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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRSDate not supplied

Sensitivity Analysis of the Human Research Program’s Impact 1.0 Model

Sensitivity analysis estimates the relative contribution of the uncertainty in input values to the uncertainty of model outputs. Partial Rank Correlation Coefficient (PRCC) and Leave One Out (LOO) are methods of conducting sensitivity analysis on non-linear simulation models like the IMPACT Model. The PRCC method estimates the sensitivity using partial correlation of the ranks of the generated input values to each generated output value. The “partial” part is due to the adjustments made for the linear effects of all the other input values in the calculation of correlation between a particular input and each output. LOO removes a medical condition from test suite and calculates the change in the outcome. This is used to identify the influence of the condition input in the model The inputs to the sensitivity procedures include the number of occurrences of each of the one hundred plus IMPACT medical conditions generated over the simulations, and the IMPACT outputs from the MEDPRAT mathematical model. The outputs total task time lost (TTL), number of return to definitive care (RTDC), and number of loss of crew lives (LOCL). The IMPACT team will report the results of using PRCC and LOO on IMPACT 1.0. Tornado plots will assist in the visualization of the condition-related input sensitivities to each of the main outcomes. The outcomes of this sensitivity analysis will drive review focus by identifying conditions where changes in uncertainty, and input values could drive changes in overall model output uncertainty. These efforts are an integral part of the overall verification, validation, and credibility review of IMPACT 1.0.

Sensitivity Anaylsis↗
NASA NTRS2024

Evolution of Spaceflight Renal Stone Risks and Update to the NASA Human Research Program (HRP) Renal Stone Evidence Report and Integrated Concept of Operations

BACKGROUND: The NASA HRP Evidence Report on the Risk of Renal Stone Formation is being updated based on new information obtained from 9 years of data from NASA’s astronaut renal stone surveillance program. In addition, the Concept of Operations for missions beyond Low Earth Orbit (LEO) was created to supplement the Evidence Report, and the NASA clinical practice guideline(CPG)for renal stone surveillance was updated. OVERVIEW: A literature review was performed to evaluate the state of literature regarding renal stone prevention, mitigation, and management both in terrestrial and spaceflight environments. Current renal stone treatment guidelines for the ISS, which were created by the Inflight Clinical Medicine Working Group and approved by the Multilateral Medical Operations Panel (MMOP)were reviewed, as well as recent ultrasound technology demonstrations onboard the ISS. This information was used in conjunction with emerging evidence from the surveillance program to update the Evidence Report and in-flight Concept of Operations. DISCUSSION: There are known and emerging renal stone prevention strategies including astronaut selection, the use of medications and resistive exercise, early diagnosis with regular urine studies and ultrasound imaging. In-flight treatment options include pharmaceuticals, use of lithotripsy and propulsive ultrasound, placement of percutaneous drains and other modalities. This information is useful to gauge future risks and update our strategies for prevention and management of renal stones in astronauts to reduce the risk of in-flight renal stone colic that could cause morbidity and mission impact.

E Stratton↗
NASA NTRSDate not supplied

Human Research Program

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Steven H Platts↗
NASA NTRSDate not supplied

Human Research Program

Explore the source record for details and available documents.

Steven H Platts↗