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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3

Integrating Data From In Vitro New Approach Methodologies for Developmental Neurotoxicity

Abstract In vivo developmental neurotoxicity (DNT) testing is resource intensive and lacks information on cellular processes affected by chemicals. To address this, DNT new approach methodologies (NAMs) are being evaluated, including: the microelectrode array neuronal network formation assay; and high-content imaging to evaluate proliferation, apoptosis, neurite outgrowth, and synaptogenesis. This work addresses 3 hypotheses: (1) a broad screening battery provides a sensitive marker of DNT bioactivity; (2) selective bioactivity (occurring at noncytotoxic concentrations) may indicate functional processes disrupted; and, (3) a subset of endpoints may optimally classify chemicals with in vivo evidence for DNT. The dataset was comprised of 92 chemicals screened in all 57 assay endpoints sourced from publicly available data, including a set of DNT NAM evaluation chemicals with putative positives (53) and negatives (13). The DNT NAM battery provides a sensitive marker of DNT bioactivity, particularly in cytotoxicity and network connectivity parameters. Hierarchical clustering suggested potency (including cytotoxicity) was important for classifying positive chemicals with high sensitivity (93%) but failed to distinguish patterns of disrupted functional processes. In contrast, clustering of selective values revealed informative patterns of differential activity but demonstrated lower sensitivity (74%). The false negatives were associated with several limitations, such as the maximal concentration tested or gaps in the biology captured by the current battery. This work demonstrates that this multi-dimensional assay suite provides a sensitive biomarker for DNT bioactivity, with selective activity providing possible insight into specific functional processes affected by chemical exposure and a basis for further research.

Carstens, Kelly E.↗

Plentiful electricity turns wholesale prices negative

In 2020, average wholesale electricity prices in the United States fell to $21/MWh, their lowest level since the beginning of the 21st century. Low natural gas prices and the proliferation of low marginal cost resources like wind and solar had already established a trend toward lower wholesale prices, and this trend was exacerbated by declining electricity demand due to the Covid-19 pandemic in 2020. Negative real-time hourly wholesale prices occurred in about 4% of all hours and wholesale market nodes across the United States, but these were not distributed evenly. Regional clusters emerged, for example, in the Permian Basin in western Texas, and in Kansas and western Oklahoma in the Southwest Power Pool (SPP), negative prices accounted for more than 25% of all hours. Negative electricity prices result either from local congestion of the transmission system leading supply to exceed demand locally or due to system-wide oversupply. Looking at the latter condition in SPP, we find that all major generator types contribute to this excess supply, because of limited ramping flexibility or self-scheduled out-of-market unit commitments. Additional monetary production incentives such as renewable energy credits or tax credits also enable negative bids; indeed, negative prices predominantly occur when demand levels are low and wind production levels are high. Frequent negative prices can inform the value of additional renewable energy investments at specific locations, the need for transmission and storage development, and opportunities load growth or adaptation.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Advancing Asset Management in Water Infrastructure Systems

Aging water system infrastructure, including drinking water, wastewater, and stormwater, poses a growing challenge for utilities and municipalities. These water systems have well documented challenges with respect to their age, condition, and level of service. ASCE annual report cards consistently rate these infrastructure systems in the United States as underfunded, overcapacity, or past service life (ASCE 2025 Report Card). For example, Chini and Stillwell (2017) estimated that the mean water loss in drinking water systems, i.e., non-revenue water, is approximately 16% across the United States. These concerns are not just relegated to the United States, with Courtenay, British Columbia, identifying 17% of their water main pipes as in a ‘poor’ condition state, defined as a category condition 5 out of 5 (City of Courtenay, 2024). These cases illustrate the challenges utilities are facing to manage extensive networks of infrastructure to deliver a consistent and high level of service. For buried infrastructure such as water systems, studies suggest that preventative interventions can lead to lower maintenance costs and fewer service disruptions (Mazumder et al, 2018; Li et al, 2014). The demonstrated need and benefit of appropriately applied asset management is juxtaposed against the relatively sparse literature that evaluates water systems within an asset management construct. Since 2020, just 37 papers specifically reference asset management in the Journal of Water Resources Planning and Management. Of those, only a few specifically look to develop strategies for improved asset management. Therefore, we highlight four key research areas that represent opportunities for advancement of asset management research for water systems. First, advances in condition assessment and forecasting are needed to better estimate asset deterioration using diverse datasets. Second, machine learning (ML) and artificial intelligence (AI) hold promise for predictive maintenance and investment prioritization, though questions of generalizability and model transparency remain. Third, applying a value of information framework can guide utilities in making cost-effective sensor deployment and data collection decisions, to direct monitoring strategies towards data-informed asset management decisions. Finally, integrated infrastructure management is critical, requiring coordinated planning with other infrastructure systems and stakeholder engagement to reduce costs and enhance service delivery.

Chini, Christopher M.↗

Exploring the role of high- j configurations in collective observables through the Coulomb excitation of 106 Cd

In this work, the shape and collectivity of 106 Cd was investigated via a sub-barrier-energy Coulomb excitation experiment performed at the NSCL ReA3 facility using the JANUS setup. Transition matrix elements between low-lying states were found to agree with adopted values, and information on the shape and collectivity of higher-lying states was extracted for the first time. Locally-optimized large-scale shell-model calculations were found to describe well the B(E2) transition strengths but failed to reproduce the spectroscopic quadrupole moments Q s . An analysis of the E2 rotational invariants and the normalized quadrupole moment q s indicates that this may be due to a significant degree of triaxiality in 106 Cd which is not captured by the present shell-model calculations. Analogous calculations for the Fe isotopes (two protons below the Z = 28 magic number) reveal the critical role of high-j neutron configurations for the description of quadrupole moments in the heavy Fe and Cd isotopes (two protons below magic Z = 50), but this effect is insufficient to explain the shape of 106 Cd, posing a puzzle for the understanding of nuclear structure towards N = 50.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Leaf water potential measurements using the pressure chamber: Synthetic testing of assumptions towards best practices for precision and accuracy

Leaf water potential (ψ leaf ), typically measured using the pressure chamber, is the most important metric of plant water status, providing high theoretical value and information content for multiple applications in quantifying critical physiological processes including drought responses. Pressure chamber measurements of ψ leaf (ψ leafPC ) are most typical, yet, the practical complexity of the technique and of the underlying theory has led to ambiguous understanding of the conditions to optimize measurements. Consequently, specific techniques and precautions diversified across the global research community, raising questions of reliability and repeatability. Here, we surveyed specific methods of ψ leafPC from multiple laboratories, and synthesized experiments testing common assumptions and practices in ψ leafPC for diverse species: (i) the need for equilibration of previously transpiring leaves; (ii) leaf storage before measurement; (iii) the equilibration of ψ leaf for leaves on bagged branches of a range of dehydration; (iv) the equilibration of ψ leaf across the lamina for bagged leaves, and the accuracy of measuring leaves with artificially ‘elongated petioles’; (v) the need in ψ leaf measurements for bagging leaves and high humidity within the chamber; (vi) the need to avoid liquid water on leaf surfaces; (vii) the use of ‘pulse’ pressurization versus gradual pressurization; and (viii) variation among experimenters in ψ leafPC determination. Based on our findings we provide a best practice protocol to maximise accuracy, and provide recommendations for ongoing species-specific tests of important assumptions in future studies.

54 ENVIRONMENTAL SCIENCES↗

Problematizing “Planning Ahead”: A Cross-Cultural Analysis of Vietnamese Health and Community Workers’ Perspectives on Advance Care Directives

Informed by values of autonomy and self-determination, advance care planning assumes that individuals should independently take control of their future health. In this article, we draw on research conducted with Vietnamese health and community workers to problematize individualized approaches to planning ahead, reframe notions of “cultural and linguistic barriers,” and expose how homogeneous messages about care at the end of life are not readily translatable within and across diverse groups. Anthropological and feminist critiques of inclusion and exclusion are used to reorientate Anglophone framings of the individual and of cultural and linguistic differences. In this article, we suggest that it is the narrow singularity of care for the self—rather than diverse relationalities of care—that should be overcome if aging and end-of-life care policy and practice is to be broadened and made relevant to migrant and non-English-speaking groups.

Nguyen, Nga↗

A proposed framework for the development and qualitative evaluation of West Nile virus models and their application to local public health decision-making

West Nile virus (WNV) is a globally distributed mosquito-borne virus of great public health concern. The number of WNV human cases and mosquito infection patterns vary in space and time. Many statistical models have been developed to understand and predict WNV geographic and temporal dynamics. However, these modeling efforts have been disjointed with little model comparison and inconsistent validation. In this paper, we describe a framework to unify and standardize WNV modeling efforts nationwide. WNV risk, detection, or warning models for this review were solicited from active research groups working in different regions of the United States. A total of 13 models were selected and described. The spatial and temporal scales of each model were compared to guide the timing and the locations for mosquito and virus surveillance, to support mosquito vector control decisions, and to assist in conducting public health outreach campaigns at multiple scales of decision-making. Our overarching goal is to bridge the existing gap between model development, which is usually conducted as an academic exercise, and practical model applications, which occur at state, tribal, local, or territorial public health and mosquito control agency levels. The proposed model assessment and comparison framework helps clarify the value of individual models for decision-making and identifies the appropriate temporal and spatial scope of each model. This qualitative evaluation clearly identifies gaps in linking models to applied decisions and sets the stage for a quantitative comparison of models. Specifically, whereas many coarse-grained models (county resolution or greater) have been developed, the greatest need is for fine-grained, short-term planning models (m–km, days–weeks) that remain scarce. We further recommend quantifying the value of information for each decision to identify decisions that would benefit most from model input.

60 APPLIED LIFE SCIENCES↗

Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS) Final Report

The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals, our specific aims are to:1.) Increase the value and information content of AMS measurements by combining molecular speciation with quantitation of defined macromolecular isolates. Specifically, develop and validate methods for macromolecule labeling, characterization and quantitation.2.) Develop and validate methods and strategies to enable AMS to become more broadly used in human studies. Specifically, demonstrate robust methods for conducting pharmacokinetic/pharmacodynamics studies in humans and model systems.3.) Increase the accessibility of AMS to the Biomedical research community and the throughput of AMS through direct coupling to separatory instruments.4.) Provide high throughput 14C BioAMS analysis for collaborative and service clients.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Rapid Computational Identification of Therapeutic Targets for Pathogens

Biological threats continue to persist and evolve as an important challenge to national security. There are multiple ways in which novel viral pathogens could emerge to pose a serious threat to human health. This project developed a pathogen target identification tool that can rapidly respond to a novel or emerging viral biological threat. A set of computational tools were developed that provide detailed information on the newly sequenced genes, their protein products and the drug target sites for the proteins that are best suited for biological countermeasure development. Three key innovations were developed in the project. 1) Development of a new extensive database of protein pocket structures with structure-based search algorithms to rapidly link novel protein targets with the complete collection of previously experimentally solved protein structures. 2) A novel clustering pipeline was introduced to group matching structures and associated small-molecule binding ligands into a consensus protein pocket with the associated small-molecule chemotypes predicted to fit in the pocket site. The matching experimentally solved structures were used to inform the value of different target sites. 3) Where there are viral protein targets with pockets structurally matched to similar human proteins, a biological knowledge graph, which links molecular interactions with human disease, was used to further assess the potential negative impact of a viral protein target with similarities to human proteins that could have important off target side effects. In total, the project produced a new resource for rapid and detailed assessment of promising targets for countermeasures, reflecting the ongoing wet lab, clinical, and computational data being collected. These capabilities will improve the ability to respond to a biological threat in multiple domains.

59 BASIC BIOLOGICAL SCIENCES↗

Quality Guidelines for Energy System Studies: Process Modeling Design Parameters

The National Energy Technology Laboratory (NETL) conducts systems analysis studies that require a large number of inputs, from ambient conditions to parameters for Aspen Plus ® (Aspen) process blocks. The sheer number of assumptions required makes it impractical to document all of them in each issued report. The purpose of the Quality Guidelines for Energy System Studies (QGESS) is to document the assumptions most commonly used in system analysis studies and the basis for those assumptions. In order to develop the systems analysis models presented in various NETL reports, significant vendor data have been obtained, and these data enhance the model outputs. Much of the vendor data obtained are considered proprietary and not suitable for public release or attribution to a specific vendor. As such, several sub-systems common in NETL reports and their process parameter data are not reported in this document to protect proprietary vendor information. The values and ranges of values presented in this report represent assumptions that have been made in previous studies.

97 MATHEMATICS AND COMPUTING↗

OB200-DV-1 Treatability Testing: Final Results

The Hanford Site in Washington state previously generated plutonium for nuclear weapons. During operations, radionuclide byproducts and chemical process fluids were intentionally and/or unintentionally released to the subsurface, resulting in more than 800 contaminated waste sites across the Central Plateau, where historical chemical separations and waste management activities took place. As the Hanford Site mission transitioned from operations to site cleanup, remediation of the vadose zone and groundwater became a priority. However, given the depth of the unsaturated zone contamination above the groundwater, the unique nature of the waste, and the continuing impacts on groundwater quality, technologies needed to be identified and evaluated for in situ remediation in the deep vadose zone (DVZ). A laboratory treatability study has been completed to evaluate site-relevant effectiveness for nine in situ technologies that may be used to treat continuing sources of contaminants in specific areas of the Central Plateau waste sites that are grouped into the 200-DV-1 Operable Unit (OU). The 200-DV-1 OU was established in 2010 to address 43 Central Plateau waste sites with complex DVZ remediation challenges. Eight of these technologies were identified through a prescreening effort that evaluated remedial technologies potentially applicable to DVZ contamination in the Central Plateau . These eight technologies were selected for further study based on site specific knowledge gaps about their effectiveness. A ninth technology was added to the treatability study based on new information from separate laboratory investigations (conducted following the prescreening effort) demonstrating the technology’s potential effectiveness (see Section 1.2 for more information) and value for inclusion in the treatability study.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Dark Energy Survey Year 6 Results: Photometric Dataset for Cosmology

We describe the photometric dataset assembled from the full 6 yr of observations by the Dark Energy Survey (DES) in support of static-sky cosmology analyses. DES Y6 Gold is a curated dataset derived from DES Data Release 2 (DR2) that incorporates improved measurement, photometric calibration, object classification and value-added information. Y6 Gold comprises nearly 5000 deg$^{2}$ of grizY imaging in the south Galactic cap and includes 669 million objects with a depth of i$_{AB}$ ∼ 23.4 mag at a signal-to-noise ratio ∼ 10 for extended objects and a top-of-the-atmosphere photometric uniformity <2 mmag. Y6 Gold augments DES DR2 with simultaneous fits to multiepoch photometry for more robust galaxy shapes, colors, and photometric redshift estimates. Y6 Gold features improved morphological star–galaxy classification with an efficiency of 98.6% and a contamination of 0.8% for galaxies with 17.5 < i$_{AB}$ < 22.5. Additionally, it includes per-object quality information, and accompanying maps of the footprint coverage, masked regions, imaging depth, survey conditions, and astrophysical foregrounds that are used for cosmology analyses. After quality selections, benchmark samples contain 448 million galaxies and 120 million stars. This publication is complemented by data access and documentation.

79 ASTRONOMY AND ASTROPHYSICS↗

Powertrain control system and method of operating the same

A system and method are provided for operating a powertrain control system. The method includes receiving data measured from a plurality of sensors, the measured data relating to distance dependent speed values, and receiving information from one or more vehicle modules, the vehicle module information relating to distance independent speed values. The method further includes building a speed trajectory profile for a horizon window that includes a plurality of speed change regions represented by at least some distance dependent speed values or at least some distance independent speed values, and creating a synthesized speed profile for the horizon window by processing the speed trajectory profile. The synthesized speed profile optimizes efficiency of the powertrain control system at each of the plurality of speed change regions.

33 ADVANCED PROPULSION SYSTEMS↗

High Spatial Resolution Mapping of Retained Fission Gas

Fission gas isotopic analysis provides quantitative high precision determination of irradiated nuclear fuel burnup, offers diagnostic value, and informs fuel performance models. A measurement capability has been developed at Idaho National Laboratory (INL) for the release of retained fission gas using a focused laser and static noble gas mass spectrometry (MS) analysis. This high resolution (10s microns spot size) capability was demonstrated using Xe implanted metal foils.

07 - ISOTOPES AND RADIATION SOURCES↗

Explainable Artificial Intelligence Technology for Predictive Maintenance

The domestic nuclear power plant fleet has relied on labor-intensive and time-consuming preventive maintenance programs, thus driving up operation and maintenance costs to achieve high-capacity factors. Artificial intelligence and machine learning can help simplify complex problems, such as diagnosing equipment degradation, to enable more effective decision-making. Benefits will be felt not only within existing analog and digital instrumentation and control, but also work processes, the integration of people with technology, and most importantly, the business case. Together, these hold promise to make nuclear power more efficient and reduce costs associated with operation and maintenance. While the artificial intelligence and machine learning technologies hold significant promise in the nuclear industry, there are challenges or barriers to their adoption. This report outlines the those different machine learning adoption barriers (categorized as historical, technical, economic, regulatory, and user) that the industry must overcome to realize the full benefits of artificial intelligence and machine learning capabilities for long-term economic sustainability. This report also provides solutions for some of these barriers by focusing on improving the explainability of machine learning to encourage trust from the end-user. Trust and explainability are essential to machine learning adoption. This report focuses on research-developed solutions to some of these barriers while analyzing a non-safety-related system, namely the circulating water system. This system frequently experiences waterbox fouling which our models preemptively diagnoses then explains to the operator how those conclusions were reached. This report presents and discusses the inherent trade-off between machine learning performance (in terms of accuracy) and explainability, where highly accurate machine learning methods (such as deep-learning) are the least explainable, and the most explainable methods (such as decision trees) are the least accurate. In addition, explainability of artificial intelligence techniques in terms of transparency and post-hoc metrics are discussed. This report outlines the importance of data novelty and value of new information in evaluating both the explainability and trustworthiness. Novelty detection helps to establish consistency or inconsistency of the new data with respect to the training data. On the other hand, value of information could be a part of the user-centric visualization recommendation system that request additional information to be collected, thereby strengthening the machine learning outcomes. During this project, a copyrighted user-centric visualization that aligns with a human-in-the-loop approach was developed. The user-centric visualization presents different levels of information and can be tailored as per user credentials to gain user confidence. One of the salient features of the user-centric visualization is it presents machine learning methods with explainability metrics. A simplified version of the user-centric visualization was presented to 32 users with varying levels of machine learning expertise. Feedback was solicited to test the hypothesis that the app contained sufficient explainability and that the users would trust the algorithm. Overall, the app was positively received, and the hypothesis was supported. This report discusses the trust-but-verify framework – a potential approach to build user trust artificial intelligence. The framework discusses trust from the human level to artificial intelligence level. The fundamental premise of the trust but verify framework is derived from an observation of nuclear safety culture (i.e., nuclear power plant personnel do not rely on a singular source of data to make a decision). This also ties back to the user-centric visualization that presents different levels of information to achieve both explainability and trustworthiness of artificial intelligence. Even so, the adoption of artificial intelligence and machine learning in the nuclear industry faces additional barriers, namely regulatory and stakeholder readiness. To overcome these challenges, new solutions must gain regulatory approval and cater to stakeholder needs. The Nuclear Regulatory Committee has a 5-year strategic plan which prepares them for reviewing artificial intelligence technologies in licensee submissions. Early and frequent engagement with the regulator is encouraged. Additionally, artificial intelligence solutions should incorporate human-in-the-loop considerations and offer explainability. Stakeholders must prepare by hiring or training staff to adapt to advancing technology in everyday plant tasks.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Markov Process to Evaluate the Value Proposition of a Risk-Informed Predictive Maintenance Strategy

To achieve high-capacity factors, the nuclear fleet has relied on labor-intensive and time-consuming operation and preventive maintenance programs for plant systems. Manually performed inspection, calibration, testing, and maintenance of plant assets at periodic frequencies, along with time-based replacement of assets irrespective of condition, have resulted in a costly, labor-centric business model. Fortunately, there are technologies that can eliminate unnecessary preventive maintenance activities by deploying risk-informed predictive maintenance, enabling the transition to a technology-centric business model. The technology-centric business model will enable plants to optimize and automate maintenance activities, leading to cost reductions since labor is a rising cost and technology is a declining cost. The implementation of scalable technologies and methodologies across plant systems and across the nuclear fleet is critical for successful deployment of a risk-informed predictive maintenance strategy at commercial nuclear power plants. The work presented in the report is being developed as part of a collaborative research effort between Idaho National Laboratory and Public Service Enterprise Group Nuclear, LLC. This report describes the technical basis using the Markov Process to evaluate the value proposition for the risk-informed predictive maintenance strategy for the circulating water system. The plant process data from the Salem nuclear plant’s circulating water system is utilized to develop a Markov chain risk models and formulation to estimate the loss and gain in revenue based on plant availability. The outcomes presented in this report provides the technical basis for extensive quantitative evaluation of a scalable risk-informed predictive maintenance strategy as part of future research.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Fault isolation and fault-tolerant control for Takagi-Sugeno fuzzy time-varying delay stochastic distribution systems

A fault isolation, estimation, and fault-tolerant control (FTC) scheme for nonlinear time-varying delay stochastic distribution control systems was presented in this paper. The Takagi-Sugeno fuzzy model was adopted to approach the nonlinear dynamics of time-varying delay systems. According to the output equivalence principle and Laplace transformation, an augmented state vector was given to solve the time-varying delay problem. When multiple actuator faults and interference occur simultaneously, fault detection, isolation and fault estimation was designed to obtained the fault information. To decouple faults and obtain the value and location information of the fault, the system was separated into two parts through the designed multiple conversion matrices, in which one subsystem was only affected by one actuator fault. This has simplified the design of fault isolation and estimation. A adaptive observer for fault estimation was given. Then, fault information such as the time, location, and size was determined. The observer gain matrices were calculated using linear matrix inequality (LMI). When a fault was detected and diagnosed, a FTC algorithm was devised using the proportional-integral control scheme to compensate the fault as much as possible. It has been shown that even if multiple faults actuator occurred simultaneously, the FTC controller still ensured the output probability density function of the system traced the desired probability density function when a fault occurred. Finally, the expected results were obtained through the simulation example, which confirmed the effectiveness of the method.

42 ENGINEERING↗

Informing Cybersecurity Decisions With the Value-at-Risk Framework

Security at every site is critical to making hydropower a strong contributor to the country's grid, but with ongoing development and expanding capabilities, the diversity of the existing hydropower fleet makes across-the-board investment decisions difficult. The threat of cyberattacks naturally increases as the interconnection of Information Technology and Operational Technology networks broadens. Hydropower plants require custom analyses that are specific to the unique challenges and characteristics of any given facility. Facilities, however, often do not have the necessary resources for managers to make informed decisions on investments based on assessed capabilities and risks.

50 EE - Wind and Water Power Program - Water (EE-4↗