Light and electron microscopic study of primate /Macaca mulatta/ liver after large doses of high-energy /2.3 BeV/ protons
Proton irradiation effects on liver cells and tissue of primates
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Proton irradiation effects on liver cells and tissue of primates
Systems engineering data and design specifications for Biosatellite active primate simulator
Circadian oscillations of deep body temperature and heart rate in ambulatory primate in controlled environment
Circuits, components, and implant site evaluations for arterial blood pressure analyses on primates
Microvillar bleb formation in proton irradiated primate hepatocytes with electron microscope, noting sinusoidal lumen
Nonhuman primate circadian rhythms as functions of phase shift carried out in advance or delay
Design development discussion of primate support system for Biosatellite
Biosatellite Primate Mission component qualifications
Histochemical detection of L-gulonolactone- phenazine methosulfate oxidoreductase activity in mammals with emphasis on vitamin C synthesis in primates
Biosatellite Primate Mission Program for component qualification levels validated by flight tests data, performing vibration tests on prime structure spacecraft
Serologic comparisons of carbonic anhydrases in human and other primate erythrocytes
GE-RESD primate life support subsystem design for NASA-ARC biosatellite program
Monitoring cardiovascular function in primates under prolonged weightlessness
Primate restraint harness of nylon jacket and cotton cot on aluminum frame padded seat for bone resorption and calcium metabolism studies
The developments are reported in physiological instrumentation, surgical procedures, measurement and data analysis techniques, and the definition of flight experiments to determine the effects of prolonged weightlessness on the cardiovascular system of subhuman primates. The development of an implantable telemetric data acquisition system is discussed along with cardiovascular research applications in renal hemodynamics. It is concluded that the implant technique permits a valid interpretation, free of emotional response, for the manipulated variable on physiological functions. It also allows a better definition of normal physiological baseline conditions.
Space related biomedical research involving nonhuman primates is reviewed. The scientific assets of various species and the instruments used for monitoring physiological processes during long duration experimentations are described.
Man's response to exposure to spaceflight and weightlessness is expressed in physiological adjustments which involve his health and ability to function. The amplitude and periodicity of fluctuations in biological processes affect various functions and responses to provocative stimuli. Primates and other species are subjected to tests to determine the consequences of an altered biorhythm on work and performance, emotional stability, biomedical evaluation in space, the ability to cope with the unexpected, and susceptibility to infection, toxicity, radiation, drugs, and stress. Factors in the environment or operational setup which can change the physiological baseline must be determined and controlled.
The different types of primates which might be used as flight animals are surveyed, and the pros and cons of using them are discussed. Various factors suggest that the most desirable animals for space studies are the rhesus, pig-tailed, Java, and squirrel monkeys. The capuchin monkey has assets for certain types of space experimentation.