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NASA NTRS2000

A national survey of policies on disclosure of conflicts of interest in biomedical research

BACKGROUND: Conflicts of interest pose a threat to the integrity of scientific research. The current regulations of the U.S. Public Health Service and the National Science Foundation require that medical schools and other research institutions report the existence of conflicts of interest to the funding agency but allow the institutions to manage conflicts internally. The regulations do not specify how to do so. METHODS: We surveyed all medical schools (127) and other research institutions (170) that received more than $5 million in total grants annually from the National Institutes of Health or the National Science Foundation; 48 journals in basic science and clinical medicine; and 17 federal agencies in order to analyze their policies on conflicts of interest. RESULTS: Of the 297 institutions, 250 (84 percent) responded by March 2000, as did 47 of the 48 journals and 16 of the 17 federal agencies. Fifteen of the 250 institutions (6 percent)--5 medical schools and 10 other research institutions--reported that they had no policy on conflicts of interest. Among the institutions that had policies, there was marked variation in the definition and management of conflicts. Ninety-one percent had policies that adhered to the federal threshold for disclosure ($10,000 in annual income or equity in a relevant company or 5 percent ownership), and 9 percent had policies that exceeded the federal guidelines. Only 8 percent had policies requiring disclosure to funding agencies, only 7 percent had such policies regarding journals, and only 1 percent had policies requiring the disclosure of information to the relevant institutional review boards or to research subjects. Twenty journals (43 percent) reported that they had policies requiring disclosure of conflicts of interest. Only four federal agencies had policies that explicitly addressed conflicts of interest in extramural research, and all but one of the agencies relied primarily on institutional discretion. CONCLUSIONS: There is substantial variation among policies on conflicts of interest at medical schools and other research institutions. This variation, combined with the fact that many scientific journals and funding agencies do not require disclosure of conflicts of interest, suggests that the current standards may not be adequate to maintain a high level of scientific integrity.

Human↗

NASA NTRS1982

Satellite observations of suprathermal electron bursts

Data from the ISIS 2 satellite are used to study the spatial distribution of the suprathermal electron bursts discovered by high-altitude sounding rockets. It is found that the bursts form an integral part of the boundary plasma sheet and are linked with the formation of discrete auroral arcs. The maximum energy of the bursts is always below the peak energy in neighboring discrete forms, and it appears that if the bursts fail to reach the minimum energy found to be necessary to sustain a discrete arc they collapse within a few seconds. It is suggested that in a pass across the auroral oval the overall envelope of the maximum energy in bursts and the peak energy in discrete auroral forms reflect the variation of the available acceleration (perhaps a parallel electric potential) across the auroral oval while the energy structure in individual forms is a function of the nonlinear processes which sustain them. This explanation appears to resolve the apparent discrepancy in scale thickness between rocket and satellite inverted V's.

Johnstone, A. D.↗

NASA NTRS1985

Finite difference operators on unstructured triangular meshes

A new form of the Laplace operator is derived which is shown to be second-order accurate when calculated at mesh triangle nodes if the cells corresponding to the nodes have a high degree of symmetry. It is demonstrated that the Laplace operator directly derived from Stokes' integral theorem is only zeroth-order accurate on these same cells. The construction of gradient and Laplace operators on unstructured triangular grids are discussed from the variational point of view. Two discrete representations of the Laplacian are compared to each other, and conclusions are drawn regarding their accuracy on a pointwise basis. Finally, geometric relations valid on arbitrary polygons are given for completeness in an appendix.

Erlebacher, G.↗

NASA NTRS1992

Conceptual analysis of a lunar base transportation system

Important to the planning for a lunar base is the development of transportation requirements for the establishment and maintenance of that base. This was accomplished as part of a lunar base systems assessment study conducted by the NASA Langley Research Center in conjunction with the NASA Johnson Space Center. Lunar base parameters are presented using a baseline lunar facility concept and timeline of developmental phases. Masses for habitation and scientific modules, power systems, life support systems, and thermal control systems were generated, assuming space station technology as a starting point. The masses were manifested by grouping various systems into cargo missions and interspersing manned flights consistent with construction and base maintenance timelines. A computer program that sizes the orbital transfer vehicles (OTV's), lunar landers, lunar ascenders, and the manned capsules was developed. This program consists of an interative technique to solve the rocket equation successively for each velocity correction (delta V) in a mission. The delta V values reflect integrated trajectory values and include gravity losses. As the program computed fuel masses, it matched structural masses from General Dynamics' modular space-based OTV design. Variables in the study included the operation mode (i.e., expendable vs. reusable and single-stage vs. two-stage OTV's), cryogenic specific impulse, reflecting different levels of engine technology, and aerobraking vs. all-propulsive return to Earth orbit. The use of lunar-derived oxygen was also examined for its general impact. For each combination of factors, the low-Earth orbit (LEO) stack masses and Earth-to-orbit (ETO) lift requirements are summarized by individual mission and totaled for the developmental phase. In addition to these discrete data, trends in the variation of study parameters are presented.

Hoy, Trevor D.↗

NASA NTRS2006

Isotope Variations in Terrestrial Carbonates and Thermal Springs as Biomarkers: Analogs for Martian Processes

Stable isotope measurements of carbonate minerals contained within ALH84001 [1] suggest that fluids were present at 3.9 Gy on Mars [2, 3, 4, 5]. Both oxygen and carbon isotopes provide independent means of deciphering paleoenvironmental conditions at the time of carbonate mineral precipitation. In terrestrial carbonate rocks oxygen isotopes not only indicate the paleotemperature of the precipitating fluid, but also provide clues to environmental conditions that affected the fluid chemistry. Carbon isotopes, on the other hand, can indicate the presence or absence of organic compounds during precipitation (i.e. biogenically vs. thermogenically-generated methane), thus serving as a potential biomarker. We have undertaken a study of micro scale stable isotope variations measured in some terrestrial carbonates and the influence of organic compounds associated with the formation of these carbonates. Preliminary results indicate that isotope variations occur within narrow and discrete intervals, providing clues to paleoenvironmental conditions that include both biological and non-biological activity. These results carry implications for deciphering Martian isotope data and therefore potential biological prospecting on the planet Mars. Recently, Fourier Transform Spectrometer observations have detected methane occurring in the Martian atmosphere [6] that could be attributed to a possible biogenic source. Indeed, Mars Express has detected the presence of methane in the Martian atmosphere [7], with evidence indicating that methane abundances are greatest above those basins with high water concentrations.

Socki, Richard A.↗

NASA NTRS2011

Covariant C and O Isotope Trends in Some Terrestrial Carbonates and ALH 84001: Possible Linkage Through Similar Formation Processes

Carbonate minerals found on the surface of Mars and in martian meteorites indicate that liquid water has played a significant role in the planet's history. These findings have raised questions regarding the history of the martian hydrosphere and atmosphere as well as the possibility of life. Sunset Crater, Arizona is a dry environment with relatively high evaporation and brief periods of precipitation. This environment resembles Mars and may make Sunset Crater a good analog to martian carbonates. In this study we sought to identify discrete micro-scale isotopic variation within the carbonate crusts in Sunset Crater to see if they resembled the micro-scale isotope variation found in ALH 84001 carbonates. Sunset Crater carbonate formation may be used as a martian analog and ultimately provide insight into carbonate formation in ALH 84001.

Volk, Kathryn E.↗

NASA NTRS1991

Cometary activity, discrete outgassing areas, and dust-jet formation

Conceptual models for various types of features observed in cometary comae (jets, spirals, halos, fans, etc.), their computer simulation, and the hydrodynamic models for jet formation are critically reviewed, and evidence for anisotropic, strongly collimated flows of ejecta emanating from discrete active regions (vents) on the rotating cometary nuclei is presented. Techniques employed to generate synthetic comet images that simulate the features observed are described, and their relevance to the primary objects of coma-morphology studies is discussed. Modeling of temporal variations in the water emission from discrete active regions suggests that production curves asymmetric with respect to perihelion should be commonplace. Critical comparisons with the activity profiles of Enke's comet and with light curves of disappearing comets and comets that undergo outbursts are presented. Recent developments in the understanding of the processes that cause the nongravitational perturbations of cometary motions are reviewed, and the observed discontinuities are identified with the birth of new sources and/or deactivation of old vents.

Sekanina, Z.↗

NASA NTRS1993

Variational approaches to CFD: Applications to potential Euler and Navier-Stokes equations

Flow simulations based on variational techniques are discussed. Variational techniques are applied for the problem formulation, for the construction of discrete schemes, and for the solution procedures. Inviscid transonic flows, as well as viscous incompressible and compressible flows, are analyzed by several methods. Variational techniques to solve the discrete systems of equations are well known. The most popular one is the conjugate gradient method. Extensions to nonsymmetric and nonpositive definite systems were under investigation for the last two decades. Variational techniques were used for convergence acceleration of iterative procedures. Some of these ideas based on recent work are examined. The lectures are organized in three parts including numerical simulation of inviscid as well as viscous incompressible and compressible flows.

Hafez, M.↗

NASA NTRS2001

Discrete-State Simulated Annealing For Traveling-Wave Tube Slow-Wave Circuit Optimization

Algorithms based on the global optimization technique of simulated annealing (SA) have proven useful in designing traveling-wave tube (TWT) slow-wave circuits for high RF power efficiency. The characteristic of SA that enables it to determine a globally optimized solution is its ability to accept non-improving moves in a controlled manner. In the initial stages of the optimization, the algorithm moves freely through configuration space, accepting most of the proposed designs. This freedom of movement allows non-intuitive designs to be explored rather than restricting the optimization to local improvement upon the initial configuration. As the optimization proceeds, the rate of acceptance of non-improving moves is gradually reduced until the algorithm converges to the optimized solution. The rate at which the freedom of movement is decreased is known as the annealing or cooling schedule of the SA algorithm. The main disadvantage of SA is that there is not a rigorous theoretical foundation for determining the parameters of the cooling schedule. The choice of these parameters is highly problem dependent and the designer needs to experiment in order to determine values that will provide a good optimization in a reasonable amount of computational time. This experimentation can absorb a large amount of time especially when the algorithm is being applied to a new type of design. In order to eliminate this disadvantage, a variation of SA known as discrete-state simulated annealing (DSSA), was recently developed. DSSA provides the theoretical foundation for a generic cooling schedule which is problem independent, Results of similar quality to SA can be obtained, but without the extra computational time required to tune the cooling parameters. Two algorithm variations based on DSSA were developed and programmed into a Microsoft Excel spreadsheet graphical user interface (GUI) to the two-dimensional nonlinear multisignal helix traveling-wave amplifier analysis program TWA3. The algorithms were used to optimize the computed RF efficiency of a TWT by determining the phase velocity profile of the slow-wave circuit. The mathematical theory and computational details of the DSSA algorithms will be presented and results will be compared to those obtained with a SA algorithm.

Wilson, Jeffrey D.↗

NASA NTRS1994

A Remarkable Auroral Event on Jupiter Observed in the Ultraviolet with the Hubble Space Telescope

Two sets of ultraviolet images of the Jovian north aurora were obtained with the Faint Object Camera on board the Hubble Space Telescope. The first series shows an intense discrete arc in near corotation with the planet. The maximum apparent molecular hydrogen emission rate corresponds to an electron precipitation of approximately 1 watt per square meter, which is about 30,000 times larger than the solar heating by extreme ultraviolet radiation. Such a particle heating rate of the auroral upper atmosphere of Jupiter should cause a large transient temperature increase and generate strong thermospheric winds. Twenty hours after initial observations, the discrete arc had decreased in brightness by more than one order of magnitude. The time scale and magnitude of the change in the ultraviolet aurora leads us to suggest that the discrete Jovian auroral precipitation is related to large-scale variations in the current system as is the case of for Earth's discrete aurorae.

Gerard, J. C.↗

NASA NTRS1990

An upwind-biased, point-implicit relaxation algorithm for viscous, compressible perfect-gas flows

An upwind-biased, point-implicit relaxation algorithm for obtaining the numerical solution to the governing equations for three-dimensional, viscous, compressible, perfect-gas flows is described. The algorithm is derived using a finite-volume formulation in which the inviscid components of flux across cell walls are described with Roe's averaging and Harten's entropy fix with second-order corrections based on Yee's Symmetric Total Variation Diminishing scheme. Viscous terms are discretized using central differences. The relaxation strategy is well suited for computers employing either vector or parallel architectures. It is also well suited to the numerical solution of the governing equations on unstructured grids. Because of the point-implicit relaxation strategy, the algorithm remains stable at large Courant numbers without the necessity of solving large, block tri-diagonal systems. Convergence rates and grid refinement studies are conducted for Mach 5 flow through an inlet with a 10 deg compression ramp and Mach 14 flow over a 15 deg ramp. Predictions for pressure distributions, surface heating, and aerodynamics coefficients compare well with experiment data for Mach 10 flow over a blunt body.

Gnoffo, Peter A.↗

NASA NTRS1990

Energy stability of thermocapillary convection in a model of the float-zone crystal-growth process

Energy stability theory has been applied to a basic state of thermocapillary convection occurring in a cylindrical half-zone of finite length to determine conditions under which the flow will be stable. Because of the finite length of the zone, the basic state must be determined numerically. Instead of obtaining stability criteria by solving the related Euler-Lagrange equations, the variational problem is attacked directly by discretization of the integrals in the energy identity using finite differences. Results of the analysis are values of the Marangoni number below which axisymmetric disturbances to the basic state will decay, for various values of the other parameters governing the problem.

Shen, Y.↗

NASA NTRS1992

Dynamic characterization, monitoring and control of rotating flexible beam-mass structures via piezo-embedded techniques

A variational principle and a finite element discretization technique were used to derive the dynamic equations for a high speed rotating flexible beam-mass system embedded with piezo-electric materials. The dynamic equation thus obtained allows the development of finite element models which accommodate both the original structural element and the piezoelectric element. The solutions of finite element models provide system dynamics needed to design a sensing system. The characterization of gyroscopic effect and damping capacity of smart rotating devices are addressed. Several simulation examples are presented to validate the analytical solution.

Lai, Steven H.-Y.↗

NASA NTRS1995

Assessment of computational models for thermoelectroelastic multilayered plates

A study is made of the accuracy of the steady-state (static) thermoelectroelastic response of multilayered hybrid composite plates predicted by five modeling approaches, based on two-dimensional plate theories. The plates consist of a combination of fiber-reinforced and piezothermoelastic layers. The standard of comparison is taken to be the exact three-dimensional thermoelectroelastic solutions, and the quantities compared include gross response characteristics (e.g., strain energy components, and average through-the-thickness displacements); detailed, through-the-thickness distributions of displacements and stresses; and sensitivity coefficients of the response quantities (derivatives of the response quantities with respect to material parameters of the plate). The modeling approaches considered include first-order theory; third-order theory; discrete-layer theory (with piecewise linear variation of the in-plane displacements, temperature and electric potential, in the thickness direction); and two predictor-corrector procedures.

Tang, Yvette T.↗

NASA NTRS2005

Computations of Flow over a Hump Model Using Higher Order Method with Turbulence Modeling

Turbulent separated flow over a two-dimensional hump is computed by solving the RANS equations with k - omega (SST) turbulence model for the baseline, steady suction and oscillatory blowing/suction flow control cases. The flow equations and the turbulent model equations are solved using a fifth-order accurate weighted essentially. nonoscillatory (WENO) scheme for space discretization and a third order, total variation diminishing (TVD) Runge-Kutta scheme for time integration. Qualitatively the computed pressure distributions exhibit the same behavior as those observed in the experiments. The computed separation regions are much longer than those observed experimentally. However, the percentage reduction in the separation region in the steady suction case is closer to what was measured in the experiment. The computations did not predict the expected reduction in the separation length in the oscillatory case. The predicted turbulent quantities are two to three times smaller than the measured values pointing towards the deficiencies in the existing turbulent models when they are applied to strong steady/unsteady separated flows.

Balakumar, P.↗

NASA NTRS2004

Computations of Flow Over a Hump Model Using Higher Order Method With Turbulence Modeling

Turbulent separated flow over a two-dimensional hump is computed by solving the RANS equations with k-omega (SST) turbulence model for the baseline, steady suction and oscillatory blowing/suction flow control cases. The flow equations and the turbulent model equations are solved using a fifth-order accurate weighted essentially nonoscillatory (WENO) scheme for space discretization and a third order, total variation diminishing (TVD) Runge-Kutta scheme for time integration. Qualitatively the computed pressure distributions exhibit the same behavior as they are observed in the experiments. The computed separation regions are much longer than that are observed. However, the percentage reduction in the separation region in the steady suction case is closer to that was measured in the experiment. The computations did not predict the expected reduction in the separation length in the oscillatory case. The predicted turbulent quantities are two to three times smaller than that are measured and it points towards the deficiencies in the existing turbulent models when they are applied to strong steady/unsteady separated flows.

Balakumar, Ponnampalam↗

NASA NTRS2005

Continuous, Full-Circle Arctangent Circuit

A circuit generates an analog voltage proportional to an angle, in response to two sinusoidal input voltages having magnitudes proportional to the sine and cosine of the angle, respectively. That is to say, given input voltages proportional to sin(Omega(t))sin(Theta) and sin(Omega(t))cos(Theta) [where Theta denotes the angle, mega denotes 2(pi) x a carrier frequency, and t denotes time], the circuit generates a steady voltage proportional to Theta. The output voltage varies continuously from its minimum to its maximum value as Theta varies from -180deg to 180deg. While the circuit could accept input modulated sine and cosine signals from any source, it must be noted that such signals are typical of the outputs of shaft-angle resolvers in electromagnetic actuators used to measure and control shaft angles for diverse purposes like aiming scientific instruments and adjusting valve openings. In effect, the circuit is an analog computer that calculates the arctangent of the ratio between the sine and cosine signals. The full-circle angular range of this arctangent circuit stands in contrast to the range of prior analog arctangent circuits, which is from slightly greater than -90deg to slightly less than +90deg. Moreover, for applications in which continuous variation of output is preferred to discrete increments of output, this circuit offers a clear advantage over resolver- to-digital integrated circuits.

Alhorn, Dean C.↗

NASA NTRS1978

Test procedures

The test procedures required to evaluate the performance of the Space Lab Bus Interface Unit (SL/BIU) are described. This level of testing involves the design evaluation of signal levels, timing, and signal-to-noise (S/N) performance. The tests are to be comprehensive in order to provide data on the operational characteristics of the SL/BIU. The evluation tests are designed to accomplish the following determinations as a minimum for component level testing of the SL/BIU: (1) the baseline operation parameters for comparison to ICD 2-05301 requirements; (2) the influence of serial data line parameter variation on the operation of SL/BIU; (3) the effects of noise on discrete and serial data lines (S/N ratio); and (4) the effects of cable length variation.

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