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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
NASA NTRS1992

Recovery of vestibular function following hair cell destruction by streptomycin

Can the vestibular periphery of warm-blooded vertebrates recover functionally from severe sensory hair cell loss? Recent findings in birds suggest a mechanism for recovery but in fact no direct functional evidence has been reported. We produced vestibular hair cell lesions using the ototoxic agent streptomycin sulfate (600 mg/kg/day, 8 days, chicks, Gallus domesticus). Compound action potentials of the vestibular nerve were used as a direct measure of peripheral vestibular function. Vestibular thresholds, neural activation latencies and amplitudes were documented. Eight days of drug treatment elevated thresholds significantly (P < 0.001) and eliminated all but remnants of vestibular activity. Virtually complete physiological recovery occurred in all animals studied over a period of 70 days following treatment. Thresholds recovered within two weeks of drug treatment whereas the return of response morphologies including activation latencies and amplitudes required an additional 6-8 weeks.

Non-NASA Center↗
NASA NTRS2003

Translocation of a Polymer Chain across a Nanopore: A Brownian Dynamics Simulation Study

We carried out Brownian dynamics simulation studies of the translocation of single polymer chains across a nanosized pore under the driving of an applied field (chemical potential gradient). The translocation process can be either dominated by the entropic barrier resulted from restricted motion of flexible polymer chains or by applied forces (or chemical gradient across the wall), we focused on the latter case in our studies. Calculation of radius of gyrations at the two opposite sides of the wall shows that the polymer chains are not in equilibrium during the translocation process. Despite this fact, our results show that the one-dimensional diffusion and the nucleation model provide an excellent description of the dependence of average translocation time on the chemical potential gradients, the polymer chain length and the solvent viscosity. In good agreement with experimental results and theoretical predictions, the translocation time distribution of our simple model shows strong non-Gaussian characteristics. It is observed that even for this simple tubelike pore geometry, more than one peak of translocation time distribution can be generated for proper pore diameter and applied field strengths. Both repulsive Weeks-Chandler-Anderson and attractive Lennard-Jones polymer-nanopore interaction were studied, attraction facilitates the translocation process by shortening the total translocation time and dramatically improve the capturing of polymer chain. The width of the translocation time distribution was found to decrease with increasing temperature, increasing field strength, and decreasing pore diameter.

Tian, Pu↗
NASA NTRSDate not supplied

NASA's Professional DEVELOPment - Evaluating 10 Weeks of Capacity Building

Under NASA’s Applied Sciences, the NASA DEVELOP Program is centered on dual capacity building. Projects bring together partners and participants to learn how Earth observation data can enhance environmental decision-making practices and inform action. During their time with DEVELOP, participants build technical skills around remotely sensed data and professional skills through interactions with team members, science advisors, and partners. To further refine the participant experience, DEVELOP explores which technical and professional skills individuals report improving during the 10-week program. An analysis of self-reported assessments from 2018 to 2021 included projects that were conducted in-person and virtually. Participants consistently indicated a strong improvement in technical and professional skills yet there was clear variation between in-person and virtual opportunities. When comparing between 2019 and 2021, self-reporting showed a higher percentage of participants reporting an increase in networking in the virtual environment and an increase in building professional relationships with project partners virtually. This analysis suggests that professional opportunities available in the virtual environment may in fact bolster early career scientists’ networking abilities. This presentation will identify DEVELOP’s approach to monitoring and evaluation, highlight interesting trends introduced by the pandemic, and lessons learned.

Sarah Payne↗
NASA NTRS2004

[Using Molecular Simulations to Understand Complex Nanoscale Dynamic Phenomena in Polymer Solutions]

The first half of the project concentrated on molecular simulation studies of the translocation of model molecules for single-stranded DNA through a nanosized pore. This has resulted in the publication, Translocation of a polymer chain across a nanopore: A Brownian dynamics simulation study, by Pu Tian and Grant D. Smith, JOURNAL OF CHEMICAL PHYSICS VOLUME 119, NUMBER 21 1 DECEMBER 2003, which is attached to this report. In this work we carried out Brownian dynamics simulation studies of the translocation of single polymer chains across a nanosized pore under the driving of an applied field (chemical potential gradient) designed to mimic an electrostatic field. The translocation process can be either dominated by the entropic barrier resulted from restricted motion of flexible polymer chains or by applied forces (or chemical gradient). We focused on the latter case in our studies. Calculation of radius of gyration of the translocating chain at the two opposite sides of the wall shows that the polymer chains are not in equilibrium during the translocation process. Despite this fact, our results show that the one-dimensional diffusion and the nucleation model provide an excellent description of the dependence of average translocation time on the chemical potential gradients, the polymer chain length and the solvent viscosity. In good agreement with experimental results and theoretical predictions, the translocation time distribution of our simple model shows strong non-Gaussian characteristics. It is observed that even for this simple tube-like pore geometry, more than one peak of translocation time distribution can be generated for proper pore diameter and applied field strengths. Both repulsive Weeks-Chandler-Anderson and attractive Lennard-Jones polymer-nanopore interaction were studied. Attraction facilitates the translocation process by shortening the total translocation time and dramatically improve the capturing of polymer chain. The width of the translocation time distribution was found to decrease with increasing temperature, increasing field strength, and decreasing pore diameter.

Smith, Grant↗
NASA NTRS1987

Femur-bending properties as influenced by gravity. V - Strength vs. calcium and gravity in rats exposed for 2 weeks

The dependence of gravitationally related changes in femur bone strength on the comparable changes in calcium content was investigated in rats exposed to chronic simulations of altered gravity from the 28th to 42nd day of age. Zero G was simulated by harness suspension and 3 G by centrifugation. Bone strength (S) was determined by bending (using modified quasi-static cantilever bending methods and equipment described by Wunder et al., 1977 and 1979) and Ca content (C, by mass pct) determined by atomic absorption spectrometry; results were compared with data obtained on both normal and harnessed control animals at 1 G. Multiple regression showed significant dependence of S upon earth's gravity, independent from C, for which there was no significant coefficient of partial regression. It is suggested that the lack of S/C correlation might have been due to the fact that considerable fraction of the calcium in these young, developing bones has not yet crystallized into the hydroxyapatite which provides strength.

Wunder, Charles C.↗
NASA NTRS2014

Human-Automation Cooperation for Separation Assurance in Future NextGen Environments

A 2012 Human-In-The-Loop air traffic control simulation investigated a gradual paradigm-shift in the allocation of functions between operators and automation. Air traffic controllers staffed five adjacent high-altitude en route sectors, and during the course of a two-week experiment, worked traffic under different function-allocation approaches aligned with four increasingly mature NextGen operational environments. These NextGen time-frames ranged from near current-day operations to nearly fully-automated control, in which the ground systems automation was responsible for detecting conflicts, issuing strategic and tactical resolutions, and alerting the controller to exceptional circumstances. Results indicate that overall performance was best in the most automated NextGen environment. Safe operations were achieved in this environment for twice todays peak airspace capacity, while being rated by the controllers as highly acceptable. However, results show that sector operations were not always safe; separation violations did in fact occur. This paper will describe in detail the simulation conducted, as well discuss important results and their implications.

air traffic control↗
NASA NTRS2001

Assimilation of GOES Land Surface Data Within a Rapid Update Cycle Format: Impact on MM5 Warm Season QPF

A technique has been developed for assimilating GOES-derived skin temperature tendencies and insolation into the surface energy budget equation of a mesoscale model so that the simulated rate of temperature change closely agrees with the satellite observations. A critical assumption of the technique is that the availability of moisture (either from the soil or vegetation) is the least known term in the model's surface energy budget. Therefore, the simulated latent heat flux, which is a function of surface moisture availability, is adjusted based upon differences between the modeled and satellite-observed skin temperature tendencies. An advantage of this technique is that satellite temperature tendencies are assimilated in an energetically consistent manner that avoids energy imbalances and surface stability problems that arise from direct assimilation of surface shelter temperatures. The fact that the rate of change of the satellite skin temperature is used rather than the absolute temperature means that sensor calibration is not as critical. The focus of this paper is to examine how the satellite assimilation technique impacts simulations of near-surface meteorology on the 0-to 12-hour time scale when implemented within a local rapid update cycle (LRUC) format. The PSU/NCAR MM5 V34 is used and configured with a 36-km CONUS domain and a 12-km nest centered over the southeastern US. The LRUC format consists of a sequence of 12-hour forecasts initialized every hour between 12 and 18 UTC seven days a week. GOES skin temperature tendencies and solar insolation are assimilated in a 1-hour period prior to the start of each twelve-hour forecast. A unique aspect of the LRUC is the satellite assimilation and the continuous recycling of the adjusted moisture availability field from one forecast cycle to the next. Preliminary results for a seven-day trial period indicate that hourly LST tendencies assimilated in a 1 hour LRUC showed improved simulated air and dewpoint temperatures for all cycles on each day. The LRUC will be used during the 2001 summer months to identify the impact of the assimilation on warm season QPF Results will be presented at the meeting.

Lapenta, William M.↗
NASA NTRS2002

Science@NASA: Direct to People!

Science@NASA is a science communication effort sponsored by NASA's Marshall Space Flight Center. It is the result of a four year research project between Marshall, the University of Florida College of Journalism and Communications and the internet communications company, Bishop Web Works. The goals of Science@NASA are to inform, inspire, and involve people in the excitement of NASA science by bringing that science directly to them. We stress not only the reporting of the facts of a particular topic, but also the context and importance of the research. Science@NASA involves several levels of activity from academic communications research to production of content for 6 websites, in an integrated process involving all phases of production. A Science Communications Roundtable Process is in place that includes scientists, managers, writers, editors, and Web technical experts. The close connection between the scientists and the writers/editors assures a high level of scientific accuracy in the finished products. The websites each have unique characters and are aimed at different audience segments: 1. http://science.nasa.gov. (SNG) Carries stories featuring various aspects of NASA science activity. The site carries 2 or 3 new stories each week in written and audio formats for science-attentive adults. 2. http://liftoff.msfc.nasa.gov. Features stories from SNG that are recast for a high school level audience. J-Track and J-Pass applets for tracking satellites are our most popular product. 3. http://kids. msfc.nasa.gov. This is the Nursemaids site and is aimed at a middle school audience. The NASAKids Club is a new feature at the site. 4. http://www.thursdaysclassroom.com . This site features lesson plans and classroom activities for educators centered around one of the science stories carried on SNG. 5. http://www.spaceweather.com. This site gives the status of solar activity and its interactions with the Earth's ionosphere and magnetosphere.

Koczor, Ronald J.↗
NASA NTRS2000

ACIS Door Failure Investigation and Mitigation Procedures

NASA's Chandra X-ray Observatory (formerly AXAF) was launched on July 23, 1999 and is currently in orbit performing scientific studies. Chandra is the third of NASA's Great Observatories to be launched, following the Hubble Space Telescope and the Compton Gamma Ray Observatory. One of four primary science instruments on Chandra, and one of only two focal plane instruments, is the Advanced CCD Imaging Spectrometer, or ACIS. The ACIS focal plane and Optical Blocking Filter (OBF) must be launched under vacuum, so a tightly sealed, functioning door and venting subsystem were implemented. The door was opened two and one-half weeks after launch (after most out-gassing of composite materials) and allowed X-rays to be imaged by the ACIS CCD's in the focal plane. A failure of this door to open on-orbit would have eliminated all ACIS capabilities, severely degrading mission science. During the final pre-flight thermal-vacuum test of the fully integrated Chandra Observatory at TRW, the ACIS door failed to open when commanded to do so. This paper describes the efforts, under considerable time pressure, by NASA, its contractors and outside review teams to investigate the failure and to develop modified hardware and procedures which would correct the problem. Of interest is the fact that the root cause of the test failure was never clearly identified despite massive effort. We ultimately focussed on hardware and procedures designed to mitigate the effects of potential, but unproven, failure modes. We describe a frequent real-world engineering situation in which one must proceed on the best basis possible in the absence of the complete set of facts.

Podgorski, William A.↗
NASA NTRSDate not supplied

Spaceflight Food System Impacts to Nutritional Adequacy, Health, Performance, and Resources in Space Exploration

Despite high physical standards and training protocols, physiological and behavioral decrements have been documented in astronauts on both short (1-2 weeks) and long (6+ month) missions in spaceflight, including dysregulation of the immune system, cardiovascular and musculoskeletal deconditioning, ophthalmic changes, weight loss, and increased stress and fatigue. Optimizing food and nutrition intakes are key underpinnings for the proper function and performance of all physiological systems and the resulting physical and behavioral health and performance outcomes of astronauts. Much has been learned about the role of nutrition in human health on Earth over the past hundred years, from the identity and role of specific vitamins to the importance of the quantities of some nutrients to immune function. The requirements for providing adequate nutrition to astronauts seem obvious. However, providing a safe, reliable, and nutritious food system for space exploration missions remains a challenge. In fact, food is one of the greatest resource and logistical challenges, which is part of why it remains a “red” risk for Mars missions.

Grace L Douglas↗
NASA NTRS2003

Photonic Interrogation and Control of Nano Processes

My research activities for the summer of 2003 consisted of two projects: One project was concerned with determining a method for predicting the static and dynamic assembly properties of nano-structures using laser tweezers. The other project was to investigate the generation of Laguerre-Gaussian modes using a spatial light modulator incorporated into an optical tweezers system. Concerning the first project, I initially pursued the approach suggested by my NASA colleague Dr. Art Decker. This approach involved mimicking the model of the structure of atomic nucleus for the assembly of 1 to 100 atoms using allowed quadruple transitions induced by orbital angular momentums of a Laguerre- Gaussian (Doughnut) laser mode. After realizing the inaptness of the nuclear model with the nanostructure model as far as the binding forces and transitions were concerned, I focused on using quantum dot modei. This model was not attuned also for the host lattice influences the electronic structure of the quantum dot. Thus one other option that I decided to pursue was the approach of molecular quantum mechanics. In this approach the nanostructure is treated as a large (10-100 nm) molecule constructed from single element or multi-elements. Subsequent to consultation with Dr. Fred Morales, a chemical engineer at NASA GRC, and Dr. David Ball, a computational chemist at Cleveland State University, I acquired a molecular-quantum computation software, Hyperchem 7.0. This software allows simulation of different molecular structures as far as their static and dynamic behaviors are concerned. The time that I spent on this project was about eight weeks. Once this suitable approach was identified, I realized the need to collaborate with a computational quantum chemist to pursue searching for stable nanostructures in the range of 10-100 nm that we can be assembled using laser tweezers. The second project was about generating laser tweezers that possess orbital angular momentum. As shown, we were able to generate laser tweezers modes of different orbital angular momentum using a spatial light modulator incorporated into a laser tweezers system. The motivation for investigating these types of modes stems from being able to spin particles at high speeds and also to orient two particles in separate traps and then join them together. Also, there has been recent intense interest on fundamental physics research on orbital angular momentum of light. The fact that circularly polarized light may have associated with it angular momentum that relates to the spin of individual photons (spin 0 for the plane polarized light, spin +1 for the right-circularly polarized light and spin -1 for the left-circularly polarized light) was first demonstrated by Beth in 1936. Orbital angular momentum is, however, distinct from spin in that the spin angular momentum of light is intrinsically linked to the behavior of the electric field in the light whereas orbital angular momentum is a consequence of inclined wavefronts. In 1992 L. Allen, et al showed that the Laguerre-Gaussian (LG) modes could possess well-defined orbital angular momentum that can exceed 1 planck's constant, i.e. l plancks constant per photon, where l is the azimuthal index of the mode.

Jassemnejad, Baha↗
NASA NTRS1985

X-ray satellite

The projected launch date has been delayed approx. 7 weeks from the planned launch date. The Engineering Model (EM) of the automatic measurement and control system (AMCS) is in the critical phase. The contract change no. 1 to the main contract has been signed. A new version of the welding seam location specifications for the wide field camera (WFC) was proposed by the WFC Consortium. The payload integration plan (PIP) has been signed. Production of the EM/QM prototype and ground station equipment has proceeded according to plan with the exception of some delays. Production of the EM equipment has begun. Preparations for the qualification tests of the EM/QM equipment and the integration of EM equipment has begun. The cause of the delay in the launch date include the combined effects of the postponement of the target date for the EM equipment, along with the fact that only a structural model is available.

Source record↗
NASA NTRS2010

The Process of the Development of an Operator

On the job training is where new employees called operators can start gaining knowledge on what they will be working on during their time in JSC. In these lessons I learned different things that are important ranging from thermal systems to electrical systems. While doing OJT classes the student will learn how to use a portable computer system which has displays that I also helped edit and clean up. The way you can also learn is by reading system briefs which describes the different systems. Due to the fact of a possible change in the ISS I updated a systems brief so that it can be relevant to what is actually on the space station. I was given a task that will help develop my skills and make myself better prepared for my future in the work field. The project that I worked on had me pulling real time data from the International Space Station. The Data I obtained from the space station will be correlated to battery performance. The group I will be working which is called REBA and we will take the telemetry and evaluate the data. I will be working with my mentor Ben Chislom and co-op Tyler along with the Pro team. They then will put this data into a graph so that they can get the discrepancies and find a way to improve the battery performance. The first weeks I read familiarization books that informed me how the ISS works, how it was built, and the systems that are used to keep the station working. This project is going to benefit NASA by finding out how electricity is being used on the ISS and enabling us to see how it can be used more efficiently. This way we can operate the ISS without wasting power. While conducting research that goes on inside the space station knowing all electricity is being used efficiently.

Banks, Terrence↗
NASA NTRS1992

International ocean services: Is it time - will it ever be time?

Considering the objectives of the Ocean Data Climate Workshop this week and trying to select a related, but not too technical subject, I decided to look at the services needed for ocean clients. I thought that it would make an interesting theme to consider how the acceptance of international ocean services is progressing over the years. Or is it? Are we closer to having a global observing system than we were twenty years ago? If so, what has changed between then and now? What is different between the efforts of twenty years or so ago to get the Integrated Global Ocean Stations System (IGOSS) off the ground and the present attempts to establish the Global Ocean Observing System (GOOS)? Is there a window of opportunity now that didn't exist then? If it doesn't happen now, a legitimate question could well be asked.... Will it ever happen? At least on historical topics I am on firm ground, having been attending IOC meetings for many years, in fact, it was in 1970 that I attended my first IGOSS meeting and a couple of years later I started what was to become regular attendances at the IOC Governing Body sessions. Despite the numbing effect of sitting through IOC related meetings for a total of what must add up to two or three years, I can still defend the IOC as an essential intergovernmental body for the oceans. One can accept the value of medicine, but one doesn't have to enjoy the taste.

Holland, Geoffrey↗
NASA NTRS2002

Preliminary Results of the GPS Flight Experiment on the High Earth Orbit AMSAT-OSCAR 40 Spacecraft

The GPS flight experiment on the High Earth Orbit (HEO) AMSAT-OSCAR 40 (AO-40) spacecraft was activated for a period of approximately six weeks between 25 September and 2 November, 2001, and the initial results have exciting implications for using GPS as a low-cost orbit determination sensor for future HEO missions. AO-40, an amateur radio satellite launched November 16, 2000, is currently in a low inclination, 1000 by 58,800 km altitude orbit. Although the GPS receiver was not initialized in any way, it regularly returned GPS observations from points all around the orbit. Raw signal to noise levels as high as 9 AMUs (Trimble Amplitude Measurement Units) or approximately 48 dB-Hz have been recorded at apogee, when the spacecraft was close to 60,000 km in altitude. On several occasions when the receiver was below the GPS constellation (below 20,000 krn altitude), observations were reported for GPS satellites tracked through side lobe transmissions. Although the receiver has not returned any point solutions, there has been at least one occasion when four satellites were tracked simultaneously, and this short arc of data was used to compute point solutions after the fact. These results are encouraging, especially considering the spacecraft is currently in a spin-stabilized attitude mode that narrows the effective field of view of the receiving antennas and adversely affects GPS tracking. Already AO-40 has demonstrated the feasibility of recording GPS observations in HEO using an unaided receiver. Furthermore, it is providing important information about the characteristics of GPS signals received by a spacecraft in a HEO, which has long been of interest to many in the GPS community. Based on the data returned so far, the tracking performance is expected to improve when the spacecraft is transitioned to a three axis stabilized, nadir pointing attitude in Summer, 2002.

Moreau, Michael C.↗
NASA NTRS2012

Desert Research and Technology Studies (DRATS) 2010 Science Operations: Operational Approaches and Lessons Learned for Managing Science during Human Planetary Surface Missions

Desert Research and Technology Studies (Desert RATS) is a multi-year series of hardware and operations tests carried out annually in the high desert of Arizona on the San Francisco Volcanic Field. These activities are designed to exercise planetary surface hardware and operations in conditions where long-distance, multi-day roving is achievable, and they allow NASA to evaluate different mission concepts and approaches in an environment less costly and more forgiving than space.The results from the RATS tests allows election of potential operational approaches to planetary surface exploration prior to making commitments to specific flight and mission hardware development. In previous RATS operations, the Science Support Room has operated largely in an advisory role, an approach that was driven by the need to provide a loose science mission framework that would underpin the engineering tests. However, the extensive nature of the traverse operations for 2010 expanded the role of the science operations and tested specific operational approaches. Science mission operations approaches from the Apollo and Mars-Phoenix missions were merged to become the baseline for this test. Six days of traverse operations were conducted during each week of the 2-week test, with three traverse days each week conducted with voice and data communications continuously available, and three traverse days conducted with only two 1-hour communications periods per day. Within this framework, the team evaluated integrated science operations management using real-time, tactical science operations to oversee daily crew activities, and strategic level evaluations of science data and daily traverse results during a post-traverse planning shift. During continuous communications, both tactical and strategic teams were employed. On days when communications were reduced to only two communications periods per day, only a strategic team was employed. The Science Operations Team found that, if communications are good and down-linking of science data is ensured, high quality science returns is possible regardless of communications. What is absent from reduced communications is the scientific interaction between the crew on the planet and the scientists on the ground. These scientific interactions were a critical part of the science process and significantly improved mission science return over reduced communications conditions. The test also showed that the quality of science return is not measurable by simple numerical quantities but is, in fact, based on strongly non-quantifiable factors, such as the interactions between the crew and the Science Operations Teams. Although the metric evaluation data suggested some trends, there was not sufficient granularity in the data or specificity in the metrics to allow those trends to be understood on numerical data alone.

Eppler, Dean↗
NASA NTRS2014

HEMODOSE: A Set of Multi-parameter Biodosimetry Tools

After the events of September 11, 2001 and recent events at the Fukushima reactors in Japan, there is an increasing concern of the occurrence of nuclear and radiological terrorism or accidents that may result in large casualty in densely populated areas. To guide medical personnel in their clinical decisions for effective medical management and treatment of the exposed individuals, biological markers are usually applied to examine the radiation induced changes at different biological levels. Among these the peripheral blood cell counts are widely used to assess the extent of radiation induced injury. This is due to the fact that hematopoietic system is the most vulnerable part of the human body to radiation damage. Particularly, the lymphocyte, granulocyte, and platelet cells are the most radiosensitive of the blood elements, and monitoring their changes after exposure is regarded as the most practical and best laboratory test to estimate radiation dose. The HEMODOSE web tools are built upon solid physiological and pathophysiological understanding of mammalian hematopoietic systems, and rigorous coarse-grained biomathematical modeling and validation. Using single or serial granulocyte, lymphocyte, leukocyte, or platelet counts after exposure, these tools can estimate absorbed doses of adult victims very rapidly and accurately. Some patient data in historical accidents are utilized as examples to demonstrate the capabilities of these tools as a rapid point-of-care diagnostic or centralized high-throughput assay system in a large scale radiological disaster scenario. Unlike previous dose prediction algorithms, the HEMODOSE web tools establish robust correlations between the absorbed doses and victim's various types of blood cell counts not only in the early time window (1 or 2 days), but also in very late phase (up to 4 weeks) after exposure

Hu, Shaowen↗
NASA NTRS2014

HEMODOSE: A Set of Multi-parameter Biodosimetry Tools

There continues to be important concerns of the possibility of the occurrence of acute radiation syndromes following nuclear and radiological terrorism or accidents that may result in mass casualties in densely populated areas. To guide medical personnel in their clinical decisions for effective medical management and treatment of the exposed individuals, biological markers are usually applied to examine radiation induced biological changes to assess the severity of radiation injury to sensitive organ systems. Among these the peripheral blood cell counts are widely used to assess the extent of radiation induced bone marrow (BM) injury. This is due to the fact that hematopoietic system is a vulnerable part of the human body to radiation damage. Particularly, the lymphocyte, granulocyte, and platelet cells are the most radiosensitive of the blood elements, and monitoring their changes after exposure is regarded as a practical and recommended laboratory test to estimate radiation dose and injury. In this work we describe the HEMODOSE web tools, which are built upon solid physiological and pathophysiological understanding of mammalian hematopoietic systems, and rigorous coarse-grained biomathematical modeling and validation. Using single or serial granulocyte, lymphocyte, leukocyte, or platelet counts after exposure, these tools can estimate absorbed doses of adult victims very rapidly and accurately to assess the severity of BM radiation injury. Some patient data from historical accidents are utilized as examples to demonstrate the capabilities of these tools as a rapid point-of-care diagnostic or centralized high-throughput assay system in a large-scale radiological disaster scenario. HEMODOSE web tools establish robust correlations between the absorbed doses and victim's various types of blood cell counts not only in the early time window (1 or 2 days), but also in very late phase (up to 4 weeks) after exposure.

Hu, Shaowen↗