Comparing Deep Neural Network Architectures using Transfer-Learning to Predict Cognitive States
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machine learning↗
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Applying the Cognitive Space Gateway to Swarm Topologies
NASA's future vision for interplanetary networking includes a lunar network, Cube Satellite (CubeSat) constellations, and deep space robotic missions, comprising what could be viewed as a network of networks. Delay-tolerant networking (DTN) architecture and protocols provide a standard network layer among these varying scenarios and mitigate many challenges of the space environment, such as long delays, unplanned service interruptions, and asymmetric links. The Cognitive Space Gateway (CSG) is a routing method in a DTN architecture that uses spiking neural networks as the learning element to optimize routing decisions in a complex environment. This work aims to further develop cognitive networking technologies in several critical areas, including DTN, the CSG algorithm, CubeSat swarm topologies, and cloud services. To test the algorithm in a realistic scenario, the emulated network topology is based on a CubeSat swarm. The swarm may function as a mesh of nodes or as a hub-and-spoke network. An emulation environment will be built upon a commercial cloud service, such as Amazon Web Services (AWS) Elastic Compute Cloud. The cloud environment may enable a flexible, lower maintenance approach versus a multi-hop network based in a physical laboratory. The cloud platform will provide a secure environment allowing for collaboration among government and academic entities.
Ricardo Lent↗
Applying the Cognitive Space Gateway to Swarm Topologies
NASA’s future vision for interplanetary networking includes a lunar network, Cube Satellite (CubeSat) constellations, and deep space robotic missions, comprising what could be viewed as a network of networks. Delay-tolerant networking (DTN) architecture and protocols provide a standard network layer among these varying scenarios and mitigate many challenges of the space environment, such as long delays, unplanned service interruptions, and asymmetric links. The Cognitive Space Gateway (CSG) is a routing method in a DTN architecture that uses spiking neural networks as the learning element to optimize outing decisions in a complex environment. This work aims to further develop cognitive networking technologies in several critical areas, including DTN, the CSG algorithm, SmallSat swarm topologies, and cloud services. The CSG algorithm is tested in a realistic scenario in which the emulated network topology is based on a SmallSat swarm. The emulation environment will be built upon a commercial cloud service, such as Amazon Web Services (AWS) Elastic Compute Cloud. This work investigates the ability of such a platform to enable a flexible, lower maintenance approach to creating a multihop network outside of a physical laboratory. The cloud platform will provide a secure environment allowing for collaboration among government and academic entities.
Ricardo Lent↗
A distributed agent architecture for real-time knowledge-based systems: Real-time expert systems project, phase 1
We propose a distributed agent architecture (DAA) that can support a variety of paradigms based on both traditional real-time computing and artificial intelligence. DAA consists of distributed agents that are classified into two categories: reactive and cognitive. Reactive agents can be implemented directly in Ada to meet hard real-time requirements and be deployed on on-board embedded processors. A traditional real-time computing methodology under consideration is the rate monotonic theory that can guarantee schedulability based on analytical methods. AI techniques under consideration for reactive agents are approximate or anytime reasoning that can be implemented using Bayesian belief networks as in Guardian. Cognitive agents are traditional expert systems that can be implemented in ART-Ada to meet soft real-time requirements. During the initial design of cognitive agents, it is critical to consider the migration path that would allow initial deployment on ground-based workstations with eventual deployment on on-board processors. ART-Ada technology enables this migration while Lisp-based technologies make it difficult if not impossible. In addition to reactive and cognitive agents, a meta-level agent would be needed to coordinate multiple agents and to provide meta-level control.
Lee, S. Daniel↗
Wideband Reconfigurable Harmonically Tuned GaN SSPA for Cognitive Radios
The paper presents the architecture of a wideband reconfigurable harmonically-tuned Gallium Nitrate (GaN) Solid State Power Amplifier (SSPA) for cognitive radios. When interfaced with the physical layer of a cognitive communication system, this amplifier topology offers broadband high efficiency through the use of multiple tuned input/output matching networks. This feature enables the cognitive radio to reconfigure the operating frequency without sacrificing efficiency. This paper additionally presents as a proof-of-concept the design, fabrication, and test results for a GaN inverse class-F type amplifier operating at X-band (8.4 GHz) that achieves a maximum output power of 5.14-W, Power Added Efficiency (PAE) of 38.6, and Drain Efficiency (DE) of 48.9 under continuous wave (CW) operation.
Cognitive↗
Multiband Reconfigurable Harmonically Tuned Gallium Nitride (GaN) Solid-State Power Amplifier (SSPA) for Cognitive Radios
The paper presents the architecture of a wideband reconfigurable harmonically-tuned Gallium Nitride (GaN) Solid State Power Amplifier (SSPA) for cognitive radios. When interfaced with the physical layer of a cognitive communication system, this amplifier topology offers broadband high efficiency through the use of multiple tuned input/output matching networks. This feature enables the cognitive radio to reconfigure the operating frequency without sacrificing efficiency. This paper additionally presents as a proof-of-concept the design, fabrication, and test results for a GaN inverse Class-F type amplifier operating at X-band (8.4 GHz) that achieves a maximum output power of 5.14-W, Power Added Efficiency (PAE) of 38.6 percent, and Drain Efficiency (DE) of 48.9 percent under continuous wave (CW) operation.
Cognitive↗
Combined discrete network. Continuous control modelling of operator behavior
The situation in which an operator is faced with a continuous control task plus one or more discrete information processing tasks is discussed. A modelling approach which has the capability of realistically representing both types of tasks and the resulting interactions is sought. The modelling approach utilizes discrete network models for the cognitive tasks and elements of an open-loop - closed-loop control representation for the continuous task. the approach is demonstrated through its application to a simulated Digital Avionics Information System in which subjects were required to perform retrieval and processing tasks as well as flight control. This model differs from conventional model in that system status sampling is not necessarily continuous or periodic. Rather, the pilot is assumed to read system status displays only as time permits and operate in a so-called open-loop preprogrammed fashion between sampling.
Miller, R. A.↗
Examination of Haines Jump in Microfluidic Experiments via Evolution Graphs and Interface Tracking
This work examines a type of rapid pore-filling event in multiphase flow through permeable media that is better known as Haines Jump. While existing microfluidic experiments on Haines Jump mostly seek to maintain quasi-steady states through very low bulk flow rates over long periods of time, this work explores the combined use of a highly structured microscale transport network, high-speed fluorescent microscopy, displacement front segmentation algorithms, and a tracking algorithm to build evolution graphs that track displacement fronts as they evolve through high-speed video recording. The resulting evolution graph allows the segmentation of a high-speed recording in both space and time, potentially facilitating topology-cognitive computation on the transport network. Occurrences of Haines Jump are identified in the microfluidic displacement experiments and their significance in bulk flow rates is qualitatively analyzed. The bulk flow rate has little effect on the significance of Haines Jump during merging and splitting, but large bulk flow rates may obscure small bursts at the narrowest part of the throat.
permeable media↗
A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p‐tau, synaptic peptides, and physical activity
INTRODUCTION: In the aging brain, cognitive abilities emerge from the coordination of complex pathways arising from a balance between protective lifestyle and environmental factors and accumulation of neuropathologies. METHODS: As part of the Rush Memory and Aging Project (n = 440), we measured accelerometer-based actigraphy, cognitive performance, and after brain autopsy, selected reaction monitoring mass spectrometry. Multilevel network analysis was used to examine the relationships among the molecular machinery of vesicular neurotransmission, Alzheimer's disease (AD) neuropathology, cognition, and late-life physical activity. RESULTS: Synaptic peptides involved in neuronal secretory function were the most influential contributors to the multilayer network, reflecting the complex interdependencies among AD pathology, synaptic processes, and late-life cognition. Older adults with lower physical activity evidenced stronger adverse relationships among phosphorylated tau peptides, markers of synaptic integrity, and tangle pathology. DISCUSSION: Network-based approaches simultaneously model interdependent biological processes and advance understanding of the role of physical activity in age-associated cognitive impairment. Highlights: Network-based approaches simultaneously model interdependent biological processes. Secretory synaptic peptides were influential contributors to the multilayer network. Older adults with lower physical activity had adverse relationships among pathology. There was interdependence among phosphorylated tau, synaptic integrity, and tangles. Network methods elucidate the role of physical activity in cognitive impairment.
60 APPLIED LIFE SCIENCES↗
Machine Learning Models to Predict Cognitive Impairment of Rodents Subjected to Space Radiation
INTRODUCTION We use artificial neural networks (ANNs) as an example machine learning (ML) tool to predict the cognitive performance impairment of rats induced by irradiation. The experimental data in the analyses is attentional set-shifting (ATSET) test scores from a rodent model exposed to ≤15 cGy of individual galactic cosmic radiation (GCR) ions: 4He, 28Si, or 56Fe, expected for a Lunar or Mars mission [1]. This work investigates rats at a subject-based level and uses applied dose and performance scores taken before irradiation to predict whether a rat will be impaired when irradiated. The results of this study are significant to crewed space missions as they support the potential of predicting an astronaut’s impairment in a specific task before spaceflight through the implementation of appropriately trained ML tools. METHODS Data used in this work are scores from the ATSET, a multi-stage constrained cognitive flexibility test [2]. Our computational model utilizes the number of attempts to reach the criterion to pass a stage as a behavioral performance measure for rats. We use the post-irradiation scores, generate thresholds from cumulative distribution plots of non-irradiated rats, and calculate the percent of irradiated rats whose scores fall below the threshold to infer how each radiation type/dose affects a population. Rats scoring above the threshold are labeled impaired while the others are non-impaired. We then employ ANNs as a typical ML technique, and use each subject’s individual scores taken before radiation along with the applied dose, to predict their personal susceptibility to cognitive impairment due to space radiation exposure. RESULTS AND CONCLUSION A significant finding is the exhibition of a dose-dependent increasing probability of impairment for 1 to 10 cGy of 28Si or 56Fe in the simple discrimination (SD) stage of the ATSET, and for 1 to 10 cGy of 56Fe in the compound discrimination (CD) stage. On a subject-based level, implementing ML classifiers such as ANNs identifies rats that have a higher tendency for impairment after GCR exposure [1]. The receiver operating characteristic (ROC) and the precision-recall (PR) curves of the ML models show a better prediction of impairment when 56Fe is the ion in question in both SD (Figure 1) and CD stages. They, however, do not depict impairment due to 4He in SD (Figure 1) and 28Si in CD, suggesting no dose-dependent impairment response in these cases. In this work, “good” prediction pertains to “better-than-random-chance”, due to the limited sample size and the high inter- and intra-individual variabilities in response to brain stimulation paradigms, as applicable to both animals and humans. More behavioral tests and biomarkers should be investigated on the same subjects, to be fed to the ML models to capture the agents responsible for performance alterations of some individuals versus others.
machine learning↗
Protecting Neural Structures and Cognitive Function During Prolonged Space Flight by Targeting the Brain Derived Neurotrophic Factor Molecular Network
Brain derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophin in the human nervous system. BDNF is implicated in production of new neurons from dentate gyrus stem cells (hippocampal neurogenesis), synapse formation, sprouting of new axons, growth of new axons, sprouting of new dendrites, and neuron survival. Alterations in the amount or activity of BDNF can produce significant detrimental changes to cortical function and synaptic transmission in the human brain. This can result in glial and neuronal dysfunction, which may contribute to a range of clinical conditions, spanning a number of learning, behavioral, and neurological disorders. There is an extensive body of work surrounding the BDNF molecular network, including BDNF gene polymorphisms, methylated BDNF gene promoters, multiple gene transcripts, varied BDNF functional proteins, and different BDNF receptors (whose activation differentially drive the neuron to neurogenesis or apoptosis). BDNF is also closely linked to mitochondrial biogenesis through PGC-1alpha, which can influence brain and muscle metabolic efficiency. BDNF AS A HUMAN SPACE FLIGHT COUNTERMEASURE TARGET Earth-based studies reveal that BDNF is negatively impacted by many of the conditions encountered in the space environment, including oxidative stress, radiation, psychological stressors, sleep deprivation, and many others. A growing body of work suggests that the BDNF network is responsive to a range of diet, nutrition, exercise, drug, and other types of influences. This section explores the BDNF network in the context of 1) protecting the brain and nervous system in the space environment, 2) optimizing neurobehavioral performance in space, and 3) reducing the residual effects of space flight on the nervous system on return to Earth
Schmidt, M. A.↗
Testing a Neural Network Accelerator on a High-Altitude Balloon
The cognitive communications project has been working to re d machine learning approaches to support their deployment and sustained use in space environments. It has historically been difficult to implement such techniques on space platforms, however, due to the computational requirements they levy onto general-purpose avionics hardware. While technologies exist to accelerate the computation of aspects of neural networks, such platforms have not historically been deployed in space environments. Given that testing payloads in such environments can be both cost- and time-prohibitive, high-altitude balloons can be used as a way to approximate a space environment at a much lower cost, thus providing a cost-effective way in which to test newer approaches to hardware acceleration for artificial intelligence which may be deployed onto spacecraft more directly. This paper describes a successful test of a commercial off- the-shelf neural network accelerator on a high-altitude balloon. It begins by explaining our selection criteria when evaluating different commercial neural network acceleration techniques: primary considerations include size, weight, and power (SWaP) as well as ease of integration. Next, the paper describes the development and implementation of an experimental flight test platform: flight and ground components are discussed. Afterward, the paper discusses the experimental payload itself: this includes the experimental procedure as well as the specific image and method used for testing. Finally, the paper concludes with an evaluation of both the experimental device tested at altitude as well as the flight test framework itself, identifying how the existing platform can be used to continue tes g commercial off-the-shelf (COTS) solutions for acceleration.
Clark, Gilbert↗
Modulation Classification of Satellite Communication Signals Using Cumulants and Neural Networks
National Aeronautics and Space Administration (NASA)'s future communication architecture is evaluating cognitive technologies and increased system intelligence. These technologies are expected to reduce the operational complexity of the network, increase science data return, and reduce interference to self and others. In order to increase situational awareness, signal classification algorithms could be applied to identify users and distinguish sources of interference. A significant amount of previous work has been done in the area of automatic signal classification for military and commercial applications. As a preliminary step, we seek to develop a system with the ability to discern signals typically encountered in satellite communication. Proposed is an automatic modulation classifier which utilizes higher order statistics (cumulants) and an estimate of the signal-to-noise ratio. These features are extracted from baseband symbols and then processed by a neural network for classification. The modulation types considered are phase-shift keying (PSK), amplitude and phase-shift keying (APSK),and quadrature amplitude modulation (QAM). Physical layer properties specific to the Digital Video Broadcasting - Satellite- Second Generation (DVB-S2) standard, such as pilots and variable ring ratios, are also considered. This paper will provide simulation results of a candidate modulation classifier, and performance will be evaluated over a range of signal-to-noise ratios, frequency offsets, and nonlinear amplifier distortions.
Signal Recognition↗
Modulation Classification of Satellite Communication Signals Using Cumulants and Neural Networks
National Aeronautics and Space Administration (NASA)'s future communication architecture is evaluating cognitive technologies and increased system intelligence. These technologies are expected to reduce the operational complexity of the network, increase science data return, and reduce interference to self and others. In order to increase situational awareness, signal classification algorithms could be applied to identify users and distinguish sources of interference. A significant amount of previous work has been done in the area of automatic signal classification for military and commercial applications. As a preliminary step, we seek to develop a system with the ability to discern signals typically encountered in satellite communication. Proposed is an automatic modulation classifier which utilizes higher order statistics (cumulants) and an estimate of the signal-to-noise ratio. These features are extracted from baseband symbols and then processed by a neural network for classification. The modulation types considered are phase-shift keying (PSK), amplitude and phase-shift keying (APSK),and quadrature amplitude modulation (QAM). Physical layer properties specific to the Digital Video Broadcasting - Satellite- Second Generation (DVB-S2) standard, such as pilots and variable ring ratios, are also considered. This paper will provide simulation results of a candidate modulation classifier, and performance will be evaluated over a range of signal-to-noise ratios, frequency offsets, and nonlinear amplifier distortions.
Signal Classification↗
Cognition from genes to ecology: individual differences incognition and its potential role in a social network
Not Available
Smith, Brian H.↗
Photothermally Activated Artificial Neuromorphic Synapses
Biological nervous systems rely on the coordination of billions of neurons with complex, dynamic connectivity to enable the ability to process information and form memories. In turn, artificial intelligence and neuromorphic computing platforms have sought to mimic biological cognition through software-based neural networks and hardware demonstrations utilizing memristive circuitry with fixed dynamics. Here, to incorporate the advantages of tunable dynamic software implementations of neural networks into hardware, we develop a proof-of-concept artificial synapse with adaptable resistivity. This synapse leverages the photothermally induced local phase transition of VO 2 thin films by temporally modulated laser pulses. Such a process quickly modifies the conductivity of the film site-selectively by a factor of 500 to “activate” these neurons and store “memory” by applying varying bias voltages to induce self-sustained Joule heating between electrodes after activation with a laser. These synapses are demonstrated to undergo a complete heating and cooling cycle in less than 120 ns.
70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
Plasma phosphorylated tau217 strongly associates with memory deficits in the Alzheimer’s disease spectrum
Abstract Plasma phosphorylated tau (p-tau) biomarkers open unprecedented opportunities for identifying carriers of Alzheimer’s disease pathophysiology in early disease stages using minimally invasive techniques. Plasma p-tau biomarkers are believed to reflect tau phosphorylation and secretion. However, it remains unclear to what extent the magnitude of plasma p-tau abnormalities reflects neuronal network disturbance in the form of cognitive impairment. To address this question, we included 103 cognitively unimpaired elderly and 40 cognitively impaired, amyloid-β-positive individuals from the TRIAD cohort, in addition to 336 cognitively unimpaired and 216 cognitively impaired, amyloid-β-positive older adults from the BioFINDER-2 cohort. Participants had tau PET scans, amyloid PET scans or amyloid CSF, p-tau217, p-tau181 and p-tau231 blood measures, structural T1-MRI and cognitive assessments. In this cross-sectional study, we used regression models and correlation analyses to assess the relationship between plasma biomarkers and cognitive scores. Furthermore, we applied receiver operating characteristic curves to assess cognitive impairment across plasma biomarkers. Finally, we categorized participants into amyloid (A), p-tau (T1) and tau PET (T2) positive (+) or negative (−) profiles and ran non-parametric comparisons to assess differences across cognitive domains. We found that plasma p-tau217 was more associated with cognitive performance than p-tau181 and p-tau231 and that this relationship was particularly strong for memory scores (TRIAD: βp-tau217 = −0.53, βp-tau181 = −0.35 and βp-tau231 = −0.24; BioFINDER-2: βp-tau217 = −0.52, βp-tau181 = −0.24 and βp-tau231 = −0.29). Associations in amyloid-β-positive participants resembled these results, but other cognitive scores also showed strong associations in cognitively impaired individuals. Moreover, plasma p-tau217 outperformed plasma p-tau181 and plasma p-tau231 in identifying memory impairment (area under the curve values for TRIAD: p-tau217 = 0.86, p-tau181 = 0.77 and p-tau231 = 0.75; and for BioFINDER-2: p-tau217 = 0.86, p-tau181 = 0.76 and p-tau231 = 0.81) and in identifying executive function impairment only in the BioFINDER-2 cohort (p-tau217 = 0.82, p-tau181 = 0.76 and p-tau231 = 0.76). Lastly, we showed that subtle memory deficits were present in A+T1+T2− participants for plasma p-tau217 (P = 0.007) and plasma p-tau181 (P = 0.01) in the TRIAD cohort and for all biomarkers across cognitive domains in A+T1+T2− and A+T1+T2− individuals (P < 0.001 in all) in the BioFINDER-2 cohort. The A+T1+T2− individuals showed cognitive deficits in both cohorts (P < 0.001 in all). Together, our results suggest that plasma p-tau217 stands out as a biomarker capable of identifying memory deficits attributable to Alzheimer’s disease and that memory impairment certainly occurs in amyloid-β- and plasma p-tau-positive individuals who have no significant amounts of tau in the neocortex.
Neurosciences & Neurology↗
Overview of the Communications and Intelligent Systems Division at the NASA Glenn Research Center
NASA's plans for advancing aeronautics and space exploration requires optimization of current capabilities and development of new ones to support its mission. A key requirement associated with these efforts is the constant upgrading and optimization of communication systems. This presentation will provide a brief overview of NASA efforts, with emphasis on those being performed at the NASA Glenn Research Center, to develop communications technologies and systems in support of NASA aerospace communications needs. Status of specific technology examples in the area of cognitive communication systems, Advanced RF Technologies, Networks, and Systems Architectures will be presented and their impact in the overall scheme of needs will be discussed. In addition, cross- cutting technologies which enable sensing, control and communications technologies to perform in extreme environments as well as non-destructive evaluations techniques for vehicle health monitoring and related purposes will be presented.
Miranda, Felix A.↗