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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS2020

The Potential Effects of Radiation on the Gut-Brain Axis

Humans may be exposed to different types of radiation in their lifetimes, typically in the form of low linear energy transfer (LET) radiation that is, for example, used as a treatment for cancer. In addition, astronauts may be exposed to high LET radiation in outer space. Here, we propose that alterations to the gastrointestinal (GI) microbiota may occur upon exposure to low or high LET radiation, and that these alterations may perturb important relationships that exist between the GI microbiota and human health. For example, the GI microbiota can communicate with the brain via various pathways and molecules, such as the enteric nervous system, the vagus nerve, microbial metabolites, and the immune system. This relationship has been termed the “gut-brain axis”. Alterations to the composition of the GI microbiome can lead to alterations in its functional metabolic output and means of communication, therefore potentially causing downstream cognitive effects. Consequently, studying how radiation can affect this important network of communication could lead to new and critical interventions, as well as prevention strategies. Herein, we review the evidence supporting a relationship between radiation exposure and disruption of the gut-brain axis as well as summarize strategies that may be used to counter the effects of radiation exposure on the GI microbiome.

Carli B. Jones↗
NASA NTRS1994

Results of time-resolved radiation exposure measurements made during U.S. shuttle missions with a tissue equivalent proportional counter

Time resolved exposure measurements inside the crew compartment have been made during recent shuttle missions with the USAF Radiation Monitoring Equipment-III (RME-III), a portable four-channel tissue equivalent proportional counter. Results from the first six missions are presented and discussed. The missions had orbital inclinations ranging from 28 degrees to 57 degrees, and altitudes from 200-600km. Dose equivalent rates ranged from 40-5300 micro Sv/dy. The RME-III measurements are in good agreement with other dosimetry measurements made aboard the vehicle. Measurements indicate that medium- and high- Linear Energy Transfer (LET) particles contribute less than 2% of the particle fluence for all missions, but up to 50% of the dose equivalent, depending on the spacecraft's altitude and orbital inclination. Isa-dose rate contours have been developed from measurements made during the ST-28 mission. The drift rate of the South Atlantic Anomaly (SAA) is estimated to be 0.49 degrees W/yr and 0.12 degrees N/yr. The calculated trapped proton and Galactic Cosmic Radiation (GCR) dose for the STS-28 mission were significantly lower than the measured values.

Golightly, M. J.↗
NASA NTRS2011

A Hypothesis on Biological Protection from Space Radiation Through the Use of New Therapeutic Gases as Medical Counter Measures

Exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. As biological damage from exposure is associated with increased oxidative stress, it would be enabling to mitigate and/or prevent stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as both chemical radioprotectors for radical scavenging and biological promoters for management of the body s response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it is concluded that this approach may have great therapeutic potential for exposure. Furthermore, it also appears to have potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion injury, acute respiratory distress syndrome, Parkinson s and Alzheimer s disease, cataracts, and aging.

Schoenfeld, Michael P.↗
NASA NTRS1972

A sealed titanium window proportional counter for the detection of .5-keV X rays.

A sealed Ti window proportional counter sensitive to X radiation in the energy range 0.35-0.45 keV and above 1.5 keV is described. Measurements of the Ti mass absorption coefficients and a graphical summary of the literature values are presented. For a proportional counter with a 930 microgram/sq cm (2.1-micron) Ti window, the peak efficiency at 0.45 keV is found to lie between 4.6% and 7.1%. An application in X-ray astronomy involving a rocket observation of Sco X-1 is discussed.

Mcclintock, J. E.↗
NASA NTRS1982

Development of cosmic ray techniques

It is pointed out that most advances of cosmic-ray physics have been directly related to the development of observational techniques. A review is presented of the history of the evolution of the techniques and equipment for the study of cosmic-ray physics, taking into account the new scientific advances accompanying each new development related to experimental technology. All of the early observations were performed by means of ionization chambers. These chambers had already been in use for a number of years, when they were first applied to the study of cosmic rays in the early years of this century. However, an application to the low-intensity cosmic radiation required special refinements. Attention is given to the design of suitable electrometers, the development of self-recording instruments, the 'tube counter', the development of the coincidence method, a cosmic-ray 'telescope', a magnetic lens for cosmic rays, an arrangement of Geiger-Mueller counters for the demonstration of secondary radiation, cloud chambers, scintillation counters, and air shower experiments.

Rossi, B.↗
NASA NTRS1965

Ionization chamber.

Ionization chamber for measuring interplanetary space radiation, using Geiger-Mueller counter as secondary detector

SPACE RADIATION↗
NASA NTRS1985

The development of a high energy cosmic ray detector for Spacelab-2

A large cosmic ray detector aimed at measurements of the energy spectra and of the elemental abundances of cosmic ray nuclei at very high energies, up to several TeV/nucleon was constructed. The instrument is an electronic counter telescope with a geometric factor of 5 sq ster. It accomplishes measurements of the particle energies through the use of gas Cerenkov counters and of transition radiation detectors. The solutions of a number of technological problems that are encountered when developing such instrumentation for Shuttle missions are discussed.

Lheureux, J.↗
NASA NTRS1986

First results from Spacelab 2

Preliminary results of physical experiments carried out during the Spacelab 2 Shuttle mission are summarized. Attention is given to experiments in the fields of plasma dynamics; solar physics; high-energy astrophysics; and astronomy. Plasma experiments included an ejectable plasma diagnosics package and measurements of the passive charging of the Shuttle vehicle in the surrounding space plasma. The solar physics instrument package consisted of a solar spectral irradiance monitor; a solar optical universal polarimeter (SOUP); and a solar helium abundance high-resolution telescope and spectrograph (HRTS). Astronomical observations were performed using a scanning infrared telescope (IRT) which consisted of a highly baffled herschelian telescope and 10 detectors covering wavelengths from 2 to 120 microns. Cosmic-ray nuclei were detected and analyzed using gas Cerenkov counters and a transition radiation detector. Addition experiments included a thin film fluid dynamics payload and analysis of blood samples taken from the mission specialists. Complete data records from the experiments have now been distributed for an analysis period which will take at least a year. A table listing the Spacelab 2 experiments and their principal investigators is provided.

Urban, E. W.↗
NASA NTRS1996

Theoretical and Numerical Investigation of Radiative Extinction of Diffusion Flames

The influence of soot radiation on diffusion flames was investigated using both analytical and numerical techniques. Soot generated in diffusion flames dominate the flame radiation over gaseous combustion products and can significantly lower the temperature of the flame. In low gravity situations there can be significant accumulation of soot and combustion products in the vicinity of the primary reaction zone owing to the absence of any convective buoyant flow. Such situations may result in substantial suppression of chemical activities in a flame, and the possibility of a radiative extinction may also be anticipated. The purpose of this work was to not only investigate the possibility of radiative extinction of a diffusion flame but also to qualitatively and quantitatively analyze the influence of soot radiation on a diffusion flame. In this study, first a hypothetical radiative loss profile of the form of a sech(sup 2) was assumed to influence a pure diffusion flame. It was observed that the reaction zone can, under certain circumstances, move through the radiative loss zone and locate itself on the fuel side of the loss zone contrary to our initial postulate. On increasing the intensity and/or width of the loss zone it was possible to extinguish the flame, and extinction plots were generated. In the presence of a convective flow, however, the movement of the temperature and reaction rate peaks indicated that the flame behavior is more complicated compared to a pure diffusional flame. A comprehensive model of soot formation, oxidation and radiation was used in a more involved analysis. The soot model of Syed, Stewart and Moss was used for soot nucleation and growth and the model of Nagle and Strickland-Constable was used for soot oxidation. The soot radiation was considered in the optically thin limit. An analysis of the flame structure revealed that the radiative loss term is countered both by the reaction term and the diffusion term. The essential balance for the soot volume fraction was found to be between the processes of soot convection and soot growth. Such a balance yielded to analytical treatment and the soot volume fraction could be expressed in the form of an integral. The integral was evaluated using two approximate methods and the results agreed very well with the numerical solutions for all cases examined.

Ray, Anjan↗