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Laboratory Directed Research and Development Program FY 2020 Annual Summary of Completed Projects

ORNL has established a program with four complementary subprograms to meet its LDRD objectives and to fulfill the particular needs of the laboratory. A provision for multiple routes of access to ORNL LDRD funds maximizes the likelihood that novel ideas with scientific and technological merit will be recognized and supported. The ORNL LDRD Program comprises the following four subprograms: 1) The Director’s R&D Program supports projects that advance research frontiers, capabilities, and expertise at ORNL in key strategic areas. 2) The Seed Program supports innovative high-risk/high-reward research to the proof-of-principle stage. 3) The Strategic Hire Program supports the research of key new staff whose expertise and capabilities address a critical strategic need for the laboratory. 4) The Distinguished Staff Fellowships assist the laboratory in bringing in exceptional early-career scientists to refresh and expand its scientific and technical expertise. The total ORNL LDRD Program budget authorized by DOE for FY 2020 was $\$$55 million. FY 2020 allocations totaled $\$$52.5 million and supported 153 projects. An additional $\$$95,827 was allocated to administrative costs for conducting proposal reviews. Overall, 96.4% of the allocated funds were spent. The expenditure of $\$$50.6 million was about 3.2% of the laboratory’s total budget of $\$$1,572 million for operating and capital expenses, which is well below the maximum of 6% allowed by DOE Order 413.2C and is in accordance with Section 309 of Division D of the Consolidated Appropriations Act.

99 GENERAL AND MISCELLANEOUS↗

Los Alamos National Laboratory Laboratory Directed Research and Development Program: FY23 Annual Progress Report- Compendium of Project Summaries

The project summaries are organized by Capability Pillar – Complex Natural and Engineered Systems, Information Science and Technology, Materials for the Future, Nuclear and Particle Futures, Science of Signatures, and Weapons Systems. Project summaries for continuing projects appear first, followed by project summaries and technical outcomes for projects that ended in FY23.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

U.S. MSR Development Programs & Supportive Efforts [Slides]

The presentation provides a summary of recent activities within the U.S. on molten salt reactors (MSRs). The presentation is intended for the Generation IV International Forum's MSR provisional system steering committee meeting in November 2023. The presentation includes U.S. government, industry, national laboratory, and university led activities.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Safeguards Technology Development Program: FY 2024 Mid-Year Report

This project has 2 major thrusts and 2 minor tasks – One of the major ones is a scoping study for improving uranium isotopics by analyzing higher energy, lower yield U-235 gamma emissions. The second major one benefits past projects such as auto-enrichment, and peak-based analysis routines previously added to GADRAS-DRF [1]. The two minor tasks involve an in-person or remote GADRAS-DRF training for the IAEA, and characterizing detectors of interest.

07 ISOTOPE AND RADIATION SOURCES↗

PCAST: Report to the President Review of the Networking and Information Technology Research and Development Program

The President’s Council of Advisors on Science and Technology (PCAST) is the sole body of advisors from outside the federal government charged with making science, technology, and innovation policy recommendations to the President and the White House. Established by Executive Order, it is an independent Federal Advisory Committee comprised of distinguished individuals from industry, academia, and non-profit organizations with a range of perspectives and expertise. On December 5, 2024, PCAST sent a report to the President with recommendations to strengthen and improve the NITRD program and its activities to provide an even greater positive impact for the Nation.

97 MATHEMATICS AND COMPUTING↗

SMART – A Comprehensive Research and Development Program to Demonstrate Application of Machine Learning for Supporting CCS Deployment

Presentation material for a paper presented at the GHGT-17 conference, Calgary, Canada, October 20-24, 2024. The objective of the US Department of Energy’s SMART Initiative, i.e., Science-informed Machine Learning (ML) for Accelerating Real-Time Decisions in Subsurface Applications, is to showcase how the utilization of ML can significantly improve efficiency and effectiveness of field-scale commercial carbon storage operations. This paper will present the results from the current phase of SMART (field deployment) for demonstrating the applicability of ML-based tools and workflows for: (a) virtual learning during the pre-injection permitting phase, (b) advanced storage reservoir imaging to better characterize fractures and faults, and (c) dynamic storage reservoir modelling and optimization to inform operational decision making and visualization of system evolution.

CO2 geologic storage↗

SMART – A Comprehensive Research and Development Program to Demonstrate Application of Machine Learning for Supporting CCS Deployment

The objective of the US Department of Energy’s SMART Initiative, i.e., Science-informed Machine Learning (ML) for Accelerating Real-Time Decisions in Subsurface Applications, is to showcase how the utilization of ML can significantly improve efficiency and effectiveness of field-scale commercial carbon storage operations. This paper will present the results from the current phase of SMART (field deployment) for demonstrating the applicability of ML-based tools and workflows for: (a) virtual learning during the pre-injection permitting phase, (b) advanced storage reservoir imaging to better characterize fractures and faults, and (c) dynamic storage reservoir modelling and optimization to inform operational decision making and visualization of system evolution.

Siriwardane, Hema↗

Los Alamos National Laboratory Double Shell Program Target Development

The Double Shell Program at Los Alamos National Laboratory is studying an alternative platform for achieving robust alpha-particle heating at the National Ignition Facility. Double shells benefit from having a low convergence ratio and lower predicted temperature for achieving volume ignition. The joint required to assemble a double shell has an imperfection in the outer shell that seeds instabilities that can greatly impact the inner capsule’s implosion at bang time. Furthermore, different variations of the shape and placement of the joint were implemented with improvements in the quality of the machining leading to measurable improvements in yield. High-Z coatings on the outer joint mitigated the impact of the 1- to 2-μm gap sometimes found in double shell assemblies.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Dose-finding studies in drug development for rare genetic diseases

The small patient populations inherent to rare genetic diseases present many challenges to the traditional drug development paradigm. One major challenge is generating sufficient data in early phase studies to inform dose selection for later phase studies and dose optimization for clinical use of the drug. However, optimizing the benefit-risk profile of drugs through appropriate dose selection during drug development is critical for all drugs, including those being developed to treat rare diseases. Recognizing the challenges of conducting dose finding studies in rare disease populations and the importance of dose selection and optimization for successful drug development, we assessed the dose-finding studies and analyses conducted for drugs recently approved for rare genetic diseases. Of the 40 marketing applications for new molecular entity (NME) drugs and biologics approved by the United States Food and Drug Administration for rare genetic diseases from 2015 to 2020, 21 (53%) of the development programs conducted at least one dedicated dose-finding study. In addition, the majority of drug development programs conducted clinical studies in healthy subjects and included population pharmacokinetic and exposure–response analyses; some programs also conducted clinical studies in patient populations other than the disease for which the drug was initially approved. The majority of primary endpoints utilized in dedicated dose-finding studies were biomarkers, and the primary endpoint of the safety and efficacy study matched the primary endpoint used in the dose finding study in 9 of 13 (69%) drug development programs where primary study endpoints were assessed. Our study showed that NME drug development programs for rare genetic diseases utilize multiple data sources for dosing information, including studies in healthy subjects, population pharmacokinetic analyses, and exposure–response analyses. In addition, our results indicate that biomarkers play a key role in dose-finding studies for rare genetic disease drug development programs. Our findings highlight the need to develop study designs and methods to allow adequate dose-finding efforts within rare disease drug development programs that help overcome the challenges presented by low patient prevalence and other factors. Furthermore, the frequent reliance on biomarkers as endpoints for dose-finding studies underscores the importance of biomarker development in rare diseases.

60 APPLIED LIFE SCIENCES↗

Solar Energy Technologies Office Workforce Request for Information and Convenings (Summary)

On May 4, 2021, the U.S. Department of Energy (DOE) Solar Energy Technologies Office (SETO) published a Request for Information (RFI) on programs that support the development of a diverse and skilled clean energy workforce. The purpose of the RFI was to solicit feedback from industry, academia, government agencies, worker organizations (including unions), and other stakeholders on issues related to the employment needs of the solar industry, and the perceived value of different workforce development programs, training strategies, and tools. To supplement the RFI, SETO hosted four virtual convenings that brought together the utility-scale solar industry, the distributed generation solar industry, and labor and other workforce training organizations to hear direct feedback on the questions in the RFI. In addition, SETO held listening sessions with about a dozen other organizations and staff who could not participate in the virtual convenings. Altogether, SETO received 45 responses from the RFI and heard directly from 80-100 other stakeholders via the convenings and listening sessions. This document summarizes the stakeholder feedback that SETO received as a result of this process. While both the RFI and convening series were focused on solar deployment and solar industry members, much of this information is relevant across clean energy technologies and programs. It is important to recognize that DOE is intentionally reviewing our workforce development programming and support to focus on clean energy careers more holistically.

14 SOLAR ENERGY↗

Liquid metal walls

Here, the plasma performance of fusion devices depends strongly on the chosen wall materials. Solid plasma-facing components (PFCs) are predominantly used in present devices, and are the most investigated candidates for fusion designs. High-Z materials such as tungsten (W) are the leading solid PFC material candidates. To date, a material choice that scales to steady-state reactor conditions has not been identified. Moreover, if plasma transient events such as edge-localized modes and disruptions cannot be altogether avoided or sufficiently mitigated, the projected peak heat and particle loads far exceed the power exhaust capabilities of solids. Liquid metal (LM) PFCs represent an intrinsic self-healing boundary that are both resilient to surface damage from transients, and that could handle high steady-state heat and particle fluxes. Flowing LM PFCs can be designed to remove “slag,” the buildup of material erosion due to plasma-material interactions, including charge exchange sputtering in the main chamber. Further, LM offer the prospect to manage hydrogenic species otherwise retained in the PFCs, which is important from a safety and inventory standpoint. The two most promising LMs are lithium (Li) and tin (Sn), although Sn–Li eutectics may be considered. While Sn offers a higher temperature window with low vapor pressure and low hydrogen retention, Li offers the prospect of enhanced energy confinement and higher acceptable core contamination limits, and this section focuses on Li PFCs. An LM PFC development research program developed LM PFC concepts for a nuclear fusion device via engineering design calculations, single-effect experiments, and staged prototypical experiments. A self-consistent design window was identified with liquid Li flow speeds ~5–10 m/s; plasma contamination was negligible for predicted Li evolution rates. While these preconceptual designs hold promise, there is substantial R&D needed to advance the technical readiness levels of LM PFCs for application to fusion power plants.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Fabrication and test of a 6-tesla-class high-temperature superconducting dipole magnet at 4.2 K

Superconducting magnets enable energy-frontier accelerators by generating strong magnetic fields to steer and focus the particles. Although high-temperature superconductors such as REBa 2 Cu 3 O x (, RE = rare earth) hold a strong potential for generating a higher magnetic field than Nb-Ti and Nb 3 Sn , the associated magnet and conductor technology for accelerator applications is still in its infancy. The U.S. Magnet Development Program is developing magnet technology in collaboration with industry. Here we report an experiment of making a dipole magnet called C3 using commercial high-temperature superconducting wires. The magnet, following a canted cos θ design, generated a dipole field of 5.99 T at 4.2 K in its clear aperture of 65 mm at 6.795 kA when a resistive voltage of 105 μ V appeared across one of the coils in the magnet. The stored energy was 53 kJ at the peak field. The magnet showed no degradation in the current-carrying capability at 4.2 K after the thermal cycle. We report on the detailed design, fabrication, and performance of the C3 magnet that can be of interest to potential users of this emerging technology. We also discuss issues and research needs to inform future magnet development. The experiment represented another step to addressing if the high-temperature superconducting accelerator magnet technology can increase the discovery capability of future particle accelerators.

Abraimov, Dmytro [National High Magnetic Field Lab↗

Robust Optical Sensor Technology for Real-Time Monitoring of Solid Oxide Fuel Cells with High Spatial Resolutions

This SOFC core technology development program will develop an integrated fiber optical sensor technology to perform real-time and high-resolution measurements in both planar and tubular fuel cells and fuel cell assembly to monitor operations and structural changes of SOFCs. The new fiber sensing solution can monitor hundreds of points in the 3D fuel cell structures with 5-mm spatial resolutions using one single optical fiber.

30 DIRECT ENERGY CONVERSION↗

High Power Superconducting Electron Linear Accelerators For Industrial Application

Fermilab is executing a technology development program to develop a compact yet powerful electron accelerator. We are leveraging R&D breakthroughs in SRF cavities, cost-effective radio-frequency sources, modern cryo-coolers, and high average current electron guns. We show that a single accelerator module can deliver average beam power as high as 1 MW through detailed thermal, RF, and particle simulations.

Thangaraj, Jayakar Tobin↗

Design, Manufacturing and Performance Considerations in Reactor System, Components and Materials

Idaho National Laboratory (INL) is the national and global leader of the Department of Energy (DOE) ’s nuclear energy research, development, and demonstration programs. Developing critical design criteria of new advanced reactor systems, components and materials requires an understanding of fabrication and the irradiation environment during normal operating and accident conditions. Next generation researchers and designers, are, therefore challenged not only by demands for ever improved performance but must also work to shorten the development and commercialization lifecycle for new nuclear reactors and systems to remain competitive. This provides unique and exciting opportunities for all contributors to this field of study. This presentation will offer a strategic overview of the competitively funded R&D awards by the Advanced Methods for Manufacturing (AMM) program of the DOE’s office of Nuclear Energy (NE). This program conducts research and development (R&D) to accelerate innovations by reducing the cost and schedule of constructing new nuclear plants and to make fabrication of nuclear power plant components faster, cheaper, and more reliable. By evaluating state-of-the-art practices found in other large manufacturing industries, the nuclear community has identified six major areas of innovation to reach the objectives of this DOE-NE program. Additionally, typical research case studies performed at INL, will be presented, showing the vast variety of opportunities for which, the next generation of researchers can seek solutions.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

The Development of Kinetic and Radiation Hydrodynamics Modeling of Thermonuclear Burn Propagation in Isochoric p - 11 B Through the Support of the INFUSE Program

The report summarizes DOE INFUSE-supported work between HB11 Energy and the University of Rochester’s TriForce Institute to improve computational modeling of advanced fusion fuels, especially proton–boron-11 (p- 11 B). The project extended the TriForce particle-in-cell/Monte Carlo collision code to include physics needed for dense, high-temperature p- 11 B burn studies, including p- 11 B fusion reactions, three-alpha-particle reaction products, relativistic Coulomb collisions, large-angle nuclear scattering, bremsstrahlung radiation, inverse bremsstrahlung absorption, and photon transport. The upgraded models were verified against focused physics tests and against known deuterium–tritium burn behavior. The study then used one-dimensional spherical simulations to estimate the conditions required for thermonuclear burn propagation in isochoric p- 11 B fuel. The calculations found that burn propagation is possible in the model, but only under very extreme hot-spot conditions, such as about 7000 g/cm 3 at 500 keV or 9000 g/cm 3 at 300 keV for a 20-micron hot spot. These conditions are much more demanding than current demonstrated inertial confinement fusion hot spots. The report concludes that the INFUSE collaboration successfully advanced kinetic and radiation modeling capabilities for p- 11 B fusion and provided useful estimates of ignition requirements. However, the simulated fuel gains remain below what would be needed for practical inertial fusion energy, and further work is needed to reconcile differences among kinetic, radiation-hydrodynamic, and analytic models and to identify more achievable target designs.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗