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Variation Principles and Applications in the Study of Cell Structure and Aging

In this report we have attempted to show that "some reality lies concealed in biological variation". This "reality" has its principles, laws, mechanisms, and rules, only a few of which we have sketched. A related idea we pursued was that important information may be lost in the process of ignoring frequency distributions of physiological variables (as is customary in experimental physiology and gerontology). We suggested that it may be advantageous to expand one's "statistical field of vision" beyond simple averages +/- standard deviations. Indeed, frequency distribution analysis may make visible some hidden information not evident from a simple qualitative analysis, particularly when the effect of some external factor or condition (e.g., aging, dietary chemicals) is being investigated. This was clearly illustrated by the application of distribution analysis in the study of variation in mouse liver cellular and fine structure, and may be true of fine structural studies in general. In living systems, structure and function interact in a dynamic way; they are "inseparable," unlike in technological systems or machines. Changes in fine structure therefore reflect changes in function. If such changes do not exceed a certain physiologic range, a quantitative analysis of structure will provide valuable information on quantitative changes in function that may not be possible or easy to measure directly. Because there is a large inherent variation in fine structure of cells in a given organ of an individual and among individuals, changes in fine structure can be analyzed only by studying frequency distribution curves of various structural characteristics (dimensions). Simple averages +/- S.D. do not in general reveal all information on the effect of a certain factor, because often this effect is not uniform; on the contrary, this will be apparent from distribution analysis because the form of the curves will be affected. We have also attempted to show in this chapter that similar general statistical principles and mechanisms may be operative in biological and technological systems. Despite the common belief that most biological and technological characteristics of interest have a symmetric bell-shaped (normal or Gaussian) distribution, we have shown that more often than not, distributions tend to be asymmetric and often resemble a so-called log-normal distribution. We saw that at least three general mechanisms may be operative, i.e., nonadditivity of influencing factors, competition among individuals for a common resource, and existence of an "optimum" value for a studied characteristic; more such mechanisms could exist.

Economos, Angelos C.↗

Radiative transition probabilities of neutral and singly ionized Europium estimated by laser-induced breakdown spectroscopy (LIBS)

Laser-induced breakdown spectroscopy (LIBS) is a versatile technique for compositional analysis for solids, liquids, or gasses. LIBS is an asset for the quantitative or qualitative analysis of resource limited materials like actinides and rare earths because it is quasi-nondestructive. Two Eu 2 O 3 pellets were synthesized to be a test and validation set, respectively. Spectral lines identified from the National Institute of Standards and Technology database with fundamental data reported were used to form Saha-Boltzmann plots. The Saha-Boltzmann plots were used to determine the plasma temperatures and electron densities of the laser-induced plasmas for both samples. These Saha-Boltzmann plots were then used to calculate previously unreported transition probabilities associated with identified peaks. Additionally, the transition probabilities presented in this paper provide the capability for calibration free LIBS to be performed more readily on europium samples and the spectroscopic analysis of stellar bodies. Eight previously unreported transition probabilities are presented in this paper; five for Eu I and three for Eu II. The transition probabilities for Eu I ranged from 0.172 to 7.38 × 10 7 s -1 and those for Eu II ranged from 1.56 to 6.75 × 10 7 s -1 .

47 OTHER INSTRUMENTATION↗

Analytical and Experimental Characterization of Gravity Induced Deformations In Subscale Gossamer Structures

The development of gossamer space structures such as solar sails and sunshields presents many challenges due to their large size and extreme flexibility. The post-deployment structural geometry exhibited during ground testing may significantly depart from the in-space configuration due to the presence of gravity-induced deformations (gravity sag) of lightly preloaded membranes. This paper describes a study carried out to characterize gravity sag in two subscale gossamer structures: a single quadrant from a 2 m, 4 quadrant square solar sail and a 1.7 m membrane layer from a multi-layer sunshield The behavior of the test articles was studied over a range of preloads and in several orientations with respect to gravity. An experimental study was carried out to measure the global surface profiles using photogrammetry, and nonlinear finite element analysis was used to predict the behavior of the test articles. Comparison of measured and predicted surface profiles shows that the finite dement analysis qualitatively predicts deformed shapes comparable to those observed in the laboratory. Quantitatively, finite element analysis predictions for peak gravity-induced deformations in both test articles were within 10% of measured values. Results from this study provide increased insight into gravity sag behavior in gossamer structures, and demonstrates the potential to analytically predict gravity-induced deformations to within reasonable accuracy.

Johnston, John D.↗

Quantitative analysis of the Dermott-Gold theory for Uranus's rings

A summary is presented of an investigation which supplements the largely qualitative analysis conducted by Dermott and Gold (1977). Dermott and Gold have attempted to explain the locations of Uranus's rings in terms of resonances between ring particles and pairs of satellites. An equation of motion, analogous to that of a pendulum, is derived, taking into account a study by Wilkens (1933) of possible three-body resonances involving one minor and two major planets. Dermott and Gold had concluded that the observed pattern is probably due primarily to the effect of Ariel-Titania and Ariel-Oberon pairs. However, on the basis of the values derived in the reported investigation it is seen that Miranda plays the key role rather than Ariel, in spite of the small mass of the former. It is concluded that a decisive test of the Dermott-Gold theory has to await further observational details concerning the Uranus's rings.

Aksnes, K.↗

An Analysis of NASA Technology Transfer

A review of previous technology transfer metrics, recommendations, and measurements is presented within the paper. A quantitative and qualitative analysis of NASA's technology transfer efforts is performed. As a relative indicator, NASA's intellectual property performance is benchmarked against a database of over 100 universities. Successful technology transfer (commercial sales, production savings, etc.) cases were tracked backwards through their history to identify the key critical elements that lead to success. Results of this research indicate that although NASA's performance is not measured well by quantitative values (intellectual property stream data), it has a net positive impact on the private sector economy. Policy recommendations are made regarding technology transfer within the context of the documented technology transfer policies since the framing of the Constitution. In the second thrust of this study, researchers at NASA Langley Research Center were surveyed to determine their awareness of, attitude toward, and perception about technology transfer. Results indicate that although researchers believe technology transfer to be a mission of the Agency, they should not be held accountable or responsible for its performance. In addition, the researchers are not well educated about the mechanisms to perform, or policies regarding, technology transfer.

Bush, Lance B.↗

Qualitative Event-Based Fault Isolation under Uncertain Observations

For many systems, automatic fault diagnosis is critical to ensuring safe and efficient operation. Fault isolation is performed by analyzing measured signals from the system, and reasoning over the system behavior to determine which faults have occurred, based on models of predicted faulty behavior. For dynamic systems, reasoning may be performed using qualitative analysis of the differences between measured signals and their predicted values, in which observations take the form of qualitative symbols. Such an approach is quick to isolate faults, but depends critically on correct generation of the qualitative symbols from the signals. In this paper, we develop an approach to qualitative event-based fault isolation for dynamic systems that is robust to incorrect qualitative observations. Observations are treated as uncertain, where multiple interpretations of an observation, each with its own probability, are considered. By interpreting observed symbols in a probabilistic manner, the approach degrades gracefully as the number of incorrectly-generated symbols increases. The approach is demonstrated on an electrical power system testbed, and experiments using real data obtained from the hardware demonstrate the improved fault isolation performance in the presence of incorrect symbol generation.

Daigle, Matthew↗

Investigation of thermal hydraulic behavior of the High Temperature Test Facility's lower plenum via large eddy simulation

A high-fidelity computational fluid dynamics (CFD) analysis was performed using the Large Eddy Simulation (LES) model for the lower plenum of the High–Temperature Test Facility (HTTF), a ¼ scale test facility of the modular high temperature gas-cooled reactor (MHTGR) managed by Oregon State University. In most next–generation nuclear reactors, thermal stress due to thermal striping is one of the risks to be curiously considered. This is also true for HTGRs, especially since the exhaust helium gas temperature is high. In order to evaluate these risks and performance, organizations in the United States led by the OECD NEA are conducting a thermal hydraulic code benchmark for HTGR, and the test facility used for this benchmark is HTTF. HTTF can perform experiments in both normal and accident situations and provide high-quality experimental data. However, it is difficult to provide sufficient data for benchmarking through experiments, and there is a problem with the reliability of CFD analysis results based on Reynolds–averaged Navier–Stokes to analyze thermal hydraulic behavior without verification. To solve this problem, high-fidelity 3-D CFD analysis was performed using the LES model for HTTF. It was also verified that the LES model can properly simulate this jet mixing phenomenon via a unit cell test that provides experimental information. As a result of CFD analysis, the lower the dependency of the sub-grid scale model, the closer to the actual analysis result. In the case of unit cell test CFD analysis and HTTF CFD analysis, the volume-averaged sub-grid scale model dependency was calculated to be 13.0% and 9.16%, respectively. As a result of HTTF analysis, quantitative data of the fluid inside the HTTF lower plenum was provided in this paper. As a result of qualitative analysis, the temperature was highest at the center of the lower plenum, while the temperature fluctuation was highest near the edge of the lower plenum wall. The power spectral density of temperature was analyzed via fast Fourier transform (FFT) for specific points on the center and side of the lower plenum. FFT results did not reveal specific frequency-dominant temperature fluctuations in the center part. It was confirmed that the temperature power spectral density (PSD) at the top increased from the center to the wake. The vortex was visualized using the well-known scalar Q-criterion, and as a result, the closer to the outlet duct, the greater the influence of the mainstream, so that the inflow jet vortex was dissipated and mixed at the top of the lower plenum. Additionally, FFT analysis was performed on the support structure near the corner of the lower plenum with large temperature fluctuations, and as a result, it was confirmed that the temperature fluctuation of the flow did not have a significant effect near the corner wall. In addition, the vortices generated from the lower plenum to the outlet duct were identified in this paper. It is considered that the quantitative and qualitative results presented in this paper will serve as reference data for the benchmark.

97 MATHEMATICS AND COMPUTING↗

Modeling Payload Stowage Impacts on Fire Risks On-Board the International Space Station

The purpose of this presentation is to determine the risks of fire on-board the ISS due to non-standard stowage. ISS stowage is constantly being reexamined for optimality. Non-standard stowage involves stowing items outside of rack drawers, and fire risk is a key concern and is heavily mitigated. A Methodology is needed to account for fire risk due to non-standard stowage to capture the risk. The contents include: 1) Fire Risk Background; 2) General Assumptions; 3) Modeling Techniques; 4) Event Sequence Diagram (ESD); 5) Qualitative Fire Analysis; 6) Sample Qualitative Results for Fire Risk; 7) Qualitative Stowage Analysis; 8) Sample Qualitative Results for Non-Standard Stowage; and 9) Quantitative Analysis Basic Event Data.

Anton, Kellie e.↗

Viscoplastic analysis of an experimental cylindrical thrust chamber liner

A viscoplastic stress-strain analysis of an experimental cylindrical thrust chamber is presented. A viscoelastic constitutive model incorporating a single internal state variable that represents kinematic hardening was employed to investigate whether such a viscoplastic model could predict the experimentally observed behavior of the thrust chamber. Two types of loading cycles were considered: a short cycle of 3.5 sec. duration that corresponded to the experiments, and an extended loading cycle of 485.1 sec. duration that is typical of the Space Shuttle Main Engine (SSME) operating cycle. The analysis qualitatively replicated the deformation behavior of the component as observed in experiments designed to simulate SSME operating conditions. The analysis also showed that the mode and location in the component may depend on the loading cycle. The results indicate that using viscoplastic models for structural analysis can lead to a more realistic life assessment of thrust chambers.

Arya, Vinod K.↗

Viscoplastic analysis of an experimental cylindrical thrust chamber liner

A viscoplastic stress-strain analysis of an experimental cylindrical thrust chamber is presented. A viscoelastic constitutive model incorporating a single internal state variable that represents kinematic hardening was employed to investigate whether such a viscoplastic model could predict the experimentally observed behavior of the thrust chamber. Two types of loading cycles were considered: a short cycle of 3.5-s duration that corresponded to the experiments, and an extended loading cycle of 485.1 s duration that is typical of the Space Shuttle Main Engine (SSME) operating cycle. The analysis qualitatively replicated the deformation behavior of the component as observed in experiments designed to simulate SSME operating conditions. The analysis also showed that the mode and location of failure in the component may depend on the loading cycle. The results indicate that using viscoplastic models for structural analysis can lead to a more realistic life assessment of thrust chambers.

Arya, Vinod K.↗

Comparison of elastic and rigid blade-element rotor models using parallel processing technology for piloted simulations

A piloted comparison of rigid and aeroelastic blade-element rotor models was conducted at the Crew Station Research and Development Facility (CSRDF) at Ames Research Center. A simulation development and analysis tool, FLIGHTLAB, was used to implement these models in real time using parallel processing technology. Pilot comments and qualitative analysis performed both on-line and off-line confirmed that elastic degrees of freedom significantly affect perceived handling qualities. Trim comparisons show improved correlation with flight test data when elastic modes are modeled. The results demonstrate the efficiency with which the mathematical modeling sophistication of existing simulation facilities can be upgraded using parallel processing, and the importance of these upgrades to simulation fidelity.

Hill, Gary↗

Quantitative Analysis of Venus Radar Backscatter Data in ArcGIS

Ongoing mapping of the Ganiki Planitia (V14) quadrangle of Venus and definition of material units has involved an integrated but qualitative analysis of Magellan radar backscatter images and topography using standard geomorphological mapping techniques. However, such analyses do not take full advantage of the quantitative information contained within the images. Analysis of the backscatter coefficient allows a much more rigorous statistical comparison between mapped units, permitting first order selfsimilarity tests of geographically separated materials assigned identical geomorphological labels. Such analyses cannot be performed directly on pixel (DN) values from Magellan backscatter images, because the pixels are scaled to the Muhleman law for radar echoes on Venus and are not corrected for latitudinal variations in incidence angle. Therefore, DN values must be converted based on pixel latitude back to their backscatter coefficient values before accurate statistical analysis can occur. Here we present a method for performing the conversions and analysis of Magellan backscatter data using commonly available ArcGIS software and illustrate the advantages of the process for geological mapping.

Long, S. M.↗

Advanced Turbine Airfoils for Efficient CHP Systems: Energy Storage Integration Analysis

This report documents the energy storage systems (ESS) integration portion of the work conducted under the Office of Energy Efficiency and Renewable Energy (EERE) advanced Manufacturing Office (AMO) Lab Call DE-LC-000L059 project titled "Advanced Turbine Airfoils for Efficient CHP Systems." The objective of this work is to analyze the previously-developed combined heat and power (CHP) plant with the upgraded gas turbine to include an ESS to improve the operational flexibility. The analysis includes identifying a candidate CHP configuration for the ESS integration and identifying possible storage systems to be integrated. A qualitative analysis was made to down select possible storage technologies and a techno-economic analysis (TEA) was made for the CHP system with the selected storage technology.

20 FOSSIL-FUELED POWER PLANTS↗

Examining Perceptions of Spanish Language Health Information Among Hispanics Living in the United States: A Qualitative Study Assessing Videos, Brochures, and Websites

Background Nationally, Hispanics experience health disparities manifested as a higher prevalence of chronic diseases in comparison to non-Hispanic Whites. Factors that influence health disparities in this population include inadequate dissemination of culturally and linguistically appropriate health information. Method Our qualitative analysis is based on data obtained from three focus groups with Spanish-speaking Hispanic adults conducted at a clinic in Nebraska. Participants were asked about their perceptions of health information in the form of videos, brochures, and websites. We followed the consolidated criteria for reporting qualitative research and used the theoretical framework of content analysis. Results For videos, attributes associated with higher levels of trust included a friendly health professional, the logo or name of a health care institute, and a reference specifying “se habla Español.” For brochures, attributes associated with trust included use of visual aids, use of numerous colors and big font sizes, the year of printing, and a health care agency logo. For websites, characteristics associated with trust were inclusion of plain language, use of pictures and videos, and date of last update. In all focus groups, participants perceived the use of mixed English/Spanish language in health information from pamphlets and websites as unprofessional. The use of unknown governmental logos in health promotional videos and websites was perceived as untrustworthy information. Conclusions Spanish-speaking Hispanics prefer health information supported by a health care agency or delivered by a health care professional. Health communication strategies should avoid the use of mixed English/Spanish language in sensitive information especially when combined with governmental logos.

De Alba Rosales, Armando↗

Compact FUV camera concept for Space Weather applications

Far ultraviolet (FUV) images of Earth from space have proven invaluable in revealing contextual phenomena associated with space weather in the high latitude auroral regions and, more recently with TIMED and IMAGE in the mid and equatorial regions. Images of this nature can be used to investigate compelling questions associated with the interaction of the ionosphere/mesosphere-magnetosphere-solar wind. Three such questions are: 1. What are the critical time and spatial scales that determine the coupling between the magnetosphere and ionosphere? 2. What are the sources and characteristics of ionospheric variability? 3. How does the configuration of the magnetosphere change as a function of internal boundary conditions established by the mesosphere/ionosphere and the external driving conditions of the solar wind? Observations that lead to quantitative analyses are required to significantly advance the state of knowledge with regard to the affects of space weather and the interaction between and within these regions of Geospace. Current available image data sets are sufficient for qualitative analysis and morphological investigations, and while quantitative analyses are possible, they are difficult and limited to few events at best. In order to qualitatively access the time, spatial, and causal phenomena on global scales, simultaneous images of various FUV emissions with a combination of better spatial, temporal and spectral resolution and sensitivity than currently available is required. We present an instrument concept that is being developed to improve the spatial, temporal and spectral resolution and sensitivity needed to perform the quantitative analysis that enable significant advancement in our understanding of the impact of space weather on Geospace. The approach is to use the self-filtering concept that combines the imaging and filtering functions and thus reduces the size of the 4-mirror off-axis optical system. The optical and filter design will de described and results of preliminary breadboard tests will be provided.

Spann, James↗

Non-Additive Voltametric Currents From a Mixture of Two, Three and Four Redox-Active Compounds and Electroanalytical Implications

We have published recently the effect of dissimilar diffusion coefficients on the size of the voltammetric waves from a mixture of two redox-active compounds. Similarly, at the potential range where three redox-active species, decamethylferrocene (dMeFc), ferrocene (Fc) and N-methylphenothiazine (MePTZ), are oxidized simultaneously with rates controlled by linear diffusion, electrogenerated radicals diffusing outwards from the electrode react with the original species diffusing towards the electrode from the bulk; thus, Fc(+) reacts with dMeFc producing Fc and dMeFc(+), while MePTZ(+) reacts both with dMeFc producing MePTZ and dMeFc(+), and with Fc producing MePTZ and Fc(+). These reactions replace dMeFc with Fc at the second plateau, and both dMeFc and Fc with MePTZ at the third plateau. Since the diffusion coefficients of the three species are not equal, the mass-transfer limited currents of the second and the third oxidation wave plateaus change by approx. 10%. Numerical simulations of the experimental voltamograms support this mechanism. Similar results were also obtained for a mixture of four redoxactive compounds. The implications of this non-additive nature of currents on: (a) the use of internal voltammetric standards for quantitative analysis of a mixture of redox-active compounds; and, (b) the half wave potentials (E1/2) of the 2nd, 3rd and 4th waves for qualitative analysis, will be discussed.

Dass, Amala↗

An evaluation of various forms of VAS retrievals in the analysis of a preconvective environment

VISSR Atmospheric Sounder (VAS) radiance data obtained over the continental United States on July 20, 1981 are used to evaluate a variety of VAS retrieval procedures and parameters in the qualitative analysis and forecasting of severe weather events. The particular case analyzed contains two significantly different mesoscale convective events in the central plains. Retrievals of temperature, dewpoint temperature, equivalent potential temperature, total column precipitable water, and lifted index are shown to be physically consistent in space and time and to compare well with available radiosonde data. The analysis of the VAS retrievals identified significant spatial gradients and temporal changes in the thermal and moisture fields, including times and locations between radiosonde observations.

Petersen, R. A.↗

Lattice Relaxations in Bixbyite‐Structured Rare‐Earth Sesquioxides

This report examines atomic relaxations in rare‐earth sesquioxides with the cubic bixbyite crystal structure. In particular, the experimentally determined unit cell atom positions in bixbyite compounds are compared to “ideal” bixbyite atom positions, where the concept of ideality is based on similarities between the bixbyite and fluorite crystal structures. Analyses indicate that all rare‐earth sesquioxide compounds deviate from ideality in similar ways and that there is a trend wherein the magnitudes of these atomic deviations decrease with increasing cationic size. The deviations from an ideal, fluorite‐like structure produce highly distorted coordination polyhedra and variations in metal‐oxygen bond lengths. A modified bond valence sum analysis revealed that the first nearest neighbor cation‐anion bond length variations lead to large (20%) variations in cation‐anion bond strength. This report also provides a qualitative analysis regarding the accuracy of atomic relaxed deviation parameters, based on x‐ray diffraction measurements. The analysis indicates that uncertainties in the accuracy of measured oxygen relaxed deviation parameters in bixbyite sesquioxides are likely much greater than the published uncertainties.

36 MATERIALS SCIENCE↗