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Clinical Outcome Metrics for Optimization of Robust Training

Introduction: The emphasis of this research is on the Human Research Program (HRP) Exploration Medical Capability's (ExMC) "Risk of Unacceptable Health and Mission Outcomes Due to Limitations of In-Flight Medical Capabilities." Specifically, this project aims to contribute to the closure of gap ExMC 2.02: We do not know how the inclusion of a physician crew medical officer quantitatively impacts clinical outcomes during exploration missions. The experiments are specifically designed to address clinical outcome differences between physician and non-physician cohorts in both near-term and longer-term (mission impacting) outcomes. Methods: Medical simulations will systematically compare success of individual diagnostic and therapeutic procedure simulations performed by physician and non-physician crew medical officer (CMO) analogs using clearly defined short-term (individual procedure) outcome metrics. In the subsequent step of the project, the procedure simulation outcomes will be used as input to a modified version of the NASA Integrated Medical Model (IMM) to analyze the effect of the outcome (degree of success) of individual procedures (including successful, imperfectly performed, and failed procedures) on overall long-term clinical outcomes and the consequent mission impacts. The procedures to be simulated are endotracheal intubation, fundoscopic examination, kidney/urinary ultrasound, ultrasound-guided intravenous catheter insertion, and a differential diagnosis exercise. Multiple assessment techniques will be used, centered on medical procedure simulation studies occurring at 3, 6, and 12 months after initial training (as depicted in the following flow diagram of the experiment design). Discussion: Analysis of procedure outcomes in the physician and non-physician groups and their subsets (tested at different elapsed times post training) will allow the team to 1) define differences between physician and non-physician CMOs in terms of both procedure performance (pre-IMM analysis) and overall mitigation of the mission medical impact (IMM analysis); 2) refine the procedure outcome and clinical outcome metrics themselves; 3) refine or develop innovative medical training products and solutions to maximize CMO performance; and 4) validate the methods and products of this experiment for operational use in the planning, execution, and quality assurance of the CMO training process The team has finalized training protocols and developed a software training/testing tool in collaboration with Butler Graphics (Detroit, MI). In addition to the "hands on" medical procedure modules, the software includes a differential diagnosis exercise (limited clinical decision support tool) to evaluate the diagnostic skills of participants. Human subject testing will occur over the next year.

Ebert, D.

Robust detection-isolation-accommodation for sensor failures

The results of a one year study to: (1) develop a theory for Robust Failure Detection and Identification (FDI) in the presence of model uncertainty, (2) develop a design methodology which utilizes the robust FDI ththeory, (3) apply the methodology to a sensor FDI problem for the F-100 jet engine, and (4) demonstrate the application of the theory to the evaluation of alternative FDI schemes are presented. Theoretical results in statistical discrimination are used to evaluate the robustness of residual signals (or parity relations) in terms of their usefulness for FDI. Furthermore, optimally robust parity relations are derived through the optimization of robustness metrics. The result is viewed as decentralization of the FDI process. A general structure for decentralized FDI is proposed and robustness metrics are used for determining various parameters of the algorithm.

Weiss, J. L.

A Robust Design Methodology for Optimal Microscale Secondary Flow Control in Compact Inlet Diffusers

It is the purpose of this study to develop an economical Robust design methodology for microscale secondary flow control in compact inlet diffusers. To illustrate the potential of economical Robust Design methodology, two different mission strategies were considered for the subject inlet, namely Maximum Performance and Maximum HCF Life Expectancy. The Maximum Performance mission maximized total pressure recovery while the Maximum HCF Life Expectancy mission minimized the mean of the first five Fourier harmonic amplitudes, i.e., 'collectively' reduced all the harmonic 1/2 amplitudes of engine face distortion. Each of the mission strategies was subject to a low engine face distortion constraint, i.e., DC60<0.10, which is a level acceptable for commercial engines. For each of these missions strategies, an 'Optimal Robust' (open loop control) and an 'Optimal Adaptive' (closed loop control) installation was designed over a twenty degree angle-of-incidence range. The Optimal Robust installation used economical Robust Design methodology to arrive at a single design which operated over the entire angle-of-incident range (open loop control). The Optimal Adaptive installation optimized all the design parameters at each angle-of-incidence. Thus, the Optimal Adaptive installation would require a closed loop control system to sense a proper signal for each effector and modify that effector device, whether mechanical or fluidic, for optimal inlet performance. In general, the performance differences between the Optimal Adaptive and Optimal Robust installation designs were found to be marginal. This suggests, however, that Optimal Robust open loop installation designs can be very competitive with Optimal Adaptive close loop designs. Secondary flow control in inlets is inherently robust, provided it is optimally designed. Therefore, the new methodology presented in this paper, combined array 'Lower Order' approach to Robust DOE, offers the aerodynamicist a very viable and economical way of exploring the concept of Robust inlet design, where the mission variables are brought directly into the inlet design process and insensitivity or robustness to the mission variables becomes a design objective.

Anderson, Bernhard H.

Chance-Constrained Guidance With Non-Convex Constraints

Missions to small bodies, such as comets or asteroids, require autonomous guidance for descent to these small bodies. Such guidance is made challenging by uncertainty in the position and velocity of the spacecraft, as well as the uncertainty in the gravitational field around the small body. In addition, the requirement to avoid collision with the asteroid represents a non-convex constraint that means finding the optimal guidance trajectory, in general, is intractable. In this innovation, a new approach is proposed for chance-constrained optimal guidance with non-convex constraints. Chance-constrained guidance takes into account uncertainty so that the probability of collision is below a specified threshold. In this approach, a new bounding method has been developed to obtain a set of decomposed chance constraints that is a sufficient condition of the original chance constraint. The decomposition of the chance constraint enables its efficient evaluation, as well as the application of the branch and bound method. Branch and bound enables non-convex problems to be solved efficiently to global optimality. Considering the problem of finite-horizon robust optimal control of dynamic systems under Gaussian-distributed stochastic uncertainty, with state and control constraints, a discrete-time, continuous-state linear dynamics model is assumed. Gaussian-distributed stochastic uncertainty is a more natural model for exogenous disturbances such as wind gusts and turbulence than the previously studied set-bounded models. However, with stochastic uncertainty, it is often impossible to guarantee that state constraints are satisfied, because there is typically a non-zero probability of having a disturbance that is large enough to push the state out of the feasible region. An effective framework to address robustness with stochastic uncertainty is optimization with chance constraints. These require that the probability of violating the state constraints (i.e., the probability of failure) is below a user-specified bound known as the risk bound. An example problem is to drive a car to a destination as fast as possible while limiting the probability of an accident to 10(exp -7). This framework allows users to trade conservatism against performance by choosing the risk bound. The more risk the user accepts, the better performance they can expect.

FROM

Deep Space Network Scheduling Using Multi-Objective Optimization with Uncertainty

We have developed a novel technique to incorporate uncertainty modeling within an evolutionary algorithm approach to multi-objective scheduling, with the goal of identifying a Pareto frontier (tradeoff curve) that recognizes the likelihood of events that can impact the schedule outcome. Our approach is particularly applicable to the generation of multiobjective optimized robust schedules, where objectives are assigned a service level, for example that we require an objective value to be greater than or equal to X with Y% confidence. We have demonstrated that such an approach can, for example, minimize scheduling on less reliable resources, based solely on a resource reliability model and not on any ad hoc heuristics. We have also investigated an alternative method of optimizing for robustness, in which we add to the set of objectives a failure risk objective to minimize. We compare the advantages and disadvantages of these two approaches. Future plans for further developing this technology include its application to space-based observatory scheduling problems.

Johnston, Mark D.

Integrated control/structure design and robustness

When a flexible structure is to be controlled actively, optimum performance is obtained by integrated, or simultaneous, design of the structure and the controller, as opposed to the common practice of designing the structure independently of control consideration and then designing a controller for a fixed structure. The primary design objective from the structural point of view usually is to minimize weight, while the control design objectives depend on the application. An important requirement for a practical control system is robustness with respect to uncertain plant parameters. This paper discusses simultaneous control/structure design when the overall design objective combines the weight of the structure and the robustness of the closed-loop control system. For numerical optimization, robustness is represented by the sensitivity of the closed-loop eigenvalues with respect to uncertain parameters. An example illustrates the optimal design of a flexible structure along with a robust compensator.

Adamian, A.

Robust Passification via Optimal Sensor Blending and Control Allocation

Robust passification is considered for uncertain linear, time invariant, systems having redundant actuators and sensors. The approach is to obtain optimal sensor blending and control allocation matrices that maximize the region in the parameter space in which the system remains passive. The approach results in a generalized eigenvalue problem consisting of a number of linear matrix inequalities (LMIs). Reduction of the number of LMIs is investigated, and a numerical example is given for demonstrating the approach.

Joshi, S. M.

Robust Passification via Optimal Sensor Blending and Control Allocation

Robust passification is considered for uncertain linear, time invariant systems having redundant actuators and sensors. The approach is to obtain optimal sensor blending and control allocation matrices that maximize the region in the parameter space in which the system remains passive. The approach results in a generalized eigenvalue problem consisting of a number of linear matrix inequalities (LMIs). Reduction of the number of LMIs is investigated, and a numerical example is given for demonstrating the approach.

Joshi, S. M.

Examination of Unified Control Approaches Incorporating Generalized Control Allocation

Transition vehicles which combine vertical take off and landing with cruise configurations pose a unique challenge for control design and implementation. For this class of vehicle, successful control designs have historically broken the flight envelope into phases and modified the control approach for each phase. This research approaches control in a unified way across the entire envelope using a robust optimal design which provides effector weighting then implemented in a generalized Affine Generalized Inverse control allocation algorithm. System performance for a Lift plus Cruise transition vehicle is presented.

unified control, robust control, optimal control,

Performance Robustness of Manipulator Collision Controller

In this paper, we propose that the manipulator impact control problem be approached from a stochastic optimal control perspective. The reason is that not only is such approach be able to model uncertainties in contact environment, force sensing, as well as manipulator dynamics, the controllers obtained is optimally robust in terms of performance. This result is verified by analyses and simulations.

model uncertainties contact environment force sens

Structural reliability and robustness properties of optimal linear-quadratic multivariable regulators

Strong sufficient conditions are derived for the robustness of optimal linear-quadratic (LQ) regulators to large parameter perturbations. In particular, it is shown that under certain conditions LQ designs remain stable in the presence of actuator channel failures. The general results can be specialized to provide insight into the gain margin, gain reduction, and phase margin properties of optimal LQ regulators.

Wong, P.-K.

A criterion for joint optimization of identification and robust control

A criterion for system identification is developed that is consistent with the intended used of the fitted model for modern robust control synthesis. Specifically, a joint optimization problem is posed which simultaneously solves the plant model estimate and control design, so as to optimize robust performance over the set of plants consistent with a specified experimental data set.

Bayard, D. S.

Robust Cislunar Trajectory Optimization Via Midcourse Correction and Optical Navigation Scheduling

This paper presents a new approach to optimal trajectory design that considers uncertainties in the system, referred to herein as robust trajectory optimization. This approach assumes an existing reference trajectory and optimizes the locations of midcourse correction burns and utilization of onboard navigation sensors to minimize dispersions in ∆v or final position. Navigation errors, maneuver execution errors, orbit insertion errors, and environmental modeling errors are considered. The application in this paper is cislunar flight with the goal of injecting into a Near-Rectilinear Halo Orbit for rendezvous with a target vehicle. Two complementary optimization problems are proposed. One problem minimizes the total ∆v dispersion subject to a final position dispersion constraint. The other problem minimizes the final position dispersion subject to a total ∆v dispersion constraint. The results from each optimization problem are shown for a complete mission profile.

Linear Covariance Analysis

Redundancy relations and robust failure detection

All failure detection methods are based on the use of redundancy, that is on (possible dynamic) relations among the measured variables. Consequently the robustness of the failure detection process depends to a great degree on the reliability of the redundancy relations given the inevitable presence of model uncertainties. The problem of determining redundancy relations which are optimally robust in a sense which includes the major issues of importance in practical failure detection is addressed. A significant amount of intuition concerning the geometry of robust failure detection is provided.

Chow, E. Y.

A Data-Driven Solution for Performance Improvement

Marketed as the "Software of the Future," Optimal Engineering Systems P.I. EXPERT(TM) technology offers statistical process control and optimization techniques that are critical to businesses looking to restructure or accelerate operations in order to gain a competitive edge. Kennedy Space Center granted Optimal Engineering Systems the funding and aid necessary to develop a prototype of the process monitoring and improvement software. Completion of this prototype demonstrated that it was possible to integrate traditional statistical quality assurance tools with robust optimization techniques in a user- friendly format that is visually compelling. Using an expert system knowledge base, the software allows the user to determine objectives, capture constraints and out-of-control processes, predict results, and compute optimal process settings.

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