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The United States Agency for International Development is drawing on U.S. Department of Energy national laboratory expertise to advance clean, resilient, and equitable energy systems in the developing world through the USAID-NREL Partnership.
Much of the population in the developing world resides in rural areas, is dependent on local agriculture for survival, and thus directly subject to increasingly volatile and variable climatic patterns. Poverty limits options for adaptation to unpredictable weather and resultant food insecurity; these concerns are particularly salient in an era of climate change, which threatens to roll back years of development gains. Examining the association between the growing environment and child survival and nutrition is important in this context. Using NASA's satellite remote sensing data with Demographic and Health Surveys (DHS) data from four West African countries (Mali, Burkina Faso, Guinea and Benin), we assess the association between a climate-related environmental variable (vegetation index - NDVI) and child survival and nutrition. NDVI had a positive association with child survival and nutrition in countries with a wide distribution of NDVI values. NDVI was more likely to be positively associated with wasting rather than stunting. We find that environmental factors can be important for child survival and nutrition outcomes in specific contexts. Additional research is needed to further explore the ways NDVI can be used to inform our understanding of the environment's impact on child survival and nutrition.
The ADS was represented at the AAS meeting with 3 poster papers and a demonstration booth. We have setup a mirror site of the Vizier data base system at the CDS. functionality of the ADC at Goddard. This will replace the Preparations for the APS and LPSC meetings in March started. We will have demonstrations at both meetings. Preparations for the APS and LPSC meetings in March continued. We will have demonstrations at both meetings. The ADS was represented with a poster at the joint AGUEGU meeting in Nice, France. Discussions about the on-going collaboration between the ADS and the CDS in Strasbourg, France were held in Strasbourg. The ADS was invited to organize a session about the ADS and its mirror sites at the next United Nations Workshop on Basic Space Sciences in the Developing World. Efforts are under way to enter the tables of contents of all conference proceedings in the SA0 library into the ADS. This requires copying the tables of contents from all volumes in the library and have them typed in. This will greatly enhance the coverage of the literature in the ADS. We started the development of a search system for the full text of all scanned material in the ADS. This will eventually allow our users search capabilities that so far do not exist in any form. I order to enable the full text searching, we have purchased OCR software and are in the process of OCRing the scanned pages in the ADS. Efforts are in progress to handle the inclusion of data set identifiers in article manuscripts. The ADS will be the central system that will allow the journals to verify data set identifiers. The "master verifier" has been implemented in prototype form at the ADS. We started to include more journals in Geosciences/Geophysics in the ADS. The Royal astronomical Society has decided to archive their on-line journals in the ADS three years after publication. We have started to process these older on-line articles in order to archive them in the ADS. Our mirror site in Korea now has a full article mirror. We developed XML output capability in the ADS. This will make it easier to exchange data with other data systems. We started the development of new indexing software that will eventually reduce the indexing time for a database from days to hours or less. The ADS was represented at the IAU General Assembly with a poster. Discussions with the IAU management were held about extending the ADS IAU collaborations.
In 1958, the United Nations (UN) formally recognized a new potential for international cooperation by establishing an ad hoc Committee on the Peaceful Uses of Outer Space (COPUOS). A year later the Committee became a permanent body, and by 1983 membership had expanded to 53 states, with more than half of the members coming from the developing world. In 1970, COPUOS established the UN Program on Space Applications in order to strengthen cooperation in space science and technology between non-industrialized and industrialized countries. In the last few years, the UN and its COPUOS have paid increasing attention to education and research in space science and technology, including basic space science. In 1991 the UN, in cooperation with ESA, initiated the organization of annual Workshops in Basic Space Science for developing countries. These Workshops are designed to be held in one of the following major regions: Asia and the Pacific, Latin America and the Caribbean, Africa, Western Asia, and Europe. Accordingly, Basic Space Science Workshops have already been held in India (1991), Costa Rica andColombia (1992), and Nigeria (1993). The fourth Workshop was held from 27 June to 1 July 1994 at the Cairo University, in Egypt, for Western Asia.
In a globalizing and rapidly-developing world, reliable, sustainable access to water and food are inextricably linked to each other and basic human rights. Achieving security and sustainability in both requires recognition of these linkages, as well as continued innovations in both science and policy. We present case studies of how Earth observations are being used in applications at the nexus of water and food security: crop monitoring in support of G20 global market assessments, water stress early warning for USAID, soil moisture monitoring for USDA's Foreign Agricultural Service, and identifying food security vulnerabilities for climate change assessments for the UN and the UK international development agency. These case studies demonstrate that Earth observations are essential for providing the data and scalability to monitor relevant indicators across space and time, as well as understanding agriculture, the hydrological cycle, and the water-food nexus. The described projects follow the guidelines for co-developing useable knowledge for sustainable development policy. We show how working closely with stakeholders is essential for transforming NASA Earth observations into accurate, timely, and relevant information for water-food nexus decision support. We conclude with recommendations for continued efforts in using Earth observations for addressing the water-food nexus and the need to incorporate the role of energy for improved food and water security assessments
Abstract Plant breeding relies on information gathered from field trials to select promising new crop varieties for release to farmers and to develop genomic prediction models that can enhance the efficiency of genetic improvement in future breeding cycles. However, generating the genetic marker data required to apply genomic prediction at the early stages of a breeding program remains costly for many public‐sector breeding programs as well as for many plant breeders operating in developing countries. As the pace of climate change intensifies, the time lag of developing and deploying new crop varieties requires plant breeders to make selection decisions without knowing the future environments those crop varieties will encounter in farmers’ fields. Therefore, both lower cost and higher accuracy methods for prediction of crop performance are essential for creating and maintaining resilient agricultural systems in the latter half of the 21 st century. To address this challenge, we conducted linked yield trials of 752 public maize ( Zea mays ) genotypes in two distinct environments. We developed and trained a phenotypic prediction model to predict yield from manually scored plant traits. The phenotypic prediction approach we employed outperformed genomic prediction in predicting yields in a second environment, with 8.7%–63% higher R 2 and 4%–13% less root mean square error than the genomic prediction. The phenotypic prediction has the potential to be applied to a wider range of breeding programs, including those that lack the resources to genotype large populations, such as programs in the developing world, breeding programs for specialty crops, and public sector programs.
As fossil fuels remain a major source of energy throughout the world, developing efficient negative emission technologies, such as direct air capture (DAC), which remove carbon dioxide (CO 2 ) from the air, becomes critical for mitigating climate change. Although all DAC processes involve CO 2 transport from air into a sorbent/solvent, through an air–solid or air–liquid interface, the fundamental roles the interfaces play in DAC remain poorly understood. In this work, we study the interfacial behavior of amino acid (AA) solvents used in DAC through a combination of vibrational sum frequency generation spectroscopy and molecular dynamics simulations. This study revealed that the absorption of atmospheric CO 2 has antagonistic effects on subsequent capture events that are driven by changes in bulk pH and specific ion effects that feedback on surface organization and interactions. Among the three AAs (leucine, valine, and phenylalanine) studied, we identify and separate behaviors from CO 2 loading, chemical changes, variations in pH, and specific ion effects that tune structural and chemical degrees of freedom at the air–aqueous interface. The fundamental mechanistic findings described here are anticipated to enable new approaches to DAC based on exploiting interfaces as a tool to address climate change.
The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a biomanufacturing platform has been limited by a lack of genetic tools. Here we report genetic engineering methods for stable, high-level expression of bioactive proteins in spirulina, including large-scale, indoor cultivation and downstream processing methods. Following targeted integration of exogenous genes into the spirulina chromosome (chr), encoded protein biopharmaceuticals can represent as much as 15% of total biomass, require no purification before oral delivery and are stable without refrigeration and protected during gastric transit when encapsulated within dry spirulina. Oral delivery of a spirulina-expressed antibody targeting campylobacter—a major cause of infant mortality in the developing world—prevents disease in mice, and a phase 1 clinical trial demonstrated safety for human administration. Spirulina provides an advantageous system for the manufacture of orally delivered therapeutic proteins by combining the safety of a food-based production host with the accessible genetic manipulation and high productivity of microbial platforms.
Significance Obesity is a major public health problem in a growing proportion of children and adults in the developed world. Estrogen influences body weight and behavioral responses to appetitive stimuli. Estrogen biosynthesis is catalyzed by the enzyme aromatase in all organs measured, including the brain. Using the aromatase radiotracer [ 11 C]vorozole, we measured aromatase availability in the amygdala in healthy-weight to obese adults. Obesity was associated with lower aromatase availability and less constraint independent of sex and age. Variability in brain estrogen synthesis may contribute to obesity by directly regulating feeding and broadly by affecting self-control. These findings suggest that brain aromatase imaging offers a method for characterizing the role of brain estrogen in obesity and other impairments in self-regulation.
Background: Cardiovascular and cancer mortality are the two leading causes of death in the developed world including the USA. However, mortality trends for these diseases are highly dynamic, and the geographic landscape is in transition. We analyze patterns of mortality improvement at county level during recent decades focusing on mortality decline and geographic diversity. Methods: We grouped age-adjusted mortality rates of cardiovascular and cancer diseases from CDC WONDER for 2959 US counties into 3-year time periods to improve reliability. We calculated percent mortality decrease between 1981–83 and 2016–19 for both causes to quantify mortality improvements for counties. Results: Using standard deviation as an index of disparities, place-based cancer mortalities were 68% larger than cardiovascular disparities. Significantly, 566 US counties had same or higher rates of cancer mortality in 2019 as in 1981. The geographic distribution of mortality improvement in either cause tends to favor largely populated areas along coasts. Less-populated, rural places in the interior and southeastern regions were experiencing less improvement. Conclusions: At the county level, large place-based disparities exist for both causes of death with the magnitude of disparities being substantially larger for the reduction in cancer deaths. Put differently, place matters, more for cancer than cardiovascular mortality.
A wide variety of symptoms is associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, and these symptoms can overlap with other conditions and diseases. Knowing the distribution of symptoms across diseases and individuals can support clinical actions on timelines shorter than those for drug and vaccine development. Here, we focus on zinc deficiency symptoms, symptom overlap with other conditions, as well as zinc effects on immune health and mechanistic zinc deficiency risk groups. There are well-studied beneficial effects of zinc on the immune system including a decreased susceptibility to and improved clinical outcomes for infectious pathogens including multiple viruses. Zinc is also an anti-inflammatory and anti-oxidative stress agent, relevant to some severe Coronavirus Disease 2019 (COVID-19) symptoms. Unfortunately, zinc deficiency is common worldwide and not exclusive to the developing world. Lifestyle choices and preexisting conditions alone can result in zinc deficiency, and we compile zinc risk groups based on a review of the literature. It is also important to distinguish chronic zinc deficiency from deficiency acquired upon viral infection and immune response and their different supplementation strategies. Zinc is being considered as prophylactic or adjunct therapy for COVID-19, with 12 clinical trials underway, highlighting the relevance of this trace element for global pandemics. Using the example of zinc, we show that there is a critical need for a deeper understanding of essential trace elements in human health, and the resulting deficiency symptoms and their overlap with other conditions. This knowledge will directly support human immune health for decreasing susceptibility, shortening illness duration, and preventing progression to severe cases in the current and future pandemics.
Quantum information science still requires basic science research to achieve its full potential. However, scientists require access to fabricated device samples if we are to utilize the full toolset for solving the pressing issues in the field such as materials, device layout, or optimal error correction methods.Currently, access to samples is either prohibitively expensive, or requires close collaboration with one of the few groups in the world developing these systems. A dedicated quantum foundry could,in principle,provide affordable samples designed with current best practices to a host of scientists who otherwise do not have access. We detail several different foundry models which we believe will assist the community in developing the science for both the underlying processes, as well as the more advanced chip layout and circuit design. Opening access to the broader community has the potential to significantly lower the barrier to entry and vastly improve the ability for researchers in fields ranging from condensed matter to materials characterization to systems engineering to contribute to accelerating the advance of quantum information science and technology.
As part of the Sustaining and Enhancing Nuclear Science (SENSe) initiative at Oak Ridge National Laboratory (ORNL), the prospect of adding new detection systems to support High Flux Isotope Reactor (HFIR) operations and to advance scientific research has prompted many ideas and discussions regarding potential features, configurations, locations, and applications. A working group of ORNL staff members was organized to further develop the concepts and recommending one or more configurations to best support future HFIR operations and scientific capacities and to provide order-of-magnitude cost estimates and timing. The areas of investigation included fast access detection systems, non-scattering beamline instruments, shielded detection instruments, and an ultracold neutron source. In each case, the focus was to develop world leading capabilities that would be unmatched by any other facility.
Nb3Sn superconducting radiofrequency (SRF) cavities can expand performance capabilities of particle accelerators for both the fundamental research and the industrial applications. The technology holds a great appeal especially to small-scale applications, where it can enable a turn-key compact cryocooler operation eliminating the need for complex sub-atmospheric liquid helium cryogenic plants. Since the research into Nb3Sn SRF coatings using vapor diffusion technique restarted in 2009 at Cornell University, there has been a growing number of SRF groups around the world developing this technology with a steady increase in cavity performance and system complexity. In this talk, after a short overview of SRF technology, I will present on some of the recent developments in Nb3Sn SRF cavities, focusing on recent efforts to complete the first-of-its-kind Nb3Sn 2-cavity CEBAF-type cryomodule, which was assembled and tested last year. The talk will conclude with a short overview on some of the ongoing projects and the future possibilities for Nb3Sn cavities in accelerator applications.
As a leading cause of bacterial-derived gastroenteritis worldwide, Campylobacter jejuni has a significant impact on human health in both the developed and developing worlds. Despite its prevalence as a human pathogen, the source of these infections remains poorly understood due to the mutation frequency of the organism and past limitations of whole genome analysis. Recent advances in both whole genome sequencing and computational methods have allowed for the high-resolution analysis of intraspecies diversity, leading multiple groups to postulate that these approaches may be used to identify the sources of Campylobacter jejuni infection. To address this hypothesis, our group conducted a regionally and temporally restricted sampling of agricultural and environmental Campylobacter sources and compared isolated C. jejuni genomes to those that caused human infections in the same region during the same time period. Through a network analysis comparing genomes from various sources, we found that human C. jejuni isolates clustered with those isolated from cattle and chickens, indicating these as potential sources of human infection in the region.
Electrical feedthrough connects both low-voltage and high-voltage signals between cryogenic environment and "outside world." Developed for cooled germanium gamma-ray detector, feedthrough has especially low capacitance and low sensitivity to microphonic noise. Its high-voltage lead is free of corona discharge and electrical breakdown to at least 5 kV.
Nitrogen (N) fertilization of agricultural systems is thought to be a major source of the increase in atmospheric N2O; NO emissions from soils have also been shown to increase due to N fertilization. While N fertilizer use is increasing rapidly in the developing world and in the tropics, nearly all of our information on gas emissions is derived from studies of temperate zone agriculture. Using chambers, we measured fluxes of N2O and NO following urea fertilization in tropical sugar cane systems growing on a variety of soil types in the Hawaiian Islands, USA. On the island of Maui, where urea is applied in irrigation lines and soils are mollisols and inceptisols, N2O fluxes were elevated for a week or less following fertilization; maximum average fluxes were typically less than 30 ng cm(exp -2)/ h. NO fluxes were often an order of magnitude less than N2O. Together, N2O and NO represented from 0.01 - 0.5% of the applied N. In fields on the island of Hawaii, where urea is broadcast on the surface and soils are andisols, N2O fluxes were similar in magnitude to Maui but remained elevated for much longer periods after fertilization. NO emissions were 2-5 times higher than N2O through most of the sampling periods. Together the gases loss represented approximately 1. 1 - 3% of the applied N. Laboratory studies indicate that denitrification is a critical source of N2O in Maui, but that nitrification is more important in Hawaii. Experimental studies suggest that differences in the pattern of N2O/NO and the processes producing them are a result of both carbon availability and placement of fertilizer, and that the more information-intensive fertilizer management practice results in lower emissions.
Earth observations are playing an increasingly significant role in informing decision making in the energy sector. In renewable energy applications, space-based observations now routinely augment sparse ground-based observations used as input for renewable energy resource assessment applications. As one of the nine Group on Earth Observations (GEO) societal benefit areas, the enhancement of management and policy decision making in the energy sector is receiving attention in activities conducted by the Committee on Earth Observation Satellites (CEOS). CEOS has become the "space arm" for the implementation of the Global Earth Observation System of Systems (GEOSS) vision. It is directly supporting the space-based, near-term tasks articulated in the GEO three-year work plan. This paper describes a coordinated program of demonstration projects conducted by CEOS member agencies and partners to utilize Earth observations to enhance energy management end-user decision support systems. I discuss the importance of engagement with stakeholders and understanding their decision support needs in successfully increasing the uptake of Earth observation products for societal benefit. Several case studies are presented, demonstrating the importance of providing data sets in formats and units familiar and immediately usable by decision makers. These projects show the utility of Earth observations to enhance renewable energy resource assessment in the developing world, forecast space-weather impacts on the power grid, and improve energy efficiency in the built environment.