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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

Development and Validation of an Automated Simulation Capability in Support of Integrated Demand Management

Integrated Demand Management (IDM) is a near- to mid-term NASA concept that proposes to address mismatches in air traffic system demand and capacity by using strategic flow management capabilities to pre-condition demand into the more tactical Time-Based Flow Management System (TBFM). This paper describes an automated simulation capability to support IDM concept development. The capability closely mimics existing human-in-the-loop (HITL) capabilities, while automating both the human components and collaboration between operational systems, and speeding up the real-time aircraft simulations. Such a capability allows for parametric studies to be carried out that can inform the HITL simulations, identifying breaking points and parameter values at which significant changes in system behavior occur. The paper describes the initial validation of the automated simulation capability against results from previous IDM HITL experiments, quantifying the differences. The simulator is then used to explore the performance of the IDM concept under the simple scenario of a capacity constrained airport under a wide range of wind conditions.

Traffic Flow Management↗
NASA NTRS2017

Workload and Performance in Air Traffic Control: Exploring the Influence of Levels of Automation and Variation in Task Demand

In air traffic control, task demand and workload have important implications for the safety and efficiency of air traffic. Task demand is dynamic, however, research on demand transitions and associated controller perception and performance is limited. In addition, there is a comparatively restricted understanding of the influence of task demand transitions on workload and performance, in association with automation. This study used an air traffic control simulation to investigate the influence of task demand transitions and two conditions of varying automation, on workload and efficiency-related performance. Findings showed that a both the direction of the task demand variation, and the amount of automation, influenced the relationship between workload and performance. Further research is needed to enhance understanding of demand transition and workload history effects on operator experience and performance, in both air traffic control and other safety-critical domains.

air traffic control↗
NASA NTRS2018

Additive Construction with Mobile Emplacement (ACME) / Automated Construction of Expeditionary Structures (ACES) Materials Delivery System (MDS)

The purpose of the Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) project is to incorporate the Liquid Goods Delivery System (LGDS) into the Dry Goods Delivery System (DGDS) structure to create an integrated and automated Materials Delivery System (MDS) for 3D printing structures with ordinary Portland cement (OPC) concrete. ACES 3 is a prototype for 3-D printing barracks for soldiers in forward bases, here on Earth. The LGDS supports ACES 3 by storing liquid materials, mixing recipe batches of liquid materials, and working with the Dry Goods Feed System (DGFS) previously developed for ACES 2, combining the materials that are eventually extruded out of the print nozzle. Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) is a project led by the US Army Corps of Engineers (USACE) and supported by NASA. The equivalent 3D printing system for construction in space is designated Additive Construction with Mobile Emplacement (ACME) by NASA.

Mueller, R. P.↗
NASA NTRS2016

Multifactor Interactions and the Air Traffic Controller: The Interaction of Situation Awareness and Workload in Association with Automation

Air traffic controllers (ATCOs) must maintain a consistently high level of human performance in order to maintain flight safety and efficiency. In current control environments, performance-influencing factors such as workload, fatigue and situation awareness (SA) can co-occur, and interact, to affect performance. However, multifactor influences and the association with performance are under-researched. This study utilized a high fidelity human in the loop enroute air traffic control simulation to investigate the relationship between workload, situation awareness and ATCO performance. The study aimed to replicate and extend Edwards, Sharples, Wilson and Kirwan's (2012) previous study and confirm multifactor interactions with a participant sample of ex-controllers. The study also aimed to extend Edwards et al.'s previous research by comparing multifactor relationships across 4 automation conditions. Results suggest that workload and SA may interact to produce a cumulative impact on controller performance, although the effect of the interaction on performance may be dependent on the context and amount of automation present. Findings have implications for human-automation teaming in air traffic control, and the potential prediction and support of ATCO performance.

Workload↗
NASA NTRS2019

Development and Analysis of the Automated Object Reentry Survival Analysis Tool Parametric Study Wrapper

The NASA Orbital Debris Program Office (ODPO) Safety Group at the Johnson Space Center analyzes reentering spacecraft at the end of life. The program primarily used by ODPO in this effort is the Object Reentry Survival Analysis Tool (ORSAT). ORSAT utilizes shape primitives as well as a variety of other parameters (material, size, thickness, aerodynamic mass, orbit inclination, etc.) to simulate the reentry process and ultimately, to determine if a spacecraft could be hazardous to the population on the ground. The NASA ODPO plans to automate the ORSAT process to run multiple ORSAT input files either concurrently or consecutively. This type of automation program will provide several benefits. First, there is a need to run large parametric studies for ORSAT analysts to gain a greater understanding of reentering object’s sensitivity to certain input variables. Secondly, a database of pre-run ORSAT cases will be used to develop a survivability model, which could be made available to spacecraft developers as a design for demise (D4D) tool. The recently completed Automated Object Reentry Survival Analysis Tool (AutoORSAT) Wrapper is currently being used to build a survivability database, the first step in developing a survivability model. Already, the data that AutoORSAT has produced provides a greater understanding of the sensitivity of variables such as the initial temperature of the spacecraft, spacecraft breakup altitude, and the aerodynamic mass of spacecraft.

Smith, Andrew N.↗
NASA NTRS2019

Integrated Design and Manufacturing Analysis for Automated Fiber Placement Structures

Automated fiber placement provides many advancements beyond traditional hand layups in terms of efficiency and reliability. However, there are also a variety of unique challenges that arise with automated fiber placement technology. In particular, steering of tows over doubly-curved tool surfaces can result in material overlaps and gaps due to path convergence/divergence, fiber angle deviation, as well defects in the tows themselves such as puckers and wrinkles. Minimization of these defects is traditionally considered a task for the manufacturing discipline. Manufacturing specifications are often created for these defects based on laminate testing and can be inflexible to avoid more tests. Recent efforts have been made under the National Aeronautics and Space Administration (NASA) Advanced Composites Project (ACP) to develop software tools and processes that provide automated coupling between design and manufacturing disciplines. The objective of this coupling is to provide information to the design discipline on the manufacturability of a laminate while the laminate is being designed. A variety of software tools, both existing commercial tools and research tools under development, will be used to achieve this objective: HyperSizer for laminate optimization, the Computer Aided Process Planning module for selection of manufacturing process parameters, Vericut Composite Programming for tow path simulation, and COMPRO for deposition and cure defects. The newly developed “Central Optimizer” tool will be used to tie the modules together and drive the design for manufacturing process.

Noevere, August↗
NASA NTRS2020

Design for Manufacturing Tool for Automated Fiber Placement Structures - Verification and Validation

A tool has been developed to address the growing Design for Manufacturing needs for composite structures, specifically those manufactured with automated fiber placement. This manufacturing approach presents unique challenges associated with puckers and wrinkling, tow overlaps and gaps, fiber deviation, and laminate strength. Achieving a satisfactory laminate design usually requires finding compromises between those four areas. The developed tool, dubbed the Central Optimizer, assists with the process of balancing competing design metrics in automated fiber placement. This tool was developed under the NASA Advanced Composites Consortium with input from industry partners. Under this program, the Central Optimizer has been exercised on three different structures to verify its functionality and validate ability to improve the design process for automated fiber placement structures.

August T Noevere↗
NASA NTRS2020

Ground-Based Automated Scheduling for the Mars 2020 Rover

The Mars 2020 Rover Mission will be using an automated ground-based scheduling system called Copilot to schedule the rover’s activities at landing. Using automated scheduling technology will allow for plans to be generated more quickly. Because automated scheduling tools have not been widely used for prior rover missions, developing users’ trust in the system is crucial. An explainable scheduling tool called Crosscheck has been developed to visualize the creation of a schedule, and to explain why activities failed to schedule given their constraints. This will allow science planners to change activity constraints to allow failed activities to successfully schedule, achieving their science goals.

Towey, S.↗
NASA NTRS2021

Ground-based Automated Scheduling for Operations of the Mars 2020 Rover Mission

The National Aeronautics and Space Administration’s (NASA) Mars 2020 Rover, named Perseverance, landed on the surface of Mars in Jezero Crater on February 18, 2021. Since the landing, the rover’s activities have been planned with the aid of a ground-based automated scheduling system called Copilot. Automated scheduling is very rare for planetary rover missions. Historically humans have created a schedule manually and ensured that the schedule satisfied all constraints. Higher levels of automation in the system allows science planners to produce schedules for the rover more quickly. In addition to scheduling user-provided activities, Copilot generates and schedules two types of support activities: sleep activities and heating activities. Some activities require the CPU to be on as they execute, so Copilot schedules wakeups and shutdowns of the CPU at the appropriate times. Some activities require areas of the rover to be heated before they can execute, and that heating must be maintained throughout the duration of the activity. Copilot schedules the preheat and maintenance heating activities for the user-provided activities that require them. To facilitate Copilot usage, the Crosscheck tool shows the science planners how Copilot constructed a schedule. For activities that fail to be scheduled, Crosscheck gives information on the constraints that the activity would have violated. This gives the users insight into how to change the input activities and constraints in order to achieve a schedule that satisfies their goals.

Towey, Shannon↗
NASA NTRS2023

Automated Fluidics Device for Extraction and Quantification of miRNA Biomarkers From Blood

Radiation Assessment DuRing Exposure And long-Duration Spaceflight (RADREADS) demonstrates space-compatible point-of-care technology for quantitative biological monitoring of blood miRNA biomarkers in response to long-term low dose radiation exposure. This individualized monitoring approach will inform targeted treatment strategies to maximize medical resource utilization by accounting for individual susceptibility to radiation-related illnesses. As human spaceflight progresses beyond Earth’s magnetic shielding, radiation exposure poses a significant risk to astronaut health and safety. Extended operation in this environment comes with an increased risk of radiation exposure, leading to higher risks of radiation sickness, cancer, central nervous system effects, and degenerative diseases. While conventional physical dosimetry techniques capture radiation dose, individualistic susceptibility to radiation damage is varied. Multiple characteristics, including age, body weight, sex, genetics, and immune status, have been found to influence radiosensitivity (Liu et al. 2011, and Bouffler 2016). This differential response necessitates individualized monitoring and targeted treatment strategies to maximize medical resource utilization; however, a practical diagnostic platform for quantifying long-term, low dose radiation-induced tissue damage does not currently exist. MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression by mediating the degradation of messenger RNA. The levels of particular miRNAs are influenced by biological processes such as inflammation and serve as biomarkers for a variety of conditions including cancer (Singh et al. 2017). MicroRNAs are found in various bodily fluids and are amenable to collection via liquid biopsies, providing a minimally invasive and easily quantifiable readout for a variety of radiosensitive reporters. A preliminary signature of 15 spaceflight sensitive miRNA has been identified in rodent and human studies, including miR-21-5p, miR-24-3p, miR-92a-3p, miR-17-5p, miR-16a-3p, miR-34a-3p, and miR-223-3p. These targets generally increased expression with radiation dose and linear energy transfer, though variation between individuals is not yet described. Current gaps in the field include a lack of understanding of longitudinal biological responses to long-term, low dose radiation exposure and the absence of space-compatible point-of-care technology for quantitative biological monitoring. In this body of work, we aim to develop an automated bleed-to-read system to process whole blood for the detection of miRNA biomarkers in order to monitor individualistic responses to radiation exposure. This will be achieved via separating serum (or plasma) from whole blood, followed by extraction, amplification, and quantification of the miRNA using a RT-qPCR reaction. Previously, the WetLab-2 hardware enabled execution of a RT-qPCR reaction aboard ISS; however, it is a manual system that requires crew manipulation and bulky components (Parra et al. 2017). To address these issues, automated fluid handling hardware was developed for each stage of sample preparation. Extraction of total RNA is achieved by sequentially pumping reagents through an off-the-shelf nucleic acid binding column (miRNeasy Serum/Plasma Advanced Kit, Qiagen). This approach eliminates several manual pipetting and centrifuging steps and limits the use of toxic chemicals commonly found in other sample processing techniques. The resulting elution will then be automatically dispensed for RT-qPCR analysis using a compact rotary qPCR (Mic qPCR Cycler, Bio Molecular Systems) that will improve spaceflight compatibility by removing bubbles from the detection region, another challenge highlighted by WetLab-2 (Parra et al. 2017). Efforts are also being made to simplify the RT-qPCR reaction to a 1-step air-dryable mix to improve long-term reagent stability at room temperature and reduce system complexity. By automating the RT-qPCR processes via microfluidic manipulation, RADREADS will reduce crewmember hands-on time and enable the personalized detection of radiation-induced tissue damage during long duration missions. Minimally invasive, longitudinal monitoring of individual’s response to radiation exposure will inform how the physiological system responds to long-term low dose space radiation and enables development of targeted countermeasures by the medical team. Ultimately, this portable technology will require minimal technical expertise and can also be used to monitor miRNA biomarkers associated with other diseases.

Tristen Head↗
NASA NTRSDate not supplied

Automated Unstructured Grid Adaptation on a Strut Fuel Injector at Hypervelocity Flow Conditions

Computational fluid dynamics (CFD) analysis is presented with the use of an automated unstructured grid adaptation tool on a strut fuel injector at hypervelocity flow conditions. The analysis was carried out with the VULCAN-CFD solver using Reynolds-averaged simulations (RAS). The hypervelocity flow conditions match the high Mach number flow of the experiments conducted as part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center (LaRC). The current work utilizes an automated grid adaptation tool recently implemented into VULCAN-CFD, and explores this tool’s ability to solve high-speed mixing problems. Simulation results obtained using the unstructured adaptive grid approach are compared to those on a user generated structured grid. These results are evaluated by analyzing how efficiently comparable fidelity results are obtained from both adapted and structured simulations. In addition, two adaptation strategies were used to explore the impact on the final solution. In the current work, the unstructured grid adaptation tool automatically generates unstructured grids and performs adaptation of the grid based on a Hessian error estimate of a specified flow field parameter. Multiple adaptations were executed using each run strategy with the one-dimensional values of the mixing efficiency used to determine grid convergence and for comparison with the structured grid simulation results. It was found that the unstructured adaptive grid simulations were able to produce results that matched closely with those on structured grids using far fewer grid cells, and thus, requiring far less computational time to reach the solution. It was also discovered that the adaptation run strategy influenced the total number of grid cells and the efficiency with which a final grid-adapted solution was reached. Overall, the investigation demonstrated that the automated unstructured grid adaptation tool implemented in VULCAN-CFD is capable of accurately and efficiently solving complex highspeed mixing problems using only a fraction of the grid cells required to obtain comparable results using a user-generated structured grid.

grid adaptation↗
NASA NTRSDate not supplied

Helicopter Pilot Assessments of the Airborne Collision Avoidance System XR With Automated Maneuvering

The Airborne Collision Avoidance System X (ACAS X) is a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant – referred to as ACAS XR – is designed to accommodate existing helicopter platforms as well as in-development, electric vertical takeoff and landing concepts, which are critical to the emerging concept of operations referred to as Advanced Air Mobility. The fundamental role of ACAS XR is to provide Detect and Avoid (DAA) and/or Collision Avoidance (CA) protection against airborne traffic. DAA alerting and guidance in the context of ACAS XR is caution-level and “suggestive,” and is to be used by the pilot if, and when, they decide to maneuver against an identified threat to DAA “well clear.” The CA alerting, by contrast, is warning-level and “directive,” with the pilot required to comply with the associated guidance to prevent a predicted Near Midair Collision (NMAC). The CA alerts generated by ACAS XR are referred to as Resolution Advisories (RAs) consistent with previous CA systems. Unlike earlier CA systems, ACAS XR issues RAs in the horizontal and vertical dimensions as well as multi-axis RAs (referred to as “Blended” RAs). According to the Minimal Operational Performance Standards of DAA systems for Unmanned Aircraft Systems, maneuvers to comply with RAs may be automated, whereas maneuvers based on DAA alerting assume a manual response. The current study was a human-in-the-loop simulation that presented rotorcraft pilots with ACAS XR alerts and guidance in a fixed-base eVTOL simulator with varying levels of automation. Objective results showed that pilots complied with all RAs within the expected 5-second time window and responded to DAA alerts quicker than in earlier studies with ACAS XU. Pilots often made larger horizontal deviations during Manual RAs, but often favored vertical and blended maneuvers. No NMACs occurred, and losses of well clear were mainly attributed to the obligation of the pilots and system to maneuver only after the CA phase of the encounter had begun. Other losses were due to pilots’ noncompliance or disregard for ACAS XR’s alerting and guidance. Noncompliance with RAs most frequently occurred when pilots determined they were too close to the terrain to continue to follow Descend RAs, performing vertical maneuvers instead of following Horizontal RAs, or rejecting Horizontal RA updates because they felt that enough maneuvering had been performed. Subjectively, pilots found the DAA and RA alerting and guidance intuitive and useful for VFR helicopter operations. Slightly more pilots preferred the Automated RA condition to the Manual RA condition. Lastly, they also felt that ACAS led to occasional unsafe Descend RAs. Caveats and future implications are discussed.

eVTOL↗
NASA NTRSDate not supplied

Helicopter Pilot Assessments of the Airborne Collision Avoidance System XR With Automated Maneuvering

The Airborne Collision Avoidance System X (ACAS X) is a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant – referred to as ACAS XR – is designed to accommodate existing helicopter platforms as well as in-development, electric vertical takeoff and landing concepts, which are critical to the emerging concept of operations referred to as Advanced Air Mobility. The fundamental role of ACAS XR is to provide Detect and Avoid (DAA) and/or Collision Avoidance (CA) protection against airborne traffic. DAA alerting and guidance in the context of ACAS XR is caution-level and “suggestive,” and is to be used by the pilot if, and when, they decide to maneuver against an identified threat to DAA “well clear.” The CA alerting, by contrast, is warning-level and “directive,” with the pilot required to comply with the associated guidance to prevent a predicted Near Midair Collision (NMAC). The CA alerts generated by ACAS XR are referred to as Resolution Advisories (RAs) consistent with previous CA systems. Unlike earlier CA systems, ACAS XR issues RAs in the horizontal and vertical dimensions as well as multi-axis RAs (referred to as “Blended” RAs). According to the Minimal Operational Performance Standards of DAA systems for Unmanned Aircraft Systems, maneuvers to comply with RAs may be automated, whereas maneuvers based on DAA alerting assume a manual response. The current study was a human-in-the-loop simulation that presented rotorcraft pilots with ACAS XR alerts and guidance in a fixed-base eVTOL simulator with varying levels of automation. Objective results showed that pilots complied with all RAs within the expected 5-second time window and responded to DAA alerts quicker than in earlier studies with ACAS XU. Pilots often made larger horizontal deviations during Manual RAs, but often favored vertical and blended maneuvers. No NMACs occurred, and losses of well clear were mainly attributed to the obligation of the pilots and system to maneuver only after the CA phase of the encounter had begun. Other losses were due to pilots’ noncompliance or disregard for ACAS XR’s alerting and guidance. Noncompliance with RAs most frequently occurred when pilots determined they were too close to the terrain to continue to follow Descend RAs, performing vertical maneuvers instead of following Horizontal RAs, or rejecting Horizontal RA updates because they felt that enough maneuvering had been performed. Subjectively, pilots found the DAA and RA alerting and guidance intuitive and useful for VFR helicopter operations. Slightly more pilots preferred the Automated RA condition to the Manual RA condition. Lastly, they also felt that ACAS led to occasional unsafe Descend RAs. Caveats and future implications are discussed.

eVTOL↗
NASA NTRSDate not supplied

Integration of Automated Systems (IAS) Flight Test Overview

The Integration of Automated Systems (IAS) Project is conducting a series of 2023 flight tests supporting NASA's Advanced Air Mobility (AAM) and National Campaign efforts. These flights include crewed, test (i.e., ownship) and traffic (i.e., intruder) aircraft that will fly with unique technologies onboard. The presentation will include overviews of the Hazard Perception and Avoidance (HPA) and Flight Path Management (FPM) technical areas but will focus primarily on HPA. HPA will test the FAA's Airborne Collision Avoidance System X (ACAS X), a next-generation collision avoidance tool developed to support different aircraft types and operations. The rotorcraft variant, ACAS Xr, is designed to accommodate existing helicopter platforms and in-development, vertical takeoff and landing (VTOL) concepts, which are critical to the emerging AAM concept of operations. Two configurations of ACAS Xr will be examined: Collision Avoidance System (CAS, similar to the Traffic Collision Avoidance System [TCAS] II) and Detect and Avoid (DAA, previously developed to provide added situational awareness for uncrewed aircraft). Additionally, this system will be explored during cruise and low-speed flight as well as flights within en-route, structured (i.e., dense/urban), and terminal airspaces. Scripted flight conflicts will be conducted, and these conflicts will be mitigated through maneuvers that are manual (i.e., performed by the pilots) or automated (i.e., achieved by the cooperation of the program middleware and onboard ownship systems). Objective data will be collected involving system and pilot performance as well as pilot decisions; subjective data will include pilot opinions of ACAS Xr's alerting and guidance as well as the automated maneuvers.

detect and avoid↗
NASA NTRSDate not supplied

Automated Unstructured Grid Adaptation on a Strut Fuel Injector at Hypervelocity Flow Conditions

Computational fluid dynamics (CFD) analysis is presented with the use of an automated unstructured grid adaptation tool on a strut fuel injector at hypervelocity flow conditions. The analysis was carried out with the VULCAN-CFD solver using Reynolds-averaged simulations (RAS). The hypervelocity flow conditions match the high Mach number flow of the experiments conducted as part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center (LaRC). The current work uses an automated grid adaptation tool recently implemented in VULCAN-CFD, and explores this tool’s ability to solve highspeed mixing problems. Simulation results obtained using the unstructured adaptive grid approach are compared to those on a user-generated structured grid. These results are evaluated by analyzing how efficiently comparable fidelity results are obtained from both adapted and structured simulations. In addition, two adaptation strategies were used to explore the impact on the final solution. In the current work, the unstructured grid adaptation tool automatically generates unstructured grids and performs adaptation of the grid based on a Hessian error estimate of a specified flowfield parameter. Multiple adaptations were executed using each run strategy with the one-dimensional values of the mixing efficiency used to determine grid convergence and for comparison with the structured grid simulation results. It was found that the unstructured adaptive grid simulations were able to produce results that matched closely with those on structured grids using far fewer grid cells, and thus, requiring far less computational time to reach the solution. It was also discovered that the adaptation run strategy influenced the total number of grid cells and the efficiency with which a final grid-adapted solution was reached. Furthermore, motivated by the grid convergence index (GCI) used for structured grid simulations, a grid convergence estimate (GCE) was developed and demonstrated for the grid adaptation. Overall, the investigation demonstrated that the automated unstructured grid adaptation tool implemented in VULCAN-CFD is capable of accurately and efficiently solving complex high-speed mixing problems with only a fraction of the grid cells required to obtain comparable results on a user-generated structured grid.

hypersonics↗
NASA NTRSDate not supplied

Automated Unstructured Grid Adaptation on a Strut Fuel Injector at Hypervelocity Flow Conditions

Computational fluid dynamics (CFD) analysis is presented with the use of an automated unstructured grid adaptation tool on a strut fuel injector at hypervelocity flow conditions. The analysis was carried out with the VULCAN-CFD solver using Reynolds-averaged simulations (RAS). The hypervelocity flow conditions match the high Mach number flow of the experiments conducted as part of the Enhanced Injection and Mixing Project (EIMP) at the NASA Langley Research Center (LaRC). The current work uses an automated grid adaptation tool recently implemented in VULCAN-CFD, and explores this tool’s ability to solve highspeed mixing problems. Simulation results obtained using the unstructured adaptive grid approach are compared to those on a user-generated structured grid. These results are evaluated by analyzing how efficiently comparable fidelity results are obtained from both adapted and structured simulations. In addition, two adaptation strategies were used to explore the impact on the final solution. In the current work, the unstructured grid adaptation tool automatically generates unstructured grids and performs adaptation of the grid based on a Hessian error estimate of a specified flowfield parameter. Multiple adaptations were executed using each run strategy with the one-dimensional values of the mixing efficiency used to determine grid convergence and for comparison with the structured grid simulation results. It was found that the unstructured adaptive grid simulations were able to produce results that matched closely with those on structured grids using far fewer grid cells, and thus, requiring far less computational time to reach the solution. It was also discovered that the adaptation run strategy influenced the total number of grid cells and the efficiency with which a final grid-adapted solution was reached. Furthermore, motivated by the grid convergence index (GCI) used for structured grid simulations, a grid convergence estimate (GCE) was developed and demonstrated for the grid adaptation. Overall, the investigation demonstrated that the automated unstructured grid adaptation tool implemented in VULCAN-CFD is capable of accurately and efficiently solving complex high-speed mixing problems with only a fraction of the grid cells required to obtain comparable results on a user-generated structured grid.

hypersonics↗
DOE OSTI2025

Leveraging Large Language Models for Real-World Data Evidence: A Framework for Automated Treatment Extraction and Data Harmonization

Background: The ability to comprehensively collect treatment information from cancer patient medical records would enable studies to evaluate real-world benefits and risks tied to specific treatments. Currently, it is difficult to system- atically collect high-quality treatment information because it is often stored in unstructured text. Manually extracting and standardizing drug and regimen data is time-intensive. Recent advances in large language models (LLMs) offer a potential solution for automated extraction of structured treatment information from clinical text. Objective: This study systematically evaluates the utility of four LLMs from the Llama family for automated extraction of oncology treatment information from clinical text. This information can guide researchers using cancer registry data to provide insights into cancer care and outcomes beyond clinical trials. Methods: Four instruction-tuned Llama models with varying parameter counts (1B, 3B, 8B, and 70B) were evaluated for their ability to extract treatment information from clinical documents. A unified oncology knowledge base integrating seven major public data sources was developed to standardize and normalize extracted entities—a critical step for harmonizing data from diverse sources. Extracted treatment data were compared against expert-annotated ground truth. Model performance was assessed using accuracy metrics (Precision, Recall, F1-Score) and opera- tional feasibility metrics, including processing speed and structural compliance of the output. Results: A strong positive correlation was observed between model size and extraction accuracy. F1-score improved from 0.609 for the 1B model to 0.710 (3B), 0.807 (8B), and 0.828 (70B). While larger models demonstrated superior accuracy and compliance, they incurred higher computational costs. The modest performance difference between 8B and 70B suggests diminishing returns with increasing model size. Conclusions: LLMs represent a viable technology for automating oncology treatment extraction. The 8B-parameter model emerged as a highly effective option, balancing high accuracy and computational efficiency. Selecting an appropriate LLM for deployment in cancer registries involves a trade-off between desired accuracy and available operational resources. Harmonizing extracted entities with the oncology knowledge base facilitates standardized integration into common data models, enhancing data quality for real-world evidence analyses.

artificial intelligence↗