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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
NASA NTRS1982

Synthesis of amino acids in weight bearing and non-weight bearing leg muscles of suspended rats

The effect of hypokinesia (HYP) for 6 days on the de novo synthesis of glutamine (GLN) and glutamate (GLU), and of alanine was tested in isolated leg muscles of intact, adrenalectomized (ADX) and ADX cortisol-treated rats. The net synthesis of GLN and GLU was lower in soleus muscles of HYP animals of these three groups of rats. The synthesis of alanine was lowered by HYP in ADX animals and apparently raised by HYP in ADX cortisol-treated rats. No HYP effect was seen in the extensor digitorum longus (EDL) muscles of these animals. Although ADX lowered the synthesis of GLN and GLU in soleus muscles of control rats, while cortisol treatment restored this process to near normal, neither ADX nor cortisol treatment produced any effect in the HYP animals. However, effects of ADX and cortisol treatment on synthesis of GLN and GLU in EDL muscles and of alanine in both muscles seemed normal in HYP animals.

Tischler, M. E.↗
NASA NTRS1984

Atmospheric environment for space shuttle (STS-13) launch

Selected atmospheric conditions observed near Space Shuttle STS-13 launch time on April 6, 1984, at Kennedy Space Center Florida are summarized. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles is given. The final meteorological tape, which consists of wind and thermodynamic parameters versus altitude, for STS-13 vehicle ascent was constructed by Marshall Space Flight Center in response to shuttle task agreement No. 561-81-22-368 with Johnson Space Center.

Johnson, D. L.↗
NASA NTRS1983

Prevention of metabolic alterations caused by suspension hypokinesia in leg muscles of rats

Rats were subjected to tail-cast suspension hypokinesia for 6 days with one leg immobilized in dorsal flexion by casting. Control animals were also tail-casted. The soleus, gastrocnemius and plantaris muscles of uncasted hypokinetic legs were smaller than control muscles. Dorsal flexion prevented atrophy of these muscles and caused the soleus to hypertrophy. The anterior muscles were unaffected by hypokinesia. The smaller size of the soleus of the uncasted leg relative to the dorsal flexed and weight bearing limbs correlated with slower protein synthesis and faster proteolysis. The capacity of this muscle to synthesize glutamine (gln), which carries nitrogenous waste from muscle was also measured. Although tissue homogenates showed higher activities of gln synthetase, the rate of de novo synthesis was not altered in intact muscle but the tissue ratio of gln/glutamate was decreased. Glutamate and ATP were not limiting for gln synthesis, but availability of ammonia may be a limiting factor for this process in hypokinesia.

Tischler, M. E.↗
NASA NTRS1984

Atmospheric environment for Space Shuttle (STS-41D) launch

Selected atmospheric conditions observed near Space Shuttle STS-41D launch time on August 30, 1984, at Kennedy Space Center, Florida are summarized. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles is given as well as wind and thermodynamic parameters representative of surface and aloft conditions in the SRB descent/impact ocean area. Final atmospheric tapes, which consist of wind and thermodynamic parameters versus altitude, for STS-41D vehicle ascent and SRB descent/impact were constructed. The STS-41D ascent meteorological data tape was constructed by Marshall Space Flight Center's Atmospheric Science Division to provide an internally consistent data set for use in post flight performance assessments.

Johnson, D. L.↗
NASA NTRS1984

Atmospheric environment for Space Shuttle (STS-41G) launch

Selected atmospheric conditions that were observed near Space Shuttle STS-41G launch time on October 5, 1984 at Kennedy Space Center in Florida are summarized. Values of ambient pressure, temperature, moisture, ground winds, visual obsrvations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere-measured vertical wind profiles is given. The final atmospheric tape consisting of wind and thermodynamic parameters versus altitude for STS-41G vehicle ascent was constructed. The STS-41G ascent atmospheric data tape was constructed. The STS-41G ascent atmospheric data tape was constructed by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post flight performance assessments.

Johnson, D. L.↗
NASA NTRS1984

Atmospheric environment for Space Shuttle (STS-51A) launch

Selected atmospheric conditions observed near Space Shuttle STS-51A launch time on November 8, 1984, are summarized. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles is reported. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51A vehicle ascent was constructed. The STS-51A ascent atmospheric data tape is constructed to provide an internally consistent data set for use in postflight performance assessments.

Johnson, D. L.↗
NASA NTRS1985

Role of Glucocorticoids in the Response to Unloading of Muscle Protein and Amino Acid Metabolism

Intact control (weight bearing) and suspended rats gained weight at a similar rate during a 6 day period. Adrenaectomized (adx) weight bearing rats gained less weight during this period while adrenalectomized suspended rats showed no significant weight gain. Cortisol treatment of both of these groups of animals caused a loss of body weight. Results from these studies show several important findings: (1) Metabolic changes in the extensor digitorum longus muscle of suspended rats are due primarily to increased circulating gluccorticoids; (2) Metabolic changes in the soleus due to higher steroid levels are probably potentiated by greater numbers of receptors; and (3) Not all metabolic responses in the unloaded soleus muscle are due to direct action of elevated glucocorticoids or increased sensitivity to these hormones.

Tischler, M. E.↗
NASA NTRS1985

Atmospheric environment for space shuttle (STS-51C) launch

Selected atmospheric conditions observed near space shuttle STS-51C launch time on January 24, 1985, at Kennedy Space Center, Florida are summarized. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles are presented. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51C vehicle ascent was constructed. The STS-51C ascent atmospheric data tape was constructed to provide an internally consistent data set for use in postflight performance assessments.

Jasper, G.↗
NASA NTRS1985

Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension

Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out.

Tischler, M. E.↗
NASA NTRS1985

Responses of skeletal muscle to unloading, a review

Suspension models were used to study muscle response to reduced activity. During 6 days of tail casting, the soleus (SOL) atrophies while the extensor digitorum longus grows relatively normally. After discounting those changes in both muscles due primarily to increased secretion of adrenal hormones, the following conclusions regarding the specific responses of the SOL could be drawn: (1) Atrophy is probably due primarily to increased protein degradation; (2) Decreased synthesis of glutamine may result from reduced availability of ammonia due to diminished use of ATP; (3) Greater muscle glycogen seems to reflect an increased response to insulin of glucose uptake which leads to greater glucose metabolism; and (4) Faster catabolism of branched-chain amino acids can be attributed to enhanced flux through ketoacid dehydrogenase. Studies by others using tail casted suspended rats showed in the SOL: (1) a gradual switch from type 1 to type 2 fibers; (2) increased acid protease activity; and (3) altered muscle function and contractile duration. Using harness suspended rats, others showed in the SOL: (1) significant atrophy; (2) increased numbers of glucocorticoid receptors; and (3) no change in muscle fatigability.

Tischler, M. E.↗
NASA NTRS1984

Atrophy and growth failure of rat hindlimb muscles in tail-cast suspension

The primary objective of the present study is related to an evaluation of a modified tail-cast suspension model as a means of identifying metabolic factors which control or are associated with muscle atrophy and growth failure. Two different control conditions (normal and tail-casted weight bearing) were studied to determine the appropriate control for tail-cast suspension. A description is presented of a model which is most useful for studying atrophy of hindlimb muscles under certain conditions. Female Sprague-Dawley rats were employed in the experiments. Attention is given to growth rate and urinary excretion of urea and ammonia in different types of rats, the relationship between body weight and skeletal muscle weight, and the relationship between animal body weight and rates of protein synthesis and protein degradation.

Jaspers, S. R.↗
NASA NTRS1985

Atmospheric environment for space shuttle (STS-51B) launch

A summary of selected atmospheric conditions observed near space shuttle STS-51B launch time on April 29, 1985, at Kennedy Space Center Florida is presented. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles is given. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51B vehicle ascent was constructed. The STS-51B ascent atmospheric data tape was constructed by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post flight performance assessments.

Jasper, G. L.↗
NASA NTRS1985

Atmospheric environment for Space Shuttle (STS-51D)

A summary of selected atmospheric conditions observed near the space shuttle STS-51D launch time on April 12, 1985, at Kennedy Space Center Florida is presented. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of prelaunch Jimsphere measured vertical wind profiles is given in this report. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51D vehicle ascent is constructed. The STS-51D ascent atmospheric data tape is compiled by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post-flight performance assessments.

Jasper, G. L.↗
NASA NTRS1985

Biochemical response to chronic shortening in unloaded soleus muscles

One leg of tail-casted suspended rats was immobilized in a plantar-flexed position to test whether chronic shortening of posterior leg muscles affected the metabolic response to unloading. The immobilized plantaris and gastrocnemius muscles of these animals showed approximately 20 percent loss of muscle mass in contrast to simply a slower growth rate with unloading. Loss of mass of the soleus muscle during suspension was not accentuated by chronic shortening. Although protein degradation in the isolated soleus muscle of the plantar-flexed limb was slightly faster than in the contralateral free limb, this difference was offset by faster synthesis of the myofibrillar protein fraction of the chronically shortened muscle. Total adenine nucleotides were 17 percent lower (P less than 0.005) in the chronically shortened soleus muscle following incubation. Glutamate, glutamine, and alanine metabolism showed little response to chronic shortening. These results suggest that, in the soleus muscle, chronic shortening did not alter significantly the metabolic responses to unloading and reduced activity.

Jaspers, S. R.↗
NASA NTRS1985

Responses of skeletal muscle to unloading - A review

Suspension models were used to study muscle response to reduced activity. During 6 days of tail casting, the soleus (SOL) atrophies while the extensor digitorum longus grows relatively normally. After discounting those changes in both muscles due primarily to increased secretion of adrenal hormones, the following conclusions regarding the specific responses of the SOL could be drawn: (1) Atrophy is probably due primarily to increased protein degradation; (2) Decreased synthesis of glutamine may result from reduced availability of ammonia due to diminished use of ATP; (3) Greater muscle glycogen seems to reflect an increased response to insulin of glucose uptake which leads to greater glucose metabolism; and (4) Faster catabolism of branched-chain amino acids can be attributed to enhanced flux through ketoacid dehydrogenase. Studies by others using tail casted suspended rats showed in the SOL: (1) a gradual switch from type 1 to type 2 fibers; (2) increased acid protease activity; and (3) altered muscle function and contractile duration. Using harness suspended rats, others showed in the SOL: (1) significant atrophy; (2) increased numbers of glucocorticoid receptors; and (3) no change in muscle fatigability.

Tischler, M. E.↗
NASA NTRS1985

Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension

Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out.

Tischler, M. E.↗
NASA NTRS1986

Atmospheric environment for space shuttle (STS-51L) launch

A summary is given of selected atmospheric conditions observed near Space Shuttle STS-51L launch time on January 28, 1986, at Kennedy Space Center, Florida. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), and winds aloft are included. The sequence of pre-launch Jimsphere measured vertical wind profiles is given. The final atmospheric tape, which consists of wind and thermodynamic parameters versus altitude, for STS-51L vehicle ascent has been constructed. The STS-51L ascent atmospheric data tape has been constructed by Marshall Space Flight Center's Atmospheric Sciences Division to provide an internally consistent data set for use in post flight performance assessments.

Jasper, G. L.↗