a public health area of concern, which can be applied to future exposure events.

urine↗