Results for “precursor discovery” — Page 3

NASA NTRS2013

Feasibility of a Dragon-Derived Mars Lander for Scientific and Human-Precursor Missions

A minimally-modified SpaceX Dragon capsule launched on a Falcon Heavy rocket presents the possibility of a new low-cost, high-capacity Mars lander for robotic missions. We have been evaluating such a "Red Dragon" platform as an option for the Icebreaker Discovery Program mission concept. Dragon is currently in service ferrying cargo to and from the International Space Station, and a crew transport version is in development. The upcoming version, unlike other Earth-return vehicles, exhibits most of the capabilities necessary to land on Mars. In particular, it has a set of high-thrust, throttleable, storable bi-propellant "SuperDraco" engines integrated directly into the capsule that are intended for launch abort and powered landings on Earth. These thrusters provide the possibility of a parachute-free, fully-propulsive deceleration at Mars from supersonic speeds to the surface, a descent approach which would also scale well to larger future human landers. We will discuss the motivations for exploring a Red Dragon lander, the current results of our analysis of its feasibility and capabilities, and the implications of the platform for the Icebreaker mission concept. In particular, we will examine entry, descent, and landing (EDL) in detail. We will also describe the modifications to Dragon necessary for interplanetary cruise, EDL, and operations on the Martian surface. Our analysis to date indicates that a Red Dragon lander is feasible and that it would be capable of delivering more than 1000 kg of payload to sites at elevations three kilometers below the Mars Orbiter Laser Altimeter (MOLA) reference, which includes sites throughout most of the northern plains and Hellas.

Karcz, John S.↗

NASA NTRSDate not supplied

Qualification of Domestic Lyocell Based Phenolic Impregnated Carbon Ablator (PICA-D) for NASA Missions

Phenolic Impregnated Carbon Ablator (PICA) is a low-density ablator that has been used as the planetary entry heatshield for several NASA missions since the late 90’s. Its low density and efficient performance characteristics have proven effective for use from Discovery to Flag-ship class missions, from Sample Return missions such as Stardust, OSIRIS-REx to large Mars Lander missions such as Mars Science Lab (MSL) and Mars 2020. The rayon-based carbon precursor raw material used in PICA preform manufacturing has experienced multiple supply chain issues. The challenge involved in finding a replacement fiber source is in processing as well as in the final performance of the ablator. Each replacement necessitates the requalification of the PICA. This has happened at least twice in the past 25 years, and a third substitution is now needed. Due to the obsolescence of the input foreign rayon fiber source, a new variant of PICA has been developed using a domestic rayon-like fiber source, Lyocell. Due to its flight heritage and proven capability, PICA is baselined as the Thermal Protection System (TPS) for Dragonfly and Mars Sample Return Sample Retrieval Lander mission and is being considered for the backshell of the Mars Sample Return Earth Entry System. All three missions are due to be launched between 2026 and 2028. The challenge this time is to ensure the PICA made with domestic material is a suitable replacement to the heritage PICA used in MSL and Mars 2020 so that the design of the heatshield can be matured without much risk. Results are presented from the recent efforts of 22 PICA-D billets that were Lot Acceptance Tested. Thermal, mechanical, and representative environment arc-jet tests have been conducted. Testing of PICA-Domestic (PICA-D) indicates very comparable performance with respect to “heritage” PICA materials and thus PICA-D is expected to be a sustainable and nearly a “drop-in” replacement solution for future NASA missions.

Matt Gasch↗

NASA NTRSDate not supplied

Qualification of Domestic Lyocell Based Phenolic Impregnated Carbon Ablator (PICA-D) for NASA Missions

Phenolic Impregnated Carbon Ablator (PICA) is a low-density ablator that has been used as the planetary entry heatshield for several NASA missions since the late 90’s. Its low density and efficient performance characteristics have proven effective for use from Discovery to Flag-ship class missions, from Sample Return missions such as Stardust, OSIRIS-REx to large Mars Lander missions such as Mars Science Lab (MSL) and Mars 2020. The rayon-based carbon precursor raw material used in PICA preform manufacturing has experienced multiple supply chain issues. The challenge involved in finding a replacement fiber source is in processing as well as in the final performance of the ablator. Each replacement necessitates the requalification of the PICA. This has happened at least twice in the past 25 years, and a third substitution is now needed. Due to the obsolescence of the input foreign rayon fiber source, a new variant of PICA has been developed using a domestic rayon-like fiber source, Lyocell. Due to its flight heritage and proven capability, PICA is baselined as the Thermal Protection System (TPS) for Dragonfly and Mars Sample Return Sample Retrieval Lander mission and is being considered for the backshell of the Mars Sample Return Earth Entry System. All three missions are due to be launched between 2026 and 2028. The challenge this time is to ensure the PICA made with domestic material is a suitable replacement to the heritage PICA used in MSL and Mars 2020 so that the design of the heatshield can be matured without much risk. Results are presented from the recent efforts of 22 PICA-D billets that were Lot Acceptance Tested. Thermal, mechanical, and representative environment arc-jet tests have been conducted. Testing of PICA-Domestic (PICA-D) indicates very comparable performance with respect to “heritage” PICA materials and thus PICA-D is expected to be a sustainable and nearly a “drop-in” replacement solution for future NASA missions.

PICA↗

NASA NTRS1999

Affordable Precursor Flight Experiment for Ultra Lightweight Mirror Technologies

As a follow-on to the spectacular success of the Hubble Space Telescope (HST), NASA is currently conducting pre-phase A studies of an even larger aperture telescope, called NGST (Next Generation Space Telescope), that will continue the phenomenal flow of astrophysical discoveries well into the next millennium. Because of the very large aperture required, current NGST concepts have been driven to elaborate schemes of foldable ultra thin and ultra light mirror segment systems that can be deployed on orbit. Due to the complexity of these optical systems, it is imperative that adequate demonstration experiments be flown to verify these new technology concepts before committing to the final design and implementation of the NGST. This paper presents a proposal for a very simple, inexpensive Hitchhiker flight experiment that will determine gravity release effects on very thin mirror segments made from current competitive materials. These experiments will provide the initial data that will be needed before more extensive demonstration flights of the NGST system can be flown.

Guffin, Orville T.↗

DOE OSTI2025

Modulation of lignin and anthocyanin homeostasis by GTP cyclohydrolase1 in maize

Summary Maize is a key biomass resource with wide agricultural applications. Anthocyanins, potent antioxidants, offer health benefits like reducing oxidative stress. The biosynthesis of anthocyanins competes with that of lignin for shared metabolic precursors, which can lead to trade‐offs in plant growth and feed quality. Higher lignin content can decrease silage digestibility, posing challenges for livestock feed. The maizebrown midrib 6(bm6) mutant, known for reduced lignin, has an unclear genetic basis. Here, we identifyZmGCH1as the candidate gene forbm6through fine mapping. Mutations inZmGCH1shift precursors from lignin to anthocyanin biosynthesis. Furthermore, we show that ZmGCH1 interacts with ZmPEBP15 to modulate chalcone synthase activity, thereby stabilizing the allocation of precursors between lignin and anthocyanin pathways. To evaluate the practical implications of our findings, we introduced thebm6mutation into Zhengdan958 and Xianyu335. In vitro rumen digestion assays confirmed that the introduction of thebm6mutation significantly improved silage digestibility. This discovery not only holds great potential for enhancing silage digestibility but also provides a broader strategy for optimizing maize production to better meet the increasing demands of both the food and livestock feed.

Biotechnology & Applied Microbiology↗

NASA NTRS2012

From EXOSAT to the High Energy Astrophysics Science Archive (HEASARC): X-ray Astronomy Comes of Age

In May 1983 the European Space Agency launched EXOSAT, its first X-ray astronomy observatory. Even though it lasted only 3 short years, this mission brought not only new capabilities that resulted in unexpected discoveries, but also a pioneering approach to operations and archiving that changed X-ray astronomy from observations led by small instrument teams, to an observatory approach open to the entire community through a guest observer program. The community use of the observatory was supported by a small dedicated team of scientists, the precursor to the data center activities created to support e.g. Chandra and XMM-Newton. The new science capabilities of EX OS AT included a 90 hr highly eccentric high earth orbit that allow unprecedented continuous coverage of sources as well as direct communication with the satellite that allowed real time decisions to respond to unexpected events through targets of opportunity. The advantages of this orbit demonstrated by EXOSAT resulted in Chandra and XMM-Newton selecting similar orbits. The three instruments on board the EXOSAT observatory were complementary, designed to give complete coverage over a wide energy band pass of 0.05-50 keY. An onboard processor could be programmed to give multiple data modes that could be optimized in response to science discoveries: These new capabilities resulted in many new discoveries including the first comprehensive study of AGN variability, new orbital periods in X-ray binaries and cataclysmic variables, new black holes, quasi-periodic oscillations from neutron stars and black holes and broad band X-ray spectroscopy. The EXOSAT team generated a well-organized database accessible worldwide over the nascent internet, allowing remote selection of data products, making samples and undertaking surveys from the data. The HEASARC was established by NASA at Goddard Space Flight Center in 1990 as the repository of NASA X-ray and Gamma-ray data. The proven EXOSAT database system became the core of the HEASARC infrastructure. The HEASARC pioneered many concepts now taken for granted including standardized formats using FITS files, restoring data from earlier missions, multi-mission analysis tools and a searchable archive over the world wide web.

White, Nicholas E.↗

NASA NTRS2004

Precursor science for the Terrestrial Planet Finder

This document outlines a path for the development of the field of extrasolar planet research, with a particular emphasis on the goals of the Terrestrial Planet Finder (TPF). Over the past decade, a new field of research has developed, the study of extrasolar planetary systems, driven by the discovery of massive planets around nearby stars. The planet count now stands at over 130. Are there Earth-like planets around nearby stars? Might any of those planets be conducive to the formation and maintenance of life? These are the questions that TPF seeks to answer.

Beichman, C. A.↗

DOE OSTI2024

Challenges, progress, and future perspectives for cyanobacterial polyhydroxyalkanoate production

Polyhydroxyalkanoates (PHA) are a promising bio-based alternative to traditional plastics derived from petroleum. Cyanobacteria are photosynthetic organisms that produce PHA from CO 2 and sunlight, which can potentially reduce production costs and environmental footprint in comparison to heterotrophic bacteria cultures because (1) they utilize inorganic carbon sources for growth and (2) they do not require intensive aeration for oxygenation. Moreover, supplementing precursors such as propionate, acetate, valerate, etc., can be used to obtain various copolymers with plastic customizable properties in comparison to the classical homopolymers, such as polyhydroxybutyrate, PHB. This critical review covers the latest advances in PHA production, including recent discoveries in the metabolism interplay between PHA and glycogen production, and new insights into cultivation strategies that enhance PHA accumulation, and purification processes. This review also addresses the challenges and suggests potential solutions for a viable industrial PHAs production process.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2024

High-throughput reaction discovery for Cs–Pb–Br nanocrystal synthesis

High-throughput reaction discovery is necessary to understand complex reaction spaces for inorganic nanocrystal synthesis. Here, we implemented a high-throughput continuous flow millifluidic reactor to perform reaction discovery for Cs–Pb–Br nanocrystal synthesis using a ligand assisted reprecipitation (LARP)-type approach. 3D-printed flow resistors enable the screening of up to 16 different mixing ratios within a single 90 s run, allowing for >270 different precursor concentration ratios to be quickly tested to explore the phase space that results in CsPbBr 3 , Cs 4 PbBr 6 , a biphasic mixture, or no product. To construct a full phase map from these high-throughput experiments, a neural network was trained and validated to predict the product composition (~500 000 points in precursor concentration space). The phase map predicts product composition/phase as a function of Cs–Pb–Br feed ratio. As a result, this approach demonstrates how high-throughput flow chemistry can be used in tandem with machine learning to rapidly explore nanocrystal reaction spaces in flow.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2024

Challenges, Progress, and Future Perspectives for Cyanobacterial Polyhydroxybutyrate Production

Polyhydroxyalkanoates (PHA) are a promising bio-based alternative to traditional plastics derived from petroleum. Cyanobacteria are photosynthetic organisms that produce PHA from CO 2 and sunlight, which can potentially reduce production costs and environmental footprint in comparison to heterotrophic bacteria cultures because (1) they utilize inorganic carbon sources for growth and (2) they do not require intensive aeration for oxygenation. Moreover, supplementing precursors such as propionate, acetate, valerate, etc., can be used to obtain various copolymers with plastic customizable properties in comparison to the classical homopolymers, such as polyhydroxybutyrate, PHB. This critical review covers the latest advances in PHA production, including recent discoveries in the metabolism interplay between PHA and glycogen production, and new insights into cultivation strategies that enhance PHA accumulation, and purification processes. This review also addresses the challenges and suggests potential solutions for a viable industrial PHAs production process.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1999

Reaching for the Stars

The NASA Administrator, Dan Goldin, has given us the challenge to literally "Reach for the Stars" by requesting an Interstellar Mission. The star that has been chosen for the design reference mission is Alpha Centauri, located at a distance of 4.3 light years from Earth. As an additional enticement for this mission, the discovery of four newly formed solar systems was announced in May of 1998. In July of 1998, a NASA/AIAA Interstellar Mission Workshop was held at the California Institute of Technology in Pasadena, California to develop the Interstellar Mission roadmap including a set of precursor missions, and to examine advanced propulsion concepts to enable these missions. This paper outlines the Interstellar Mission, related Precursor Interstellar Missions, and the advanced propulsion research and technology development activities being conducted to support these missions.

Barrett, Chris↗

NASA NTRS2002

Novel High Efficient Organic Photovoltaic Materials: Appendix for Summary of Research

There are many different kinds of conjugated polymers that may be useful in photovoltaic devices. So far, the most popular and successful conjugated polymers used in photovoltaic devices include poly(1,4-)phenylenevinylenes (PPV), C60 and their derivatives. The discovery of electro-luminescence in PPV has stimulated a great deal of interest in developing "plastic" solid-state semiconductor devices. The overall synthetic methodology for the preparation of PPV can be divided into three main categories: (1) side chain derivatization, (2) precursor approach, and (3) in-situ polymerization. In this project, the first method was adopted. As discussed in project proposal and literatures, the overall efficiency of photovoltaic devices containing conjugated polymers is determined by the materials ability to generate excitons from incoming radiation, and then to separate the charges at donor/acceptor interfaces, and then to transport charges to respective electrodes. Given that effective exciton diffusion range are typical less then 30 nm, unique morphological structures are needed. This need led to several research groups to the idea that interpenetrating or bi-continuous networks of donor (electron donating) and acceptor (electron withdrawing) polymers should give better results. One approach involved the use of functionalized PPV. The attachment of electron withdrawing cyano groups to a PPV forms the CN-PPV, making it a strong electron acceptor. Underivatized PPV is a generally considered a hole-transporting material. Using blends of MEH-PPV, a soluble donor PPV derivative, as a hole transporter and CN-PPV as an electron transporter, a quantum efficiencies of up to 6% was achieved.

Sun, Sam↗

NASA NTRS1990

A reverse KREBS cycle in photosynthesis: consensus at last

The Krebs cycle (citric acid or tricarboxylic acid cycle), the final common pathway in aerobic metabolism for the oxidation of carbohydrates, fatty acids and amino acids, is known to be irreversible. It liberates CO2 and generates NADH whose aerobic oxidation yields ATP but it does not operate in reverse as a biosynthetic pathway for CO2 assimilation. In 1966, our laboratory described a cyclic pathway for CO2 assimilation (Evans, Buchanan and Arnon 1966) that was unusual in two respects: (i) it provided the first instance of an obligate photoautotroph that assimilated CO2 by a pathway different from Calvin's reductive pentose phosphate cycle (Calvin 1962) and (ii) in its overall effect the new cycle was a reversal of the Krebs cycle. Named the 'reductive carboxylic acid cycle' (sometimes also called the reductive tricarboxylic acid cycle) the new cycle appeared to be the sole CO2 assimilation pathway in Chlorobium thiosulfatophilum (Evans et al. 1966) (now known as Chlorobium limicola forma thiosulfatophilum). Chlorobium is a photosynthetic green sulfur bacterium that grows anaerobically in an inorganic medium with sulfide and thiosulfate as electron donors and CO2 as an obligatory carbon source. In the ensuing years, the new cycle was viewed with skepticism. Not only was it in conflict with the prevailing doctrine that the 'one important property ... shared by all (our emphasis) autotrophic species is the assimilation of CO2 via the Calvin cycle' (McFadden 1973) but also some of its experimental underpinnings were challenged. It is only now that in the words of one of its early skeptics (Tabita 1988) 'a long and tortuous controversy' has ended with general acceptance of the reductive carboxylic acid cycle as a photosynthetic CO2 assimilation pathway distinct from the pentose cycle. (Henceforth, to minimize repetitiveness, the reductive pentose phosphate cycle will often be referred to as the pentose cycle and the reductive carboxylic acid cycle as the carboxylic acid cycle.) Aside from photosynthetic pathways which are the focus of this article, CO2 assimilation is also known to sustain autotrophic growth via the acetyl-CoA pathway (Wood et al. 1986). Our aim here is to discuss (i) the findings that led our group to the discovery of the reductive carboxylic acid cycle, (ii) the nature and resolution of the controversy that followed, and (iii) the possible evolutionary implications of the cycle as an ancient mechanism for photosynthetic CO2 assimilation that preceded the pentose cycle and served as a precursor of the Krebs cycle in aerobic metabolism.

Non-NASA Center↗

NASA NTRS2019

Gamma Rays in the Modern Multi-Messenger Astronomy Era

Summary: GW170817 / GRB 170817A is one of the best observed transient and highlights the science impact of multi-messenger observations; Many open questions remain, with increased GW (Gravitational Wave) interferometer sensitivity, there will be more joint detections with GBM (Gamma-ray Burst Monitor), enabling deeper population studies of SGRBs (Short Gamma-Ray Bursts) -Additional distance measures which yield source energetics -Constrain jet structure and opening angle distribution -Cocoon emission from SGRBs -Causes of precursor and extended emission -Rates of SGRBs in the universe with implications for source evolution; Fermi GBM is currently the most prolific short GRB detector -Subthreshold searches are crucial to increasing GBM sensitivity and the detection horizon to weakevents like GRB 170817A; Looking forward to future multimessenger discoveries -Neutron star...Black hole merger, neutrinos, Fast Radio Bursts?

Gamma-Ray Burst↗

DOE OSTI2024

Absence of hydrogen insertion into highly crystalline superconducting infinite layer nickelates

Here, the discovery of superconductivity in the infinite layer nickelates introduced a materials system analogous to the cuprates for the study of unconventional superconductivity. The synthesis of infinite layer nickelates, (RNiO 2 , R = lanthanide) often uses calcium hydride (CaH 2 ) to facilitate the deintercalation of apical site oxygen atoms from a precursor perovskite (RNiO 3 ) phase via topotactic reduction. However, it remains uncertain whether the use of CaH 2 results in the insertion of hydrogen into the infinite layer structure, and if it does, what the implications are for superconductivity. To quantify the hydrogen composition of highly crystalline infinite layer nickelates, we synthesized Nd 1-x⁢ Sr x ⁢NiO 2 thin films on LSAT substrates and conducted time-of-flight secondary ion mass spectroscopy measurements to generate hydrogen depth profiles. We compare the hydrogen density of nickelates prepared with and without a SrTiO 3 capping layer. Additionally, we measure the hydrogen content in nickelate samples at various doping levels spanning the superconducting phase space, including the underdoped, optimally doped, and overdoped regime. We report no significant increase in hydrogen density between the perovskite and infinite layer phases in any of the measured samples. Furthermore, we put an upperbound on the hydrogen concentration of our nickelate samples to Nd 1-x Sr x ⁢NiO 2 ⁢H 0.05 . Our results imply that hydrogen is not responsible for the emergence of superconductivity in the infinite layer nickelates.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

NASA NTRS2011

Mineralized three-dimensional bone constructs

The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

Clarke, Mark S. F.↗

NASA NTRS2013

Mineralized Three-Dimensional Bone Constructs

The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.

Clarke, Mark S. F.↗

NASA NTRS2000

Discovery of a 6.4 keV Emission Line in a Burst from SGR 1900+14

We present evidence of a 6.4 key emission line during a burst from the soft gamma repeater SGR 1900+14. The Rossi X-Ray Timing Explorer (RXTE) monitored this source extensively during its outburst in the summer of 1998. A strong burst observed on 1998 August 29 revealed a number of unique properties. The burst exhibits a precursor and is followed by a long (approx. 10(exp 3) s) tail modulated at the 5.16 s stellar rotation period. The precursor has a duration of approx. equals 0.85 s and shows both significant spectral evolution as well as an emission feature centered near 6.4 keV during the first 0.3 s of the event, when the X-ray spectrum was hardest. The continuum during the burst is well fit with an optically thin thermal bremsstrahlung spectrum with the temperature ranging from approx. equals 40 to 10 keV. The line is strong, with an equivalent width of approx. 400 eV, and is consistent with Fe K(alpha) fluorescence from relatively coot material. If the rest-frame energy is indeed 6.4 keV, then the lack of an observed redshift indicates that the source is at least approx. 80 km above the neutron star surface. We discuss the implications of the line detection in the context of models for SGRs.

Strohmayer, Tod E.↗