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NASA NTRS2003

Cell Science and Cell Biology Research at MSFC: Summary

The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

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NASA NTRS1997

Seasonal and Vegetational Variation in Albedo Measured During CERES Ground-Validation Pilot Study

The Clouds and the Earth's Radiant Energy System (CERES) satellite is scheduled for launch in the Fall of 1997 aboard the Tropical Rainfall Measuring Mission (TRMM). A surface measurement pilot study has been initiated in a 37-km region near Richmond, VA, for comparison with the CERES surface flux retrievals. Two-minute averaged upwelling and downwelling surface fluxes over a mostly deciduous forest have been recorded daily for the past two years, and show a broadband, shortwave daily albedo increase during the summer months. Evidence is presented that indicates vegetational changes in the forest as the overriding mechanism for this change. Upwelling flux measured over the entire region by helicopter-mounted instrumentation has been processed for four solar seasons. Future plans include the installation of four more albedo surface sites over various types of vegetation throughout the region.

Schuster, G. L.↗

NASA NTRS2003

Microsystems Fabrication Laboratory-New Class 100 Cleanroom Completed and Certified

A new Microsystems Fabrication Laboratory (MFL), a Class 100 cleanroom fabrication facility, was completed and certified in 2002 at the NASA Glenn Research Center. This facility, to be used by Glenn's Instrumentation and Controls Division, was designed and built as part of the NASA Construction of Facilities Program. The design, construction, and certification phases were managed by personnel from Glenn s Facilities and Test Engineering Division. Because of time constraints and the need for specialized cleanroom expertise, this 1000 ft2 laboratory was completed using a design-build procurement. Facility Planning & Resources (Pittsburgh, PA) was selected as the prime contractor and provided the architectural design and project management. A major subcontractor, AdvanceTEC, LLC (Richmond, VA), provided the mechanical and electrical design and performed the construction services. Throughout this fast-track project, Facilities and Test Engineering Division personnel provided overall project management and worked closely with the contractors to ensure that the customers needs were addressed and that the impact of the project implementation was minimized.

Borato, Frances M.↗

NASA NTRS2008

Integrated Software Systems for Crew Management During Extravehicular Activity in Planetary Terrain Exploration

Initial planetary explorations with the Apollo program had a veritable ground support army monitoring the safety and health of the 12 astronauts who performed lunar surface extravehicular activities (EVAs). Given the distances involved, this will not be possible on Mars. A spacesuit for Mars must be smart enough to replace that army. The next generation suits can do so using 2 software systems serving as virtual companions, LEGACI (Life support, Exploration Guidance Algorithm and Consumable Interrogator) and VIOLET (Voice Initiated Operator for Life support and Exploration Tracking). The system presented in this study integrates data inputs from a suite of sensors into the MIII suit s communications, avionics and informatics hardware for distribution to remote managers and data analysis. If successful, the system has application not only for Mars but for nearer term missions to the Moon, and the next generation suits used on ISS as well. Field tests are conducted to assess capabilities for next generation spacesuits at Johnson Space Center (JSC) as well as the Mars and Lunar analog (Devon Island, Canada). LEGACI integrates data inputs from a suite of noninvasive biosensors in the suit and the astronaut (heart rate, suit inlet/outlet lcg temperature and flowrate, suit outlet gas and dewpoint temperature, pCO2, suit O2 pressure, state vector (accelerometry) and others). In the Integrated Walkback Suit Tests held at NASA-JSC and the HMP tests at Devon Island, communication and informatics capabilities were tested (including routing by satellite from the suit at Devon Island to JSC in Houston via secure servers at VCU in Richmond, VA). Results. The input from all the sensors enable LEGACI to compute multiple independent assessments of metabolic rate, from which a "best" met rate is chosen based on statistical methods. This rate can compute detailed information about the suit, crew and EVA performance using test-derived algorithms. VIOLET gives LEGACI voice activation capability, allowing the crew to query the suit, and receive feedback and alerts that will lead to corrective action. LEGACI and VIOLET can also automatically control the astronaut's cooling and consumable use rate without crew input if desired. These findings suggest that non-invasive physiological and environmental sensors supported with data analysis can allow for more effective management of mission task performance during EVA. Integrated remote and local view of data metrics allow crewmember to receive real time feedback in synch with mission control in preventing performance shortcomings for EVA in exploration missions.

Kuznetz, Lawrence↗

NASA NTRS2008

Engineering Design Unit Primary Mirror Segment

The James Webb Space Telescope Primary Mirror Engineering Design Unit (EDU) recently demonstrated the final manufacturing process at L-3-SSG/Tinsley in Richmond, California. Shown in the picture below, the EDU is a prototype 1.4 meter diameter Beryllium mirror that is identical to the 18 flight mirror segments and is used to check out all mirror manufacturing processes prior to the actual flight mirror processing. This recent result gives confidence that all manufacturing processes are in place to figure the 18 flight mirrors. Lessons learned from the EDU have been applied to the flight mirrors improving the performance and processing time and all 18 flight mirrors are well along in their processing at L3-SSG/Tinsley. As a result of completing the final manufacturing demonstration, the EDU mirror was sent to Ball Aerospace in Boulder, Colorado where it is now undergoing integration with the hexapod mount assembly and optical testing checkout. After integration to mount assemblies, flight mirrors will be sent for cryogenic (50 degrees Kelvin) optical testing where the cryogenic distortions will be measured. After cryogenic testing, mirrors will eventually be returned to Tinsley for final cryogenic polishing. During final cryogenic polishing, the inverse of the measured cryogenic distortions will be polished into the mirror to assure the mirror works at it's cryogenic operating temperature. Once cryogenic polishing is completed to final specifications, the mirror will be coated and sent for final cryogenic testing.

Alongi, Chris↗

NASA NTRS2010

Improving Customer Waiting Time at a DMV Center Using Discrete-Event Simulation

Virginia's Department of Motor Vehicles (DMV) serves a customer base of approximately 5.6 million licensed drivers and ID card holders and 7 million registered vehicle owners. DMV has more daily face-to-face contact with Virginia's citizens than any other state agency [1]. The DMV faces a major difficulty in keeping up with the excessively large customers' arrival rate. The consequences are queues building up, stretching out to the entrance doors (and sometimes even outside) and customers complaining. While the DMV state employees are trying to serve at their fastest pace, the remarkably large queues indicate that there is a serious problem that the DMV faces in its services, which must be dealt with rapidly. Simulation is considered as one of the best tools for evaluating and improving complex systems. In this paper, we use it to model one of the DMV centers located in Norfolk, VA. The simulation model is modeled in Arena 10.0 from Rockwell systems. The data used is collected from experts of the DMV Virginia headquarter located in Richmond. The model created was verified and validated. The intent of this study is to identify key problems causing the delays at the DMV centers and suggest possible solutions to minimize the customers' waiting time. In addition, two tentative hypotheses aiming to improve the model's design are tested and validated.

Arnaout, Georges M.↗

NASA NTRS2010

Hyperspectral Systems Increase Imaging Capabilities

In 1983, NASA started developing hyperspectral systems to image in the ultraviolet and infrared wavelengths. In 2001, the first on-orbit hyperspectral imager, Hyperion, was launched aboard the Earth Observing-1 spacecraft. Based on the hyperspectral imaging sensors used in Earth observation satellites, Stennis Space Center engineers and Institute for Technology Development researchers collaborated on a new design that was smaller and used an improved scanner. Featured in Spinoff 2007, the technology is now exclusively licensed by Themis Vision Systems LLC, of Richmond, Virginia, and is widely used in medical and life sciences, defense and security, forensics, and microscopy.

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NASA NTRS2016

Jwst from Below: An Overview of the Construction of the James Webb Space Telescope, Interesting Metrology, and Cryogenic-Vacuum Testing

NASA's James Webb Space Telescope (JWST) is a 6.6m diameter, segmented, deployable telescope for cryogenic IR space astronomy (40K). The JWST Observatory includes the Optical Telescope Element (OTE) and the Integrated Science Instrument Module (ISIM) that contains four science instruments (SI) and the guider. The SIs are mounted to a composite metering structure. The SI and guider units are integrated to the ISIM structure and optically tested at NASA Goddard Space Flight Center as a suite using a telescope simulator (Optical Telescope Element SIMulator; OSIM). OSIM is a full field, cryogenic JWST telescope simulator. SI performance, including alignment and wavefront error, is evaluated using OSIM. This is an overview presentation to undergraduate students and other personnel at the University of Richmond, planned for 12 Oct, 2016. It uses material previously released by NASA on the Internet (e.g., via Flickr) or at engineering conferences (e.g., SPIE). This presentation provides an overview of the status of the project, with an emphasis on optics and measurement.

instrument development↗

NASA NTRSDate not supplied