Symptomatology under storm conditions in the north atlantic in control subjects and in persons with bilateral labyrinthine defects
Motion sickness under conditions of stress and anxiety - role of vestibular apparatus
ANXIETY↗
SEARCH · Search NASA
Results for “VESTIBULAR APPARATUS”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Effect of chronic gamma irradiation on functions of the vestibular analyzer and the role of the time factor in radiation reactions of the nervous system
Chronic gamma radiation effects on vestibular apparatus of guinea pigs and role of time factor in radiation reactions of nervous system
GAMMA RADIATION↗
Preliminary studies of vestibular damage in guinea pigs following high acceleration
Vestibular apparatus damage in guinea pigs from high impact deceleration
IMPACT DECELERATION↗
Vestibular reactions of astronauts during flight in Voskhod spacecraft
It is shown that differing human vestibular resistances to weightlessness stress are connected with the nonuniform initial sensitivity of the vestibular apparatus, as well as with different lengths of vestibular training. However, intensive vestibular training of persons with a moderate degree of sensitivity of the vestibular analyzer does not ensure vestibular stability under weightlessness conditions.
Yuganov, Y. M.↗
Lack of effects of astemizole on vestibular ocular reflex, motion sickness, and cognitive performance in man
Astemizole was orally administered to 20 subjects in a randomized, double-blind design to assess the efficacy of this peripherally active antihistamine as an antimotion sickness drug possessing no central side-effects. Measures of vestibular ocular reflex (VOR) were made to evaluate the agent as a selective vestibular depressant. Following one week of orally administered astemizole (30 mg daily), a Staircase Profile Test, a VOR test, and a variety of tests of cognitive performance were administered. These tests revealed no statistically significant effects of astemizole. This leads to the conclusion that, although the drug probably reaches the peripheral vestibular apparatus in man by crossing the blood-vestibular barrier, a selective peripheral antihistamine (H1) action is inadequate to control motion sickness induced through cross-coupled accelerative semicircular canal stimulation in a rotating chair.
Kohl, Randall L.↗
Conditioned taste aversion induced by motion is prevented by selective vagotomy in the rat
The role of the vagus nerve in motion-induced conditioned taste aversion (CTA) was studied in hooded rats. Animals with complete, selective gastric vagotomy failed to form conditioned taste aversion after multiple conditioning sessions in which the conditioned stimulus (a cider vinegar solution) was drunk immediately before a 30-min exposure to vertical axis rotation at 150 deg/s. Results are discussed with reference to the use of CTA as a measure of motion-induced 'sickness' or gastrointestinal disturbance, and because motion-induced CTA requires that both the vagus nerve and the vestibular apparatus be intact, in light of the possible convergence of vegal and vestibular functions.
Robert A Fox↗
Vestibular-induced vomiting after vestibulocerebellar lesions
Vestibular stimulation, by sinusoidal electrical polarization of the labyrinths of decerebrate cats which can produce vomiting and related activity which resembles motion sickness was examined. The symptoms include panting, salivation, swallowing, and retching as well as vomiting. These symptoms can be produced in cats with lesions of the posterior cerebellar vermis. It is suggested that a transcerebellar pathway from the vestibular apparatus through the nodulus and uvula to the vomiting center is not essential for vestibular induced vomiting and the occurrence of many symptoms of motion.
Miller, A. D.↗
Vestibular-induced vomiting after vestibulocerebellar lesions
Vestibular stimulation, by sinusoidal electrical polarization of the labyrinths of decerebrate cats which can produce vomiting and related activity which resembles motion sickness was examined. The symptoms include panting, salivation, swallowing, and retching as well as vomiting. These symptoms can be produced in cats with lesions of the posterior cerebellar vermis. It is suggested that a transcerebellar pathway from the vestibular apparatus through the nodulus and uvula to the vomiting center is not essential for vestibular induced vomiting and the occurrence of many symptoms of motion.
Miller, A. D.↗
Problems of space biology. Volume 50: Nystagmometry for evaulation of the status of the vestibular function
Various aspects of nystagmometry are studied, primarily those in which the study of hystagmus serves as a means to learn about the vestibular apparatus. Along with exhaustive published material, the monograph presents data from many years of research on the physioloigical mechanisms of nystagmus, the features of nystagmus when vestibular stimulation is combined with optokinetic, the pole of vertibular afferentation asymmetry in the asymmetry of reactions to optokinetic stimulus, a nystagmometric approach to studying the hydrodynamic interaction among semicircular canals, as well as several other questions. A great deal of attention is given to methods of recording nystagmus, calibrating nystagmograms, quantitative evaluation of nystagmographic material, new nystagmometric characteristics and diagnostic techniques. A diagnostic model is proposed which makes it possible to obtain important information on the condition of the vestibular system from results of vestibular testing.
Levashov, M. M.↗
Effects of rectilinear acceleration, optokinetic and caloric stimuli in space
The set of experiments comprising the Spacelab 1ES201 package designed to investigate the human vestibular system and equilibratory function in weightlessness are described. The specific objectives of the experiments include: (1) the determination of the threshold of perception of linear oscillatory motion; (2) measurement of physiological and subjective responses to supra threshold, linear and angular motion stimuli; (3) study of the postural adjustments, eye movements, and illusions of attitude and motion evoked by optokinetic stimuli, (i.e., moving visual patterns) in order to assess visual/vestibular interactions; (4) examination of the effect of thermal stimulations of the vestibular apparatus to determine if the eye movements elicited by the 'caloric test' are used by a density gradient in the semicircular canal; and (5) investigation of the pathogenesis of space motion sickness by recording signs and symptoms during the course of vestibular stimulation and, specifically, when the test subject is exposed to sustained, linear oscillatory motion.
Vonbaumgarten, R.↗
The vestibular system of the owl
Five owls were given vestibular examinations, and two of them were sacrificed to provide serial histological sections of the temporal bones. The owls exhibited a curious variability in the postrotatory head nystagmus following abrupt deceleration; sometimes a brisk nystagnus with direction opposite to that appropriate to the stimulus would occur promptly after deceleration. It was found also that owls can exhibit a remarkable head stability during angular movement of the body about any axis passing through the skull. The vestibular apparatus in the owl is larger than in man, and a prominent crista neglecta is present. The tectorial membrane, the cupula, and the otolithic membranes of the utricle, saccule, and lagena are all attached to surfaces in addition to the surfaces hearing hair cells. These attachments are very substantial in the utricular otolithic membrane and in the cupula.
Money, K. E.↗
Central neural mechanisms governing postural cardiovascular mechanisms
The results of the vestibular apparatus and cerebellum in orthostatic reflex control are summarized. Mechanisms within the brain which govern circulation reflexes and the consequences of disturbances in their function are also included.
Reis, D. J.↗
Quantitation of Na+, K+-atpase Enzymatic Activity in Tissues of the Mammalian Vestibular System
In order to quantify vestibular Na(+), K(+)-ATPase, a microassay technique was developed which is sufficiently sensitive to measure the enzymatic activity in tissue from a single animal. The assay was used to characterize ATPase in he vestibular apparatus of the Mongolian gerbil. The quantitative procedure employs NPP (5 mM) as synthetic enzyme substrate. The assay relies upon spectrophotometric measurement (410 nm) of nitrophenol (NP) released by enzymatic hydrolysis of the substrate. Product formation in the absence of ouabain reflects both specific (Na(+), K(+)-ATPase) and non-specific (Mg(++)-ATPase) enzymatic activity. By measuring the accumulation of reaction product (NP) at three-minute intervals during the course of incubation, it is found that the overall enzymatic reaction proceeds linearly for at least 45 minutes. It is therefore possible to determine two separate reaction rates from a single set of tissues. Initial results indicate that total activity amounts to 53.3 + or - 11.2 (S.E.M.) nmol/hr/mg dry tissue, of which approximately 20% is ouabain-sensitive.
Kerr, T. P.↗
Physiological adaptation - Crew health in space
The experiments planned for the Spacelab Life Sciences-1 (SLS-1) Shuttle mission, which is dedicated to investigating biomedical issues pertinent to the man's presence in space, are discussed. The areas of research will include human and animal experiments concerned with the cardiovascular system, the vestibular apparatus, and metabolic experiments related to renal endocrine function, hematology, immune system, and muscle and bone/calcium metabolism, with particular attention given to the physiological complications resulting from short-duration space flight and subsequent return to the 1-G environment. The hardware systems to be used on the SLS-1 mission represent prototypes of systems to be developed for the medical and research facilities of the Space Station. The results of the experiments will be used to address issues related to long-duration space flight required for the Space Station and interplanetary travels.
Brand, Susan↗
Perception of the Body in Space: Mechanisms
The principal topic is the perception of body orientation and motion in space and the extent to which these perceptual abstraction can be related directly to the knowledge of sensory mechanisms, particularly for the vestibular apparatus. Spatial orientation is firmly based on the underlying sensory mechanisms and their central integration. For some of the simplest situations, like rotation about a vertical axis in darkness, the dynamic response of the semicircular canals furnishes almost enough information to explain the sensations of turning and stopping. For more complex conditions involving multiple sensory systems and possible conflicts among their messages, a mechanistic response requires significant speculative assumptions. The models that exist for multisensory spatial orientation are still largely of the non-rational parameter variety. They are capable of predicting relationships among input motions and output perceptions of motion, but they involve computational functions that do not now and perhaps never will have their counterpart in central nervous system machinery. The challenge continues to be in the iterative process of testing models by experiment, correcting them where necessary, and testing them again.
Young, Laurence R.↗
Self-Motion Perception: Assessment by Real-Time Computer Generated Animations
Our overall goal is to develop materials and procedures for assessing vestibular contributions to spatial cognition. The specific objective of the research described in this paper is to evaluate computer-generated animations as potential tools for studying self-orientation and self-motion perception. Specific questions addressed in this study included the following. First, does a non- verbal perceptual reporting procedure using real-time animations improve assessment of spatial orientation? Are reports reliable? Second, do reports confirm expectations based on stimuli to vestibular apparatus? Third, can reliable reports be obtained when self-motion description vocabulary training is omitted?
Parker, Donald E.↗
Effects of rotation on the sleep state-dependent midlatency auditory evoked P50 potential in the human
Sopite syndrome, characterized by loss of initiative, sensitivity to normally innocuous sensory stimuli, and impaired concentration amounting to a sensory gating deficit, is commonly associated with Space Motion Sickness (SMS). The amplitude of the P50 potential is a measure of level of arousal, and a paired-stimulus paradigm can be used to measure sensory gating. We used the rotary chair to elicit the sensory mismatch that occurs with SMS by overstimulating the vestibular apparatus. The effects of rotation on the manifestation of the P50 midlatency auditory evoked response were then assessed as a measure of arousal and distractibility. Results showed that rotation-induced motion sickness produced no change in the level of arousal but did produce a significant deficit in sensory gating, indicating that some of the attentional and cognitive deficits observed with SMS may be due to distractibility induced by decreased habituation to repetitive stimuli.
Clinical Trial↗
Visual-vestibular integration motion perception reporting
Self-orientation and self/surround-motion perception derive from a multimodal sensory process that integrates information from the eyes, vestibular apparatus, proprioceptive and somatosensory receptors. Results from short and long duration spaceflight investigations indicate that: (1) perceptual and sensorimotor function was disrupted during the initial exposure to microgravity and gradually improved over hours to days (individuals adapt), (2) the presence and/or absence of information from different sensory modalities differentially affected the perception of orientation, self-motion and surround-motion, (3) perceptual and sensorimotor function was initially disrupted upon return to Earth-normal gravity and gradually recovered to preflight levels (individuals readapt), and (4) the longer the exposure to microgravity, the more complete the adaptation, the more profound the postflight disturbances, and the longer the recovery period to preflight levels. While much has been learned about perceptual and sensorimotor reactions and adaptation to microgravity, there is much remaining to be learned about the mechanisms underlying the adaptive changes, and about how intersensory interactions affect perceptual and sensorimotor function during voluntary movements. During space flight, SMS and perceptual disturbances have led to reductions in performance efficiency and sense of well-being. During entry and immediately after landing, such disturbances could have a serious impact on the ability of the commander to land the Orbiter and on the ability of all crew members to egress from the Orbiter, particularly in a non-nominal condition or following extended stays in microgravity. An understanding of spatial orientation and motion perception is essential for developing countermeasures for Space Motion Sickness (SMS) and perceptual disturbances during spaceflight and upon return to Earth. Countermeasures for optimal performance in flight and a successful return to Earth require the development of preflight and in-flight training to help astronauts acquire and maintain a dual adaptive state. Despite the considerable experience with, and use of, an extensive set of countermeasures in the Russian space program, SMS and perceptual disturbances remain an unresolved problem on long-term flights. Reliable, valid perceptual reports are required to develop and refine stimulus rearrangements presented in the PAT devices currently being developed as countermeasures for the prevention of motion sickness and perceptual disturbances during spaceflight, and to ensure a less hazardous return to Earth. Prior to STS-8, crew member descriptions of their perceptual experiences were, at best, anecdotal. Crew members were not schooled in the physiology or psychology of sensory perception, nor were they exposed to the appropriate professional vocabulary. However, beginning with the STS-8 Shuttle flight, a serious effort was initiated to teach astronauts a systematic method to classify and quantify their perceptual responses in space, during entry, and after flight. Understanding, categorizing, and characterizing perceptual responses to spaceflight has been greatly enhanced by implementation of that training system.
Harm, Deborah L.↗