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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

High‐Concentration Antibody Formulation via Solvent‐Based Dehydration

Abstract Although subcutaneous (SC) delivery is the preferred administration route for immunotherapies and other biologics for improved patient compliance and lower healthcare costs, it necessitates high‐concentration antibody formulations. However, high‐concentration antibody solutions face significant instabilities and prohibitively high viscosities. Other approaches for high‐concentration formulations have been developed, including non‐aqueous solutions, which can be irritating or painful, and antibody‐laden hydrogel microparticles, which require centrifugation and are limited to concentrations <300 mg mL −1 . This work presents a new formulation process wherein the antibody is concentrated and encapsulated into hydrogel microparticles via solvent‐based dehydration. The final dosage form is an aqueous particle suspension with a formulation concentration of 360 mg mL −1 . In this process, microparticles are synthesized continuously, and antibody precipitation is realized simultaneously to dehydration, which allows for higher antibody concentrations. Antibody phase behavior and precipitation–dehydration kinetics are analyzed. The antibody is structurally and functionally stable in the microparticle post‐processing and after 4 months. Injectability of the suspension meets clinical standards with glide force <20 N. For the first time, an aqueous antibody formulation at high concentrations comparable to non‐aqueous formulations is presented, ideal for subcutaneous administration. The process is envisioned to be generalizable as a platform for SC delivery in multiple clinical applications.

Zheng, Talia [Department of Chemical Engineering M↗
NASA NTRS1992

An unusual volcano on Venus

Materials that issued from an unusual Venusian volcano produced (1) a complex domical structure about 100 km across with thick, broad flow lobes up to 41 wide, (2) an extensive sheet of thick flows, and (3) radar-bright surfaces that extend to 360-400 km from the volcano. Altimetry indicates that the relief of the domical structure is about 0.5-1.1 km. The lobes and flows have prominant regularly spaced ridges about 686-820 m apart. Thick flows with large ridge separations and broad lobes are rare on Venus. The viscosities of these flows were larger than those of most lava flows on Venus. Comparisons of the dimensions of the volcano's lobes with lava flows on earth suggest that the Venusian lavas may have large silica contents. Radar-bright surfaces around the volcano may represent the result of an explosive eruption or very thin deposits of low-viscosity lavas. Thus, the radar-bright surfaces and lavas of the volcano were derived from a magma that differentiated within the crust or mantle of Venus. The differentiation produced (1) a gas-rich low-viscosity phase, (2) high-viscosity lavas, and (3) a residual primary magma.

Moore, H. J.↗
NASA NTRS1995

A source-sink model of the generation of plate tectonics from non-Newtonian mantle flow

A model of mantle convection which generates plate tectonics requires strain rate- or stress-dependent rheology in order to produce strong platelike flows with weak margins as well as strike-slip deformation and plate spin (i.e., toroidal motion). Here, we employ a simple model of source-sink driven surface flow to determine the form of such a rheology that is appropriate for Earth's present-day plate motions. In this model, lithospheric motion is treated as shallow layer flow driven by sources and sinks which correspond to spreading centers and subduction zones, respectively. Two plate motion models are used to derive the source sink field. As originally implied in the simpler Cartesian version of this model, the classical power law rheologies do not generate platelike flows as well as the hypothetical Whitehead-Gans stick-slip rheology (which incorporates a simple self-lubrication mechanism). None of the fluid rheologies examined, however, produce more than approximately 60% of the original maximum shear. For either plate model, the viscosity fields produced by the power law rheologies are diffuse, and the viscosity lows over strike-slip shear zones or pseudo-margins are not as small as over the prescribed convergent-divergent margins. In contrast, the stick-slip rheology generates very platelike viscosity fields, with sharp gradients at the plate boundaries, and margins with almost uniformly low viscosity. Power law rheologies with high viscosity contrasts, however, lead to almost equally favorable comparisons, though these also yield the least platelike viscosity fields. This implies that the magnitude of toroidal flow and platelike strength distributions are not necessarily related and thus may present independent constraints on the determination of a self-consistent plate-mantle rheology.

Bercovici, David↗
NASA NTRS1996

An Inversion of Gravity and Topography for Mantle and Crustal Structure on Mars

Analysis of the gravity and topography of Mars presently provides our primary quantitative constraints on the internal structure of Mars. We present an inversion of the long-wavelength (harmonic degree less than or equal to 10) gravity and topography of Mars for lateral variations of mantle temperature and crustal thickness. Our formulation incorporates both viscous mantle flow (which most prior studies have neglected) and isostatically compensated density anomalies in the crust and lithosphere. Our nominal model has a 150-km-thick high-viscosity surface layer over an isoviscous mantle, with a core radius of 1840 km. It predicts lateral temperature variations of up to a few hundred degrees Kelvin relative to the mean mantle temperature, with high temperature under Tharsis and to a lesser extent under Elysium and cool temperatures elsewhere. Surprisingly, the model predicts crustal thinning beneath Tharsis. If correct, this implies that thinning of the crust by mantle shear stresses dominates over thickening of the crust by volcanism. The major impact basins (Hellas, Argyre, Isidis, Chryse, and Utopia) are regions of crustal thinning, as expected. Utopia is also predicted to be a region of hot mantle, which is hard to reconcile with the surface geology. An alternative model for Utopia treats it as a mascon basin. The Utopia gravity anomaly is consistent with the presence of a 1.2 to 1.6 km thick layer of uncompensated basalt, in good agreement with geologic arguments about the amount of volcanic fill in this area. The mantle thermal structure is the dominant contributor to the observed geoid in our inversion. The mantle also dominates the topography at the longest wavelengths, but shorter wavelengths (harmonic degrees greater than or equal to 4) are dominated by the crustal structure. Because of the uncertainty about the appropriate numerical values for some of the model's input parameters, we have examined the sensitivity of the model results to the planetary structural model (core radius and core and mantle densities), the mantle's viscosity stratification, and the mean crustal thickness. The model results are insensitive to the specific thickness or viscosity contrast of the high-viscosity surface layer and to the mean crustal thickness in the range 25 to 100 km. Models with a large core radius or with an upper mantle low-viscosity zone require implausibly large lateral variations in mantle temperature.

Kiefer, Walter S.↗
NASA NTRS1991

Viscosity of high-temperature iodine

The viscosity coefficient of iodine in the temperature range 500 - 3000 K is calculated. Because of the low dissociation energy of the I2 molecules, the dissociation degree of the gas increases quickly with temperature, and I + I2 and I + I collisions must be taken into account in calculation of viscosity at temperatures greater than 1000 deg. Several possible channels for atom-atom interaction are considered, and the resulting collision integrals are averaged over all the important channels. It is also shown that the rigid-sphere model is inaccurate in predictions of the viscosity.

Kang, Steve H.↗
DOE OSTI2020

A Comparative Study of Imidazolium-Based Ionic Liquid-Single-Walled Carbon Nanotube Composites with Enhanced Conductivity Properties for Supercapacitor Applications

Mixtures of ionic liquids (ILs) containing single-walled carbon nanotubes (SWCNTs) were prepared and characterized to obtain electrolytes with optimized transport properties for use in energy storage devices such as supercapacitors. Imidazolium ILs bearing cations with side chains of different functionality coupled with bis(trifluoromethylsulfonyl)amide (NTf 2- ) or bis(fluorosulfonyl)-amide (FSA-) anions, were used in mixtures containing up to 5 wt% SWCNTs. At and above 2 wt% nanotube loading, the mixtures exhibited higher conductivities than the pure ILs, in spite of the extremely high viscosities. Loadings of 5 wt% produced very high conductivities, and studies of the temperature dependence indicated a change in the charge transport mechanism between 2 and 5 wt% loading. At 5 wt% loading, the highest conductivities (up to 540 mS/cm at 25 °C) were obtained for the ILs containing the NTf 2- anion. Overall, these results can significantly contribute to the development of improved energy storage devices.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS2005

High-Performance Polymers Having Low Melt Viscosities

High-performance polymers that have improved processing characteristics, and a method of making them, have been invented. One of the improved characteristics is low (relative to corresponding prior polymers) melt viscosities at given temperatures. This characteristic makes it possible to utilize such processes as resin-transfer molding and resin-film infusion and to perform autoclave processing at lower temperatures and/or pressures. Another improved characteristic is larger processing windows that is, longer times at low viscosities. Other improved characteristics include increased solubility of uncured polymer precursors that contain reactive groups, greater densities of cross-links in cured polymers, improved mechanical properties of the cured polymers, and greater resistance of the cured polymers to chemical attack. The invention is particularly applicable to poly(arylene ether)s [PAEs] and polyimides [PIs] that are useful as adhesives, matrices of composite materials, moldings, films, and coatings. PAEs and PIs synthesized according to the invention comprise mixtures of branched, linear, and star-shaped molecules. The monomers of these polymers can be capped with either reactive end groups to obtain thermosets or nonreactive end groups to obtain thermoplastics. The synthesis of a polymeric mixture according to the invention involves the use of a small amount of a trifunctional monomer. In the case of a PAE, the trifunctional monomer is a trihydroxy- containing compound for example, 1,3,5-trihydroxybenzene (THB). In the case of a PI, the trifunctional monomer is a triamine for example, triamino pyrimidine or melamine. In addition to the aforementioned trifunctional monomer, one uses the difunctional monomers of the conventional formulation of the polymer in question (see figure). In cases of nonreactive end caps, the polymeric mixtures of the invention have melt viscosities and melting temperatures lower than those of the corresponding linear polymers of equal molecular weights. The lower melting temperatures and melt viscosities provide larger processing windows. In cases of reactive end caps, the polymeric mixtures of the invention have lower melt viscosities before curing and the higher cross-link densities after curing (where branching in the uncured systems would become cross-links in the cured systems), relative to the corresponding linear polymers of equal molecular weights. The greater cross-link densities afford increased resistance to chemical attack and improved mechanical properties.

Jensen, Brian J.↗
DOE OSTI2020

Development of a variable tensioning system to reduce separation force in large scale stereolithography

Projection micro stereolithography (PµSL) is an additive manufacturing tool that offers multiple advantages, including unparalleled resolution and throughput, but the ability to print high viscosity resin for large-scale parts is limited. One of the key challenges in PµSL is to separate a newly polymerized layer from the vat floor without damaging the part. Since the separation force scales with the printing area, the risk of damaging the part increases significantly with larger-scale systems and must be addressed. In this paper, a novel roll-to-roll, variable tensioning system is proposed to reduce the separation force during printing. A mathematical model is proposed to predict the separation force for different 2D geometries, and a set of experiments is conducted on an experimental prototype to validate the model. Finally, the effects of different separation parameters including peel rate and peel angle are discussed in detail. The results show that the proposed tensioning system reduces the separation force significantly.

36 MATERIALS SCIENCE↗
DOE OSTI2022

Observations of phase changes in monoolein during high viscous injection

Serial crystallography of membrane proteins often employs high-viscosity injectors (HVIs) to deliver micrometre-sized crystals to the X-ray beam. Typically, the carrier medium is a lipidic cubic phase (LCP) media, which can also be used to nucleate and grow the crystals. However, despite the fact that the LCP is widely used with HVIs, the potential impact of the injection process on the LCP structure has not been reported and hence is not yet well understood. The self-assembled structure of the LCP can be affected by pressure, dehydration and temperature changes, all of which occur during continuous flow injection. These changes to the LCP structure may in turn impact the results of X-ray diffraction measurements from membrane protein crystals. To investigate the influence of HVIs on the structure of the LCP we conducted a study of the phase changes in monoolein/water and monoolein/buffer mixtures during continuous flow injection, at both atmospheric pressure and under vacuum. The reservoir pressure in the HVI was tracked to determine if there is any correlation with the phase behaviour of the LCP. The results indicated that, even though the reservoir pressure underwent (at times) significant variation, this did not appear to correlate with observed phase changes in the sample stream or correspond to shifts in the LCP lattice parameter. During vacuum injection, there was a three-way coexistence of the gyroid cubic phase, diamond cubic phase and lamellar phase. During injection at atmospheric pressure, the coexistence of a cubic phase and lamellar phase in the monoolein/water mixtures was also observed. The degree to which the lamellar phase is formed was found to be strongly dependent on the co-flowing gas conditions used to stabilize the LCP stream. A combination of laboratory-based optical polarization microscopy and simulation studies was used to investigate these observations.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1985

Long term evaluation of grease type lubricants in selected environments

The operating life of grease-type lubricants in various environments is evaluated. The test equipment and procedures are described. The lubricants were placed in the rolling element bearings of hysteresis synchronous motors and exposed to environments of a vacuum at 60 C, a vacuum at 93.3 C, 10 psia oxygen at 90 percent relative humidity at 60 C, 14.7 psia air at 90 percent relative humidity at 60 C, start-stop operation, and low temperature start capability for one or five years. The weights of the bearings were measured before and after lubrication; the weight data for each environment are analyzed. The data reveal that the high viscosity index perfluoroalkypolyether grease performs the best in a vacuum at moderate and high temperature, in low temperature start capability, and in start-stop steps; however, the grease does not work well in oxidizing and high relative humidity environments.

Dolan, F. J.↗
DOE OSTI2023

Tuning and high throughput experimental screening of eutectic electrolytes with co-solvents for redox flow batteries

Eutectic solvents, with high salt concentrations and suppressed volatility, are promising alternatives to aqueous and volatile organic electrolytes for grid-scale energy storage devices such as redox flow batteries (RFBs). However, it is not known a priori which hydrogen bond acceptors and donors would form a eutectic solvent and at which compositions of these mixtures would yield desirable properties for RFBs. Specifically, the known deep eutectic solvents generally have high viscosities and low ionic conductivities, especially in the landscape of RFB electrolytes. We report a high throughput experimental (HTE) study was carried out to assess the properties of eutectic solvents based on choline chloride as the hydrogen bond acceptor and ethylene glycol and aniline as the hydrogen bond donors. In addition, water, acetonitrile, and dimethyl sulfoxide as co-solvents were examined in terms of tuning the viscosity, conductivity, and solubility of two redox-active species: methyl viologen dichloride hydrate (MVCl 2 ·H 2 O, or MV for simplicity) and 2,1,3-benzothiadiazole (BTZ) that are relevant to RFBs. The HTE framework enabled the development of a rapid and comprehensive understanding of the design of new eutectic electrolytes incorporating co-solvents to improve the physicochemical and electrochemical properties for RFBs.

25 ENERGY STORAGE↗
NASA NTRS1962

Estimated Viscosities and Thermal Conductivities of Gases at High Temperatures

Viscosities and thermal conductivities, suitable for heat-transfer calculations, were estimated for about 200 gases in the ground state from 100 to 5000 K and 1-atmosphere pressure. Free radicals were included, but excited states and ions were not. Calculations for the transport coefficients were based upon the Lennard-Jones (12-6) potential for all gases. This potential was selected because: (1) It is one of the most realistic models available and (2) intermolecular force constants can be estimated from physical properties or by other techniques when experimental data are not available; such methods for estimating force constants are not as readily available for other potentials. When experimental viscosity data were available, they were used to obtain the force constants; otherwise the constants were estimated. These constants were then used to calculate both the viscosities and thermal conductivities tabulated in this report. For thermal conductivities of polyatomic gases an Eucken-type correction was made to correct for exchange between internal and translational energies. Though this correction may be rather poor at low temperatures, it becomes more satisfactory with increasing temperature. It was not possible to obtain force constants from experimental thermal conductivity data except for the inert atoms, because most conductivity data are available at low temperatures only (200 to 400 K), the temperature range where the Eucken correction is probably most in error. However, if the same set of force constants is used for both viscosity and thermal conductivity, there is a large degree of cancellation of error when these properties are used in heat-transfer equations such as the Dittus-Boelter equation. It is therefore concluded that the properties tabulated in this report are suitable for heat-transfer calculations of gaseous systems.

HEAT TRANSFER↗
NASA NTRS1992

Estimation of the viscosities of silicate liquids at high pressure from measurements of oxygen diffusivity

The dynamics and evolution of a magma ocean depend significantly on the structure and physical properties of silicate liquids at high pressure. Viscosity is particularly important because of its effect on the dynamics of convection and crystal setting. Traditionally, the viscosities of silicate liquids have been measured at high pressure by falling sphere viscometry but, due to some limitations of this technique, few measurements have been made at pressures exceeding 2.5 GPa. An alternative approach, which has previously been proven up to 2 GPa, is to use high pressure measurements of oxygen self-diffusivity (D) to estimate viscosity (eta) from the Eyring relationship eta = kT/D lambda (where k is the Boltzmann constant, T is absolute temperature, and lambda is the diffusive jump distance). We have performed preliminary experiments on Na2Si4O9 liquid in order to explore the feasibility of this method up to pressures in excess of 10 GPa. Diffusion couples were prepared from glass starting materials with one half of the sample enriched in O-18 and the other half containing the natural abundance (0.2 wt percent). Diffusion experiments were performed at 1600 to 1800 C at pressures in the range of 2.5 to 10 GPa for times up to 6 minutes using a 1200 ton multianvil apparatus. Oxygen diffusivities were derived from the resulting O-18 concentration profiles, which were analyzed using an ion microprobe. At 1800 C, oxygen diffusivities increase continuously from 1 x 10(exp -10) m(exp -2) s(exp -1) at 2.5 Gpa to 5 x 10(exp -10) m(exp -2) s(exp -1) at 10 GPa. From the Eyring relationship, the viscosity of Na2SiO9 liquid is predicted to decrease by approx. 0.7 log units over this pressure range at 1800 C. These trends, which can be related to changes in the structure of the liquid at high pressure, are in agreement with results of molecular dynamics calculations. These results suggest that it should be possible to estimate the viscosities of silicate liquids up to at least 15 GPa and 2200 C by this method.

Rubie, D. C.↗
NASA NTRS1999

Viscosity Measurement of Highly Viscous Liquids Using Drop Coalescence in Low Gravity

The method of drop coalescence is being investigated for use as a method for determining the viscosity of highly viscous undercooled liquids. Low gravity environment is necessary in this case to minimize the undesirable effects of body forces and liquid motion in levitated drops. Also, the low gravity environment will allow for investigating large liquid volumes which can lead to much higher accuracy for the viscosity calculations than possible under 1 - g conditions. The drop coalescence method is preferred over the drop oscillation technique since the latter method can only be applied for liquids with vanishingly small viscosities. The technique developed relies on both the highly accurate solution of the Navier-Stokes equations as well as on data from experiments conducted in near zero gravity environment. In the analytical aspect of the method two liquid volumes are brought into contact which will coalesce under the action of surface tension alone. The free surface geometry development as well as its velocity during coalescence which are obtained from numerical computations are compared with an analogous experimental model. The viscosity in the numerical computations is then adjusted to bring into agreement of the experimental results with the calculations. The true liquid viscosity is the one which brings the experiment closest to the calculations. Results are presented for method validation experiments performed recently on board the NASA/KC-135 aircraft. The numerical solution for this validation case was produced using the Boundary Element Method. In these tests the viscosity of a highly viscous liquid, in this case glycerine at room temperature, was determined to high degree of accuracy using the liquid coalescence method. These experiments gave very encouraging results which will be discussed together with plans for implementing the method in a shuttle flight experiment.

Antar, Basil N.↗
DOE OSTI2022

A level set approach for the computational study of a yield stress fluid filling a thin mold

Many important engineering and scientific applications such as cement slurries, foams, crude oil, and granular avalanches involve the concept of yield stress. Therefore, modeling yield stress fluids in different flow configurations, including the accurate prediction of the yield surface, is important. In this paper, we present a computational model based on the finite element method to study the flow of yield stress fluids in a thin mold and compare the results with data from flow visualization experiments. Here, we use the level set method to describe the interface between the filling fluid and air. We use polypropylene glycol as a model Newtonian fluid and Carbopol for the model yield stress fluid, as the Carbopol solution demonstrates yielding without thixotropy. To describe the yielding and shear-thinning behavior, we use a generalized Newtonian constitutive equation with a Bingham–Carreau–Yasuda form. We compare the results obtained from the mold filling experiments with the results from the three-dimensional (3D) model and from a reduced-order Hele-Shaw (HS) model that is two-dimensional, including the effect of shear-thinning along the thin direction only approximately. We show that both the 3D and the HS model can capture the experimental meniscus shape reasonably well for all the fluids considered at three different flow rates. This indicates that the shape evolution is insensitive to the dimensionality of the model. However, the viscosity and yield surfaces predicted by the 3D and HS models are different. The HS model underestimates the high viscosity and unyielded regions compared to the estimation by the 3D model.

42 ENGINEERING↗
DOE OSTI2024

Characterization of partial wetting by CMAS droplets using multiphase many-body dissipative particle dynamics and data-driven discovery based on PINNs

The molten sand that is a mixture of calcia, magnesia, alumina and silicate, known as CMAS, is characterized by its high viscosity, density and surface tension. The unique properties of CMAS make it a challenging material to deal with in high-temperature applications, requiring innovative solutions and materials to prevent its buildup and damage to critical equipment. Here, we use multiphase many-body dissipative particle dynamics simulations to study the wetting dynamics of highly viscous molten CMAS droplets. The simulations are performed in three dimensions, with varying initial droplet sizes and equilibrium contact angles. We propose a parametric ordinary differential equation (ODE) that captures the spreading radius behaviour of the CMAS droplets. The ODE parameters are then identified based on the physics-informed neural network (PINN) framework. Subsequently, the closed-form dependency of parameter values found by the PINN on the initial radii and contact angles are given using symbolic regression. Finally, we employ Bayesian PINNs (B-PINNs) to assess and quantify the uncertainty associated with the discovered parameters. In brief, this study provides insight into spreading dynamics of CMAS droplets by fusing simple parametric ODE modelling and state-of-the-art machine-learning techniques.

Mechanics↗