Rearranging the Nernst equation to make a dosage-controllable membrane delivery system
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bio-inspired, energy storage (including batteries ↗
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Results for “DOSAGE”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Increased mortality in mice following immunoprophylaxis therapy with high dosage of nicotinamide in Burkholderia persistent infections
Bacterial persistence, known as non-inherited antibacterial resistance, is a contributing factor to the establishment of long-lasting chronic bacterial infections. In this study, we examined the ability of nicotinamide (NA) to potentiate different classes of antibiotics against Burkholderia thailandensis persister cells. Here we demonstrate that addition of NA in in vitro models of B. thailandensis infection resulted in a significant depletion of the persister population in response to various classes of antibiotics. We applied microfluidic bioreactors with a continuous media flow to study the effect of supplementation with a NA gradient on the recovery of B. thailandensis persister populations. A co-culture of human neutrophils pre-activated with 50 µM NA and B. thailandensis resulted in the most efficient reduction in the persister population. Applying single cell RNA FISH analysis and quantitative PCR, we found that NA inhibited gene expression of the stringent response regulator relA , implicated in the regulation of the persister metabolic state. In conclusion, we also demonstrate that a therapeutic dose of NA (250mg/kg), previously applied as immunoprophylaxis against antibiotic-resistant bacterial species, produced adverse effects in an in vivo murine infection model of the highly pathogenic Burkholderia pseudomallei , indicating that therapeutic dose and metabolite effects have to be carefully evaluated and tailored for every case of potential clinical application.
60 APPLIED LIFE SCIENCES↗
Development of In Vitro Dissolution Testing Methods to Simulate Fed Conditions for Immediate Release Solid Oral Dosage Forms
Not provided.
Pharmacology & Pharmacy↗
Using Monte Carlo methods to estimate occupational dosage during 225 Ac production
Since alpha emitting isotopes such as 225 Ac, ideal for radiation treatment, are in short supply, the Medical Isotope Research and Production program at Brookhaven National Laboratory (BNL) is devel- oping new pathways for 225 Ac production. One proposed pathway is to resurrect the EBCO cyclotron at BNL to irradiate a 226 Ra target for 40 hours in a 16 MeV proton beam. Using MCNPX and CINDER software to simulate this process, we found that 1.26 Ci of 225 Ac could be produced from 300 mg of 226 Ra. To ensure workplace safety, we modeled the detailed geometry of lab 2-66C in Bldg. 801 and performed Monte Carlo simulations to estimate the radiation outside the lab as the irradiated sample is processed in a hot cell. We found the maximum dose outside the lab to be about 9 x 10 -5 rem/h. To reduce occupational dose, we recommend 200 thick steel shielding covering the sample insertion passage. These 225 Ac production runs could help cover the EBCO cyclotron's operational costs.
43 PARTICLE ACCELERATORS↗
RADIATION DOSAGES FROM ELECTRONS AND BREMSSTRAHLUNG IN THE VAN ALLEN BELTS
Radiation dose from electrons and bremsstrahlung in van allen belt - spacecraft shielding
RADIATION DOSE↗
A simple code for use in shielding and radiation dosage analyses
A simple code for use in analyses of gamma radiation effects in laminated materials is described. Simple and good geometry is assumed so that all multiple collision and scattering events are excluded from consideration. The code is capable of handling laminates up to six layers. However, for laminates of more than six layers, the same code may be used to incorporate two additional layers at a time, making use of punch-tape outputs from previous computation on all preceding layers. Spectrum of attenuated radiation are obtained as both printed output and punch tape output as desired.
Wan, C. C.↗
Drug-dosage indicator
Simple indicator, easily incorporated into drug container, allows patient to keep track of medication intake. Device can be used with loose tablets or liquids.
Neupert, W. M.↗
Apollo-Soyuz pamphlet no. 6: Cosmic ray dosage
The radiation hazard inside spacecraft is discussed with emphasis on its effects on the crew, biological specimens, and spacecraft instruments. The problem of light flash sensations in the eyes of astronauts is addressed and experiment MA-106 is described. In this experiment, light flashes seen by blindfolded astronauts were counted and high energy cosmic ray intensity in the command module cabin were measured. The damage caused by cosmic ray hits on small living organisms was investigated in the Biostack 3 experiment (MA-107). Individual cosmic rays were tracked through layers of bacterial spores, small seeds, and eggs interleaved with layers of AgCl-crystal wafers, special plastic, and special photographic film that registered each cosmic ray particle passed.
Page, L. W.↗
Correlation of Radiation Dosage With Mechanical Properties of Thin Films
The objective of this investigation was to examine the relationship between irradiation level (proton dose), microstructure, and stress levels in chemical vapor deposited diamond and polysilicon film using crosssectioned specimens. However, the emphasis was placed on the diamond specimen because diamond holds much promise for use in advanced technologies. The use of protons allows not only the study of the charged particle that may cause the most microstructural damage in Earth-orbit microelectromechanical systems (MEMS) devices, but also allows the study of relatively deeply buried damage inside the diamond material. Using protons allows these studies without having to resort to megaelectronvolt implant energies that may create extensive damage due to the high energy that is needed for the implantation process. Since 1 MEMS devices operating in space will not have an opportunity to reverse radiation damage via annealing, only nonannealed specimens were investigated. The following three high spatial resolution techniques were used to examine these relationships: (I) Scanning electron microscopy, (2) micro-Raman spectroscopy, and (3) micro x-ray diffraction.
Newton, R. L.↗
Space-Shielding Radiation Dosage Code Evaluation - Phase 1: SHIELDOSE-2 Radiation-Assessment Code
Radiation-transport codes or radiation-analysis tools are used in the spacecraft-design community to define and assess the local radiation levels. Among various radiation-transport/analysis tools available, SHIELDOSE-2 is commonly used in the early spacecraft-design phases because it has been established that it provides reasonably reliable results with relatively rapid computation time. The NASA Engineering and Safety Center initiated a two-phased study: (1) to better understand and document the SHIELDOSE-2 code capabilities and limitations, and (2) to recommend alternative tools to use for cases where SHIELDOSE-2 is not applicable. This report provides a summary of the Phase 1 study.
SHIELDOSE-2↗
Space-Shielding Radiation Dosage Code Evaluation Phase 2: SHIELDOSE-2 Radiation-Assessment Code
Radiation-transport codes or radiation-analysis tools are used in the spacecraft-design community to define and assess the local radiation levels. Among various radiation-transport/analysis tools available, SHIELDOSE-2 is commonly used in the early spacecraft-design phases because it has been established that it provides reasonably reliable results with relatively rapid computation time. The NASA Engineering and Safety Center initiated a two-phased study: (1) to better understand and document the SHIELDOSE-2 code capabilities and limitations, and (2) to identify alternative tools to use for cases where SHIELDOSE-2 is not applicable. This report provides a summary of the Phase 2 study.
SHIELDOSE-2↗
Dosage Compensation for Uniform Printing with Non-uniform Beams in Projection Two-Photon Lithography
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Engineering↗
Induced and natural variation affect traits independently in hybrid Populus
Abstract The genetic control of many plant traits can be highly complex. Both allelic variation (sequence change) and dosage variation (copy number change) contribute to a plant's phenotype. While numerous studies have investigated the effect of allelic or dosage variation, very few have documented both within the same system, leaving their relative contribution to phenotypic effects unclear. The Populus genome is highly polymorphic, and poplars are fairly tolerant of gene dosage variation. Here, using a previously established Populus hybrid F1 population, we assessed and compared the effect of natural allelic variation and induced dosage variation on biomass, phenology, and leaf morphology traits. We identified QTLs for many of these traits, but our results indicate limited overlap between the QTLs associated with natural allelic variation and induced dosage variation. Additionally, the integration of data from both allelic and dosage variation identifies a larger set of QTLs that together explain a larger percentage of the phenotypic variance. Finally, our results suggest that the effect of the large indels might mask that of allelic QTLs. Our study helps clarify the relationship between allelic and dosage variation and their effects on quantitative traits.
Guo, Weier (ORCID:0000000251789334)↗
A Novel Poplar Biomass Germplasm Resource for Functional Genomics and Breeding
Interspecific hybridization is the most effective method for producing poplar clones for commercial applications, including biomass production. Previous research has shown that commercial F1 hybrids frequently exhibit dosage variation, i.e. variation in the number of pieces or entire chromosomes, and that these variants can have novel or more extreme phenotypes compared to their parents, that can be desirable for biomass production. Poplar is a convenient system for studying and exploiting gene dosage because germplasm can very easily be propagated vegetatively, via cuttings, for research and production, and advanced genome-enabled tools can be directly employed on the actual feedstock. In the previous funding cycle, we had produced and characterized a population of interspecific hybrids carrying insertions and deletions, which together, tile the entire genome with dosage variation. In this funding cycle, we completed the development of this unique resource for the research community and started using the germplasm to investigate the role of gene dosage in poplar hybrid performance, and to identify chromosomal regions and genes that contribute to poplar bioenergy traits. Our specific goals were to: i) maintain and finish the characterization of this resource ii) investigate the phenotypic effects of dosage change iii) exploit the indel germplasm for functional genomics.
59 BASIC BIOLOGICAL SCIENCES↗
AN ACID BAKING APPROACH TO ENHANCE RARE EARTH ELEMENT RECOVERY FROM BITUMINOUS COAL SOURCES
Rare earth elements (REE) are a group of 17 elements typically classified as light and heavy rare earth elements, which play a crucial role in developing the latest technologies for energy, defense, and medical sectors. Even though REEs have been found in more than 200 minerals, only bastnaesite, monazite and xenotime are commercially exploited for REE extraction. However, the recent exponential increase in REE demand has spurred countries such as the United States into research for the extraction of REEs from secondary sources such as coal, acid mine drainage, and coal ash. Several coal sources (e.g., Fire Clay seam coal) across the United States have been identified to contain elevated concentrations of rare earth elements (>600 ppm), and various researchers have investigated the feasibility of both physical and hydrometallurgical extraction techniques for rare earth concentration and subsequent extraction. However, both physical and direct leaching were concluded to be inefficient for RE beneficiation and extraction due to low recoveries. Alternatively, thermal treatment provides promising means for RE recovery from bituminous coal sources. The positive impact of thermal treatment/calcination was established to be due to the decarbonization and dehydroxylation of the clays, which released entrapped rare earth elements within the dominant minerals and converted them into an acid-soluble form. Nonetheless, the improvement in recovery was limited to the light REEs (LREEs) with an insignificant increase in the heavy REEs (HREE). It was demonstrated that the light and heavy REEs in the material were associated with difficult-to-leach minerals such as monazite, xenotime, and zircon, which were not decomposed by simple calcination due to their high thermal stability. Hence, roasting in the presence of chemicals was necessary to ensure the decomposition of those REE-containing minerals. As such, this study was focused on the acid baking treatment of bituminous coals with an aim to enhance REE recovery, especially HREEs. Based on the presence of REE minerals like monazite and xenotime, three pre-leach treatment methods, i.e., 1) roasting, 2) direct acid baking, and 3) acid baking after roasting were investigated. Roasting tests at 600 ⁰C revealed that the recovery of light REEs (LREEs) was enhanced while the recovery of HREEs remained relatively unaffected. LREE and HREE recovery values of 38.3% and 21.3%, respectively, were achieved using a 50 g/L sulfuric acid solution at 5% solid concentration and a solution temperature of 75 ⁰C for 2 hours. Comparatively, direct acid baking at 250 °C provided substantial increased LREE and HREE recovery values to approximately 49.4% and 53.0%, respectively, using an equivalent acid dosage. Recoveries were maximized to 77.0% and 79.6% for LREE and HREE, respectively, by roasting followed by acid baking. Similar results were obtained from the treatment of a second bituminous coal source. Due to strong correlations between REE and Al recovery values, tests were performed on kaolinite and illite, which were prominent clay minerals within the source coals. These experiments revealed that the REE recovery improvements were likely a result of dehydroxylation of clays and subsequent release and decomposition of REE-bearing minerals such as monazite, xenotime and zircon. Subsequently, a parametric study was conducted to identify the impact of acid baking parameters on rare earth element recovery. The factors investigated using a three-level statistical experimental program were acid baking time, acid solution concentration, baking temperature, and acid solution-to-solids ratio which were found to significantly impact REE and contaminant element (Al, Fe, and Ca) recovery. An increase in baking temperature up to around 250 ⁰C improved the light and heavy REE recovery values by more than 50 absolute percentage points relative to performances achieved when direct leaching. As aforementioned, acid baking was needed to both decompose the clay minerals and liberate the REE minerals, which allowed access for the acid to solubilize the REEs. Acid concentration of the solution used for acid baking was studied as a means of minimizing the amount of acid needed to achieve a target REE recovery. However, thermo-gravimetric and differential scanning calorimetry analysis (TGA-DSC) of sulfuric acid under oxidizing atmosphere revealed that the addition of water decreased the evaporation temperature, which explains the lower REE recovery values obtained when using acid concentrations less than 100%. Using pure sulfuric acid at an acid-to-solid ratio of 0.8:1 resulted in recovery values of around 70% for both LREEs and HREEs. The decomposition reaction time was relatively quick with 65% of the TREEs recovered within the first 10 minutes. Following the identification of optimum operating conditions through the parametric study, a systematic leaching study was carried out to examine the impact of leaching parameters, such as solid-to-liquid (S/L) ratio, temperature, and time, on REE recovery using acid baking conditions of 1:1 acid to solids ratio at 250 °C for 30 minutes. The solid-to-liquid ratio was varied from 1-20% by weight at 25 °C, 50 °C, and 75 °C solution temperatures. The results indicated that reaction time and solution temperature considerably impacted the recovery of heavy and light REEs. Interestingly, LREE recovery reduced from 68% at 5% S/L to 58% at 20%S/L, whereas HREE recovery of 78% remained unaffected. The decrease in the LREE recovery was determined to be due to La and Ce precipitation, likely through isomorphic substitution with calcium in gypsum. The kinetic data indicated that 67% LREE and 77% HREE recovery could be obtained within the first 15 minutes of the reaction, suggesting fast reaction kinetics. Furthermore, raising the solution temperature from 25 °C to 75 °C increased the LREE and HREE recovery from 60% and 32% to 67% and 79%, respectively. The kinetic modeling results demonstrated that the rate-limiting step in the LREE dissolution was diffusion and chemical reaction, whereas the HREE extraction was controlled by only chemical reaction. The leaching study concluded that using 20% S/L at 75 °C for 15 minutes maximized LREE and HREE recovery. The lab-scale precipitation study showed that Fe and Al in solution could be removed at pH 4.5 followed by REE precipitation at pH 6.0 using 6 mol/L NaOH. Finally, the bench-scale data was used to develop a process flowsheet for REE recovery from low-grade bituminous coal sources using acid baking. Finally, based on the proposed flowsheet, a concentrated RE-cake obtained through selective precipitation at pH 6.5 was re-leached using HCl at pH 1.5. The resultant leachate was used to identify the impact of various operating parameters on REE recovery and purity with an aim to maximize REE precipitation efficiency while minimizing the oxalic acid dosage. The operating parameters for this investigation were oxalic acid dosage, iron (III) contamination, solution pH and temperature. The resultant model suggested that oxalic acid dosage and reaction pH are the most significant factors for the REE precipitation efficiency, followed by the interaction of oxalic dosage and Fe concentration. Test results indicated that increasing the oxalic acid concentration from 0g/L to 80g/L improved the REE precipitation efficiency from approximately 4.2% to 95.0%. Furthermore, raising the solution pH from 0.5 to 2.5 considerably enhanced the precipitation efficiency from 0.0% to 98.9%. A solution temperature elevation decreased REE recovery, which indicated an exothermic reaction between REEs and oxalate anions. Finally, a high level of Fe contamination adversely impacted REE precipitation efficiency. The speciation analysis revealed that the dominant iron species in the solution system were Fe-(C₂O₄)₃³⁻, Fe-(C₂O₄)²⁻, and Fe-(C₂O₄)⁺, which consumed the majority of the oxalate anions
rare earth elements, acid baking, high-temperature↗
Influence of set retarding admixtures on calcium sulfoaluminate cement hydration and property development
Little published data is available to guide specification calcium sulfoaluminate cement (CSA) mixtures with citric acid retarder dosage rates capable of achieving adequate field working times, nor to understand the effect of retarder dosage on hydration and property development, representing a significant barrier to widespread CSA concrete use. Thus, this study investigated the use of citric acid with two commercially-available CSA cements, tracking the effects of dosage on phase development, hydration, setting, and compressive strengths. Key findings were that: citric acid successfully retarded initial set past 120 min for both cements despite significantly different chemistries; increasing cement anhydrite content reduced retarder effectiveness and altered hardened binder microstructure, reducing compressive strengths; greater retarder dosages did not negatively affect cumulative hydration, nor strengths; and the time at which the maximum rate of heat evolution occurred correlated with final setting, a relationship useful for predicting field mixture behavior based on laboratory testing.
36 MATERIALS SCIENCE↗
Parametric study and speciation analysis of rare earth precipitation using oxalic acid in a chloride solution system
Oxalic acid precipitation is a common step in the purification of rare earth elements (REE) from a concentrated pregnant leach solution (PLS). However, the presence of contaminants such as Al, Fe, and Ca in given amounts decreases the REE precipitation efficiency and product purity while also increasing the amount of oxalic acid needed to maximize recovery. As such, a statistically designed test program was performed to identify the optimal conditions necessary for a relatively low REE content PLS containing elevated concentrations of contaminant ions. The performance objective was maximization of REE precipitation efficiency while minimizing the oxalic acid dosage. A central composite design was utilized to quantify performance impacts and identify the ultimate set of parameter values for oxalic acid dosage, Fe(III) contamination concentration, solution pH, and reaction temperature. The resultant model suggested that oxalic acid dosage and reaction pH are the most significant factors for the REE precipitation efficiency, followed by the interaction of oxalic dosage and Fe concentration. Test results indicate that increasing the oxalic acid concentration from 0 g/L to 80 g/L improved the REE precipitation efficiency from approximately 4.2% to 95.0%. Furthermore, raising the solution pH from 0.5 to 2.5 considerably enhanced the precipitation efficiency from 0.0% to 98.9%. A solution temperature elevation decreased REE recovery, which indicated an exothermic reaction between REEs and oxalate anions. Finally, a high level of Fe contamination adversely impacted REE precipitation efficiency. Here, to further the understanding of the REE-oxalate system, a fundamental solution chemistry study was performed using the equilibrium constants of the reactions. The study resulted in the development of oxalate speciation diagrams and provided an analysis of the REE precipitation characteristics at various oxalate anion concentrations and Fe(III) contamination levels using MINTEQ software. The dominant Fe(III) species in the solution system were found to be Fe-(C 2 O 4 ) 3 3- , Fe-(C 2 O 4 ) 2- , and Fe-(C 2 O 4 ) + , which consume the majority of the oxalate anions. The simulated model was found to be in agreement with the experimental findings and helped to explain the adverse impact of increased iron concentrations on REE precipitation efficiency.
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗