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Straight Line Geometric Path Lengths – Examples and Distributions

The straight line geometric path distribution of different shapes is a fundamental parameter of any a detector sensitive and in the presence of high energy charged particles such as galactic cosmic rays (GCRs). Knowledge of the straight line path distribution can yield first estimates of the expected energy distribution due to minimum ionizing particles. This predicted shape provides a valuable interpretation tool of spectra of particles that are unlikely to stop in a detector and may present a background or desired signal. These quantities have been calculated many times before including analytically, Coleman (1973), and even in Geant4 software, (Agostinelli, Allison et al. 2003, Santin, Ivanchenko et al. 2005). For this work we utilize the Rapid Adaptable Multi-threaded Particle and Radiation Transport (RAMPART) simulation framework and collect some common shapes all with the same volume to serve as a reference of path lengths and instructions manual for computing other shapes as desired.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Nuclear Data for High Energy Ion Interactions and Secondary Particle Production

Understanding the harmful effects of galactic cosmic rays (GCRs) on space exploration requires a substantial amount of nuclear data. Specifically, the interaction of energetic GCR charged particles with spacecraft materials generates secondary radiations that, through energy deposition, can harm astronauts and electronic systems. By identifying the gaps in our knowledge of the relevant nuclear data – interaction cross sections – and identifying ways to fill those gaps – with measurements, compilations, evaluations, disseminations, reaction modeling, sensitivity studies, and uncertainty quantification – the safety and viability of space exploration can be improved. This work surveys the state of the art in this interdisciplinary field and identifies promising collaborative research topics that have significant potential to advance our understanding of the effects of the space radiation environment on space exploration.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats

Introduction Effects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic rays (GCRs). One of the limitations of previous studies on simulated weightlessness using hindlimb unloading (HU) is that a control HU condition was not included. Methods We characterized the behavioral performance of male Fischer rats 2 months after sham or total body irradiation with a simplified 5-ion 6-mixed-beam exposure representative of GCRs in the absence or presence of HU. Six months later, the plasma, hippocampus, and cortex were processed to determine whether the behavioral effects were associated with long-term alterations in the metabolic pathways. Results In the open field without and with objects, interactions were observed for radiation × HU. In the plasma of animals that were not under the HU or control HU condition, the riboflavin metabolic pathway was affected most for sham irradiation vs. 0.75 Gy exposure. Analysis of the effects of control HU on plasma in the sham-irradiated animals showed that the alanine, aspartate, glutamate, riboflavin, and glutamine metabolisms as well as arginine biosynthesis were affected. The effects of control HU on the hippocampus in the sham-irradiated animals showed that the phenylalanine, tyrosine, and tryptophan pathway was affected the most. Analysis of effects of 0.75 Gy irradiation on the cortex of control HU animals showed that the glutamine and glutamate metabolic pathway was affected similar to the hippocampus, while the riboflavin pathway was affected in animals that were not under the control HU condition. The effects of control HU on the cortex in sham-irradiated animals showed that the riboflavin metabolic pathway was affected. Animals receiving 0.75 Gy of irradiation showed impaired glutamine and glutamate metabolic pathway, whereas animals receiving 1.5 Gy of irradiation showed impaired riboflavin metabolic pathways. A total of 21 plasma metabolites were correlated with the behavioral measures, indicating that plasma and brain biomarkers associated with behavioral performance are dependent on the environmental conditions experienced. Discussion Phenylalanine, tyrosine, and tryptophan metabolism as well as phenylalanine and tryptophan as plasma metabolites are biomarkers that can be considered for spaceflight as they were revealed in both Fischer and WAG/Rij rats exposed to simGCRsim and/or HU.

Physiology↗

Immediate effects of acute Mars mission equivalent doses of SEP and GCR radiation on the murine gastrointestinal system-protective effects of curcumin-loaded nanolipoprotein particles (cNLPs)

Introduction: Missions beyond low Earth orbit (LEO) will expose astronauts to ionizing radiation (IR) in the form of solar energetic particles (SEP) and galactic cosmic rays (GCR) including high atomic number and energy (HZE) nuclei. The gastrointestinal (GI) system is documented to be highly radiosensitive with even relatively low dose IR exposures capable of inducing mucosal lesions and disrupting epithelial barrier function. IR is also an established risk factor for colorectal cancer (CRC) with several studies examining long-term GI effects of SEP/GCR exposure using tumor-prone APC mouse models. Studies of acute short-term effects of modeled space radiation exposures in wildtype mouse models are more limited and necessary to better define charged particle- induced GI pathologies and test novel medical countermeasures (MCMs) to promote astronaut safety. Methods: In this study, we performed ground-based studies where male and female C57BL/6J mice were exposed to γ-rays, 50 MeV protons, or 1 GeV/n Fe-56 ions at the NASA Space Radiation Laboratory (NSRL) with histology and immunohistochemistry endpoints measured in the first 24 h post-irradiation to define immediate SEP/GCR-induced GI alterations. Results: Our data show that unlike matched γ-ray controls, acute exposures to protons and iron ions disrupts intestinal function and induces mucosal lesions, vascular congestion, epithelial barrier breakdown, and marked enlargement of mucosa-associated lymphoid tissue. We also measured kinetics of DNA double-strand break (DSB) repair using gamma-H2AX- specific antibodies and apoptosis via TUNEL labeling, noting the induction and disappearance of extranuclear cytoplasmic DNA marked by gamma-H2AX only in the charged particle-irradiated samples. We show that 18 h pre-treatment with curcumin-loaded nanolipoprotein particles (cNLPs) delivered via IV injection reduces DSB-associated foci levels and apoptosis and restore crypt villi lengths. Discussion: These data improve our understanding of physiological alterations in the GI tract immediately following exposures to modeled space radiations and demonstrates effectiveness of a promising space radiation MCM.

59 BASIC BIOLOGICAL SCIENCES↗

Nuclear data for space exploration

Understanding the harmful effects of galactic cosmic rays (GCRs) on space exploration requires a substantial amount of nuclear data. Specifically, the interaction of energetic GCR charged particles with spacecraft materials generates secondary radiations that, through energy deposition, can harm astronauts and electronic systems. By identifying the gaps in our knowledge of the relevant nuclear data—such as interaction cross sections—and identifying ways to fill those gaps—with measurements, compilations, evaluations, dissemination, reaction modeling, sensitivity studies, and uncertainty quantification—the safety and viability of space exploration can be improved. This work surveys the state of the art in this interdisciplinary field and identifies promising collaborative research topics that have significant potential to advance our understanding of the effects of the space radiation environment on space exploration.

42 ENGINEERING↗

Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation

Galactic cosmic rays are primarily composed of protons (85%), helium (14%), and high charge/high energy ions (HZEs) such as 56 Fe, 28 Si, and 16 O. HZE exposure is a major risk factor for astronauts during deep-space travel due to the possibility of HZE-induced cancer. A systems biology integrated omics approach encompassing transcriptomics, proteomics, lipidomics, and functional biochemical assays was used to identify microenvironmental changes induced by HZE exposure. C57BL/6 mice were placed into six treatment groups and received the following irradiation treatments: 600 MeV/n 56 Fe (0.2 Gy), 1 GeV/n 16 O (0.2 Gy), 350 MeV/n 28 Si (0.2 Gy), 137 Cs (1.0 Gy) gamma rays, 137 Cs (3.0 Gy) gamma rays, and sham irradiation. Left liver lobes were collected at 30, 60, 120, 270, and 360 days post-irradiation. Analysis of transcriptomic and proteomic data utilizing ingenuity pathway analysis identified multiple pathways involved in mitochondrial function that were altered after HZE irradiation. Lipids also exhibited changes that were linked to mitochondrial function. Molecular assays for mitochondrial Complex I activity showed significant decreases in activity after HZE exposure. HZE-induced mitochondrial dysfunction suggests an increased risk for deep space travel. Microenvironmental and pathway analysis as performed in this research identified possible targets for countermeasures to mitigate risk.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

C{sub 2}N{sub 2} Vertical Profile in Titan’s Stratosphere

In this paper, we present the first measurements of the vertical distribution of cyanogen (C{sub 2}N{sub 2}) in Titan’s lower atmosphere at different latitudes and seasons, using Cassini’s Composite Infrared Spectrometer far-infrared data. We also study the vertical distribution of three other minor species detected in our data: methylacetylene (C{sub 3}H{sub 4}), diacetylene (C{sub 4}H{sub 2}), and H{sub 2}O, in order to compare them to C{sub 2}N{sub 2}, but also to get an overview of their seasonal and meridional variations in Titan’s lower stratosphere from 85 km to 225 km. We measured an average volume mixing ratio of C{sub 2}N{sub 2} of 6.2±0.8×10{sup −11} at 125 km at the equator, but poles exhibit a strong enrichment in C{sub 2}N{sub 2} (up to a factor 100 compared to the equator), greater than what was measured for C{sub 3}H{sub 4} or C{sub 4}H{sub 2}. Measuring C{sub 2}N{sub 2} profiles provides constraints on the processes controlling its distribution, such as bombardment by Galactic Cosmic Rays which seem to have a smaller influence on C{sub 2}N{sub 2} than predicted by photochemical models.

79 ASTRONOMY AND ASTROPHYSICS↗

Search for New Cosmic-Ray Acceleration Sites within the 4FGL Catalog Galactic Plane Sources

Cosmic rays are mostly composed of protons accelerated to relativistic speeds. When those protons encounter interstellar material, they produce neutral pions, which in turn decay into gamma-rays. This offers a compelling way to identify the acceleration sites of protons. A characteristic hadronic spectrum, with a low-energy break around 200 MeV, was detected in the gamma-ray spectra of four supernova remnants (SNRs), IC 443, W44, W49B, and W51C, with the Fermi Large Area Telescope. This detection provided direct evidence that cosmic-ray protons are (re-)accelerated in SNRs. Here, we present a comprehensive search for low-energy spectral breaks among 311 4FGL catalog sources located within 5° from the Galactic plane. Using 8 yr of data from the Fermi Large Area Telescope between 50 MeV and 1 GeV, we find and present the spectral characteristics of 56 sources with a spectral break confirmed by a thorough study of systematic uncertainty. Our population of sources includes 13 SNRs for which the proton–proton interaction is enhanced by the dense target material; the high-mass gamma-ray binary LS I+61 303; the colliding wind binary η Carinae; and the Cygnus star-forming region. This analysis better constrains the origin of the gamma-ray emission and enlarges our view to potential new cosmic-ray acceleration sites.

79 ASTRONOMY AND ASTROPHYSICS↗

Searches for Neutrinos from Large High Altitude Air Shower Observatory Ultra-high-energy $γ$-Ray Sources Using the IceCube Neutrino Observatory

Galactic PeV cosmic-ray accelerators (PeVatrons) are Galactic sources theorized to accelerate cosmic rays up to PeV in energy. The accelerated cosmic rays are expected to interact hadronically with nearby ambient gas or the interstellar medium, resulting in $γ$-rays and neutrinos. Recently, the Large High Altitude Air Shower Observatory (LHAASO) identified 12 $γ$-ray sources with emissions above 100 TeV, making them candidates for PeVatrons. While at these high energies the Klein–Nishina effect exponentially suppresses leptonic emission from Galactic sources, evidence for neutrino emission would unequivocally confirm hadronic acceleration. Here, we present the results of a search for neutrinos from these $γ$-ray sources and stacking searches testing for excess neutrino emission from all 12 sources as well as their subcatalogs of supernova remnants and pulsar wind nebulae with 11 yr of track events from the IceCube Neutrino Observatory. No significant emissions were found. Based on the resulting limits, we place constraints on the fraction of $γ$-ray flux originating from the hadronic processes in the Crab Nebula and LHAASO J2226+6057.

79 ASTRONOMY AND ASTROPHYSICS↗

Cosmic-ray cooling in active galactic nuclei as a new probe of inelastic dark matter

We present a novel way to probe inelastic dark matter using cosmic-ray (CR) cooling in active galactic nuclei (AGNs). Dark matter (DM) in the vicinity of supermassive black holes may scatter off CRs, resulting in the rapid cooling of CRs for sufficiently large cross sections. This in turn can alter the high-energy neutrino and gamma-ray fluxes detected from these sources. We show that AGN cooling bounds obtained through the multimessenger data of NGC 1068 and TXS 0506 + 056 allows us to reach unprecedently large mass splittings for inelastic DM (≳ TeV), orders of magnitude larger than those probed by direct detection experiments and DM capture in neutron stars. Furthermore, we demonstrate that cooling bounds from AGNs can probe thermal light DM with small mass splittings. This provides novel and complementary constraints in parts of a parameter space accessible solely by colliders and beam-dump experiments.

astronomical black holes↗

Can the Solar Atmosphere Generate Very-High-Energy Cosmic Rays?

The origin and acceleration of high-energy particles, constituting cosmic rays, is likely to remain an important topic in modern astrophysics. Among the two categories galactic and solar cosmic rays, the latter are much less investigated. The primary source of solar cosmic ray particles are impulsive explosions of the magnetized plasma, known as solar flares and coronal mass ejections. These particles, however, are characterized by relatively low energies compared to their galactic counterparts. In this work, we explore the resonance wave–wave (RWW) interaction between the polarized electromagnetic radiation emitted by the solar active regions and the quantum waves associated with high-energy, relativistic electrons generated during solar flares. Mathematically, the RWW interaction problem boils down to analyzing a Klein–Gordon Equation (spinless electrons) embedded in the electromagnetic field. We find that RWW could accelerate the relativistic electrons to enormous energies even comparable to energies in the galactic cosmic rays.

acceleration of particles↗

Galactic Center Neutrinos from Cosmic Ray-Dark Matter Interactions

The IceCube and ANTARES collaborations have recently reported evidence for high-energy neutrinos associated with the Galactic plane and the Galactic Ridge, offering a new pathway to search for dark matter (DM). Deep inelastic scattering of cosmic rays with sub-GeV DM in the Galactic halo produces a distinctive neutrino signature from meson decays. Using detailed Galactic cosmic-ray maps and ANTARES observations, we derive 99% C.L. upper limits on the DM-nucleon cross section that extend down to keV-scale masses. These results establish Galactic neutrino telescopes as a powerful, complementary probe of light DM, with substantial improvements expected from upcoming IceCube-Gen2 and KM3NeT observations.

Terol Calvo, Jorge [INFN, Turin]↗

Search for High-energy Neutrino Emission from Galactic X-Ray Binaries with IceCube

We present the first comprehensive search for high-energy neutrino emission from high- and low-mass X-ray binaries conducted by IceCube. Galactic X-ray binaries are long-standing candidates for the source of Galactic hadronic cosmic rays and neutrinos. The compact object in these systems can be the site of cosmic-ray acceleration, and neutrinos can be produced by interactions of cosmic rays with radiation or gas, in the jet of a microquasar, in the stellar wind, or in the atmosphere of the companion star. We study X-ray binaries using 7.5 yr of IceCube data with three separate analyses. In the first, we search for periodic neutrino emission from 55 binaries in the Northern Sky with known orbital periods. In the second, the X-ray light curves of 102 binaries across the entire sky are used as templates to search for time-dependent neutrino emission. Finally, we search for time-integrated emission of neutrinos for a list of 4 notable binaries identified as microquasars. In the absence of a significant excess, we place upper limits on the neutrino flux for each hypothesis and compare our results with theoretical predictions for several binaries. In addition, we evaluate the sensitivity of the next generation neutrino telescope at the South Pole, IceCube-Gen2, and demonstrate its power to identify potential neutrino emission from these binary sources in the Galaxy.

79 ASTRONOMY AND ASTROPHYSICS↗

Investigation of the Microquasar SS 433 with VERITAS

Microquasars such as SS 433 are considered potential contributors to cosmic rays up to the knee of the cosmic-ray energy spectrum (∼4 PeV), where a transition in the dominant acceleration processes is expected. The SS 433 system, located within the W50 supernova remnant, is a Galactic microquasar with relativistic jets interacting with the surrounding medium over parsec scales, providing an example for studying jet-driven particle acceleration. A deep morphological and spectral study of SS 433 is performed using more than 150 hr of observations with VERITAS, sensitive to γ-ray energies >100 GeV. With an angular resolution better than 0$^°_.$1, extended TeV γ-ray emission is resolved from both the eastern and western jet lobes, located tens of parsecs from the central binary. The emission appears elongated along the jet axis and coincides with regions where the jets interact with the surrounding supernova remnant. No TeV emission is detected from the central binary, nor is significant emission observed between the central binary and the jet lobes. Phase-resolved analyses show no evidence for variability in the orbital or precessional phase, supporting a steady emission scenario. The observed morphology and spectra are consistent with scenarios where particles are accelerated in the lobes of the jets, possibly through shocks or alternative processes such as magnetic reconnection. The extended TeV emission from the jet lobes of SS 433 favors a leptonic origin in the VERITAS energy range, suggesting that any hadronic acceleration is subdominant. The results offer valuable constraints on how microquasar jets may contribute to the Galactic cosmic-ray population toward the knee.

Archer, A. [DePauw University, Greencastle, IN (Un↗

First observations of solar halo gamma rays over a full solar cycle

We analyze 15 years of Fermi-LAT data and produce a detailed model of the Sun’s inverse-Compton scattering emission (solar halo), which is powered by interactions between ambient cosmic-ray electrons and positrons with sunlight. By developing a novel analysis method to analyze moving sources, we robustly detect the solar halo at energies between 31.6 MeV and 100 GeV, and angular extensions up to 45° from the Sun, providing new insight into spatial regions where there are no direct measurements of the Galactic cosmic-ray flux. The large statistical significance of our signal allows us to subdivide the data and provide the first 𝛾-ray probes into the time variation and azimuthal asymmetry of the solar modulation potential, finding time-dependent changes in solar modulation both parallel and perpendicular to the ecliptic plane. Our results are consistent with (but with independent uncertainties from) local cosmic-ray measurements, unlocking new probes into astrophysical processes near the solar surface.

79 ASTRONOMY AND ASTROPHYSICS↗

Gamma-Ray Emission from Galaxies Hosting Molecular Outflows

Many star-forming galaxies and those hosting active galactic nuclei show evidence of massive outflows of material in a variety of phases including ionized, neutral atomic, and molecular. Molecular outflows in particular have been the focus of recent interest as they may be responsible for removing gas from the galaxy, thereby suppressing star formation. As material is ejected from the cores of galaxies, interactions of the outflowing material with the interstellar medium can accelerate cosmic rays and produce high-energy gamma rays. In this work, we search for gamma-ray emission from a sample of local galaxies known to host molecular outflows using data collected by the Fermi Large Area Telescope. We employ a stacking technique in order to search for and characterize the average gamma-ray emission properties of the sample. Gamma-ray emission is detected from the galaxies in our sample at the 4.4σ level with a power-law photon index of Γ ≈ 2 in the 1–800 GeV energy range. The emission is found to correlate with tracers of star formation activity, namely the 8–1000 μm infrared luminosity. We also find that the observed signal can be predominantly attributed to H II galaxies hosting energy-driven outflows. While we do not find evidence suggesting that the outflows are accelerating charged particles directly, galaxies with molecular outflows may produce more gamma rays than galaxies without outflows. In particular, the set consisting of gamma-ray-detected galaxies with molecular outflows are nearly perfect calorimeters and may be future targets for searches of high-energy neutrinos.

79 ASTRONOMY AND ASTROPHYSICS↗

Statistical properties of the population of the Galactic centre filaments – II. The spacing between filaments

ABSTRACT We carry out a population study of magnetized radio filaments in the Galactic centre using MeerKAT data by focusing on the spacing between the filaments that are grouped. The morphology of a sample of 43 groupings containing 174 magnetized radio filaments are presented. Many grouped filaments show harp-like, fragmented cometary tail-like, or loop-like structures in contrast to many straight filaments running mainly perpendicular to the Galactic plane. There are many striking examples of a single filament splitting into two prongs at a junction, suggestive of a flow of plasma along the filaments. Spatial variations in spectral index, brightness, bending, and sharpening along the filaments indicate that they are evolving on a 105−6-yr time-scale. The mean spacings between parallel filaments in a given grouping peaks at ∼16 arcsec. We argue by modeling that the filaments in a grouping all lie on the same plane and that the groupings are isotropically oriented in 3D space. One candidate for the origin of filamentation is interaction with an obstacle, which could be a compact radio source, before a filament splits and bends into multiple filaments. In this picture, the obstacle or sets the length scale of the separation between the filaments. Another possibility is synchrotron cooling instability occurring in cometary tails formed as a result of the interaction of cosmic ray driven Galactic centre outflow with obstacles such as stellar winds. In this picture, the mean spacing and the mean width of the filaments are expected to be a fraction of a parsec, consistent with observed spacing.

79 ASTRONOMY AND ASTROPHYSICS↗

Implications of the non-observation of 6 Li in halo stars for the primordial 7 Li problem

The primordial Lithium Problem is intimately connected to the assumption that the 7 Li abundance observed in metal-poor halo stars is unchanged from its primordial value, which lies significantly below the predictions of standard big-bang nucleosynthesis. Two key lines of evidence have argued that these stars have not significantly depleted their initial (mostly primordial) 7 Li: i) the lack of dispersion in Li abundance measurements at low metallicity (and high surface temperature); and ii) the detection of the more fragile 6 Li isotope in at least two halo stars. The purported 6 Li detections were in good agreement with predictions from cosmic-ray nucleosynthesis which is responsible for the origin of 6 Li. This concordance left little room for 6 Li depletion, and the apparent 6 Li survival implied that 7 Li largely evaded destruction, because stellar interiors destroy 6 Li more vigorously then than 7 Li. Recent (re)-observations of halo stars challenge the evidence against 7 Li depletion: i) lithium elemental abundances now show significant dispersion, and ii) sensitive 6 Li searches now reveal only upper limits to the 6 Li/ 7 Li ratio. We discuss the consequences of these 6 Li non-detections on the primordial 7 Li Problem, Galactic cosmic-ray nucleosynthesis, and the question of differential depletion of Li in stars. The tight new 6 Li upper limits generally fall far below the predictions of cosmic-ray nucleosynthesis, implying that substantial 6 Li depletion has occurred — by factors up to 50. We show that in stars with 6 Li limits and thus lower bounds on 6 Li depletion, an equal amount of 7 Li depletion is more than sufficient to resolve the primordial 7 Li Problem. This picture is consistent with well-studied stellar models in which 7 Li is less depleted than 6 Li, and strengthen the case that the Lithium Problem has an astrophysical solution. We conclude by suggesting future observations that could test these ideas.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗